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EA200601578A1 - Стабильные фармацевтические растворы для дозированных ингаляторов под давлением - Google Patents

Стабильные фармацевтические растворы для дозированных ингаляторов под давлением

Info

Publication number
EA200601578A1
EA200601578A1 EA200601578A EA200601578A EA200601578A1 EA 200601578 A1 EA200601578 A1 EA 200601578A1 EA 200601578 A EA200601578 A EA 200601578A EA 200601578 A EA200601578 A EA 200601578A EA 200601578 A1 EA200601578 A1 EA 200601578A1
Authority
EA
Eurasian Patent Office
Prior art keywords
under pressure
stable pharmaceutical
pharmaceutical solutions
hydroxy
dosed
Prior art date
Application number
EA200601578A
Other languages
English (en)
Other versions
EA010311B1 (ru
Inventor
Дэвид Льюис
Дэвид Гандертон
Брайан Миакин
Маурицио Дельканале
Фаусто Пиветти
Original Assignee
Кьези Фармачеутичи С. П. А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кьези Фармачеутичи С. П. А. filed Critical Кьези Фармачеутичи С. П. А.
Publication of EA200601578A1 publication Critical patent/EA200601578A1/ru
Publication of EA010311B1 publication Critical patent/EA010311B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0222—Materials for reducing friction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Аэрозольные составы в виде раствора для применения в аэрозольном ингаляторе, которые содержат 8-гидрокси-5-[(1R)-1-гидрокси-2-[[(1R)-2-(4-метоксифенил)-1-метилэтил]амино]этил]-2(1Н)-хинолинон или его соль, в частности гидрохлоридную соль (ТА 2005), в качестве активного ингредиента, пропеллент, содержащий гидрофторалкан, и сорастворитель, стабилизированные путём добавления конкретного небольшого количества высококонцентрированной фосфорной кислоты и, возможно, за счёт применения подходящего контейнера, вся внутренняя металлическая поверхность которого или её часть облицована инертным органическим покрытием.
EA200601578A 2004-02-27 2005-02-25 Состав аэрозоля, дозированный ингалятор под давлением и способ его заполнения EA010311B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54779804P 2004-02-27 2004-02-27
EP04011424A EP1595531A1 (en) 2004-05-13 2004-05-13 Stable pharmaceutical solution formulations for pressurized metered dose inhalers
PCT/EP2005/002042 WO2005084640A1 (en) 2004-02-27 2005-02-25 Stable pharmaceutical solution formulations for pressurized metered dose inhalers

Publications (2)

Publication Number Publication Date
EA200601578A1 true EA200601578A1 (ru) 2007-02-27
EA010311B1 EA010311B1 (ru) 2008-08-29

Family

ID=34924994

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601578A EA010311B1 (ru) 2004-02-27 2005-02-25 Состав аэрозоля, дозированный ингалятор под давлением и способ его заполнения

Country Status (12)

Country Link
US (1) US7381402B2 (ru)
EP (2) EP1595531A1 (ru)
JP (1) JP2007523942A (ru)
AU (1) AU2005218750A1 (ru)
BR (1) BRPI0507225A2 (ru)
CA (1) CA2557435A1 (ru)
EA (1) EA010311B1 (ru)
MY (1) MY143075A (ru)
NZ (1) NZ549138A (ru)
SG (1) SG150558A1 (ru)
TN (1) TNSN06250A1 (ru)
WO (1) WO2005084640A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2562017C2 (ru) * 2010-02-10 2015-09-10 Астразенека Юкей Лимитед Способ получения заполненного контейнера для ингалятора

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CN1213732C (zh) * 2000-05-22 2005-08-10 奇斯药制品公司 用于加压计量吸入器的稳定药用溶液制剂
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2562017C2 (ru) * 2010-02-10 2015-09-10 Астразенека Юкей Лимитед Способ получения заполненного контейнера для ингалятора

Also Published As

Publication number Publication date
EA010311B1 (ru) 2008-08-29
US20050220718A1 (en) 2005-10-06
AU2005218750A1 (en) 2005-09-15
EP1595531A1 (en) 2005-11-16
US7381402B2 (en) 2008-06-03
MY143075A (en) 2011-02-28
TNSN06250A1 (en) 2007-12-03
JP2007523942A (ja) 2007-08-23
BRPI0507225A2 (pt) 2017-05-30
CA2557435A1 (en) 2005-09-15
NZ549138A (en) 2009-08-28
SG150558A1 (en) 2009-03-30
WO2005084640A1 (en) 2005-09-15
EP1715849A1 (en) 2006-11-02

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