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EA200600992A1 - Амиды тиазолидинона, амиды тиазолидинкарбоновой кислоты, способы их получения и их применение - Google Patents

Амиды тиазолидинона, амиды тиазолидинкарбоновой кислоты, способы их получения и их применение

Info

Publication number
EA200600992A1
EA200600992A1 EA200600992A EA200600992A EA200600992A1 EA 200600992 A1 EA200600992 A1 EA 200600992A1 EA 200600992 A EA200600992 A EA 200600992A EA 200600992 A EA200600992 A EA 200600992A EA 200600992 A1 EA200600992 A1 EA 200600992A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amida
methods
acid
tiazolidinona
thiazolidincarbonic
Prior art date
Application number
EA200600992A
Other languages
English (en)
Inventor
Дуэйн Д. Миллер
Виреса Гудудуру
Джеймс Т. Далтон
Юнджу Херх
Original Assignee
Юниверсити Оф Теннесси Рисерч Фаундейшн
Огайо Стейт Юниверсити Рисерч Фаундейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юниверсити Оф Теннесси Рисерч Фаундейшн, Огайо Стейт Юниверсити Рисерч Фаундейшн filed Critical Юниверсити Оф Теннесси Рисерч Фаундейшн
Publication of EA200600992A1 publication Critical patent/EA200600992A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Описаны замещенные амиды тиазолидинонкарбоновой кислоты и замещенные амиды тиазолидинкарбоновой кислоты формул (I) и (II), в которых различные заместители такие, как определено в описании. Также описаны способы получения этих соединений, фармацевтические композиции, содержащие указанные соединения, и их применение, особенно для лечения или профилактики рака.
EA200600992A 2003-11-18 2004-11-18 Амиды тиазолидинона, амиды тиазолидинкарбоновой кислоты, способы их получения и их применение EA200600992A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52307903P 2003-11-18 2003-11-18
PCT/US2004/038662 WO2005049591A1 (en) 2003-11-18 2004-11-18 Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof

Publications (1)

Publication Number Publication Date
EA200600992A1 true EA200600992A1 (ru) 2006-10-27

Family

ID=34619564

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600992A EA200600992A1 (ru) 2003-11-18 2004-11-18 Амиды тиазолидинона, амиды тиазолидинкарбоновой кислоты, способы их получения и их применение

Country Status (11)

Country Link
US (3) US7307093B2 (ru)
EP (1) EP1692121A1 (ru)
JP (1) JP2007513090A (ru)
CN (1) CN1902184A (ru)
AU (1) AU2004291539A1 (ru)
BR (1) BRPI0416674A (ru)
CA (1) CA2546324A1 (ru)
EA (1) EA200600992A1 (ru)
IL (1) IL175633A0 (ru)
MX (1) MXPA06005528A (ru)
WO (1) WO2005049591A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1692121A1 (en) * 2003-11-18 2006-08-23 University of Tennessee Research Foundation Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof
JPWO2005054468A1 (ja) * 2003-12-01 2008-03-13 株式会社リバース・プロテオミクス研究所 抗糖尿病剤の標的タンパク質及び対応する新規抗糖尿病剤「インスフル」
EP1926487A2 (en) * 2005-07-19 2008-06-04 University of Tennessee Research Foundation Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents
JP2009538270A (ja) * 2006-03-21 2009-11-05 ヨーロピアン モレキュラー バイオロジー ラボラトリー 細胞複製破壊剤および病的状態を阻止する際のその使用
WO2008090356A1 (en) * 2007-01-25 2008-07-31 Betagenon Ab Thiazolidinone derivatives useful in the treatment of cancer and disorders caused by excess adiposity
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US9334242B2 (en) 2008-06-16 2016-05-10 Gtx, Inc. Compounds for treatment of cancer
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
LT2303021T (lt) 2008-06-16 2019-06-25 University Of Tennessee Research Foundation Junginiai, skirti vėžio gydymui
CN109568312A (zh) 2013-03-05 2019-04-05 田纳西大学研究基金会 用于治疗癌症的化合物
CA3232320A1 (en) * 2013-03-15 2014-09-18 Cancer Research Technology, Llc Methods and compositions for gamma-glutamyl cycle modulation
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1030415A (zh) 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
PT798298E (pt) 1994-12-15 2001-11-30 Sankyo Co Derivados da tiazolidinona ou da oxazolidinona para o tratamento da angina de peito ou composicoes contendo estes compostos como ingredientes activos
RU2141956C1 (ru) 1995-03-02 1999-11-27 Санкио Компани Лимитед Оптически активное производное тиазолидинона, способы его получения, композиция для профилактики и лечения стенокардии, способ расширения коллатеральных сосудов при лечении или профилактики стенокардии, способ лечения или профилактики язвенной болезни
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
RU2004132719A (ru) * 2002-04-08 2005-08-27 Торрент Фармасьютикалз Лтд. (In) Тиазолидин-4-карбонитрилы и их аналоги, применение указанных соединений в качестве ингибиторов дипептидилпептидаз
EP1692121A1 (en) 2003-11-18 2006-08-23 University of Tennessee Research Foundation Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof
US20060014740A1 (en) 2003-11-18 2006-01-19 Miller Duane D Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof

Also Published As

Publication number Publication date
CN1902184A (zh) 2007-01-24
US20070155807A1 (en) 2007-07-05
WO2005049591A1 (en) 2005-06-02
AU2004291539A1 (en) 2005-06-02
EP1692121A1 (en) 2006-08-23
IL175633A0 (en) 2006-09-05
US7662842B2 (en) 2010-02-16
US20090143446A1 (en) 2009-06-04
US7307093B2 (en) 2007-12-11
JP2007513090A (ja) 2007-05-24
US20060040998A1 (en) 2006-02-23
CA2546324A1 (en) 2005-06-02
BRPI0416674A (pt) 2007-02-13
MXPA06005528A (es) 2007-01-30

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