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EA200600918A1 - Васе455, вариант альтернативного сплайсинга бета-секретазы человека - Google Patents

Васе455, вариант альтернативного сплайсинга бета-секретазы человека

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Publication number
EA200600918A1
EA200600918A1 EA200600918A EA200600918A EA200600918A1 EA 200600918 A1 EA200600918 A1 EA 200600918A1 EA 200600918 A EA200600918 A EA 200600918A EA 200600918 A EA200600918 A EA 200600918A EA 200600918 A1 EA200600918 A1 EA 200600918A1
Authority
EA
Eurasian Patent Office
Prior art keywords
secretase
present
diseases
vase455
man
Prior art date
Application number
EA200600918A
Other languages
English (en)
Inventor
Лоран Дезир
Original Assignee
Игзонхит Терапьютикс Са
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Игзонхит Терапьютикс Са filed Critical Игзонхит Терапьютикс Са
Publication of EA200600918A1 publication Critical patent/EA200600918A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P9/12—Antihypertensives
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

Настоящее изобретение в общем относится к области генетики, биохимии, медицинской химии и медицины. Более конкретно, настоящее изобретение раскрывает идентификацию варианта гена человека, вовлеченного в невропатологические заболевания, и способы диагностики, профилактики и лечения таких заболеваний и сопутствующих нарушений, а также скрининга терапевтически активных лекарств. Настоящее изобретение касается каталитически активных вариантов β-секретазы (memapsin2, ВАСЕ) и кодирующих их нуклеиновых кислот. Изобретение применимо при идентификации агентов, ингибирующих активность определенной изоформы ВАСЕ, а тем самым и агентов, и способов терапии, влияющих на генезис, развитие или прогрессирование невропатологических заболеваний, в том числе болезни Альцгеймера и деменции (слабоумия).
EA200600918A 2003-11-06 2004-11-05 Васе455, вариант альтернативного сплайсинга бета-секретазы человека EA200600918A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51740103P 2003-11-06 2003-11-06
PCT/IB2004/003897 WO2005045021A1 (en) 2003-11-06 2004-11-05 Bace455, an alternative splice variant of the human beta-secretase

Publications (1)

Publication Number Publication Date
EA200600918A1 true EA200600918A1 (ru) 2006-10-27

Family

ID=34572941

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600918A EA200600918A1 (ru) 2003-11-06 2004-11-05 Васе455, вариант альтернативного сплайсинга бета-секретазы человека

Country Status (9)

Country Link
US (2) US7790864B2 (ru)
EP (1) EP1680505A1 (ru)
JP (1) JP2007510425A (ru)
CN (1) CN1875100A (ru)
AU (1) AU2004288034B2 (ru)
CA (1) CA2543837A1 (ru)
EA (1) EA200600918A1 (ru)
IL (1) IL175137A0 (ru)
WO (1) WO2005045021A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1739179A1 (en) * 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
US8772457B2 (en) 2010-11-10 2014-07-08 Genentech, Inc. BACE1 antibodies
KR101511737B1 (ko) * 2012-12-31 2015-04-20 대한민국 Sumo1 및 bace1의 결합 억제제를 유효성분으로 함유하는 퇴행성 뇌질환 예방 및 치료용 약학적 조성물
CN103757102A (zh) * 2013-12-23 2014-04-30 成都艾迪康医学检测实验室有限公司 用于检测b型tel-abl融合基因的方法和寡核苷酸
JP6859259B2 (ja) 2014-11-19 2021-04-14 ジェネンテック， インコーポレイテッド ＢＡＣＥｌに対する抗体及び神経疾患免疫療法のためのその使用
JP6993228B2 (ja) 2014-11-19 2022-03-03 ジェネンテック， インコーポレイテッド 抗トランスフェリン受容体／抗ｂａｃｅ１多重特異性抗体および使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6583275B1 (en) * 1997-07-02 2003-06-24 Genome Therapeutics Corporation Nucleic acid sequences and expression system relating to Enterococcus faecium for diagnostics and therapeutics
US6699671B1 (en) * 1998-09-24 2004-03-02 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
US20020169304A1 (en) * 1999-12-22 2002-11-14 Matthew R. Kaser Aspartyl proteases

Also Published As

Publication number Publication date
US20100317830A1 (en) 2010-12-16
WO2005045021A1 (en) 2005-05-19
AU2004288034B2 (en) 2011-07-21
CA2543837A1 (en) 2005-05-19
EP1680505A1 (en) 2006-07-19
AU2004288034A1 (en) 2005-05-19
US20070142277A1 (en) 2007-06-21
CN1875100A (zh) 2006-12-06
US7790864B2 (en) 2010-09-07
IL175137A0 (en) 2006-09-05
JP2007510425A (ja) 2007-04-26

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