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EA200401199A1 - Ингибиторы гистондеацетилазы - Google Patents

Ингибиторы гистондеацетилазы

Info

Publication number
EA200401199A1
EA200401199A1 EA200401199A EA200401199A EA200401199A1 EA 200401199 A1 EA200401199 A1 EA 200401199A1 EA 200401199 A EA200401199 A EA 200401199A EA 200401199 A EA200401199 A EA 200401199A EA 200401199 A1 EA200401199 A1 EA 200401199A1
Authority
EA
Eurasian Patent Office
Prior art keywords
histondeacetylase
inhibitors
compounds
pharmaceuticals
formula
Prior art date
Application number
EA200401199A
Other languages
English (en)
Other versions
EA008245B1 (ru
Inventor
Кристоф Ван Эмелен
Марк Густаф Селин Вердонк
Свен Францискус Анна Ван Брандт
Патрик Рене Анжибо
Ливен Мерпул
Алексей Борисович Дяткин
Original Assignee
Янссен Фармацевтика Н. В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н. В. filed Critical Янссен Фармацевтика Н. В.
Publication of EA200401199A1 publication Critical patent/EA200401199A1/ru
Publication of EA008245B1 publication Critical patent/EA008245B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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Abstract

Данное изобретение относится к новым соединениям формулы (I)где n, R, R, R, R, Q, X, Y и Z имеют определенные значения, обладающим ингибирующей ферментативной активностью в отношении гистондеацетилазы, их получению, композициям, содержащим указанные соединения, и их применению в качестве лекарственных средств.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401199A 2002-03-13 2003-03-11 Ингибиторы гистондеацетилазы EA008245B1 (ru)

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ATE424395T1 (de) 2009-03-15
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