EA200301299A1 - Применение ингибиторов il-18 для лечения и предотвращения повреждений цнс - Google Patents
Применение ингибиторов il-18 для лечения и предотвращения повреждений цнсInfo
- Publication number
- EA200301299A1 EA200301299A1 EA200301299A EA200301299A EA200301299A1 EA 200301299 A1 EA200301299 A1 EA 200301299A1 EA 200301299 A EA200301299 A EA 200301299A EA 200301299 A EA200301299 A EA 200301299A EA 200301299 A1 EA200301299 A1 EA 200301299A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitors
- prevention
- treatment
- cns damage
- damage
- Prior art date
Links
- 230000006378 damage Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000008736 traumatic injury Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Данное изобретение относится к применению ингибиторов IL-18 в получении лекарственного препарата для лечения и/или предотвращения повреждения центральной нервной системы, в особенности травматического повреждения головы.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01112067 | 2001-05-25 | ||
| PCT/EP2002/005666 WO2002096456A1 (en) | 2001-05-25 | 2002-05-23 | Use of il-18 inhibitors for treating or preventing cns injuries |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200301299A1 true EA200301299A1 (ru) | 2004-04-29 |
| EA006744B1 EA006744B1 (ru) | 2006-04-28 |
Family
ID=8177454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200301299A EA006744B1 (ru) | 2001-05-25 | 2002-05-23 | Применение ингибиторов il-18 для лечения и предотвращения повреждений цнс |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7655616B2 (ru) |
| EP (1) | EP1390070B1 (ru) |
| JP (1) | JP4344142B2 (ru) |
| KR (1) | KR20040030625A (ru) |
| CN (1) | CN1305529C (ru) |
| AU (1) | AU2002314103B2 (ru) |
| BG (1) | BG66395B1 (ru) |
| BR (1) | BR0210007A (ru) |
| CA (1) | CA2445664C (ru) |
| CY (1) | CY1119190T1 (ru) |
| CZ (1) | CZ307321B6 (ru) |
| DK (1) | DK1390070T3 (ru) |
| EA (1) | EA006744B1 (ru) |
| EE (1) | EE05263B1 (ru) |
| ES (1) | ES2617084T3 (ru) |
| HR (1) | HRP20030842B1 (ru) |
| HU (1) | HU230294B1 (ru) |
| IL (2) | IL159014A0 (ru) |
| LT (1) | LT1390070T (ru) |
| ME (1) | ME00550B (ru) |
| MX (1) | MXPA03010743A (ru) |
| NO (1) | NO331882B1 (ru) |
| PL (1) | PL216228B1 (ru) |
| PT (1) | PT1390070T (ru) |
| RS (1) | RS56006B1 (ru) |
| SK (1) | SK288413B6 (ru) |
| UA (1) | UA80396C2 (ru) |
| WO (1) | WO2002096456A1 (ru) |
| ZA (1) | ZA200308172B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080076708A1 (en) | 2003-05-13 | 2008-03-27 | Valter Altarocca | Active Variants of the Il-18 Binding Protein and Medical Uses Thereof |
| EP1780542A4 (en) * | 2004-06-30 | 2008-05-14 | Atsuo Sekiyama | AGENT INDICATING A NON-INFLAMMATORY RESPONSE TO A STRESS AND USE THEREOF |
| DK1888100T3 (da) * | 2005-06-03 | 2012-01-23 | Merck Serono Sa | Anvendelse af IL-18BP-isoformer til behandling og/eller forebyggelse af neurologiske inflammatoriske sygdomme |
| PL2267024T3 (pl) | 2005-06-03 | 2012-10-31 | Ares Trading Sa | Wytwarzanie rekombinowanego białka wiążącego IL-18 |
| HRP20110948T1 (hr) | 2005-06-10 | 2012-01-31 | Ares Trading S.A. | Postupak za pročišćavanje il-18 vezujućeg proteina |
| US8685400B2 (en) * | 2007-07-30 | 2014-04-01 | University Of Miami | Modulating inflammasome activity and inflammation in the central nervous system |
| AU2014317035B2 (en) * | 2013-09-05 | 2020-02-27 | Ab2 Bio Sa | IL-18 binding protein (IL-18BP) in inflammatory diseases |
| SG11201706879UA (en) * | 2015-03-05 | 2017-09-28 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873453A (ja) * | 1994-09-02 | 1996-03-19 | Otsuka Pharmaceut Co Ltd | サイトカイン阻害剤 |
| IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| ES2244178T3 (es) * | 1998-03-09 | 2005-12-01 | Vertex Pharmaceuticals Incorporated | Derivados de 1,2-diazepan como inhibidores de la enzima convertidora de interleuquina-1 beta. |
| CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| KR100798545B1 (ko) | 2000-05-05 | 2008-01-28 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | 죽상경화증의 치료 또는 예방을 위한 ｉｌ-18 저해물질의용도 |
| EP1292288B1 (en) * | 2000-06-23 | 2004-09-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | 2-arachidonylglycerol (2-ag) - an inhibitor of tumor necrosis factor -alfa and neuroprotector of brain in closed head injury |
| AU2002224417A1 (en) * | 2000-10-18 | 2002-04-29 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| US6671553B1 (en) * | 2001-05-23 | 2003-12-30 | Pacesetter, Inc. | Implantable cardiac lead having terminating connector strain relief and method of manufacture |
-
2002
- 2002-05-23 HR HRP20030842AA patent/HRP20030842B1/hr not_active IP Right Cessation
- 2002-05-23 PL PL367545A patent/PL216228B1/pl unknown
- 2002-05-23 LT LTEP02740641.2T patent/LT1390070T/lt unknown
- 2002-05-23 EP EP02740641.2A patent/EP1390070B1/en not_active Expired - Lifetime
- 2002-05-23 EA EA200301299A patent/EA006744B1/ru not_active IP Right Cessation
- 2002-05-23 CZ CZ2003-3268A patent/CZ307321B6/cs not_active IP Right Cessation
- 2002-05-23 ES ES02740641.2T patent/ES2617084T3/es not_active Expired - Lifetime
- 2002-05-23 CA CA2445664A patent/CA2445664C/en not_active Expired - Lifetime
- 2002-05-23 EE EEP200300582A patent/EE05263B1/xx unknown
- 2002-05-23 UA UA20031212328A patent/UA80396C2/uk unknown
- 2002-05-23 PT PT2740641T patent/PT1390070T/pt unknown
- 2002-05-23 BR BR0210007-0A patent/BR0210007A/pt not_active Application Discontinuation
- 2002-05-23 KR KR10-2003-7015310A patent/KR20040030625A/ko not_active Ceased
- 2002-05-23 DK DK02740641.2T patent/DK1390070T3/en active
- 2002-05-23 RS YU89403A patent/RS56006B1/sr unknown
- 2002-05-23 WO PCT/EP2002/005666 patent/WO2002096456A1/en not_active Ceased
- 2002-05-23 JP JP2002592965A patent/JP4344142B2/ja not_active Expired - Lifetime
- 2002-05-23 MX MXPA03010743A patent/MXPA03010743A/es active IP Right Grant
- 2002-05-23 US US10/478,614 patent/US7655616B2/en not_active Expired - Lifetime
- 2002-05-23 CN CNB028147510A patent/CN1305529C/zh not_active Expired - Lifetime
- 2002-05-23 IL IL15901402A patent/IL159014A0/xx unknown
- 2002-05-23 AU AU2002314103A patent/AU2002314103B2/en not_active Expired
- 2002-05-23 SK SK1603-2003A patent/SK288413B6/sk not_active IP Right Cessation
- 2002-05-23 HU HU0304067A patent/HU230294B1/hu unknown
- 2002-05-23 ME MEP-2008-618A patent/ME00550B/me unknown
-
2003
- 2003-10-21 ZA ZA200308172A patent/ZA200308172B/xx unknown
- 2003-11-20 NO NO20035160A patent/NO331882B1/no not_active IP Right Cessation
- 2003-11-23 IL IL159014A patent/IL159014A/en active IP Right Grant
- 2003-12-15 BG BG108451A patent/BG66395B1/bg unknown
-
2017
- 2017-05-08 CY CY20171100494T patent/CY1119190T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |