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EA200300492A1 - 2-, 3-, 4- или 5-замещенные n1-(бензолсульфонил)индолы и их применение в терапии - Google Patents

2-, 3-, 4- или 5-замещенные n1-(бензолсульфонил)индолы и их применение в терапии

Info

Publication number
EA200300492A1
EA200300492A1 EA200300492A EA200300492A EA200300492A1 EA 200300492 A1 EA200300492 A1 EA 200300492A1 EA 200300492 A EA200300492 A EA 200300492A EA 200300492 A EA200300492 A EA 200300492A EA 200300492 A1 EA200300492 A1 EA 200300492A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
application
benzolsulphonil
indols
therapy
Prior art date
Application number
EA200300492A
Other languages
English (en)
Other versions
EA006132B1 (ru
Inventor
Патриция Кальдирола
Гари Йоханссон
Бьерн М. Нильссон
Original Assignee
Биовитрум Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0003810A external-priority patent/SE0003810D0/xx
Application filed by Биовитрум Аб filed Critical Биовитрум Аб
Publication of EA200300492A1 publication Critical patent/EA200300492A1/ru
Publication of EA006132B1 publication Critical patent/EA006132B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В изобретение предлагаются 2-, 3-, 4- или 5-замещенные N1-(1-бензолсульфонил)индольные соединения общей формулы (I), в которой Ar, R, R, Rи Rпринимают определенные в описании значения. Указанные соединения обладают сродством к рецептору 5-HTи могут быть использованы при лечении и профилактике заболеваний, относящихся к указанному рецептору, таких как ожирение и расстройства ЦНС.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300492A 2000-10-20 2001-10-19 2-, 3-, 4- или 5-замещенные n-(1-(арил-, гетероарил- или арилалкил)сульфонил)индолы и их применение в терапии EA006132B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0003810A SE0003810D0 (sv) 2000-10-20 2000-10-20 Novel compounds their use and preparations
US24311500P 2000-10-25 2000-10-25
PCT/SE2001/002319 WO2002032863A1 (en) 2000-10-20 2001-10-19 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy

Publications (2)

Publication Number Publication Date
EA200300492A1 true EA200300492A1 (ru) 2003-10-30
EA006132B1 EA006132B1 (ru) 2005-10-27

Family

ID=26655269

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300492A EA006132B1 (ru) 2000-10-20 2001-10-19 2-, 3-, 4- или 5-замещенные n-(1-(арил-, гетероарил- или арилалкил)сульфонил)индолы и их применение в терапии

Country Status (13)

Country Link
US (2) US7087750B2 (ru)
EP (1) EP1326830A1 (ru)
KR (1) KR100823908B1 (ru)
AU (2) AU9619301A (ru)
BR (1) BR0114552A (ru)
CA (1) CA2422717A1 (ru)
EA (1) EA006132B1 (ru)
IL (1) IL154685A0 (ru)
MX (1) MXPA03003397A (ru)
NO (1) NO325259B1 (ru)
NZ (1) NZ524675A (ru)
PL (1) PL361887A1 (ru)
WO (1) WO2002032863A1 (ru)

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Also Published As

Publication number Publication date
KR100823908B1 (ko) 2008-04-21
NZ524675A (en) 2004-09-24
MXPA03003397A (es) 2004-06-30
US20020165251A1 (en) 2002-11-07
BR0114552A (pt) 2003-07-01
US7087750B2 (en) 2006-08-08
CA2422717A1 (en) 2002-04-25
US20050256106A1 (en) 2005-11-17
NO20031589D0 (no) 2003-04-08
AU2001296193B2 (en) 2006-04-27
US7524839B2 (en) 2009-04-28
WO2002032863A1 (en) 2002-04-25
EP1326830A1 (en) 2003-07-16
NO325259B1 (no) 2008-03-17
EA006132B1 (ru) 2005-10-27
AU9619301A (en) 2002-04-29
IL154685A0 (en) 2003-09-17
NO20031589L (no) 2003-05-28
HK1084109A1 (en) 2006-07-21
KR20030038825A (ko) 2003-05-16
PL361887A1 (en) 2004-10-04

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