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EA200300478A1 - Полизамещенные имидазопиридины в качестве ингибиторов желудочной секреции - Google Patents

Полизамещенные имидазопиридины в качестве ингибиторов желудочной секреции

Info

Publication number
EA200300478A1
EA200300478A1 EA200300478A EA200300478A EA200300478A1 EA 200300478 A1 EA200300478 A1 EA 200300478A1 EA 200300478 A EA200300478 A EA 200300478A EA 200300478 A EA200300478 A EA 200300478A EA 200300478 A1 EA200300478 A1 EA 200300478A1
Authority
EA
Eurasian Patent Office
Prior art keywords
imidazopiridine
gas
disposed
inhibitor inhibitors
inhibitors
Prior art date
Application number
EA200300478A
Other languages
English (en)
Other versions
EA008151B1 (ru
Inventor
Вольфганг-Александер Зимон
Штефан Постиус
Вольфганг Кромер
Вильм Бур
Бернхард Коль
Йорг Зенн-Бильфингер
Петер Циммерманн
Original Assignee
Алтана Фарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алтана Фарма Аг filed Critical Алтана Фарма Аг
Publication of EA200300478A1 publication Critical patent/EA200300478A1/ru
Publication of EA008151B1 publication Critical patent/EA008151B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к имидазопиридинам определенной формулы 1, в которой заместители и символы имеют значения, указанные в описании. Соединения обладают ингибирующими желудочную секрецию свойствами.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300478A 2000-10-25 2001-10-23 Полизамещенные имидазопиридины в качестве ингибиторов желудочной секреции EA008151B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00123133 2000-10-25
PCT/EP2001/012207 WO2002034749A1 (en) 2000-10-25 2001-10-23 Polysubstituted imidazopyridines as gastric secretion inhibitors

Publications (2)

Publication Number Publication Date
EA200300478A1 true EA200300478A1 (ru) 2003-12-25
EA008151B1 EA008151B1 (ru) 2007-04-27

Family

ID=8170193

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300478A EA008151B1 (ru) 2000-10-25 2001-10-23 Полизамещенные имидазопиридины в качестве ингибиторов желудочной секреции

Country Status (19)

Country Link
US (2) US6869949B2 (ru)
EP (1) EP1332143A1 (ru)
JP (1) JP2004512338A (ru)
KR (1) KR20040011423A (ru)
CN (1) CN1692113A (ru)
AU (2) AU2002210563B2 (ru)
BR (1) BR0114873A (ru)
CA (1) CA2426616A1 (ru)
EA (1) EA008151B1 (ru)
HR (1) HRP20030323A2 (ru)
HU (1) HUP0302308A2 (ru)
IL (1) IL154850A0 (ru)
MX (1) MXPA03003706A (ru)
NO (1) NO325736B1 (ru)
NZ (1) NZ525281A (ru)
PL (1) PL360412A1 (ru)
SK (1) SK5072003A3 (ru)
WO (1) WO2002034749A1 (ru)
ZA (1) ZA200302038B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034749A1 (en) * 2000-10-25 2002-05-02 Altana Pharma Ag Polysubstituted imidazopyridines as gastric secretion inhibitors
DE10145457A1 (de) * 2001-09-14 2003-04-03 Basf Ag Substituierte Imidazo[1,2-a]-5,6,7,8-tetrahydropyridin-8-one, Verfahren zu ihrer Herstellung, sowie deren Verwendung zur Herstellung von Imidazo[1,2,-a]pyridinen
AU2003206879A1 (en) 2002-02-15 2003-09-04 Altana Pharma Ag Tricyclic n-acyl compounds
TWI295575B (en) * 2002-04-24 2008-04-11 Altana Pharma Ag Nitrosated imidazopyridines
CA2509882A1 (en) * 2002-12-20 2004-07-08 Altana Pharma Ag Silyl ethers
RS20050603A (sr) * 2003-02-17 2007-09-21 Altana Pharma Ag., NOVE KOMBINACIJE I NOVA PRIMENA FARMACEUTSKIH AKTIVNIH JEDINjENjA
US20060194972A1 (en) * 2003-04-03 2006-08-31 Altana Pharma Ag Process for the production of imidazopyridin-8-ones
AR044129A1 (es) * 2003-05-06 2005-08-24 Altana Pharma Ag Compuestos intermedios de imidazopiridina. proceso de preparacion.
US20080280944A1 (en) 2003-11-03 2008-11-13 Paula Fernstrom Imidazo[1,2-A]Pyridine Derivatives For The Treatment Of Silent Gastro-Esophageal Reflux
AR046893A1 (es) * 2003-12-16 2005-12-28 Altana Pharma Ag Bencimidazoles triciclicos
AR046941A1 (es) * 2003-12-19 2006-01-04 Altana Pharma Ag Imidazopiridinas triciclicas y su uso como inhibidores de secrecion de acido gastrico
WO2005058894A1 (en) 2003-12-19 2005-06-30 Altana Pharma Ag Intermediates for the preparation of tricyclic dihydropyrano -imidazo -pyridines derivatives
CA2582256A1 (en) * 2004-10-01 2006-04-13 Altana Pharma Ag Substituted tricyclic benzimidazoles
AR051375A1 (es) * 2004-10-15 2007-01-10 Altana Pharma Ag Imidazopiridinas difluoro substituidas
WO2008058990A1 (en) * 2006-11-16 2008-05-22 Nycomed Gmbh 7,7-disubstituted pyrano-[2,3-c]-imidazo-[1,2-a]-pyridine derivatives and their use as gastric acid secretion inhibitors
WO2012027240A1 (en) * 2010-08-23 2012-03-01 Schering Corporation Fused tricyclic inhibitors of mammalian target of rapamycin

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468400A (en) * 1982-12-20 1984-08-28 Schering Corporation Antiulcer tricyclic imidazo [1,2-a]pyridines
US4673679A (en) * 1986-05-14 1987-06-16 E. I. Du Pont De Nemours And Company Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
FI935298A7 (fi) * 1991-05-31 1993-11-29 Pfizer Rapamysiinin esilääkkeiden käyttö immunosuppressiivisina aineina
DE4308095A1 (de) * 1993-03-13 1994-09-15 Hoechst Ag Prodrug-Derivate von Arzneimittelwirkstoffen mit Hydroxylgruppen, Verfahren zu deren Herstellung und ihre Verwendung
SE9401197D0 (sv) * 1994-04-11 1994-04-11 Astra Ab Active compounds
ID22718A (id) * 1997-03-24 1999-12-09 Byk Gulden Lomberg Chem Fab Senyawa-senyawa tetrahidropirido
ZA982445B (en) * 1997-03-24 1998-09-24 Byk Gulden Lomberg Chem Fab Tetrahydropyrido compounds
WO1998042707A1 (en) * 1997-03-24 1998-10-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahydropyrido compounds
IL132608A0 (en) * 1997-05-28 2001-03-19 Byk Gulden Lomberg Chem Fab Fused dihydropyran compounds medicaments containing the same and the use thereof
ATE231862T1 (de) * 1998-09-23 2003-02-15 Altana Pharma Ag Tetrahydropyridoether
JP2002528548A (ja) 1998-11-03 2002-09-03 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング イミダゾナフチリジン
DE60002855T2 (de) * 1999-04-17 2004-05-06 Altana Pharma Ag Haloalkoxy-imidazonaphthyridine
ES2267737T3 (es) * 2000-03-29 2007-03-16 Altana Pharma Ag Derivados de imidazopiridinas alquiladas.
PL365824A1 (en) * 2000-03-29 2005-01-10 Altana Pharma Ag Pyrano[2,3-c]imidazo[-1,2-a]pyridine derivatives for the treatment of gastrointestinal disorders
ES2253376T3 (es) 2000-03-29 2006-06-01 Altana Pharma Ag Profarmacos de derivados de imidazopiridina.
CN1221553C (zh) * 2000-03-29 2005-10-05 奥坦纳医药公司 三环咪唑并吡啶类化合物及药物组合物
WO2002034749A1 (en) * 2000-10-25 2002-05-02 Altana Pharma Ag Polysubstituted imidazopyridines as gastric secretion inhibitors

Also Published As

Publication number Publication date
US6869949B2 (en) 2005-03-22
IL154850A0 (en) 2003-10-31
NO20031830L (no) 2003-04-24
MXPA03003706A (es) 2005-01-25
NO20031830D0 (no) 2003-04-24
EA008151B1 (ru) 2007-04-27
US20040214852A1 (en) 2004-10-28
CN1692113A (zh) 2005-11-02
HRP20030323A2 (hr) 2005-04-30
KR20040011423A (ko) 2004-02-05
AU2002210563B2 (en) 2007-03-01
ZA200302038B (en) 2004-04-22
NO325736B1 (no) 2008-07-14
HUP0302308A2 (hu) 2003-11-28
US20040106642A1 (en) 2004-06-03
NZ525281A (en) 2004-11-26
CA2426616A1 (en) 2002-05-02
PL360412A1 (en) 2004-09-06
BR0114873A (pt) 2003-07-01
AU1056302A (en) 2002-05-06
US7141567B2 (en) 2006-11-28
JP2004512338A (ja) 2004-04-22
WO2002034749A1 (en) 2002-05-02
EP1332143A1 (en) 2003-08-06
SK5072003A3 (en) 2003-09-11

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU