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EA200300123A1 - HIGHLY EFFICIENT IMMUNITABLE MULTI-ALTERNATOR - Google Patents

HIGHLY EFFICIENT IMMUNITABLE MULTI-ALTERNATOR

Info

Publication number
EA200300123A1
EA200300123A1 EA200300123A EA200300123A EA200300123A1 EA 200300123 A1 EA200300123 A1 EA 200300123A1 EA 200300123 A EA200300123 A EA 200300123A EA 200300123 A EA200300123 A EA 200300123A EA 200300123 A1 EA200300123 A1 EA 200300123A1
Authority
EA
Eurasian Patent Office
Prior art keywords
immunitable
alternator
ethanol
highly efficient
extraction
Prior art date
Application number
EA200300123A
Other languages
Russian (ru)
Other versions
EA006318B1 (en
Inventor
Дэвид Стэнли Паско
Нирмал Пу
Самир Росс
Махмуд Элсохли
Хала Ниази Элсохли
Original Assignee
Университет Миссисипи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Университет Миссисипи filed Critical Университет Миссисипи
Publication of EA200300123A1 publication Critical patent/EA200300123A1/en
Publication of EA006318B1 publication Critical patent/EA006318B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Virology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Immunostimulatory polysaccharides can be preferentially extracted from food-grade microalgae using an aqueous ethanol extraction procedure. The resulting preparations exhibit extremely potent immunostimulatory activity. The preferential extraction of these immunostimulatory polysaccharides is dependent on the concentration of ethanol used and the extraction temperature. The most efficient conditions are 50% ethanol concentration at temperatures between 60° and 70° C. The isolated polysaccharide preparations are potentially useful as a botanical or pharmaceutical preparation to improve immune function.
EA200300123A 2000-07-10 2001-07-10 Potent immunostimulators from microalgae EA006318B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21700100P 2000-07-10 2000-07-10
PCT/US2001/021770 WO2002004000A1 (en) 2000-07-10 2001-07-10 Potent immunostimulants from microalgae

Publications (2)

Publication Number Publication Date
EA200300123A1 true EA200300123A1 (en) 2004-02-26
EA006318B1 EA006318B1 (en) 2005-10-27

Family

ID=22809278

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300123A EA006318B1 (en) 2000-07-10 2001-07-10 Potent immunostimulators from microalgae

Country Status (20)

Country Link
US (2) US7205284B2 (en)
EP (1) EP1301191B1 (en)
JP (1) JP2004502737A (en)
KR (1) KR100831408B1 (en)
CN (2) CN1278691C (en)
AT (1) ATE311892T1 (en)
AU (2) AU7333001A (en)
BR (1) BR0112424A (en)
CA (1) CA2412600C (en)
DE (1) DE60115654T2 (en)
DK (1) DK1301191T3 (en)
EA (1) EA006318B1 (en)
ES (1) ES2254451T3 (en)
IL (2) IL153503A0 (en)
MX (1) MXPA03000220A (en)
NO (1) NO329221B1 (en)
NZ (1) NZ523695A (en)
PL (1) PL203814B1 (en)
WO (1) WO2002004000A1 (en)
ZA (1) ZA200301050B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001287382B9 (en) 2000-08-10 2006-10-26 Ocean Nutrition Canada Limited Chlorella preparations exhibiting immunomodulating properties
US6814961B1 (en) 2001-05-14 2004-11-09 Gitte S. Jensen Method for enhancing stem cell trafficking
KR100956195B1 (en) 2002-02-01 2010-05-06 어리어드 파마슈티칼스, 인코포레이티드 Phosphorus-containing compounds and uses thereof
FR2850277B1 (en) * 2003-01-24 2005-04-08 Lanatech COMPOSITION COMPRISING A FLOS-AQUAE APHANIZOMENON EXTRACT, ITS USE AND PREPARATION
NO320429B1 (en) * 2003-06-03 2005-12-05 Sinvent As Pharmaceutical composition for increasing the resistance to diseases caused by pathogenic microorganisms and the use of glucan for the preparation of a pharmaceutical composition.
WO2006015115A2 (en) * 2004-07-30 2006-02-09 University Of Mississippi Potent immunostimulatory extracts from microalgae
US7651690B2 (en) * 2005-06-24 2010-01-26 Desert Lake Technologies Purified component of blue-green algae and method of use
AU2007264043B2 (en) * 2006-06-27 2012-03-15 Nutratec S.R.L. Extracts of Aphanizomenon Flos Aquae and nutritional, cosmetic and pharmaceutical compositions containing the same
CA2662550A1 (en) * 2006-09-08 2008-03-13 University Of Mississippi Potent immunostimulatory component in microalgae extract
US20110104189A1 (en) * 2008-05-06 2011-05-05 Ocean Nutrition Canada Limited Compositions obtained from chlorella extract having immunomodulating properties
US8115022B2 (en) 2010-04-06 2012-02-14 Heliae Development, Llc Methods of producing biofuels, chlorophylls and carotenoids
US8211308B2 (en) 2010-04-06 2012-07-03 Heliae Development, Llc Extraction of polar lipids by a two solvent method
MX2012011555A (en) 2010-04-06 2013-01-29 Heliae Dev Llc Methods of and systems for isolating carotenoids and omega- 3 rich oils from algae.
US8273248B1 (en) 2010-04-06 2012-09-25 Heliae Development, Llc Extraction of neutral lipids by a two solvent method
US8308951B1 (en) 2010-04-06 2012-11-13 Heliae Development, Llc Extraction of proteins by a two solvent method
US8313648B2 (en) 2010-04-06 2012-11-20 Heliae Development, Llc Methods of and systems for producing biofuels from algal oil
US8211309B2 (en) 2010-04-06 2012-07-03 Heliae Development, Llc Extraction of proteins by a two solvent method
US8475660B2 (en) 2010-04-06 2013-07-02 Heliae Development, Llc Extraction of polar lipids by a two solvent method
US8202425B2 (en) 2010-04-06 2012-06-19 Heliae Development, Llc Extraction of neutral lipids by a two solvent method
US9200236B2 (en) 2011-11-17 2015-12-01 Heliae Development, Llc Omega 7 rich compositions and methods of isolating omega 7 fatty acids
US9217119B2 (en) 2011-11-28 2015-12-22 Southwest Research Institute Extraction of lipids from living cells utilizing liquid CO2
GB201208325D0 (en) * 2012-05-11 2012-06-27 Glycomar Ltd Saccharides
CN103463141A (en) * 2013-09-22 2013-12-25 汤永强 Chlorella spray
KR20150102308A (en) 2014-02-28 2015-09-07 주식회사 코아로직 Touch panel for discernable key touch
EP3034612A1 (en) 2014-12-16 2016-06-22 Greenaltech, S.L. Chitin and chitosan producing methods
JP6788882B2 (en) * 2016-08-09 2020-11-25 イマジン・グローバル・ケア株式会社 Polysaccharides having an innate immunity activating effect and innate immunity activators or foods and drinks containing the polysaccharides
WO2018052082A1 (en) * 2016-09-14 2018-03-22 株式会社Ｔｅｓホールディングス Lin28a ACTIVATOR AND USE THEREFOR
CN107625783A (en) * 2017-08-09 2018-01-26 天津科技大学 Sulfation chlorella, spirulina complex polysaccharide immunomodulating regimens application
TWI763916B (en) 2017-08-30 2022-05-11 遠東生物科技股份有限公司 Cyanobacterial extracts, processes for preparing the same and uses thereof
EP4025181A1 (en) 2019-09-06 2022-07-13 Beautypaste LLC Enhanced toothpaste and kits
CN110742900B (en) * 2019-11-22 2022-06-14 湘潭大学 Chlorella extracellular polysaccharide compound with immunoregulation activity and preparation method and application thereof
CN111205376B (en) * 2020-01-07 2021-11-02 华侨大学 A kind of preparation method and application of polysaccharide
FR3121351B1 (en) 2021-03-30 2024-03-08 Axeen Pharma Composition based on spirulina and its uses for strengthening immunity
CN114195907B (en) * 2021-10-20 2022-10-21 中国科学院南海海洋研究所 Low-molecular-weight spirulina polysaccharide and preparation method and application thereof
CN114544527B (en) * 2022-01-26 2023-05-02 浙江夸克生物科技有限公司 Salivation sugar chain antigen KL-6 determination kit and preparation method thereof
WO2023192811A1 (en) * 2022-03-30 2023-10-05 Om Biome, Inc. Method for tissue renewal using a microalgae-based biologically friendly base formula to reverse disease progression and foster tissue regeneration in conditions of mucosal injury and inflammation in the mouth and gastrointestinal tract

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US3462412A (en) * 1966-04-20 1969-08-19 Tohoku Yakult Seizo Kk Process of producing an active substance for stimulating the function of the reticulo-endothelial system
JPS5896025A (en) 1981-12-02 1983-06-07 Kitasato Inst:The Novel physiologically active substance ch-1 and its preparation
HU188311B (en) * 1982-03-04 1986-04-28 Szendrei,Kalman,Hu Process for producing biologically active polisaccharide concentrates and pharmaceutical compositions containing them as active agents
JPS6178729A (en) * 1984-09-26 1986-04-22 Nisshin Oil Mills Ltd:The Immuno-activating component
JPS61167620A (en) * 1985-01-19 1986-07-29 Toa Nenryo Kogyo Kk Carcinostatic agent containing polysaccharide
JPS61197525A (en) 1985-02-27 1986-09-01 Nisshin Oil Mills Ltd:The Immuno-activating agent having antitumor activity
JPS6219528A (en) * 1985-07-16 1987-01-28 Kurorera Kogyo Kk Carcinostatic agent
EP0295956B1 (en) * 1987-06-18 1996-09-11 Kureha Kagaku Kogyo Kabushiki Kaisha Use of a protein-bound polysaccharide for making a drug for treating AIDS.
US5084386A (en) * 1989-03-31 1992-01-28 Sri International Production of beta-1,3-glucan in euglena
JPH06253881A (en) * 1993-03-01 1994-09-13 Kurorera Kogyo Kk Glycoprotein complex and its production
JP3020387B2 (en) 1993-07-27 2000-03-15 日石三菱株式会社 Antiviral substance
JPH0937265A (en) * 1995-07-18 1997-02-07 Toshiba Corp Image decoding device
JPH09176022A (en) * 1995-12-26 1997-07-08 Dainippon Ink & Chem Inc Tumor metastasis inhibitor
CN1150003C (en) * 1996-01-26 2004-05-19 宝酒造株式会社 apoptosis inducer

Also Published As

Publication number Publication date
US7205284B2 (en) 2007-04-17
NZ523695A (en) 2004-07-30
ES2254451T3 (en) 2006-06-16
CN1823848A (en) 2006-08-30
KR100831408B1 (en) 2008-05-21
NO20026130L (en) 2003-03-10
BR0112424A (en) 2003-07-01
MXPA03000220A (en) 2003-10-15
EA006318B1 (en) 2005-10-27
EP1301191A4 (en) 2004-02-25
CN1447695A (en) 2003-10-08
NO329221B1 (en) 2010-09-13
DK1301191T3 (en) 2006-05-22
ATE311892T1 (en) 2005-12-15
AU2001273330C1 (en) 2006-01-12
DE60115654T2 (en) 2006-09-07
PL203814B1 (en) 2009-11-30
PL359269A1 (en) 2004-08-23
CA2412600C (en) 2011-09-27
JP2004502737A (en) 2004-01-29
NO20026130D0 (en) 2002-12-19
US20070059317A1 (en) 2007-03-15
ZA200301050B (en) 2004-05-06
IL153503A0 (en) 2003-07-06
KR20030069974A (en) 2003-08-27
DE60115654D1 (en) 2006-01-12
AU2001273330B2 (en) 2005-07-28
WO2002004000A1 (en) 2002-01-17
IL153503A (en) 2008-11-26
EP1301191A1 (en) 2003-04-16
AU7333001A (en) 2002-01-21
CA2412600A1 (en) 2002-01-17
US20070264271A1 (en) 2007-11-15
CN1278691C (en) 2006-10-11
EP1301191B1 (en) 2005-12-07

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU