EA200201158A1 - Бициклические циклогексиламины и их применение в качестве антагонистов nmda-рецепторов - Google Patents
Бициклические циклогексиламины и их применение в качестве антагонистов nmda-рецепторовInfo
- Publication number
- EA200201158A1 EA200201158A1 EA200201158A EA200201158A EA200201158A1 EA 200201158 A1 EA200201158 A1 EA 200201158A1 EA 200201158 A EA200201158 A EA 200201158A EA 200201158 A EA200201158 A EA 200201158A EA 200201158 A1 EA200201158 A1 EA 200201158A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antagonists
- application
- cyclogexylamines
- bicyclic
- nmda
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 title 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 title 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 208000010496 Heart Arrest Diseases 0.000 abstract 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
- HOKKHZGPKSLGJE-UHFFFAOYSA-N N-methyl-D-aspartic acid Natural products CNC(C(O)=O)CC(O)=O HOKKHZGPKSLGJE-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003946 cyclohexylamines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000023516 stroke disease Diseases 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Описаны бициклзамещенные циклогексиламины формулы (I) и их фармацевтически приемлемые соли. Данные соединения являются антагонистами NMDA-рецептор-канальных комплексов (NMDA - N-метил-D-аспарагиновая кислота), полезными для лечения церебральных сосудистых расстройств, таких как, например, церебральная ишемия, остановка сердца, удар и болезнь Паркинсона. Заместители охарактеризованы в описании изобретения.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20824100P | 2000-05-31 | 2000-05-31 | |
| PCT/US2001/014763 WO2001092239A1 (en) | 2000-05-31 | 2001-05-08 | Biciclic cyclohexylamines and their use as nmda receptor antogonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200201158A1 true EA200201158A1 (ru) | 2003-04-24 |
Family
ID=22773822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200201158A EA200201158A1 (ru) | 2000-05-31 | 2001-05-08 | Бициклические циклогексиламины и их применение в качестве антагонистов nmda-рецепторов |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6794402B2 (ru) |
| EP (1) | EP1286975B1 (ru) |
| JP (1) | JP2003535083A (ru) |
| KR (1) | KR20030007797A (ru) |
| CN (1) | CN1438996A (ru) |
| AP (1) | AP2002002697A0 (ru) |
| AT (1) | ATE302763T1 (ru) |
| AU (1) | AU2001259618A1 (ru) |
| BG (1) | BG107375A (ru) |
| BR (1) | BR0111301A (ru) |
| CA (1) | CA2409006A1 (ru) |
| DE (1) | DE60112924T2 (ru) |
| DZ (1) | DZ3361A1 (ru) |
| EA (1) | EA200201158A1 (ru) |
| EE (1) | EE200200667A (ru) |
| ES (1) | ES2245985T3 (ru) |
| HR (1) | HRP20021018A2 (ru) |
| HU (1) | HUP0302323A2 (ru) |
| IL (1) | IL153170A0 (ru) |
| IS (1) | IS6625A (ru) |
| MA (1) | MA26907A1 (ru) |
| MX (1) | MXPA02011926A (ru) |
| NO (1) | NO20025762L (ru) |
| OA (1) | OA12275A (ru) |
| PL (1) | PL359260A1 (ru) |
| SK (1) | SK16632002A3 (ru) |
| WO (1) | WO2001092239A1 (ru) |
| ZA (1) | ZA200209325B (ru) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02002749A (es) * | 2001-03-27 | 2002-10-28 | Warner Lambert Co | Derivados de ciclohexilamina como antagonistas del subtipo selectivo del n-metil-d-aspartato. |
| GB0116594D0 (en) | 2001-07-06 | 2001-08-29 | Cancer Res Ventures Ltd | Therapeutic compounds |
| DE10210779A1 (de) | 2002-03-12 | 2003-10-09 | Merck Patent Gmbh | Cyclische Amide |
| AU2003233244B2 (en) * | 2002-06-07 | 2010-05-20 | Cortical Pty Ltd | Therapeutic molecules and methods-1 |
| MXPA05006650A (es) | 2002-12-20 | 2005-09-30 | Cancer Rec Tech Ltd | Compuestos de 4-(1-(sulfonil)-1h-indol-2-il)-4-(hidroxi)-ciclohexa-2,5-dienona y analogos de los mismos como agentes terapeuticos. |
| CN101087618A (zh) * | 2004-12-23 | 2007-12-12 | 航行药物公司 | 醋酸亮丙瑞林和乙酰胆碱酯酶抑制剂或nmda受体抑制剂在阿尔茨海默氏病治疗中的应用 |
| JP5270943B2 (ja) * | 2008-03-28 | 2013-08-21 | 大阪瓦斯株式会社 | フルオレン誘導体およびこのフルオレン誘導体を用いたアミノ基含有フルオレン誘導体の製造方法 |
| US9345848B2 (en) | 2009-10-20 | 2016-05-24 | Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti. | Dry powder inhaler |
| AR080056A1 (es) * | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| KR20150000875A (ko) | 2012-01-27 | 2015-01-05 | 내셔날 유니버시티 코포레이션 유니버시티 오브 토야마 | 세린 라세마제 저해제 |
| CN105152966A (zh) * | 2015-07-20 | 2015-12-16 | 湖南华腾制药有限公司 | 一种叠氮化合物的制备方法 |
| CN105001118A (zh) * | 2015-07-20 | 2015-10-28 | 湖南华腾制药有限公司 | 一种含碘叠氮化合物的制备方法 |
| CN105153020A (zh) * | 2015-07-20 | 2015-12-16 | 湖南华腾制药有限公司 | 一种芳香叠氮化合物的制备方法 |
| CN105061254A (zh) * | 2015-07-20 | 2015-11-18 | 湖南华腾制药有限公司 | 一种含溴叠氮化合物的合成方法 |
| WO2018033525A1 (en) * | 2016-08-16 | 2018-02-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Agonists or partial agonists of the histamine site of the nmda receptor for use in the treatment of central nervous system diseases |
| CN107043335A (zh) * | 2017-05-31 | 2017-08-15 | 湖南华腾制药有限公司 | 一种2‑氟苯基叠氮化合物的制备方法 |
| WO2019043217A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROBENZIMIDAZOLONES |
| WO2025232878A1 (zh) * | 2024-05-09 | 2025-11-13 | 苏州旺山旺水生物医药股份有限公司 | 一类含取代的苯基的胺类化合物、其制备方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4438055A1 (de) * | 1994-10-25 | 1996-05-02 | Thomae Gmbh Dr K | Ring- und N-substituierte N-Benzyl-cycloalkylamine, ihre Salze mit physiologisch verträglichen organischen oder anorganischen Säuren, Verfahren zur Herstellung dieser Verbindungen und diese enthaltende Arzneimittel |
| DE19812331A1 (de) * | 1998-03-20 | 1999-09-23 | Merck Patent Gmbh | Piperidinderivate |
| EP0982026B1 (en) | 1998-08-18 | 2006-05-17 | F. Hoffmann-La Roche Ag | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers |
-
2001
- 2001-05-08 US US10/276,054 patent/US6794402B2/en not_active Expired - Fee Related
- 2001-05-08 SK SK1663-2002A patent/SK16632002A3/sk not_active Application Discontinuation
- 2001-05-08 EA EA200201158A patent/EA200201158A1/ru unknown
- 2001-05-08 ES ES01933173T patent/ES2245985T3/es not_active Expired - Lifetime
- 2001-05-08 CA CA002409006A patent/CA2409006A1/en not_active Abandoned
- 2001-05-08 DZ DZ013361A patent/DZ3361A1/fr active
- 2001-05-08 MX MXPA02011926A patent/MXPA02011926A/es active IP Right Grant
- 2001-05-08 OA OA1200200358A patent/OA12275A/en unknown
- 2001-05-08 AP APAP/P/2002/002697A patent/AP2002002697A0/en unknown
- 2001-05-08 EP EP01933173A patent/EP1286975B1/en not_active Expired - Lifetime
- 2001-05-08 WO PCT/US2001/014763 patent/WO2001092239A1/en not_active Ceased
- 2001-05-08 IL IL15317001A patent/IL153170A0/xx unknown
- 2001-05-08 AU AU2001259618A patent/AU2001259618A1/en not_active Abandoned
- 2001-05-08 HR HR20021018A patent/HRP20021018A2/hr not_active Application Discontinuation
- 2001-05-08 JP JP2002500853A patent/JP2003535083A/ja active Pending
- 2001-05-08 PL PL01359260A patent/PL359260A1/xx not_active Application Discontinuation
- 2001-05-08 AT AT01933173T patent/ATE302763T1/de not_active IP Right Cessation
- 2001-05-08 KR KR1020027016301A patent/KR20030007797A/ko not_active Withdrawn
- 2001-05-08 EE EEP200200667A patent/EE200200667A/xx unknown
- 2001-05-08 DE DE60112924T patent/DE60112924T2/de not_active Expired - Fee Related
- 2001-05-08 HU HU0302323A patent/HUP0302323A2/hu unknown
- 2001-05-08 BR BR0111301-1A patent/BR0111301A/pt not_active IP Right Cessation
- 2001-05-08 CN CN01811676A patent/CN1438996A/zh active Pending
-
2002
- 2002-11-15 ZA ZA200209325A patent/ZA200209325B/en unknown
- 2002-11-18 IS IS6625A patent/IS6625A/is unknown
- 2002-11-27 MA MA26924A patent/MA26907A1/fr unknown
- 2002-11-29 NO NO20025762A patent/NO20025762L/no not_active Application Discontinuation
- 2002-12-11 BG BG107375A patent/BG107375A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE302763T1 (de) | 2005-09-15 |
| AU2001259618A1 (en) | 2001-12-11 |
| NO20025762D0 (no) | 2002-11-29 |
| HRP20021018A2 (en) | 2004-02-29 |
| ES2245985T3 (es) | 2006-02-01 |
| WO2001092239A1 (en) | 2001-12-06 |
| DE60112924T2 (de) | 2006-03-16 |
| KR20030007797A (ko) | 2003-01-23 |
| CN1438996A (zh) | 2003-08-27 |
| IS6625A (is) | 2002-11-18 |
| JP2003535083A (ja) | 2003-11-25 |
| ZA200209325B (en) | 2004-02-16 |
| PL359260A1 (en) | 2004-08-23 |
| US20030236252A1 (en) | 2003-12-25 |
| AP2002002697A0 (en) | 2002-12-31 |
| HUP0302323A2 (hu) | 2003-10-28 |
| EE200200667A (et) | 2004-06-15 |
| EP1286975B1 (en) | 2005-08-24 |
| US6794402B2 (en) | 2004-09-21 |
| EP1286975A1 (en) | 2003-03-05 |
| DE60112924D1 (de) | 2005-09-29 |
| BG107375A (bg) | 2003-09-30 |
| MXPA02011926A (es) | 2003-04-22 |
| SK16632002A3 (sk) | 2003-08-05 |
| OA12275A (en) | 2003-12-11 |
| CA2409006A1 (en) | 2001-12-06 |
| BR0111301A (pt) | 2003-06-10 |
| IL153170A0 (en) | 2003-06-24 |
| MA26907A1 (fr) | 2004-12-20 |
| NO20025762L (no) | 2003-01-09 |
| DZ3361A1 (fr) | 2001-12-06 |
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