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EA200201057A1 - Новый способ синтеза периндоприла и его фармацевтически приемлемых солей - Google Patents

Новый способ синтеза периндоприла и его фармацевтически приемлемых солей

Info

Publication number
EA200201057A1
EA200201057A1 EA200201057A EA200201057A EA200201057A1 EA 200201057 A1 EA200201057 A1 EA 200201057A1 EA 200201057 A EA200201057 A EA 200201057A EA 200201057 A EA200201057 A EA 200201057A EA 200201057 A1 EA200201057 A1 EA 200201057A1
Authority
EA
Eurasian Patent Office
Prior art keywords
perindopril
pharmaceutically acceptable
acceptable salts
synthesis
new method
Prior art date
Application number
EA200201057A
Other languages
English (en)
Other versions
EA005079B1 (ru
Inventor
Паскаль Ланглуа
Юг Тюрб
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8848925&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200201057(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200201057A1 publication Critical patent/EA200201057A1/ru
Publication of EA005079B1 publication Critical patent/EA005079B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Способ промышленного синтеза периндоприла формулы (I)и его фармацевтически приемлемых солей.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200201057A 2000-04-06 2001-04-05 Способ синтеза периндоприла и его фармацевтически приемлемых солей EA005079B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004379A FR2807431B1 (fr) 2000-04-06 2000-04-06 Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2001/001026 WO2001058868A1 (fr) 2000-04-06 2001-04-05 Procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (2)

Publication Number Publication Date
EA200201057A1 true EA200201057A1 (ru) 2003-06-26
EA005079B1 EA005079B1 (ru) 2004-10-28

Family

ID=8848925

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200201057A EA005079B1 (ru) 2000-04-06 2001-04-05 Способ синтеза периндоприла и его фармацевтически приемлемых солей

Country Status (34)

Country Link
US (1) US6835843B2 (ru)
EP (1) EP1268424B1 (ru)
JP (1) JP3939553B2 (ru)
KR (1) KR100507616B1 (ru)
CN (1) CN1296355C (ru)
AP (1) AP1385A (ru)
AT (1) ATE369338T1 (ru)
AU (2) AU2001248470B2 (ru)
BG (1) BG65984B1 (ru)
BR (1) BRPI0109836B1 (ru)
CA (1) CA2405486C (ru)
CY (1) CY1108522T1 (ru)
CZ (1) CZ302575B6 (ru)
DE (1) DE60129800T2 (ru)
DK (1) DK1268424T3 (ru)
EA (1) EA005079B1 (ru)
EE (1) EE05032B1 (ru)
ES (1) ES2291307T3 (ru)
FR (1) FR2807431B1 (ru)
GE (1) GEP20063797B (ru)
HR (1) HRP20020876B1 (ru)
HU (1) HU227674B1 (ru)
ME (1) ME00441B (ru)
MX (1) MXPA02009706A (ru)
NO (1) NO324174B1 (ru)
NZ (1) NZ521454A (ru)
OA (1) OA12242A (ru)
PL (1) PL204471B1 (ru)
PT (1) PT1268424E (ru)
RS (1) RS50808B (ru)
SK (1) SK286921B6 (ru)
UA (1) UA75070C2 (ru)
WO (1) WO2001058868A1 (ru)
ZA (1) ZA200207419B (ru)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
EP1333026B1 (en) * 2002-01-30 2007-06-27 Les Laboratoires Servier Process for the preparation of high purity perindopril and intermediates useful in the synthesis
JP2005256847A (ja) * 2002-02-28 2005-09-22 Nsk Ltd 車輪用軸受ユニット
GB2395195A (en) 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
DE60301930T2 (de) * 2003-02-28 2006-07-27 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze
PT1403277E (pt) 2003-02-28 2005-11-30 Servier Lab Novo processo de sintese de derivados do acido (2s, 3as, 7as)-1-((s)-alanil)-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese do perindopril
CA2517205C (en) 2003-02-28 2010-08-24 Lupin Limited Process for preparation of perindopril and salts thereof
DK1338591T3 (da) * 2003-02-28 2006-01-23 Servier Lab Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse heraf ved syntese af perindopril
DE60300106T2 (de) * 2003-03-12 2005-10-13 Les Laboratoires Servier Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
ES2231760T3 (es) * 2003-03-12 2005-05-16 Les Laboratoires Servier Nuevo procedimiento de sintesis del acido(2s, 3as,7as)perhidroindol-2-carboxilico y de sus esteres, y su aplicacion a la sintesis de perindopril.
PT1321471E (pt) * 2003-03-12 2005-07-29 Servier Lab Novo processo de sintese do perindopril e dos seus sais aceitaveis sob o ponto de vista farmaceutico
WO2004099138A2 (en) * 2003-05-12 2004-11-18 Cipla Limited Process for the preparation of perindopril
CN101333181A (zh) 2003-06-24 2008-12-31 瑟维尔实验室 培哚普利特丁胺的新晶形
DE60307721T2 (de) * 2003-07-31 2007-10-18 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
ES2271497T3 (es) * 2003-07-31 2007-04-16 Les Laboratoires Servier Nuevo procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
DK1675827T3 (da) * 2003-10-21 2010-04-19 Servier Lab Ny fremgangsmåde til fremstilling af krystallint perindopril erbumin
ES2300555T3 (es) * 2003-12-10 2008-06-16 Les Laboratoires Servier Procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
EP1729739B1 (en) * 2004-03-29 2016-09-28 Les Laboratoires Servier Process for preparing a solid pharmaceutical composition
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
EP1679072B9 (en) * 2005-01-06 2009-09-02 IPCA Laboratories Limited Process for for synthesis of (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indole-2- carboxylic acid derivatives and use in the synthesis of perindopril
US7291745B2 (en) * 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
DE102005058166A1 (de) * 2005-12-05 2007-06-06 Hexal Ag Matrixkontrolliertes transdermales System mit Amin-Salzen der ACE-Hemmer-Dicarbonsäuren
WO2007085933A2 (en) * 2006-01-25 2007-08-02 Glenmark Pharmaceuticals Limited Process for the preparation of n-[1-(s)-ethoxycarbonyl-1-butyl]-(s)-alanine-dmt complex and its use in the preparation of perindopril
EP2137148A1 (en) * 2007-03-22 2009-12-30 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
FR2961105B1 (fr) * 2010-06-15 2013-02-08 Servier Lab Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque
JP2015534581A (ja) * 2012-10-10 2015-12-03 ピラマル エンタープライジーズ リミテッド ペリンドプリル中間体を調製するための改良された製法
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN107098949B (zh) * 2017-04-20 2021-03-16 上药东英（江苏）药业有限公司 一种制备培哚普利叔丁胺盐的绿色合成新工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides

Also Published As

Publication number Publication date
KR100507616B1 (ko) 2005-08-10
HUP0101336A3 (en) 2003-03-28
EP1268424A1 (fr) 2003-01-02
ME00441B (me) 2011-10-10
BR0109836A (pt) 2003-06-24
US20030069431A1 (en) 2003-04-10
CZ20023291A3 (cs) 2003-02-12
OA12242A (en) 2003-12-08
NO20024808L (no) 2002-10-04
JP3939553B2 (ja) 2007-07-04
ATE369338T1 (de) 2007-08-15
BG107249A (bg) 2003-07-31
SK14182002A3 (sk) 2003-02-04
HRP20020876B1 (en) 2010-10-31
DE60129800T2 (de) 2008-06-05
EP1268424B1 (fr) 2007-08-08
ES2291307T3 (es) 2008-03-01
GEP20063797B (en) 2006-04-25
BG65984B1 (bg) 2010-08-31
HU0101336D0 (en) 2001-06-28
HU227674B1 (hu) 2011-11-28
EE05032B1 (et) 2008-06-16
EA005079B1 (ru) 2004-10-28
HRP20020876A2 (en) 2004-02-29
NZ521454A (en) 2004-03-26
CN1296355C (zh) 2007-01-24
DE60129800D1 (de) 2007-09-20
AU2001248470B2 (en) 2005-01-20
ZA200207419B (en) 2003-09-16
CN1420867A (zh) 2003-05-28
AP1385A (en) 2005-04-08
AU4847001A (en) 2001-08-20
SK286921B6 (sk) 2009-07-06
BRPI0109836B1 (pt) 2015-08-04
CA2405486C (fr) 2008-07-29
AP2002002630A0 (en) 2002-09-30
RS50808B (sr) 2010-08-31
CZ302575B6 (cs) 2011-07-20
WO2001058868A1 (fr) 2001-08-16
CY1108522T1 (el) 2014-04-09
YU73802A (sh) 2006-01-16
PL346555A1 (en) 2001-09-10
HUP0101336A2 (hu) 2002-02-28
JP2003531825A (ja) 2003-10-28
EE200200575A (et) 2004-04-15
KR20030013381A (ko) 2003-02-14
NO324174B1 (no) 2007-09-03
MXPA02009706A (es) 2004-09-06
DK1268424T3 (da) 2007-12-17
PL204471B1 (pl) 2010-01-29
NO20024808D0 (no) 2002-10-04
CA2405486A1 (fr) 2001-08-16
FR2807431B1 (fr) 2002-07-19
US6835843B2 (en) 2004-12-28
UA75070C2 (ru) 2006-03-15
HK1053309A1 (en) 2003-10-17
PT1268424E (pt) 2007-10-16
FR2807431A1 (fr) 2001-10-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU