EA200200284A1 - MESOPROGESTINES (PROGESTERONE RECEPTOR MODULATORS) AS A COMPONENT OF WOMEN'S CONTRACEPTIVES - Google Patents
MESOPROGESTINES (PROGESTERONE RECEPTOR MODULATORS) AS A COMPONENT OF WOMEN'S CONTRACEPTIVESInfo
- Publication number
- EA200200284A1 EA200200284A1 EA200200284A EA200200284A EA200200284A1 EA 200200284 A1 EA200200284 A1 EA 200200284A1 EA 200200284 A EA200200284 A EA 200200284A EA 200200284 A EA200200284 A EA 200200284A EA 200200284 A1 EA200200284 A1 EA 200200284A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- mesoprogestins
- progesterone receptor
- contraception
- mesoprogestines
- contraceptives
- Prior art date
Links
- 229940124558 contraceptive agent Drugs 0.000 title 1
- 239000003433 contraceptive agent Substances 0.000 title 1
- 239000002379 progesterone receptor modulator Substances 0.000 title 1
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 title 1
- 102000003998 progesterone receptors Human genes 0.000 abstract 3
- 108090000468 progesterone receptors Proteins 0.000 abstract 3
- 230000001270 agonistic effect Effects 0.000 abstract 2
- 230000003042 antagnostic effect Effects 0.000 abstract 2
- 230000000708 anti-progestin effect Effects 0.000 abstract 1
- 239000003418 antiprogestin Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 239000000583 progesterone congener Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
В заявке описано применение мезопрогестинов для приготовления фармацевтического средства, предназначенного для женской контрацепции, фармацевтическая композиция, предназначенная для женской контрацепции, и способ осуществления женской контрацепции, предусматривающий введение эффективных количеств мезопрогестина женщине, нуждающейся в контрацепции. Мезопрогестин необязательно можно применять в сочетании с эстрогеном. Мезопрогестины в контексте настоящего описания определяются как соединения, обладающие как агонистической, так и антагонистической активностями в отношении рецептора прогестерона (PR) in vivo. Они стабилизируют функцию PR на уровне, который является промежуточным между агонистическим и антагонистическим уровнем. Соответствующие функциональные состояния не могут быть достигнуты с помощью прогестинов или антипрогестинов. Предпочтительными мезопрогестинами по изобретению являются J 867, J 912, J 956 и J 1042.Отчет о международном поиске был опубликован 2002.01.17.The application describes the use of mesoprogestins for the preparation of a pharmaceutical product intended for female contraception, a pharmaceutical composition intended for female contraception, and a method for performing female contraception, comprising administering effective amounts of mesoprogestin to a woman in need of contraception. Mesoprogestin can optionally be used in combination with estrogen. In the context of the present description, mesoprogestins are defined as compounds having both agonistic and antagonistic activities against the progesterone receptor (PR) in vivo. They stabilize PR function at a level that is intermediate between agonistic and antagonistic levels. The corresponding functional states cannot be achieved with progestins or antiprogestins. Preferred mesoprogestins of the invention are J 867, J 912, J 956 and J 1042. The international search report was published 2002.01.17.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38613399A | 1999-08-31 | 1999-08-31 | |
| PCT/IB2000/002053 WO2001026603A2 (en) | 1999-08-31 | 2000-08-31 | Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200200284A1 true EA200200284A1 (en) | 2002-10-31 |
| EA006805B1 EA006805B1 (en) | 2006-04-28 |
Family
ID=23524305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200200284A EA006805B1 (en) | 1999-08-31 | 2000-08-31 | Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP1605949A2 (en) |
| JP (1) | JP2003511399A (en) |
| KR (1) | KR20020038745A (en) |
| CN (1) | CN1384748A (en) |
| AR (1) | AR025455A1 (en) |
| AU (1) | AU781835B2 (en) |
| BG (1) | BG106441A (en) |
| BR (1) | BR0013711A (en) |
| CA (1) | CA2383650A1 (en) |
| CO (1) | CO5190694A1 (en) |
| CZ (1) | CZ2002707A3 (en) |
| EA (1) | EA006805B1 (en) |
| EE (1) | EE200200103A (en) |
| HR (1) | HRP20020265A2 (en) |
| HU (1) | HUP0202515A3 (en) |
| IL (1) | IL148415A0 (en) |
| LT (1) | LT5001B (en) |
| LV (1) | LV12940B (en) |
| MX (1) | MXPA02002186A (en) |
| NO (1) | NO20020998L (en) |
| NZ (1) | NZ517470A (en) |
| PE (1) | PE20010579A1 (en) |
| PL (1) | PL353994A1 (en) |
| SI (1) | SI20853A (en) |
| SK (1) | SK2982002A3 (en) |
| UA (1) | UA77150C2 (en) |
| WO (1) | WO2001026603A2 (en) |
| YU (1) | YU13902A (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005539016A (en) * | 2002-08-02 | 2005-12-22 | シエーリング アクチエンゲゼルシャフト | Progesterone receptor modulators with enhanced anti-gonadotropin activity for female fertility regulation and hormone replacement therapy |
| DE10236405A1 (en) | 2002-08-02 | 2004-02-19 | Schering Ag | New 4-(3-oxo-estra-4,9-dien-11 beta-yl)-benzaldehyde oximes, are progesterone receptor modulators useful in female contraception, hormone replacement therapy and treatment of gynecological disorders |
| EP1624848A4 (en) * | 2003-05-02 | 2009-02-25 | Duramed Pharmaceuticals Inc | Methods of hormornal treatment utilizing extended cycle contraceptive regimens |
| US20050215535A1 (en) * | 2004-03-24 | 2005-09-29 | Kristof Chwalisz | Sequential SPRM/progestin treatment |
| MXPA06014579A (en) * | 2004-07-07 | 2007-03-01 | Wyeth Corp | Cyclic progestin regimens and kits. |
| DE102005050729A1 (en) * | 2005-10-19 | 2007-04-26 | Schering Ag | Method of preventive on-demand hormonal contraception |
| PT2419108T (en) | 2009-04-14 | 2016-11-07 | Hra Pharma Lab | Method for on-demand contraception |
| CN110548034A (en) * | 2019-07-12 | 2019-12-10 | 广州莎蔓生物科技有限公司 | Pregnancy-blocking medicine |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2054271A (en) | 1932-05-17 | 1936-09-15 | Schering Kahlbaum Ag | Production of crystallized hormone esters |
| DE699310C (en) | 1936-11-20 | 1940-11-27 | Chemische Ind Ges | Process for the preparation of compounds of the estradiol type which are esterified in the 3-position |
| US2225419A (en) | 1937-03-01 | 1940-12-17 | Schering Corp | Process for the conversion of 17-cisalcohols of the cyclopentanopolyhydrophenanthrene series into the corresponding 17-trans-alcohols |
| US2611773A (en) | 1951-08-21 | 1952-09-23 | Upjohn Co | Estradiol 17-cyclopenetanepropionate |
| US2990414A (en) | 1957-03-26 | 1961-06-27 | Syntex Sa | 17-undecenoate of estradiol |
| DE3337450A1 (en) | 1983-10-12 | 1985-04-25 | Schering AG, 1000 Berlin und 4709 Bergkamen | PROSTAGLANDINE AND ANTIGESTAGE FOR PREGNANCY ABORT |
| ES2169030T3 (en) * | 1987-09-24 | 2002-07-01 | Jencap Res Ltd | PACKAGING CONTAINERS CONTAINING STROGEN AND PROGESTINE. |
| US5439913A (en) | 1992-05-12 | 1995-08-08 | Schering Aktiengesellschaft | Contraception method using competitive progesterone antagonists and novel compounds useful therein |
| US5516769A (en) | 1993-02-19 | 1996-05-14 | The Medical College Of Hampton Roads | Method of inhibiting fertilization |
| DE4332283A1 (en) | 1993-09-20 | 1995-04-13 | Jenapharm Gmbh | Novel 11-benzaldoximestradiene derivatives, processes for their preparation and medicaments containing these compounds |
| DE4332284C2 (en) * | 1993-09-20 | 1997-05-28 | Jenapharm Gmbh | 11-Benzaldoxime-17beta-methoxy-17alpha-methoxymethyl-estradiene derivatives, process for their preparation and medicaments containing these compounds |
| DE4429397C2 (en) | 1994-08-09 | 2003-11-20 | Jenapharm Gmbh | Estra-1,3,5 (10) -triene derivatives, processes for their preparation and pharmaceutical compositions containing these compounds |
| DE4447714C2 (en) | 1994-08-09 | 1998-02-05 | Jenapharm Gmbh | Oestrogen compsn contg. 3-sulphamoyl:oxy-oestratriene cpd. |
| PT787002E (en) * | 1994-10-24 | 2007-03-30 | Schering Ag | COMPETITIVE PROGESTERONE ANTAGONISTS FOR NEED-ORIENTED FEMALE FERTILITY CONTROL |
| US6040340A (en) * | 1996-05-07 | 2000-03-21 | Schering Aktiengesellschaft | Implantation rates after in vitro fertilization, treatment of infertility and early pregnancy loss with a nitric oxide donor alone or in combination with progesterone, and a method for contraception with nitric oxide inhibitors |
| WO1997049407A1 (en) * | 1996-06-25 | 1997-12-31 | Akzo Nobel N.V. | Progestogen-anti-progestogen regimens |
| WO1998005679A2 (en) * | 1996-08-05 | 1998-02-12 | Duke University | Mixed agonists of the progesterone receptor and assays therefor |
| DE19809845A1 (en) * | 1998-03-03 | 1999-09-09 | Jenapharm Gmbh | S-substituted 11beta-benzaldoxime-estra-4,9-diene-carbonic acid thiol esters, processes for their preparation and pharmaceutical preparations containing these compounds |
| HK1043788A1 (en) * | 1999-05-04 | 2002-09-27 | American Home Products Corporation | Tetracyclic progesterone receptor modulator compounds and methods |
-
2000
- 2000-08-31 NZ NZ517470A patent/NZ517470A/en unknown
- 2000-08-31 SK SK298-2002A patent/SK2982002A3/en unknown
- 2000-08-31 JP JP2001529395A patent/JP2003511399A/en active Pending
- 2000-08-31 HU HU0202515A patent/HUP0202515A3/en unknown
- 2000-08-31 HR HR20020265A patent/HRP20020265A2/en not_active Application Discontinuation
- 2000-08-31 WO PCT/IB2000/002053 patent/WO2001026603A2/en not_active Ceased
- 2000-08-31 AR ARP000104536A patent/AR025455A1/en unknown
- 2000-08-31 MX MXPA02002186A patent/MXPA02002186A/en not_active Application Discontinuation
- 2000-08-31 CN CN00812308A patent/CN1384748A/en active Pending
- 2000-08-31 CO CO00065517A patent/CO5190694A1/en not_active Application Discontinuation
- 2000-08-31 PL PL00353994A patent/PL353994A1/en not_active Application Discontinuation
- 2000-08-31 EP EP00991299A patent/EP1605949A2/en not_active Withdrawn
- 2000-08-31 IL IL14841500A patent/IL148415A0/en unknown
- 2000-08-31 BR BR0013711-1A patent/BR0013711A/en not_active IP Right Cessation
- 2000-08-31 CA CA002383650A patent/CA2383650A1/en not_active Abandoned
- 2000-08-31 YU YU13902A patent/YU13902A/en unknown
- 2000-08-31 PE PE2000000894A patent/PE20010579A1/en not_active Application Discontinuation
- 2000-08-31 EA EA200200284A patent/EA006805B1/en not_active IP Right Cessation
- 2000-08-31 EE EEP200200103A patent/EE200200103A/en unknown
- 2000-08-31 CZ CZ2002707A patent/CZ2002707A3/en unknown
- 2000-08-31 UA UA2002032429A patent/UA77150C2/en unknown
- 2000-08-31 SI SI200020043A patent/SI20853A/en not_active IP Right Cessation
- 2000-08-31 AU AU32150/01A patent/AU781835B2/en not_active Ceased
- 2000-08-31 KR KR1020027002785A patent/KR20020038745A/en not_active Ceased
-
2002
- 2002-02-26 BG BG06441A patent/BG106441A/en unknown
- 2002-02-28 NO NO20020998A patent/NO20020998L/en not_active Application Discontinuation
- 2002-03-26 LT LT2002035A patent/LT5001B/en not_active IP Right Cessation
- 2002-03-28 LV LVP-02-52A patent/LV12940B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU781835B2 (en) | 2005-06-16 |
| SI20853A (en) | 2002-10-31 |
| BR0013711A (en) | 2002-05-07 |
| KR20020038745A (en) | 2002-05-23 |
| BG106441A (en) | 2002-09-30 |
| YU13902A (en) | 2006-01-16 |
| LT2002035A (en) | 2002-10-25 |
| EE200200103A (en) | 2003-04-15 |
| IL148415A0 (en) | 2002-09-12 |
| EP1605949A2 (en) | 2005-12-21 |
| CZ2002707A3 (en) | 2002-11-13 |
| NZ517470A (en) | 2004-03-26 |
| NO20020998D0 (en) | 2002-02-28 |
| CA2383650A1 (en) | 2001-04-19 |
| MXPA02002186A (en) | 2002-09-02 |
| WO2001026603A3 (en) | 2002-01-17 |
| LT5001B (en) | 2003-03-25 |
| HUP0202515A3 (en) | 2004-06-28 |
| PE20010579A1 (en) | 2001-06-04 |
| LV12940B (en) | 2003-06-20 |
| WO2001026603A2 (en) | 2001-04-19 |
| AU3215001A (en) | 2001-04-23 |
| HRP20020265A2 (en) | 2004-02-29 |
| CN1384748A (en) | 2002-12-11 |
| PL353994A1 (en) | 2003-12-15 |
| NO20020998L (en) | 2002-03-14 |
| HUP0202515A2 (en) | 2002-12-28 |
| AR025455A1 (en) | 2002-11-27 |
| CO5190694A1 (en) | 2002-08-29 |
| EA006805B1 (en) | 2006-04-28 |
| UA77150C2 (en) | 2006-11-15 |
| SK2982002A3 (en) | 2002-07-02 |
| JP2003511399A (en) | 2003-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Registration of transfer to a eurasian application by force of assignment | ||
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY RU |