EA200100062A1 - PHTHALASINE DERIVATIVES OF THE INHIBITORS OF DERIVATIVES PHOSPHODYSTERASE 4 - Google Patents
PHTHALASINE DERIVATIVES OF THE INHIBITORS OF DERIVATIVES PHOSPHODYSTERASE 4Info
- Publication number
- EA200100062A1 EA200100062A1 EA200100062A EA200100062A EA200100062A1 EA 200100062 A1 EA200100062 A1 EA 200100062A1 EA 200100062 A EA200100062 A EA 200100062A EA 200100062 A EA200100062 A EA 200100062A EA 200100062 A1 EA200100062 A1 EA 200100062A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- aryl
- alkoxy
- heterocycle
- optionally substituted
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- -1 nitro, carboxy Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 abstract 1
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Pyridine Compounds (AREA)
Abstract
Соединения формулы (I), в которой === представляет собой простую или двойную связь; Z представляет собой NH, метилен, (C-C)алкиленовую цепь, необязательно разветвленную, и/или ненасыщенную, и/или разорванную (C-C)циклоалкильным остатком; A представляет собой фенил или гетероцикл, необязательно замещенный на один или более заместителей, выбранных из оксо-, нитро-, карбоксигрупп и атомов галогена, или CORгруппу, в которой Rпредставляет собой гидрокси, (C-C)алкокси, амино, необязательно замещенный на одну или две (C-C)алкильные группы или на гидрокси; R представляет собой (C-C)алкил или полифтор(C-C)алкильную группу; Rотсутствует, если === представляет собой двойную связь или если === представляет собой простую связь, то он представляет собой а) водород; б) (C-C)алкил, необязательно замещенный на арил, на гетероцикл или на CORгруппу, в которой Rпредставляет собой гидрокси, (C-C)алкокси или гидроксиамино; в) -COR, где Rпредставляет собой водород, арил, арил-(C-C)алкил, необязательно алкилированный или моногидроксилированный амино, гидрокси, (C-C)алкокси, карбокси, (C-C)алкоксикарбонил, формулу (1) или (C-C)алкил, необязательно замещенный на гетероцикл; г) (C-C)алкилсульфонил; Rпредставляет собой два атома водорода или группу =0, если === представляет собой простую связь или если === представляет собой двойную связь, то Rпредставляет собой водород, циано, (C-C)алкоксикарбонил, амидо, необязательно замещенный арил или гетероцикл, (C-C)алкил, (C-C)алкенил или (C-C)алкинил, необязательно разветвленный и/или замещенный на арил или гетероцикл; арилокси, гетероциклилокси, арил-(C-C)-алкокси, гетероциклил-(C-C)алкокси, амино, замещенный на одну или две (C-C)алкильные группы, ариламино, гетероциклиламино, арил-(C-C)алкиламино, гетероциклил-(C-C)алкиламино; Rпредставляет собойThe compounds of formula (I) in which === represents a single or double bond; Z is NH, methylene, (C-C) alkylene chain, optionally branched, and / or unsaturated, and / or broken by (C-C) cycloalkyl residue; A is phenyl or heterocycle optionally substituted with one or more substituents selected from oxo, nitro, carboxy and halogen atoms, or a COR group in which R represents hydroxy, (CC) alkoxy, amino, optionally substituted with one or two (CC) alkyl groups or on hydroxy; R is a (C-C) alkyl or polyfluoro (C-C) alkyl group; R is absent, if === is a double bond or if === is a simple bond, then it is a) hydrogen; b) (C-C) alkyl, optionally substituted on aryl, on a heterocycle or on a COR group, in which R represents hydroxy, (C-C) alkoxy or hydroxyamino; C) -COR, where R represents hydrogen, aryl, aryl- (CC) alkyl, optionally alkylated or monohydroxylated amino, hydroxy, (CC) alkoxy, carboxy, (CC) alkoxycarbonyl, formula (1) or (CC) alkyl, optionally substituted on a heterocycle; d) (C-C) alkylsulfonyl; R represents two hydrogen atoms or a group = 0, if === represents a simple bond or if === represents a double bond, then R represents a hydrogen, cyano, (CC) alkoxycarbonyl, amido, optionally substituted aryl or heterocycle, (CC a) alkyl, (CC) alkenyl or (CC) alkynyl, optionally branched and / or substituted with aryl or heterocycle; aryloxy, heterocyclyloxy, aryl- (C-C) -alkoxy, heterocyclyl- (C-C) alkoxy, amino, substituted with one or two (C-C) alkyl groups, arylamino, heterocyclylamino, aryl- (C-C) alkylamino, heterocyclyl-C-C) alkyl; R represents
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98MI001670A ITMI981670A1 (en) | 1998-07-21 | 1998-07-21 | PHTHALAZINIC DERIVATIVES INHIBITORS OF PHOSPHODIESTERASE 4 |
| PCT/EP1999/004904 WO2000005218A1 (en) | 1998-07-21 | 1999-07-13 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200100062A1 true EA200100062A1 (en) | 2001-08-27 |
Family
ID=11380474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200100062A EA200100062A1 (en) | 1998-07-21 | 1999-07-13 | PHTHALASINE DERIVATIVES OF THE INHIBITORS OF DERIVATIVES PHOSPHODYSTERASE 4 |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US6329370B1 (en) |
| EP (2) | EP1371648A1 (en) |
| JP (1) | JP2002521370A (en) |
| KR (1) | KR20010087161A (en) |
| CN (1) | CN1127486C (en) |
| AP (1) | AP2000001993A0 (en) |
| AR (1) | AR019409A1 (en) |
| AT (1) | ATE279397T1 (en) |
| AU (1) | AU765457B2 (en) |
| BG (1) | BG105063A (en) |
| BR (1) | BR9911175A (en) |
| CA (1) | CA2338044A1 (en) |
| CO (1) | CO5090842A1 (en) |
| DE (1) | DE69921139T2 (en) |
| EA (1) | EA200100062A1 (en) |
| EE (1) | EE200100039A (en) |
| HK (1) | HK1039124B (en) |
| HR (1) | HRP20010057A2 (en) |
| HU (1) | HUP0102646A3 (en) |
| ID (1) | ID28874A (en) |
| IL (1) | IL139490A0 (en) |
| IS (1) | IS5772A (en) |
| IT (1) | ITMI981670A1 (en) |
| MX (1) | MXPA01000670A (en) |
| NO (1) | NO318988B1 (en) |
| NZ (1) | NZ507926A (en) |
| OA (1) | OA11582A (en) |
| PA (1) | PA8478301A1 (en) |
| PE (1) | PE20000755A1 (en) |
| PL (1) | PL345187A1 (en) |
| SK (1) | SK1002001A3 (en) |
| TW (1) | TW509682B (en) |
| UA (1) | UA68383C2 (en) |
| WO (1) | WO2000005218A1 (en) |
| YU (1) | YU77500A (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO4950519A1 (en) * | 1997-02-13 | 2000-09-01 | Novartis Ag | PHTHALAZINES, PHARMACEUTICAL PREPARATIONS THAT UNDERSTAND THEM AND THE PROCESS FOR THEIR PREPARATION |
| IT1296984B1 (en) * | 1997-12-19 | 1999-08-03 | Zambon Spa | PHTHALAZINE DERIVATIVES INHIBITORS OF PHOSPHODIESTERASE 4 |
| ITMI981671A1 (en) | 1998-07-21 | 2000-01-21 | Zambon Spa | PHTHALAZINIC DERIVATIVES INHIBITORS OF PHOSPHODISTERASE 4 |
| DE19921567A1 (en) * | 1999-05-11 | 2000-11-16 | Basf Ag | Use of phthalazine derivatives |
| DE19963607B4 (en) * | 1999-12-23 | 2005-12-15 | Schering Ag | Process for the preparation of 4- (heteroaryl-methyl) halo-1 (2H) -phthalazinones |
| ITMI20000261A1 (en) | 2000-02-16 | 2001-08-16 | Zambon Group | PROCESS FOR THE PREPARATION OF PYRIDYLIDEN-PHTHALIDES |
| US6703390B2 (en) * | 2000-04-13 | 2004-03-09 | Transgenomic, Inc. | Sulfur containing dihydrophthalazine antagonists of excitatory amino acid receptors |
| US6525049B2 (en) * | 2000-07-05 | 2003-02-25 | Pharmacia & Upjohn Company | Pyrroloquinolones as antiviral agents |
| AU2002220241A1 (en) * | 2000-12-01 | 2002-06-11 | Iconix Pharmaceuticals, Inc. | Parb inhibitors |
| ITMI20022738A1 (en) * | 2002-12-23 | 2004-06-24 | Zambon Spa | PHTHALAZINE DERIVATIVES INHIBITORS OF PHOSPHODIESTERASE 4. |
| ITMI20022739A1 (en) * | 2002-12-23 | 2004-06-24 | Zambon Spa | PHTHALAZINE DERIVATIVES INHIBITORS OF PHOSPHODIESTERASE 4. |
| AU2004215624B2 (en) * | 2003-02-25 | 2011-06-02 | Topotarget Uk Limited | Hydroxamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors |
| ITMI20031451A1 (en) * | 2003-07-16 | 2005-01-17 | Zambon Spa | DIIDRO-FTALAZIN DERIVATIVES INHIBITORS OF PHOSPHODIESTERASE 4 |
| WO2006004589A2 (en) * | 2004-05-08 | 2006-01-12 | Neurogen Corporation | 3-aryl-5,6-disubstituted pyridazines |
| EP1833803A4 (en) * | 2005-01-03 | 2009-08-05 | Myriad Genetics Inc | PHARMACEUTICAL COMPOUNDS COMPRISING CASPASE ACTIVATORS AND INDUCERS OF APOPTOSIS AND THE USE THEREOF |
| US20090221664A1 (en) | 2005-10-19 | 2009-09-03 | Abhijit Ray | Pharmaceutical compositions of muscarinic receptor antagonists |
| EP2131656A4 (en) | 2006-11-15 | 2011-12-07 | Forest Lab Holdings Ltd | Phthalazine derivatives |
| US8969348B2 (en) | 2008-08-13 | 2015-03-03 | Boehringer Ingelheim International Gmbh | Chymase inhibitors |
| CN102108078B (en) * | 2009-12-24 | 2013-10-30 | 沈阳药科大学 | 1,4-substituted phthalazine compound and preparation method and applications thereof |
| CN104203919A (en) * | 2011-11-09 | 2014-12-10 | 艾伯维德国有限责任两合公司 | eterocyclic carboxamides useful as inhibitors of phosphodiesterase type 10A |
| CN117924243B (en) * | 2024-01-16 | 2025-09-12 | 沈阳药科大学 | A quinoline derivative and its pharmaceutical composition and application |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2063249A (en) * | 1979-10-09 | 1981-06-03 | Mitsubishi Yuka Pharma | 4-Phenylphthalazine derivatives |
| JPH03106873A (en) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | 1-pyridylphthalazine derivative and inhibitor of blood platelet agglutination containing same derivative |
| DE69105572T2 (en) * | 1990-03-30 | 1995-05-11 | Mitsubishi Chem Ind | 4-phenylphthalazine derivatives. |
| EP0634404A1 (en) | 1993-07-13 | 1995-01-18 | Rhone Poulenc Agriculture Ltd. | Phtalazin derivatives and their use as pesticides |
| WO1996005176A1 (en) * | 1994-08-09 | 1996-02-22 | Eisai Co., Ltd. | Fused pyridazine compound |
| IT1296984B1 (en) * | 1997-12-19 | 1999-08-03 | Zambon Spa | PHTHALAZINE DERIVATIVES INHIBITORS OF PHOSPHODIESTERASE 4 |
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1998
- 1998-07-21 IT IT98MI001670A patent/ITMI981670A1/en unknown
-
1999
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- 1999-07-13 US US09/743,813 patent/US6329370B1/en not_active Expired - Fee Related
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- 1999-07-13 EP EP99938229A patent/EP1097142B1/en not_active Expired - Lifetime
- 1999-07-13 WO PCT/EP1999/004904 patent/WO2000005218A1/en not_active Ceased
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2000
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2001
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