[go: up one dir, main page]

EA200000900A1 - Способ получения защищенного 4-аминометилпирролидин-3-она - Google Patents

Способ получения защищенного 4-аминометилпирролидин-3-она

Info

Publication number
EA200000900A1
EA200000900A1 EA200000900A EA200000900A EA200000900A1 EA 200000900 A1 EA200000900 A1 EA 200000900A1 EA 200000900 A EA200000900 A EA 200000900A EA 200000900 A EA200000900 A EA 200000900A EA 200000900 A1 EA200000900 A1 EA 200000900A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compound
aminomethylprolidin
produce
obtaining protected
Prior art date
Application number
EA200000900A
Other languages
English (en)
Other versions
EA002499B1 (ru
Inventor
Кванг Юл Моон
Вон Суп Ким
Тае Хи Ли
Джей Хиок Чанг
Original Assignee
Эл Джи Кемикал Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эл Джи Кемикал Лтд. filed Critical Эл Джи Кемикал Лтд.
Publication of EA200000900A1 publication Critical patent/EA200000900A1/ru
Publication of EA002499B1 publication Critical patent/EA002499B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Способ получения соединения формулы (1), в которой Pи P- защитные группы; включающий a) взаимодействие соединения формулы (5), где P- такой, как определено для формулы (1); с катализатором никель Ренея в растворителе в атмосфере водорода с получением соединения формулы (6), где P- такой, как определено для формулы (1); b) защиту аминогруппы с получением соединения формулы (7), где Pи P- такие, как определено для формулы (1); и c) селективное восстановление двойной связи с получением соединения формулы (1).Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000900A 1998-03-04 1999-03-04 Способ получения защищенного 4-аминометилпирролидин-3-она, промежуточные соединения и способ получения 3-аминометил-4-алкоксииминопирролидина EA002499B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19980007079 1998-03-04
KR1019980043636A KR100286874B1 (ko) 1998-03-04 1998-10-19 보호된 4-아미노메틸-피롤리딘-3-온의 제조방법
PCT/KR1999/000099 WO1999044991A1 (en) 1998-03-04 1999-03-04 Process for preparing a protected 4-aminomethyl-pyrrolidin-3-one

Publications (2)

Publication Number Publication Date
EA200000900A1 true EA200000900A1 (ru) 2001-02-26
EA002499B1 EA002499B1 (ru) 2002-06-27

Family

ID=26633492

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000900A EA002499B1 (ru) 1998-03-04 1999-03-04 Способ получения защищенного 4-аминометилпирролидин-3-она, промежуточные соединения и способ получения 3-аминометил-4-алкоксииминопирролидина

Country Status (29)

Country Link
US (1) US6307059B1 (ru)
EP (1) EP1068182B1 (ru)
JP (1) JP3374155B2 (ru)
KR (1) KR100286874B1 (ru)
CN (1) CN1149192C (ru)
AP (1) AP1305A (ru)
AT (1) ATE297379T1 (ru)
AU (1) AU742497B2 (ru)
BG (1) BG64674B1 (ru)
BR (1) BRPI9908472B8 (ru)
CA (1) CA2322540C (ru)
CZ (1) CZ301011B6 (ru)
DE (1) DE69925721T2 (ru)
EA (1) EA002499B1 (ru)
ES (1) ES2242382T3 (ru)
HU (1) HU228309B1 (ru)
ID (1) ID25901A (ru)
IL (1) IL137828A0 (ru)
IN (1) IN190979B (ru)
IS (1) IS2296B (ru)
NO (1) NO317258B1 (ru)
NZ (2) NZ506312A (ru)
OA (1) OA11482A (ru)
PT (1) PT1068182E (ru)
SK (1) SK285595B6 (ru)
TR (3) TR200002526T2 (ru)
TW (1) TW453993B (ru)
UA (1) UA71907C2 (ru)
WO (1) WO1999044991A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2718920C1 (ru) * 2017-05-31 2020-04-15 Даевунг Фармасьютикал Ко., Лтд. Способ получения промежуточного соединения для получения производного 4-метоксипиррола

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
MA24500A1 (fr) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
GB9920919D0 (en) * 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
KR20020018560A (ko) * 2000-09-01 2002-03-08 성재갑 3-아미노메틸-4-ｚ-메톡시이미노피롤리딘의 신규 제조방법
PT1412078E (pt) * 2001-08-02 2009-01-08 Lg Life Sciences Ltd Processos para a produção de derivados amino-protegidos da 4- aminometileno-pirrolidin-3-ona, gemifloxacina ou um seu sal
HUP0402310A2 (hu) * 2001-09-26 2005-02-28 Bayer Pharmaceuticals Corporation 1,6-Naftiridin-származékok mint antidiabetikumok és ezeket tartalmazó gyógyszerkészítmények
KR100517638B1 (ko) * 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
KR100515591B1 (ko) * 2003-02-12 2005-09-16 주식회사 엘지화학 4[Ｎ-(ｔ-부톡시카르보닐)아미노)메틸렌]-1-Ｎ-(ｔ-부톡시카르보닌)피롤리돈-3-온의 제조방법
KR100653334B1 (ko) 2003-03-07 2006-12-04 주식회사 엘지생명과학 4-아미노메틸-3-알콕시이미노피롤리딘 메탄설폰산염의 신규한 제조 방법
DE102004010943A1 (de) * 2004-03-03 2005-09-29 Degussa Ag Verfahren zur Herstellung von N-geschützten 4-Ketprolinderivaten
US7185495B2 (en) * 2004-09-07 2007-03-06 General Electric Company System and method for improving thermal efficiency of dry low emissions combustor assemblies
CN104693088B (zh) * 2013-12-06 2018-01-05 常州市勇毅生物药业有限公司 一种吉米沙星侧链的制备方法
CN106349083A (zh) * 2016-08-26 2017-01-25 大连奇凯医药科技有限公司 2,4,6‑三氟苯甲胺的制备方法
CN113773240B (zh) * 2021-10-12 2022-05-31 北京阳光诺和药物研究股份有限公司 吉米沙星侧链化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3309368A (en) * 1965-11-19 1967-03-14 American Cyanamid Co Substituted isoxazoles and methods of preparing the same
US5137892A (en) * 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
JPH0673056A (ja) * 1992-08-26 1994-03-15 Kaken Pharmaceut Co Ltd キノリンカルボン酸誘導体およびその塩
DE69509442T2 (de) 1994-06-16 1999-09-02 Lg Chemical Ltd. Chinolincarbonsäurederivate mit 7-(4-Amino-methyl-3-oxim)-pyrrolidin-Substituenten und Verfahren zu ihrer Herstellung

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2718920C1 (ru) * 2017-05-31 2020-04-15 Даевунг Фармасьютикал Ко., Лтд. Способ получения промежуточного соединения для получения производного 4-метоксипиррола
US10710961B2 (en) 2017-05-31 2020-07-14 Daewoong Pharmaceutical Co., Ltd. Method for preparing intermediate of 4-methoxypyrrole derivative

Also Published As

Publication number Publication date
CA2322540A1 (en) 1999-09-10
ES2242382T3 (es) 2005-11-01
NO317258B1 (no) 2004-09-27
US6307059B1 (en) 2001-10-23
HU228309B1 (en) 2013-03-28
IN190979B (ru) 2003-09-06
NO20004288L (no) 2000-10-25
SK285595B6 (sk) 2007-04-05
EP1068182B1 (en) 2005-06-08
CZ301011B6 (cs) 2009-10-14
AP1305A (en) 2004-09-10
BG104767A (en) 2001-05-31
EA002499B1 (ru) 2002-06-27
OA11482A (en) 2004-05-03
SK12992000A3 (sk) 2001-11-06
TW453993B (en) 2001-09-11
IS5600A (is) 2000-08-22
ID25901A (id) 2000-11-09
AP2000001890A0 (en) 2000-09-30
TR200101801T2 (tr) 2002-06-21
KR100286874B1 (ko) 2001-04-16
AU2643399A (en) 1999-09-20
IS2296B (is) 2007-10-15
DE69925721T2 (de) 2006-03-23
CZ20003109A3 (cs) 2001-07-11
TR200002526T2 (tr) 2001-03-21
ATE297379T1 (de) 2005-06-15
KR19990076521A (ko) 1999-10-15
DE69925721D1 (de) 2005-07-14
JP3374155B2 (ja) 2003-02-04
IL137828A0 (en) 2001-10-31
CN1291975A (zh) 2001-04-18
NO20004288D0 (no) 2000-08-25
BR9908472B1 (pt) 2013-11-05
AU742497B2 (en) 2002-01-03
EP1068182A1 (en) 2001-01-17
JP2002505322A (ja) 2002-02-19
PT1068182E (pt) 2005-10-31
TR200101800T2 (tr) 2002-04-22
UA71907C2 (ru) 2005-01-17
HUP0101094A2 (hu) 2001-08-28
NZ516778A (en) 2002-12-20
CA2322540C (en) 2004-11-30
CN1149192C (zh) 2004-05-12
WO1999044991A1 (en) 1999-09-10
BG64674B1 (bg) 2005-11-30
HUP0101094A3 (en) 2001-11-28
NZ506312A (en) 2002-04-26
BRPI9908472B8 (pt) 2021-05-25
BR9908472A (pt) 2000-12-05

Similar Documents

Publication Publication Date Title
EA200000900A1 (ru) Способ получения защищенного 4-аминометилпирролидин-3-она
DE19882892T1 (de) Herstellung von 3-substituierten Adeninen und Imidazopyridinen
ES2091000T3 (es) Metodo para elaborar intermedios utiles en la sintesis de inhibidores de proteasas retroviricas.
CA2356188A1 (en) Method for the preparation of 5-cyanophthalide
BR9907962A (pt) Composição farmacêntica, composto, e, processo para preparar o mesmo
EA200200253A1 (ru) Ингибиторы клеточной адгезии
EA200400129A1 (ru) Способ получения периндоприла, его аналогов и солей с использованием 2,5-диоксооксазолидиновых промежуточных соединений
ATE342273T1 (de) Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase
BR9710190A (pt) Ligante divisível enzimaticamente processo para sua preparação e uso do mesmo
KR960007548A (ko) 니트로 치환된 아릴아미드 및 아릴아민의 제조 방법
DE69031623D1 (de) Thioacylierungsmittel und zwischenprodukte, thiopeptide, und verfahren zu deren herstellung und anwendung
EA200000924A3 (ru) СПОСОБ ПОЛУЧЕНИЯ ПИРАЗОЛО[4,3-d]ПИРИМИДИН-7-ОН-3-ПИРИДИЛСУЛЬФОНИЛЬНЫХ СОЕДИНЕНИЙ И ИХ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ
EA200000413A1 (ru) Способ синтеза пирроламидов
ZA877862B (en) The synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
BR9808047B1 (pt) processo para a preparação de 2-nitroguanidinas 1,3-dissubstituìdas.
EA200500224A1 (ru) МИКРОБИОЛОГИЧЕСКИЕ СПОСОБЫ ПОЛУЧЕНИЯ 7α-ЗАМЕЩЁННЫХ 11α-ГИДРОКСИСТЕРОИДОВ
ES8601099A1 (es) Procedimiento para la preparacion de nuevos derivados de n-(metoxifenacil)-amina
GB9812937D0 (en) Compounds
ATE34169T1 (de) Verfahren zur herstellung von methyl-nmethylanthranilat.
EP0786460A3 (en) 2-Arylquinolines and process for producing the same
DK1109782T3 (da) Fremgangsmåde til fremstilling af N-beskyttede azetidin-2-carboxylsyrer (AzeOH'er)
JPS6416792A (en) Guanidine related compound containing tetraphenylborate ion, its production and use thereof in peptide synthesis
MXPA05014007A (es) Proceso para la preparacion de un activo cosmetico.
IT1251845B (it) Procedimento per la preparazione di 1-/(2s)-3-merca-prometil-1- ossopropil-/l-prolina
HU9603189D0 (en) Process for producing n-z protected n-alkylated amino acids

Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
QB4A Registration of a licence in a contracting state
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM TJ TM

QB4A Registration of a licence in a contracting state
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY MD

NF4A Restoration of lapsed right to a eurasian patent

Designated state(s): AM BY

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM

MK4A Patent expired

Designated state(s): AZ BY KZ KG RU