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EA199900824A1 - Хинолиновые антагонисты лейкотриенов - Google Patents

Хинолиновые антагонисты лейкотриенов

Info

Publication number
EA199900824A1
EA199900824A1 EA199900824A EA199900824A EA199900824A1 EA 199900824 A1 EA199900824 A1 EA 199900824A1 EA 199900824 A EA199900824 A EA 199900824A EA 199900824 A EA199900824 A EA 199900824A EA 199900824 A1 EA199900824 A1 EA 199900824A1
Authority
EA
Eurasian Patent Office
Prior art keywords
quinoline
leukotrienes
antagonists
compounds
useful
Prior art date
Application number
EA199900824A
Other languages
English (en)
Other versions
EA001797B1 (ru
Inventor
Байрон Х. Эрисон
Суреш К. Балани
Томас А. Бэйлли
Клод Дюфресн
Original Assignee
Мерк Энд Ко., Инк.
Мерк Фросст Кэнада Энд Ко./Мерк Фросст Кэнада Э Ко.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26311611&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199900824(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9711030.8A external-priority patent/GB9711030D0/en
Application filed by Мерк Энд Ко., Инк., Мерк Фросст Кэнада Энд Ко./Мерк Фросст Кэнада Э Ко. filed Critical Мерк Энд Ко., Инк.
Publication of EA199900824A1 publication Critical patent/EA199900824A1/ru
Publication of EA001797B1 publication Critical patent/EA001797B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Соединения формулы (I) являются антагонистами действия лейкотриенов. Эти соединения применяют в качестве противоастматических, противоаллергических, противовоспалительных и цитозащитных (защищающих клетки) агентов. Их также применяют при лечении стенокардии, мозгового спазма, гломерулярного нефрита, гепатита, при наличии в крови эндотоксинов, увеита и при отторжении аллотрансплантата.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900824A 1997-03-13 1998-03-10 Хинолиновые антагонисты лейкотриенов EA001797B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4041397P 1997-03-13 1997-03-13
GBGB9711030.8A GB9711030D0 (en) 1997-05-29 1997-05-29 Quinoline leukrotriene antagonists
PCT/US1998/004609 WO1998039970A1 (en) 1997-03-13 1998-03-10 Quinoline leukotriene antagonists

Publications (2)

Publication Number Publication Date
EA199900824A1 true EA199900824A1 (ru) 2000-04-24
EA001797B1 EA001797B1 (ru) 2001-08-27

Family

ID=26311611

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900824A EA001797B1 (ru) 1997-03-13 1998-03-10 Хинолиновые антагонисты лейкотриенов

Country Status (14)

Country Link
EP (1) EP0971587B1 (ru)
JP (1) JP2001514660A (ru)
AT (1) ATE317224T1 (ru)
AU (1) AU726210B2 (ru)
CA (1) CA2283101C (ru)
DE (1) DE69833429T2 (ru)
EA (1) EA001797B1 (ru)
EE (1) EE03732B1 (ru)
ES (1) ES2256933T3 (ru)
ID (1) ID23656A (ru)
IS (1) IS5167A (ru)
PL (1) PL335604A1 (ru)
TR (1) TR199902242T2 (ru)
WO (1) WO1998039970A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903995D0 (sv) * 1999-11-03 1999-11-03 Astra Ab New combination
ITMI20050247A1 (it) * 2005-02-18 2006-08-19 Chemi Spa Processo per la preparazione di montelukast
KR100774088B1 (ko) * 2006-12-14 2007-11-06 한미약품 주식회사 몬테루카스트의 제조방법 및 이에 사용되는 중간체
JP2012067070A (ja) * 2010-06-25 2012-04-05 Sumitomo Chemical Co Ltd α−ケトカルボン酸の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920130A (en) * 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4918081A (en) * 1988-06-20 1990-04-17 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene d4
US5565473A (en) * 1990-10-12 1996-10-15 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5750539A (en) * 1995-06-07 1998-05-12 Merck Frosst Canada Heteroaryl diol acids as leukotriene antagonists

Also Published As

Publication number Publication date
ATE317224T1 (de) 2006-02-15
AU726210B2 (en) 2000-11-02
TR199902242T2 (xx) 1999-12-21
JP2001514660A (ja) 2001-09-11
DE69833429T2 (de) 2006-11-09
CA2283101A1 (en) 1998-09-17
EE03732B1 (et) 2002-06-17
CA2283101C (en) 2008-01-22
IS5167A (is) 1999-08-30
EP0971587B1 (en) 2006-02-08
AU6758998A (en) 1998-09-29
ES2256933T3 (es) 2006-07-16
EE9900406A (et) 2000-04-17
WO1998039970A1 (en) 1998-09-17
EP0971587A1 (en) 2000-01-19
PL335604A1 (en) 2000-05-08
EA001797B1 (ru) 2001-08-27
EP0971587A4 (en) 2004-08-04
DE69833429D1 (de) 2006-04-20
ID23656A (id) 2000-05-11

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU