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EA199900433A1 - Производные 2-метоксифенилпиперазина - Google Patents

Производные 2-метоксифенилпиперазина

Info

Publication number
EA199900433A1
EA199900433A1 EA199900433A EA199900433A EA199900433A1 EA 199900433 A1 EA199900433 A1 EA 199900433A1 EA 199900433 A EA199900433 A EA 199900433A EA 199900433 A EA199900433 A EA 199900433A EA 199900433 A1 EA199900433 A1 EA 199900433A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
imidazo
relates
formula
well
Prior art date
Application number
EA199900433A
Other languages
English (en)
Inventor
Иштван Ласловски
Дьердь Домани
Тибор Ач
Дьердь Ференци
Чаба мл. Сантаи
Кальман Эстер Туроцине
Эржебет Лапиш
Ференц Тришлер
Бела Хегедуш
Ференц Аут
Моника Чейтеи
Эгон Карпати
Бела Кишш
Юдит Ласи
Пароцаи Маргит Пеллионисне
Адам Шаркади
Шандор Сабо
Original Assignee
Рихтер Гедеон Ведьесети Дьяр Рт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рихтер Гедеон Ведьесети Дьяр Рт. filed Critical Рихтер Гедеон Ведьесети Дьяр Рт.
Publication of EA199900433A1 publication Critical patent/EA199900433A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к новым конденсированным гетероциклическим соединениям с кольцевым соединяющим атомом азота формулы (I)где Q - 2-индолизинил, 2-имидазо [1,2-а] пиридинил, 2-имидазо[1,2-а] пиримидинил, 6-(2,3-дигидроимидазо [2,1-b] тиазол)-ил или 6-имидазо [2,1-b] тиазолил; и n - целое число от 2 до 4, а также к их терапевтически полезным солям. Изобретение также относится к фармацевтическим композициям, включающим эти соединения, а также к способу получения указанных соединений и композиций. Новые соединения формулы (I) проявляют, в основном, нейролептическую активность, поэтому изобретение относится также к способу лечения шизофрении, органических умственных расстройств, эмоциональных расстройств, состояния беспокойства и изменения личности.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900433A 1996-10-30 1997-10-22 Производные 2-метоксифенилпиперазина EA199900433A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9603001A HUP9603001A3 (en) 1996-10-30 1996-10-30 Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
PCT/HU1997/000069 WO1998018797A1 (en) 1996-10-30 1997-10-22 2-methoxyphenylpiperazine derivatives

Publications (1)

Publication Number Publication Date
EA199900433A1 true EA199900433A1 (ru) 1999-10-28

Family

ID=89994394

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900433A EA199900433A1 (ru) 1996-10-30 1997-10-22 Производные 2-метоксифенилпиперазина

Country Status (25)

Country Link
US (1) US6103724A (ru)
EP (1) EP0935599A1 (ru)
JP (1) JP2001503048A (ru)
KR (1) KR20000052872A (ru)
CN (1) CN1235606A (ru)
AP (1) AP9901532A0 (ru)
AR (1) AR010260A1 (ru)
AU (1) AU4962097A (ru)
BG (1) BG103370A (ru)
BR (1) BR9712588A (ru)
CA (1) CA2269814A1 (ru)
CZ (1) CZ132099A3 (ru)
EA (1) EA199900433A1 (ru)
EE (1) EE9900182A (ru)
HU (1) HUP9603001A3 (ru)
IL (1) IL129418A0 (ru)
IS (1) IS5026A (ru)
NO (1) NO992059L (ru)
OA (1) OA11041A (ru)
PL (1) PL333076A1 (ru)
SK (1) SK49499A3 (ru)
TR (1) TR199900946T2 (ru)
TW (1) TW406083B (ru)
WO (1) WO1998018797A1 (ru)
ZA (1) ZA979617B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0982030A3 (en) 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
DK1216249T3 (da) * 1999-09-14 2004-03-15 Aventis Pharma Inc Usubstituerede ethyl- og propylderivater af phenoxythienoisoxazoler som D4-antagonister
US7253165B2 (en) * 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
KR20020027647A (ko) * 1999-09-14 2002-04-13 게리 디. 스트리트, 스티븐 엘. 네스비트 Ｄ4 길항제로서 유용한, 티에노이속사졸릴- 및티에닐피라졸릴-페녹시 치환된 프로필 유도체
AU2001249679A1 (en) * 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
TW200811175A (en) * 2006-06-21 2008-03-01 Nihon Mediphysics Co Ltd Novel compound with affinity with amyloid
CN101903381A (zh) * 2007-10-24 2010-12-01 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物
CA2704027A1 (en) * 2007-10-26 2009-04-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
US7985752B2 (en) * 2008-05-29 2011-07-26 Sk Holdings Co., Ltd. Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof
US7964605B2 (en) * 2008-05-29 2011-06-21 Sk Holdings Co., Ltd. Phenyl piperazine compounds, pharmaceutical composition comprising the same, and use thereof
CN106187873B (zh) * 2016-07-25 2019-11-05 宜春学院 一种芳胺基烷基氧类化合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880824A (en) * 1987-09-21 1989-11-14 Ortho Pharmaceutical Corporation Phenyl and benzoyl substituted imidazo-fused heterocyclic calcium channel blockers
US5688949A (en) * 1991-04-22 1997-11-18 Otsuka Pharmaceutical Factory, Inc. Pyrazolo 1,5-A!pyrimidine derivatives and anti-inflammatory agent containing the same
US5486517A (en) * 1994-05-10 1996-01-23 Warner-Lambert Company Benzimidazoles and imidazopyridines as central nervous system agents
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases

Also Published As

Publication number Publication date
NO992059D0 (no) 1999-04-29
AP9901532A0 (en) 1999-06-30
US6103724A (en) 2000-08-15
BG103370A (bg) 2000-05-31
JP2001503048A (ja) 2001-03-06
CN1235606A (zh) 1999-11-17
AU4962097A (en) 1998-05-22
EE9900182A (et) 1999-12-15
TR199900946T2 (xx) 1999-07-21
HU9603001D0 (en) 1996-12-30
WO1998018797A1 (en) 1998-05-07
TW406083B (en) 2000-09-21
OA11041A (en) 2003-03-07
KR20000052872A (ko) 2000-08-25
PL333076A1 (en) 1999-11-08
AR010260A1 (es) 2000-06-07
SK49499A3 (en) 2000-03-13
HUP9603001A3 (en) 1999-07-28
NO992059L (no) 1999-04-29
HUP9603001A2 (hu) 1998-07-28
IS5026A (is) 1999-04-15
CA2269814A1 (en) 1998-05-07
IL129418A0 (en) 2000-02-17
EP0935599A1 (en) 1999-08-18
CZ132099A3 (cs) 1999-08-11
BR9712588A (pt) 1999-10-26
ZA979617B (en) 1998-05-21

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