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EA199800745A1 - Устовершенствования в области контрастных агентов - Google Patents

Устовершенствования в области контрастных агентов

Info

Publication number
EA199800745A1
EA199800745A1 EA199800745A EA199800745A EA199800745A1 EA 199800745 A1 EA199800745 A1 EA 199800745A1 EA 199800745 A EA199800745 A EA 199800745A EA 199800745 A EA199800745 A EA 199800745A EA 199800745 A1 EA199800745 A1 EA 199800745A1
Authority
EA
Eurasian Patent Office
Prior art keywords
contrast agents
stabilized
developments
field
microbubble
Prior art date
Application number
EA199800745A
Other languages
English (en)
Other versions
EA001135B1 (ru
Inventor
Харальд Дугстад
Йо Клавенесс
Поль Ронгвед
Роальд Скуртвейт
Йорун Бренден
Original Assignee
Нюкомед Имагинг А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9625663.1A external-priority patent/GB9625663D0/en
Application filed by Нюкомед Имагинг А/С filed Critical Нюкомед Имагинг А/С
Publication of EA199800745A1 publication Critical patent/EA199800745A1/ru
Publication of EA001135B1 publication Critical patent/EA001135B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Дисперсии микропузырьков, стабилизированные фосфолипидами, содержащими преимущественно молекулы, которые индивидуально имеют общий результирующий заряд, проявляют улучшенную стабильность, что позволяет использовать их в качестве эффективных контрастных веществ. Кроме того, описан усовершенствованный способ получения контрастных веществ, содержащих микропузырьки, который включает лиофилизацию водной дисперсии газовых микропузырьков, стабилизированных одним или несколькими мембранообразующими липидами, с получением сухого продукта, который можно повторно перевести в контрастное вещество, содержащее микропузырьки, в жидком носителе, пригодном для инъекций.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800745A 1996-02-19 1997-02-19 Усовершенствования в области контрастных агентов EA001135B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GBGB9625663.1A GB9625663D0 (en) 1996-12-11 1996-12-11 Improvements in or relating to contrast agents
PCT/GB1997/000459 WO1997029783A1 (en) 1996-02-19 1997-02-19 Improvements in or relating to contrast agents

Publications (2)

Publication Number Publication Date
EA199800745A1 true EA199800745A1 (ru) 1999-02-25
EA001135B1 EA001135B1 (ru) 2000-10-30

Family

ID=27268137

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800745A EA001135B1 (ru) 1996-02-19 1997-02-19 Усовершенствования в области контрастных агентов

Country Status (24)

Country Link
US (4) US6221337B1 (ru)
EP (2) EP0881915B1 (ru)
JP (1) JP4418033B2 (ru)
KR (1) KR100500334B1 (ru)
CN (1) CN1278740C (ru)
AP (1) AP890A (ru)
AT (1) ATE238072T1 (ru)
AU (1) AU726503B2 (ru)
BG (1) BG102758A (ru)
CA (1) CA2246779C (ru)
CZ (1) CZ293986B6 (ru)
DE (1) DE69721235T2 (ru)
EA (1) EA001135B1 (ru)
EE (1) EE04224B1 (ru)
ES (1) ES2197986T3 (ru)
HU (1) HU229090B1 (ru)
IL (1) IL125748A (ru)
NZ (1) NZ331509A (ru)
OA (1) OA10839A (ru)
PL (1) PL328406A1 (ru)
PT (1) PT881915E (ru)
SK (1) SK284200B6 (ru)
TR (1) TR199801613T2 (ru)
WO (1) WO1997029783A1 (ru)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU784367B2 (en) * 1996-08-02 2006-03-16 Ge Healthcare As Improvements in or relating to contrast agents
IL128345A (en) 1996-08-02 2003-06-24 Amersham Health As Enhanced contrast agent for ultrasound imaging of the liver
CA2268324C (en) * 1997-08-12 2007-06-12 Bracco Research S.A. Administrable compositions and methods for magnetic resonance imaging
GB9717476D0 (en) * 1997-08-18 1997-10-22 Nycomed Imaging As Process
GB9717588D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
GB9717589D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9726773D0 (en) * 1997-12-18 1998-02-18 Nycomed Imaging As Improvements in or relating to ultrasonagraphy
JP2002512886A (ja) * 1998-04-28 2002-05-08 ニユコメド・イメージング・アクシエセルカペト 分離方法におけるまたはこれに関する改良
GB9813568D0 (en) 1998-06-23 1998-08-19 Nycomed Imaging As Improvements in or relating to cardiac imaging
US6514209B1 (en) 1999-06-07 2003-02-04 Drexel University Method of enhancing ultrasonic techniques via measurement of ultraharmonic signals
US20030103960A1 (en) * 1999-12-22 2003-06-05 Pierre Philippart Sealant and bone generating product
EP1289565B1 (en) 2000-06-02 2015-04-22 Bracco Suisse SA Compounds for targeting endothelial cells
NO20004795D0 (no) 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
KR100373712B1 (ko) * 2000-12-23 2003-02-25 사회복지법인삼성생명공익재단(삼성서울병원) 초음파 조영제 및 그의 제조방법
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
EP1387637B1 (en) 2001-04-06 2007-10-31 Bracco Research S.A. Apparatus for measuring local physical parameters in a fluid filled cavity
DE60305438T2 (de) * 2002-02-01 2006-12-21 Shimoda Biotech (Pty.) Ltd., Mill Park Lyophilisierte pharmazeutische zusammensetzung von propofol
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
ES2506142T3 (es) 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
NO20024755D0 (no) * 2002-10-03 2002-10-03 Amersham Health As Metode
CA2504668A1 (en) 2002-11-29 2004-06-17 Amersham Health As Ultrasound triggering method
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
AU2004210221B2 (en) * 2003-02-04 2008-11-20 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
EP2949658B1 (en) 2003-03-03 2018-08-08 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
JP2007522085A (ja) * 2003-06-27 2007-08-09 スミスクライン・ビーチャム・コーポレイション 安定化されたトポテカンリポソーム組成物および方法
US20050019379A1 (en) 2003-07-22 2005-01-27 Kimberly-Clark Worldwide, Inc. Wipe and methods for improving skin health
NO20035401D0 (no) * 2003-12-04 2003-12-04 Amersham Health As Metode
CN100563718C (zh) * 2003-12-22 2009-12-02 伯拉考开发股份有限公司 用于反差成像的充气微囊组件
EP1696965B1 (en) * 2003-12-22 2014-12-10 Bracco Suisse SA Assembly of gas-filled microvesicle with active component for contrast imaging
US7025726B2 (en) 2004-01-22 2006-04-11 The Regents Of The University Of Nebraska Detection of endothelial dysfunction by ultrasonic imaging
JP4837663B2 (ja) 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物
WO2006044997A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for localized measurement and imaging of viscosity of tissues
WO2006044996A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for automated boundary detection of body structures
CN100574811C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用微粒类助剂及其应用
CN100574809C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用氟碳乳剂类助剂及其应用
CN100427142C (zh) * 2005-01-10 2008-10-22 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用助剂及其筛选方法
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
EP1937151A4 (en) * 2005-09-19 2011-07-06 Univ Columbia Systems and methods for opening of the blood-brain barrier of a subject using ultrasound
KR101658439B1 (ko) 2005-12-09 2016-09-21 브라코 스위스 에스.에이. 표적화 벡터-포스포리피드 컨쥬게이트
EP1797919A1 (en) 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
TW200738752A (en) 2006-01-31 2007-10-16 Bayer Schering Pharma Ag Modulation of MDL-1 activity for treatment of inflammatory disease
WO2008016992A1 (en) 2006-08-01 2008-02-07 Scimed Life Systems, Inc. Pulse inversion sequences for nonlinear imaging
US8150128B2 (en) * 2006-08-30 2012-04-03 The Trustees Of Columbia University In The City Of New York Systems and method for composite elastography and wave imaging
DE602007006968D1 (de) 2006-09-05 2010-07-15 Bracco Research Sa Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden
EP2005970A1 (de) 2007-06-22 2008-12-24 Berlin Science Partners GmbH i.V. Bildgebende Diagnostik durch Kombination von Kontrastmitteln
WO2011035312A1 (en) 2009-09-21 2011-03-24 The Trustees Of Culumbia University In The City Of New York Systems and methods for opening of a tissue barrier
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
WO2010014977A1 (en) 2008-08-01 2010-02-04 The Trustees Of Columbia University In The City Of New York Systems and methods for matching and imaging tissue characteristics
WO2010030819A1 (en) 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
WO2010030779A1 (en) * 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Isolation of microbubbles of selected size range from polydisperse microbubbles
EP2470287A4 (en) 2009-08-28 2015-01-21 Univ Columbia SYSTEMS, METHODS AND DEVICES FOR PRODUCING GAS-FILLED MICROBUBBLES
US9107950B2 (en) * 2009-09-15 2015-08-18 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for microbubbles
US9700640B2 (en) * 2009-09-21 2017-07-11 Drexel University Stabilized ultrasound contrast agent
US8834846B2 (en) 2010-05-06 2014-09-16 Bruker Biospin Corporation Fluorescent NIRF activatable probes for disease detection
EP2600771A1 (en) * 2010-08-06 2013-06-12 The Trustees of Columbia University in the City of New York Medical imaging contrast devices, methods, and systems
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
WO2012162664A1 (en) 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
CA2871684C (en) 2012-04-30 2021-01-05 Ge Healthcare As Method for filling a container with a foamable composition
MX354719B (es) 2012-06-26 2018-03-16 Ge Healthcare As Preparacion de una composicion que comprende microburbujas de gas.
WO2014059170A1 (en) 2012-10-10 2014-04-17 The Trustees Of Columbia University In The City Of New York Systems and methods for mechanical mapping of cardiac rhythm
EP2934740B1 (en) 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
US9255907B2 (en) 2013-03-14 2016-02-09 Empire Technology Development Llc Identification of surgical smoke
EP2983687B1 (en) 2013-03-15 2019-09-04 The Regents of The University of California Peptides having reduced toxicity that stimulate cholesterol efflux
US9247921B2 (en) 2013-06-07 2016-02-02 The Trustees Of Columbia University In The City Of New York Systems and methods of high frame rate streaming for treatment monitoring
US10322178B2 (en) 2013-08-09 2019-06-18 The Trustees Of Columbia University In The City Of New York Systems and methods for targeted drug delivery
US10028723B2 (en) 2013-09-03 2018-07-24 The Trustees Of Columbia University In The City Of New York Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
SI3233136T1 (sl) 2014-12-18 2019-08-30 Bracco Suisse Sa Formulacije s plinom napolnjenih usmerjenih mikroveziklov
CN107708742B (zh) * 2015-06-10 2021-01-15 学校法人帝京大学 诊断治疗用气泡制剂(tb)及其使用方法
CN107233583B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种具有超长持续时间的超声造影剂及其制备方法
GB201821049D0 (en) * 2018-12-21 2019-02-06 Ge Healthcare As Ultrasound contrast agent and methods for use therof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
IN172208B (ru) * 1990-04-02 1993-05-01 Sint Sa
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
DE4328642A1 (de) * 1993-08-26 1995-03-02 Byk Gulden Lomberg Chem Fab Ultraschallkontrastmittel
GB9511488D0 (en) * 1995-06-07 1995-08-02 Nycomed Imaging As Improvements in or relating to contrast agents
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator

Also Published As

Publication number Publication date
HUP9900813A3 (en) 1999-11-29
US20050201942A1 (en) 2005-09-15
DE69721235T2 (de) 2004-02-05
EA001135B1 (ru) 2000-10-30
ES2197986T3 (es) 2004-01-16
SK284200B6 (sk) 2004-10-05
EP1331013A3 (en) 2004-03-24
DE69721235D1 (de) 2003-05-28
EP1331013A2 (en) 2003-07-30
WO1997029783A1 (en) 1997-08-21
JP4418033B2 (ja) 2010-02-17
KR100500334B1 (ko) 2005-09-09
CN1213972A (zh) 1999-04-14
US6221337B1 (en) 2001-04-24
HK1014872A1 (en) 1999-10-08
PL328406A1 (en) 1999-01-18
OA10839A (en) 2001-08-13
AU726503B2 (en) 2000-11-09
EP0881915A1 (en) 1998-12-09
ATE238072T1 (de) 2003-05-15
CZ293986B6 (cs) 2004-09-15
HU229090B1 (en) 2013-07-29
AP890A (en) 2000-11-13
NZ331509A (en) 2000-04-28
CA2246779A1 (en) 1997-08-21
BG102758A (en) 1999-09-30
JP2000511510A (ja) 2000-09-05
IL125748A0 (en) 1999-04-11
IL125748A (en) 2002-05-23
EE9800249A (et) 1999-02-15
EP0881915B1 (en) 2003-04-23
PT881915E (pt) 2003-09-30
HUP9900813A2 (hu) 1999-07-28
SK112698A3 (en) 1999-04-13
CN1278740C (zh) 2006-10-11
TR199801613T2 (xx) 1998-11-23
AU1884797A (en) 1997-09-02
KR19990082669A (ko) 1999-11-25
EE04224B1 (et) 2004-02-16
CZ262598A3 (cs) 1999-05-12
CA2246779C (en) 2008-04-29
US20030202942A1 (en) 2003-10-30
AP9801319A0 (en) 1998-09-30
US20010010811A1 (en) 2001-08-02

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