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EA199800611A1 - Производные фенилтиазола с противогерпетическими свойствами - Google Patents

Производные фенилтиазола с противогерпетическими свойствами

Info

Publication number
EA199800611A1
EA199800611A1 EA199800611A EA199800611A EA199800611A1 EA 199800611 A1 EA199800611 A1 EA 199800611A1 EA 199800611 A EA199800611 A EA 199800611A EA 199800611 A EA199800611 A EA 199800611A EA 199800611 A1 EA199800611 A1 EA 199800611A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phenylthiazole
derivatives
methods
deputy
herpetic
Prior art date
Application number
EA199800611A
Other languages
English (en)
Inventor
Джеймс Дж. Крат
Анне-Мари Фоше
Кристине А. Грайгон
Карл Д. Харгрэйв
Бруно Симонэ
Баунхэм Чэвенхэм
Original Assignee
Берингер, Ингельхайм Фармасьютиклс, Инк.
Берингер, Ингельхайм (Канада) Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Берингер, Ингельхайм Фармасьютиклс, Инк., Берингер, Ингельхайм (Канада) Лтд. filed Critical Берингер, Ингельхайм Фармасьютиклс, Инк.
Publication of EA199800611A1 publication Critical patent/EA199800611A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к способам подавления репликации вируса герпеса и лечения герпетической инфекции млекопитающих путем ингибирования герпетического ферментного комплекса хеликазы-праймазы. Настоящее изобретение раскрывает производные фенилтиазола формулы I, ингибирующие герпетическую хеликазу-праймазу, и их фармацевтические составы, содержащие производные фенилтиазола, способы применения и способы получения производных фенилтиазола. В формуле I, где заместитель Z является отличительной особенностью, заместители R и Z имеют значения, приведенные в заявке.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800611A 1995-12-29 1996-12-04 Производные фенилтиазола с противогерпетическими свойствами EA199800611A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US943395P 1995-12-29 1995-12-29
US2320996P 1996-08-02 1996-08-02
PCT/US1996/019131 WO1997024343A1 (en) 1995-12-29 1996-12-04 Phenyl thiazole derivatives with anti herpes virus properties

Publications (1)

Publication Number Publication Date
EA199800611A1 true EA199800611A1 (ru) 1999-04-29

Family

ID=26679472

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800611A EA199800611A1 (ru) 1995-12-29 1996-12-04 Производные фенилтиазола с противогерпетическими свойствами

Country Status (26)

Country Link
US (3) US6057451A (ru)
EP (1) EP0871619B1 (ru)
JP (1) JP4327249B2 (ru)
KR (1) KR19990076964A (ru)
AR (1) AR037060A1 (ru)
AT (1) ATE227279T1 (ru)
AU (1) AU1682897A (ru)
BG (1) BG102583A (ru)
BR (1) BR9612435A (ru)
CA (1) CA2192433C (ru)
CZ (1) CZ207298A3 (ru)
DE (1) DE69624728T2 (ru)
DK (1) DK0871619T3 (ru)
EA (1) EA199800611A1 (ru)
EE (1) EE9800154A (ru)
ES (1) ES2186811T3 (ru)
HU (1) HUP9902341A2 (ru)
IL (1) IL124436A0 (ru)
MX (1) MX9805291A (ru)
NO (1) NO982950D0 (ru)
NZ (1) NZ331104A (ru)
PL (1) PL327582A1 (ru)
PT (1) PT871619E (ru)
SK (1) SK89398A3 (ru)
TR (1) TR199801244T2 (ru)
WO (1) WO1997024343A1 (ru)

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Also Published As

Publication number Publication date
CZ207298A3 (cs) 1998-11-11
JP2000502702A (ja) 2000-03-07
US6057451A (en) 2000-05-02
AU1682897A (en) 1997-07-28
US6458959B1 (en) 2002-10-01
BG102583A (bg) 1999-06-30
US6348477B1 (en) 2002-02-19
JP4327249B2 (ja) 2009-09-09
WO1997024343A1 (en) 1997-07-10
PT871619E (pt) 2003-03-31
NZ331104A (en) 2000-03-27
IL124436A0 (en) 1998-12-06
DE69624728D1 (de) 2002-12-12
EE9800154A (et) 1998-12-15
CA2192433A1 (en) 1997-06-30
CA2192433C (en) 2008-01-08
SK89398A3 (en) 1998-11-04
EP0871619B1 (en) 2002-11-06
AR037060A1 (es) 2004-10-20
KR19990076964A (ko) 1999-10-25
NO982950L (no) 1998-06-25
ATE227279T1 (de) 2002-11-15
BR9612435A (pt) 1999-07-13
HUP9902341A2 (hu) 1999-10-28
DE69624728T2 (de) 2003-07-10
TR199801244T2 (xx) 1998-12-21
EP0871619A1 (en) 1998-10-21
NO982950D0 (no) 1998-06-25
MX9805291A (es) 1998-10-31
DK0871619T3 (da) 2003-03-03
ES2186811T3 (es) 2003-05-16
PL327582A1 (en) 1998-12-21

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