[go: up one dir, main page]

EA199700160A1 - Производные индола в качестве антагонистов eaa - Google Patents

Производные индола в качестве антагонистов eaa

Info

Publication number
EA199700160A1
EA199700160A1 EA199700160A EA199700160A EA199700160A1 EA 199700160 A1 EA199700160 A1 EA 199700160A1 EA 199700160 A EA199700160 A EA 199700160A EA 199700160 A EA199700160 A EA 199700160A EA 199700160 A1 EA199700160 A1 EA 199700160A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indola
eaa
antagonists
derivatives
preparation
Prior art date
Application number
EA199700160A
Other languages
English (en)
Other versions
EA000308B1 (ru
Inventor
Надия Конти
Романо Ди Фабио
Элизабетта Де Маджистрис
Альдо Ферьяни
Original Assignee
ГЛАКСО ВЕЛЛКАМ С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ГЛАКСО ВЕЛЛКАМ С.п.А. filed Critical ГЛАКСО ВЕЛЛКАМ С.п.А.
Publication of EA199700160A1 publication Critical patent/EA199700160A1/ru
Publication of EA000308B1 publication Critical patent/EA000308B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Соединение формулы (I)или его соль, или метаболически лабильный сложный эфир, способы их получения, их применение в медицине и промежуточные соединения для их получения.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700160A 1995-03-04 1996-03-01 Производные индола в качестве антагонистов возбуждающих аминокислот EA000308B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9504361.8A GB9504361D0 (en) 1995-03-04 1995-03-04 Heterocyclic compounds
PCT/EP1996/000840 WO1996027588A1 (en) 1995-03-04 1996-03-01 Indole derivatives as eaa antagonists

Publications (2)

Publication Number Publication Date
EA199700160A1 true EA199700160A1 (ru) 1998-02-26
EA000308B1 EA000308B1 (ru) 1999-04-29

Family

ID=10770638

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700160A EA000308B1 (ru) 1995-03-04 1996-03-01 Производные индола в качестве антагонистов возбуждающих аминокислот

Country Status (23)

Country Link
US (1) US5919811A (ru)
EP (1) EP0813524A1 (ru)
JP (1) JPH11501041A (ru)
KR (1) KR19980702735A (ru)
CN (1) CN1182417A (ru)
AR (1) AR002711A1 (ru)
AU (1) AU708291B2 (ru)
BR (1) BR9607346A (ru)
CA (1) CA2214583A1 (ru)
CO (1) CO4700452A1 (ru)
CZ (1) CZ277997A3 (ru)
EA (1) EA000308B1 (ru)
GB (1) GB9504361D0 (ru)
HU (1) HUP9801838A3 (ru)
IL (1) IL117331A (ru)
MX (1) MX9706605A (ru)
NO (1) NO309323B1 (ru)
NZ (1) NZ303200A (ru)
PE (1) PE62396A1 (ru)
PL (1) PL322084A1 (ru)
TW (1) TW438773B (ru)
WO (1) WO1996027588A1 (ru)
ZA (1) ZA961697B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5886191A (en) * 1997-08-18 1999-03-23 Dupont Pharmaceuticals Company Amidinoindoles, amidinoazoles, and analogs thereof
GB9902455D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
MXPA04005427A (es) * 2001-12-10 2005-04-19 Amgen Inc Ligandos de receptor vainilloide y su uso en tratamientos.
GB0205176D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
WO2004064730A2 (en) * 2003-01-14 2004-08-05 Cytokinetics, Inc. Compounds, compositions and methods
AU2005264988B2 (en) 2004-06-17 2011-09-22 Cytokinetics, Inc. Substituted urea derivatives for treating cardiac diseases
US7176222B2 (en) 2004-07-27 2007-02-13 Cytokinetics, Inc. Syntheses of ureas
US7538223B2 (en) * 2005-08-04 2009-05-26 Cytokinetics, Inc. Compounds, compositions and methods
EP1959947A2 (en) * 2005-12-15 2008-08-27 Cytokinetics, Inc. Certain chemical entities, compositions and methods
US7825120B2 (en) * 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
US20070208000A1 (en) * 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
EP1959960B1 (en) * 2005-12-15 2013-04-10 Cytokinetics, Inc. Certain chemical entities, compositions and methods
EP1959962A2 (en) 2005-12-16 2008-08-27 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
US7989455B2 (en) * 2005-12-19 2011-08-02 Cytokinetics, Inc. Compounds, compositions and methods
WO2009035927A2 (en) * 2007-09-13 2009-03-19 Arete Therapeutics, Inc. Bis-cyclyl substitued ureas or amides as soluble epoxide hydrolase inhibitors
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
US9024018B2 (en) 2009-06-23 2015-05-05 Pharminox Limited 3-substituted-8-substituted-3H-imidazo[5,1-d][1,2,3,5]tetrazin-4-one compounds and their use
WO2011107726A1 (en) 2010-03-01 2011-09-09 Pharminox Ltd Methods and intermediates for the synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines
WO2012085501A1 (en) 2010-12-20 2012-06-28 Pharminox Limited 8 - sulfo - imidazotetrazin- 4 - one compounds and their use as anticancer drug
TWI882026B (zh) 2019-11-11 2025-05-01 荷蘭商卡普三世責任有限公司 工業規模上用於生產ε-己內醯胺及硫酸銨之方法及設備

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity
GB9208492D0 (en) * 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
GB9504361D0 (en) 1995-04-26
IL117331A0 (en) 1996-07-23
ZA961697B (en) 1997-10-01
NO974043L (no) 1997-11-03
AR002711A1 (es) 1998-04-29
KR19980702735A (ko) 1998-08-05
WO1996027588A1 (en) 1996-09-12
US5919811A (en) 1999-07-06
CO4700452A1 (es) 1998-12-29
TW438773B (en) 2001-06-07
BR9607346A (pt) 1997-12-30
CZ277997A3 (cs) 1998-06-17
AU4943896A (en) 1996-09-23
CA2214583A1 (en) 1996-09-12
NZ303200A (en) 1999-01-28
NO974043D0 (no) 1997-09-03
EA000308B1 (ru) 1999-04-29
IL117331A (en) 2000-06-29
PL322084A1 (en) 1998-01-05
HUP9801838A3 (en) 2000-04-28
JPH11501041A (ja) 1999-01-26
CN1182417A (zh) 1998-05-20
HUP9801838A2 (hu) 1998-12-28
PE62396A1 (es) 1997-01-11
AU708291B2 (en) 1999-07-29
NO309323B1 (no) 2001-01-15
EP0813524A1 (en) 1997-12-29
MX9706605A (es) 1998-02-28

Similar Documents

Publication Publication Date Title
EA199700160A1 (ru) Производные индола в качестве антагонистов eaa
EA199900083A1 (ru) Замещенные пиридо- или пиримидосодержащие 6,6 или 6,7-бициклические производные
EA199900166A1 (ru) Замещенные 6,6-гетеробициклические производные
EA199700280A1 (ru) Ингибиторы протеинкиназы с
EA200000391A1 (ru) Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов
FI944729L (fi) Perhydroisoindolijohdannaiset substanssi P:n antagonisteina
EA200201179A1 (ru) Производные 2-аминокарбонил-9h-пурина
EA199900598A1 (ru) Производные 1-арил- и пиридилпиразола с пестицидными свойствами
EA200300050A1 (ru) Гликопептидфосфонатные производные
EA200300118A1 (ru) Тетрагидропиридино- или пиперидиногетероциклические производные
EA200200530A1 (ru) Гетероциклические замещенные пиразолоны
EA200000920A1 (ru) Производные бициклических гидроксамовых кислот
DK1413582T3 (da) Dimere pyrrolobenzodiazepiner
EA200100412A1 (ru) Замещенные 3-цианохинолины в качестве ингибиторов протеинтирозинкиназ
EA200400432A1 (ru) Производные мочевины
EA200200873A1 (ru) Новые пиперазиновые производные
RU94036004A (ru) Промежуточные соединения для получения ароматических аминоспиртовых производных
TR199902593T2 (xx) �kame edilmi� fenil t�revleri, bunlar�n haz�rlanmas� ve kullan�m�.
EA200200510A1 (ru) 4-карбоксиамино-2-этил-1,2,3,4-тетрагидрохинолин в кристаллической форме как ингибитор сетр
LV10949A (lv) Aizvietoti 4-fenil-4piperidinkarboksamidi to iegusanas panemiens farmaceitiska kompozicija
EA199800230A1 (ru) Тетрагидрохинолины в качестве антагонистов nmda (n-метил-d-аспарагиновой кислоты)
EA199801028A1 (ru) Применение производных п-аминофенола для проготовления фармацевтических композиций, используемых при лечении нейродегенеративных заболеваний
EA199900385A1 (ru) Соединения 1-арил-2-ациламиноэтана и их применение в качестве антагонистов нейрокинина, в частности нейрокинина 1
EA200000094A1 (ru) Способ получения замещенного пергидроизоиндола
DE69330601D1 (de) Serotoninergische ergolin derivate

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU