DZ2964A1 - Diphénylurées substituées nouvelles, et compositions pharmaceutiques les contenant. - Google Patents
Diphénylurées substituées nouvelles, et compositions pharmaceutiques les contenant.Info
- Publication number
- DZ2964A1 DZ2964A1 DZ990264A DZ990264A DZ2964A1 DZ 2964 A1 DZ2964 A1 DZ 2964A1 DZ 990264 A DZ990264 A DZ 990264A DZ 990264 A DZ990264 A DZ 990264A DZ 2964 A1 DZ2964 A1 DZ 2964A1
- Authority
- DZ
- Algeria
- Prior art keywords
- diphenylureas
- pharmaceutical compositions
- compositions containing
- new substituted
- substituted
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11248198P | 1998-12-16 | 1998-12-16 | |
| US13700399P | 1999-06-01 | 1999-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DZ2964A1 true DZ2964A1 (fr) | 2004-03-15 |
Family
ID=26810001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DZ990264A DZ2964A1 (fr) | 1998-12-16 | 1999-12-12 | Diphénylurées substituées nouvelles, et compositions pharmaceutiques les contenant. |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US6500863B1 (fr) |
| EP (1) | EP1161232B1 (fr) |
| JP (1) | JP2002532419A (fr) |
| KR (1) | KR20010101243A (fr) |
| CN (1) | CN1334726A (fr) |
| AR (1) | AR029605A1 (fr) |
| AT (1) | ATE262328T1 (fr) |
| AU (1) | AU748799B2 (fr) |
| BG (1) | BG105661A (fr) |
| BR (1) | BR9916159A (fr) |
| CA (1) | CA2355890A1 (fr) |
| CO (1) | CO4990929A1 (fr) |
| CZ (1) | CZ20012150A3 (fr) |
| DE (1) | DE69915888T2 (fr) |
| DK (1) | DK1161232T3 (fr) |
| DZ (1) | DZ2964A1 (fr) |
| EA (1) | EA005210B1 (fr) |
| ES (1) | ES2217871T3 (fr) |
| HK (1) | HK1043535B (fr) |
| HU (1) | HUP0104686A3 (fr) |
| IL (1) | IL143507A0 (fr) |
| MA (1) | MA25366A1 (fr) |
| NO (1) | NO20012948L (fr) |
| NZ (1) | NZ511993A (fr) |
| OA (1) | OA11731A (fr) |
| PE (1) | PE20001323A1 (fr) |
| PL (1) | PL348179A1 (fr) |
| PT (1) | PT1161232E (fr) |
| SK (1) | SK8222001A3 (fr) |
| TR (1) | TR200101772T2 (fr) |
| UY (1) | UY25842A1 (fr) |
| WO (1) | WO2000035442A1 (fr) |
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|---|---|---|---|---|
| US7517880B2 (en) * | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| WO2000042012A1 (fr) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | DIPHENYLUREES A SUBSTITUANTS φ-CARBOXYARYLES, INHIBITRICES DE KINASE RAF |
| US7351834B1 (en) | 1999-01-13 | 2008-04-01 | Bayer Pharmaceuticals Corporation | ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| AR029637A1 (es) * | 1999-05-28 | 2003-07-10 | Smithkline Beecham Corp | Compuestos de guanidina, antagonistas de los receptores de la il-8, una composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de un medicamento |
| EP1265905A4 (fr) * | 2000-03-01 | 2003-03-12 | Smithkline Beecham Corp | Antagonistes du recepteur de l'interleukine 8 (il-8) |
| MY133845A (en) * | 2000-03-10 | 2007-11-30 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| EP1261329A4 (fr) * | 2000-03-10 | 2005-08-17 | Smithkline Beecham Corp | Antagonistes du recepteur de il-8 |
| EP1274415A4 (fr) * | 2000-03-14 | 2005-09-07 | Smithkline Beecham Corp | Antagonistes du recepteur de il-8 |
| AR030689A1 (es) * | 2000-03-14 | 2003-09-03 | Smithkline Beecham Corp | Compuestos de 3-aminosulfonil-2-hidroxifenil urea, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la manufactura de medicamentos para tratar enfermedades mediadas por quimioquinas |
| AR031098A1 (es) * | 2000-03-16 | 2003-09-10 | Smithkline Beecham Corp | Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina |
| US6664259B2 (en) * | 2000-03-16 | 2003-12-16 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| UY26627A1 (es) * | 2000-03-24 | 2001-09-28 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
| WO2001076530A2 (fr) | 2000-04-07 | 2001-10-18 | Smithkline Beecham Corporation | Antagonistes vis-a-vis du recepteur de l'interleukine-8 (il-8) |
| EP1309595A2 (fr) * | 2000-08-09 | 2003-05-14 | Boehringer Ingelheim Pharmaceuticals Inc. | Synthese de (r)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-h-imidazo 1,2-a]imidazol-2-one |
| UA82827C2 (en) * | 2000-12-18 | 2008-05-26 | Inhibitors against the production and release of inflammatory cytokines | |
| US20040048897A1 (en) * | 2001-01-16 | 2004-03-11 | Mccleland Brent | Il-8 receptor antagonists |
| KR20030088044A (ko) * | 2001-03-30 | 2003-11-15 | 스미스클라인 비참 코포레이션 | 페놀-함유 화합물의 합성 방법 |
| TW200303742A (en) * | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
| US20030207872A1 (en) * | 2002-01-11 | 2003-11-06 | Bayer Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| MXPA04007832A (es) | 2002-02-11 | 2005-09-08 | Bayer Pharmaceuticals Corp | Aril-ureas con actividad inhibitoria de angiogenesis. |
| TW200410671A (en) * | 2002-06-05 | 2004-07-01 | Inst Med Molecular Design Inc | Medicines for inhibiting the activation of AP-1 |
| CN1658855B (zh) | 2002-06-06 | 2010-04-28 | 株式会社医药分子设计研究所 | O-取代羟基芳基衍生物 |
| MY143477A (en) * | 2002-10-29 | 2011-05-31 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| WO2009039091A1 (fr) * | 2007-09-21 | 2009-03-26 | Smithkline Beecham Corporation | Procédé de traitement |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| EP1636585B2 (fr) | 2003-05-20 | 2012-06-13 | Bayer HealthCare LLC | Diaryl-urees presentant une activite d'inhibition des kinases |
| HRP20060073B1 (hr) | 2003-07-23 | 2014-03-14 | Bayer Healthcare Llc | Fluoro supstituirana omega-karboksiaril difenil urea za lijeäśenje i prevenciju bolesti i stanja |
| US20070249625A1 (en) * | 2004-10-20 | 2007-10-25 | Jakob Busch-Petersen | Il-8 Receptor Antagonists |
| CA2650007A1 (fr) * | 2006-04-21 | 2007-11-01 | Smithkline Beecham Corporation | Antagonistes du recepteur de l'il-8 |
| AR060562A1 (es) | 2006-04-21 | 2008-06-25 | Smithkline Beecham Corp | Compuestos heterociclicos como antagonistas del receptor il-8. procesos de obtencion y composiciones farmaceuticas. |
| US7671058B2 (en) | 2006-06-21 | 2010-03-02 | Institute Of Medicinal Molecular Design, Inc. | N-(3,4-disubstituted phenyl) salicylamide derivatives |
| PE20080943A1 (es) | 2006-06-23 | 2008-09-27 | Smithkline Beecham Corp | Sal toluenosulfonato de 4-{[6-cloro-3-({[(2-cloro-3-fluorofenil)amino]carbonil}amino)-2-hidroxifenil]sulfonil}-1-piperazinacarboxilato de 1,1-dimetiletilo como antagonista del receptor de il-8 |
| EP2110019A1 (fr) | 2008-04-19 | 2009-10-21 | Bayer CropScience AG | Composés herbicides à base de N-azinyl-N'-pyridylsulfonylurées |
| EP2406389B1 (fr) | 2009-03-13 | 2019-05-08 | Agios Pharmaceuticals, Inc. | Procédés et compositions pour des troubles liés à la prolifération cellulaire |
| CA2944788C (fr) | 2009-06-29 | 2023-08-22 | Agios Pharmaceuticals, Inc. | Composes, et compositions associees, qui modulent la pyruvate kinase m2, et methodes de fabrication associees |
| CA2793835C (fr) | 2009-10-21 | 2021-07-20 | Agios Pharmaceuticals, Inc. | Procedes et compositions pour des troubles relatifs |
| US8962606B2 (en) * | 2009-10-21 | 2015-02-24 | Bayer Intellectual Property Gmbh | Substituted benzosulphonamides |
| WO2011050211A2 (fr) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Procédés et compositions pour troubles associés à la prolifération cellulaire |
| WO2011073248A1 (fr) | 2009-12-17 | 2011-06-23 | Galderma Research & Development | Utilisation de composés dans traitement ou prévention d'affections cutanées |
| KR101873543B1 (ko) | 2011-05-03 | 2018-07-02 | 아지오스 파마슈티컬스 아이엔씨. | 치료에 사용하기 위한 피루베이트 키나아제 활성제 |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| SG11201403878QA (en) | 2012-01-06 | 2014-08-28 | Agios Pharmaceuticals Inc | Therapeutically active compounds and their methods of use |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| HK1213798A1 (zh) * | 2012-10-15 | 2016-07-15 | 安吉奥斯医药品有限公司 | 治療性化合物和組合物 |
| WO2015003360A2 (fr) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Composés thérapeutiquement actifs et leurs méthodes d'utilisation |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| WO2015003355A2 (fr) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Composés thérapeutiquement actifs et leurs méthodes d'utilisation |
| NZ715738A (en) | 2013-07-11 | 2021-06-25 | Agios Pharmaceuticals Inc | N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as idh2 mutants inhibitors for the treatment of cancer |
| CA2917671A1 (fr) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Composes de 2,4 ou de 4,6-diaminopyrimidine en tant qu'inhibiteurs des mutants idh2 pour le traitement du cancer |
| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| CA2942072C (fr) | 2014-03-14 | 2022-07-26 | Agios Pharmaceuticals, Inc. | Compositions pharmaceutiques et utilisation de (s)-1-(2-chlorophenyle)-2-((3,3-di fluorocyclobutyle)amino)-2-oxoethyle)-1-(4-cyanopyridin-2-yl)-n-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
| FR3030515B1 (fr) | 2014-12-23 | 2017-01-20 | Galderma Res & Dev | Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines |
| DK3307271T3 (da) | 2015-06-11 | 2023-10-09 | Agios Pharmaceuticals Inc | Fremgangsmåder til anvendelse af pyruvatkinase-aktivatorer |
| MA71411A (fr) | 2015-10-15 | 2025-04-30 | Les Laboratoires Servier | Polythérapie pour le traitement de tumeurs malignes |
| DK3362066T3 (da) | 2015-10-15 | 2021-11-22 | Les Laboratoires Servier Sas | Kombinationsterapi til behandling af maligniteter |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| CN112778167A (zh) * | 2019-11-01 | 2021-05-11 | 邵阳学院 | 一种快速制备n-苯磺酰基氨基酸酯类化合物的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3972886A (en) * | 1972-07-13 | 1976-08-03 | Leo Pharmaceutical Products Ltd. | Certain 4-phenoxy-3-heteroarylmethyl or ethyl sulfamyl benzoic acid derivatives |
| US4155930A (en) * | 1978-07-11 | 1979-05-22 | American Cyanamid Company | Ureylene phenylene anionic naphthalenesulfonic acids |
| US4786316A (en) * | 1984-07-13 | 1988-11-22 | E. I. Du Pont De Nemours And Company | Herbicidal ortho-sulfamoyl sulfonamides |
| HUP9903922A3 (en) * | 1996-06-27 | 2001-12-28 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| EP0932405A4 (fr) * | 1996-06-27 | 2001-10-17 | Smithkline Beckman Corp | Antagonistes des recepteurs d'il-8 |
| DE1019040T1 (de) * | 1997-05-23 | 2001-02-08 | Bayer Corp., West Haven | Hemmung von p38 kinase aktivität durch arylharnstoff |
-
1999
- 1999-12-09 UY UY25842A patent/UY25842A1/es unknown
- 1999-12-12 DZ DZ990264A patent/DZ2964A1/fr active
- 1999-12-13 CO CO99077673A patent/CO4990929A1/es unknown
- 1999-12-14 AR ARP990106373A patent/AR029605A1/es not_active Application Discontinuation
- 1999-12-14 PE PE1999001243A patent/PE20001323A1/es not_active Application Discontinuation
- 1999-12-15 DK DK99965288T patent/DK1161232T3/da active
- 1999-12-15 HK HK02103608.6A patent/HK1043535B/en not_active IP Right Cessation
- 1999-12-15 US US09/868,165 patent/US6500863B1/en not_active Expired - Fee Related
- 1999-12-15 IL IL14350799A patent/IL143507A0/xx unknown
- 1999-12-15 CZ CZ20012150A patent/CZ20012150A3/cs unknown
- 1999-12-15 JP JP2000587762A patent/JP2002532419A/ja not_active Ceased
- 1999-12-15 EA EA200100659A patent/EA005210B1/ru not_active IP Right Cessation
- 1999-12-15 TR TR2001/01772T patent/TR200101772T2/xx unknown
- 1999-12-15 PL PL99348179A patent/PL348179A1/xx not_active Application Discontinuation
- 1999-12-15 EP EP99965288A patent/EP1161232B1/fr not_active Expired - Lifetime
- 1999-12-15 DE DE1999615888 patent/DE69915888T2/de not_active Expired - Lifetime
- 1999-12-15 ES ES99965288T patent/ES2217871T3/es not_active Expired - Lifetime
- 1999-12-15 BR BR9916159-1A patent/BR9916159A/pt not_active IP Right Cessation
- 1999-12-15 SK SK822-2001A patent/SK8222001A3/sk unknown
- 1999-12-15 AU AU31237/00A patent/AU748799B2/en not_active Ceased
- 1999-12-15 HU HU0104686A patent/HUP0104686A3/hu unknown
- 1999-12-15 NZ NZ511993A patent/NZ511993A/en not_active IP Right Cessation
- 1999-12-15 WO PCT/US1999/029940 patent/WO2000035442A1/fr not_active Ceased
- 1999-12-15 PT PT99965288T patent/PT1161232E/pt unknown
- 1999-12-15 CA CA002355890A patent/CA2355890A1/fr not_active Abandoned
- 1999-12-15 KR KR1020017007504A patent/KR20010101243A/ko not_active Ceased
- 1999-12-15 OA OA1200100154A patent/OA11731A/en unknown
- 1999-12-15 CN CN99816125A patent/CN1334726A/zh active Pending
- 1999-12-15 AT AT99965288T patent/ATE262328T1/de active
-
2001
- 2001-06-13 MA MA26236A patent/MA25366A1/fr unknown
- 2001-06-14 NO NO20012948A patent/NO20012948L/no not_active Application Discontinuation
- 2001-06-29 BG BG105661A patent/BG105661A/xx unknown
-
2002
- 2002-11-18 US US10/299,503 patent/US20030109527A1/en not_active Abandoned
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