DK471384D0 - Substituerede 2-mercoptoimidazoler og fremgangsmaade til fremstilling deraf - Google Patents
Substituerede 2-mercoptoimidazoler og fremgangsmaade til fremstilling derafInfo
- Publication number
- DK471384D0 DK471384D0 DK471384A DK471384A DK471384D0 DK 471384 D0 DK471384 D0 DK 471384D0 DK 471384 A DK471384 A DK 471384A DK 471384 A DK471384 A DK 471384A DK 471384 D0 DK471384 D0 DK 471384D0
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- substituted
- group
- compounds
- image
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- -1 1-substituted-5-hydroxymethyl-2-mercapto-imidazoles Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KEQUNHIAUQQPAC-UHFFFAOYSA-N Dihydroxyacetone (dimer) Chemical compound OCC1(O)COC(O)(CO)CO1 KEQUNHIAUQQPAC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 abstract 1
- 229940116357 potassium thiocyanate Drugs 0.000 abstract 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Epoxy Resins (AREA)
- Cephalosporin Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI833794 | 1983-10-18 | ||
| FI833794A FI833794A0 (fi) | 1983-10-18 | 1983-10-18 | Substituerade 2-merkapto-imidazoler |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK471384D0 true DK471384D0 (da) | 1984-10-02 |
| DK471384A DK471384A (da) | 1985-04-19 |
| DK174201B1 DK174201B1 (da) | 2002-09-16 |
Family
ID=8517935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198404713A DK174201B1 (da) | 1983-10-18 | 1984-10-02 | Substituerede 2-mercoptoimidazoler eller syreadditionssalte deraf samt fremgangsmåde til fremstilling af disse forbindelser |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4584383A (da) |
| EP (1) | EP0146228B1 (da) |
| JP (1) | JPS60149568A (da) |
| AT (1) | ATE32064T1 (da) |
| AU (1) | AU566437B2 (da) |
| DD (1) | DD236730A1 (da) |
| DE (1) | DE3468869D1 (da) |
| DK (1) | DK174201B1 (da) |
| ES (1) | ES8507507A1 (da) |
| FI (1) | FI833794A0 (da) |
| HU (1) | HU191960B (da) |
| IE (1) | IE57591B1 (da) |
| IL (1) | IL73255A (da) |
| NO (1) | NO159167C (da) |
| NZ (1) | NZ209896A (da) |
| SU (1) | SU1301313A3 (da) |
| UA (1) | UA5972A1 (da) |
| ZA (1) | ZA848112B (da) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634711A (en) * | 1985-08-02 | 1987-01-06 | Smithkline Beckman Corporation | Pyridylalkyl imidazole-2-thiols |
| US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
| US4882348A (en) * | 1987-12-29 | 1989-11-21 | Smithkline Beckman Corporation | 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors |
| US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
| US5210079A (en) * | 1988-01-07 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists |
| CA1338238C (en) | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| US5354867A (en) * | 1988-12-06 | 1994-10-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| JP2568315B2 (ja) * | 1989-06-30 | 1997-01-08 | イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー | 縮合環アリール置換イミダゾール |
| US5073566A (en) * | 1989-11-30 | 1991-12-17 | Eli Lilly And Company | Angiotensin ii antagonist 1,3-imidazoles and use thereas |
| US5332820A (en) * | 1991-05-20 | 1994-07-26 | E. I. Du Pont De Nemours And Company | Dibenzobicyclo(2.2.2) octane angiotensin II antagonists |
| US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| US5401851A (en) * | 1992-06-03 | 1995-03-28 | Eli Lilly And Company | Angiotensin II antagonists |
| IT1295405B1 (it) | 1997-09-30 | 1999-05-12 | Merck Sharp & Dohme Italia S P | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di |
| KR100567183B1 (ko) * | 1997-11-14 | 2006-06-13 | 론자 아게 | 포르밀이미다졸의제조방법 |
| US6630593B1 (en) | 1999-09-06 | 2003-10-07 | Lg Chem Investment Ltd. | Process for preparing a 1-substituted 5-hydroxymethyl imidazole |
| KR100388788B1 (ko) * | 1999-09-06 | 2003-06-25 | 주식회사 엘지생명과학 | 1-치환된-5-하이드록시메틸 이미다졸의 신규 제조방법 |
| US6620939B2 (en) * | 2001-09-18 | 2003-09-16 | General Electric Company | Method for producing bisphenol catalysts and bisphenols |
| US7112702B2 (en) * | 2002-12-12 | 2006-09-26 | General Electric Company | Process for the synthesis of bisphenol |
| FI116292B (fi) | 2003-01-08 | 2005-10-31 | Juvantia Pharma Ltd Oy | Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita |
| US7132575B2 (en) * | 2003-07-01 | 2006-11-07 | General Electric Company | Process for the synthesis of bisphenol |
| FI20050391A0 (fi) * | 2005-04-15 | 2005-04-15 | Orion Corp | Detomidiinihydrokloridin kiteytysmenetelmä |
| CN101747280B (zh) * | 2008-11-28 | 2011-11-09 | 上海迪赛诺医药发展有限公司 | 制备地托咪定及其中间体的方法 |
| US20210323929A1 (en) | 2018-07-18 | 2021-10-21 | Clexio Biosciences Ltd. | Purified Detomidine, Process of Preparing and Methods of Use |
| EP3782989A1 (en) | 2019-08-23 | 2021-02-24 | Andreas Sachse | Detomidine hydrochloride monohydrate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2541924A (en) * | 1948-09-17 | 1951-02-13 | Lilly Co Eli | Synthesis of substituted imidazoles |
| AU518569B2 (en) * | 1979-08-07 | 1981-10-08 | Farmos-Yhtyma Oy | 4-benzyl- and 4-benzoyl imidazole derivatives |
| GB2092569B (en) * | 1981-02-05 | 1984-09-19 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
-
1983
- 1983-10-18 FI FI833794A patent/FI833794A0/fi not_active Application Discontinuation
-
1984
- 1984-09-24 ES ES536186A patent/ES8507507A1/es not_active Expired
- 1984-10-02 DK DK198404713A patent/DK174201B1/da not_active IP Right Cessation
- 1984-10-16 NZ NZ209896A patent/NZ209896A/en unknown
- 1984-10-16 AT AT84307095T patent/ATE32064T1/de not_active IP Right Cessation
- 1984-10-16 JP JP59218160A patent/JPS60149568A/ja not_active Expired - Lifetime
- 1984-10-16 AU AU34263/84A patent/AU566437B2/en not_active Expired
- 1984-10-16 IL IL73255A patent/IL73255A/xx not_active IP Right Cessation
- 1984-10-16 DE DE8484307095T patent/DE3468869D1/de not_active Expired
- 1984-10-16 IE IE2652/84A patent/IE57591B1/en not_active IP Right Cessation
- 1984-10-16 US US06/661,487 patent/US4584383A/en not_active Expired - Lifetime
- 1984-10-16 DD DD84268430A patent/DD236730A1/de not_active IP Right Cessation
- 1984-10-16 EP EP84307095A patent/EP0146228B1/en not_active Expired
- 1984-10-17 NO NO844139A patent/NO159167C/no not_active IP Right Cessation
- 1984-10-17 UA UA3801008A patent/UA5972A1/uk unknown
- 1984-10-17 SU SU843801008A patent/SU1301313A3/ru active
- 1984-10-17 ZA ZA848112A patent/ZA848112B/xx unknown
- 1984-10-17 HU HU843890A patent/HU191960B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE57591B1 (en) | 1993-01-13 |
| EP0146228A1 (en) | 1985-06-26 |
| EP0146228B1 (en) | 1988-01-20 |
| NO159167B (no) | 1988-08-29 |
| NO844139L (no) | 1985-04-19 |
| DE3468869D1 (en) | 1988-02-25 |
| IL73255A0 (en) | 1985-01-31 |
| ES536186A0 (es) | 1985-09-01 |
| IL73255A (en) | 1988-11-30 |
| ATE32064T1 (de) | 1988-02-15 |
| AU3426384A (en) | 1985-04-26 |
| UA5972A1 (uk) | 1994-12-29 |
| ZA848112B (en) | 1985-06-26 |
| DK174201B1 (da) | 2002-09-16 |
| HUT35649A (en) | 1985-07-29 |
| DD236730A1 (de) | 1986-06-18 |
| SU1301313A3 (ru) | 1987-03-30 |
| AU566437B2 (en) | 1987-10-22 |
| JPS60149568A (ja) | 1985-08-07 |
| IE842652L (en) | 1985-04-18 |
| DK471384A (da) | 1985-04-19 |
| FI833794A0 (fi) | 1983-10-18 |
| US4584383A (en) | 1986-04-22 |
| NO159167C (no) | 1988-12-07 |
| NZ209896A (en) | 1987-02-20 |
| HU191960B (en) | 1987-04-28 |
| ES8507507A1 (es) | 1985-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PUP | Patent expired |