DK4182308T3 - Pyridazinylamino derivatives as ALK5 inhibitors - Google Patents
Pyridazinylamino derivatives as ALK5 inhibitors Download PDFInfo
- Publication number
- DK4182308T3 DK4182308T3 DK21743186.5T DK21743186T DK4182308T3 DK 4182308 T3 DK4182308 T3 DK 4182308T3 DK 21743186 T DK21743186 T DK 21743186T DK 4182308 T3 DK4182308 T3 DK 4182308T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyridazinylamino
- derivatives
- alk5 inhibitors
- alk5
- inhibitors
- Prior art date
Links
- -1 Pyridazinylamino Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20185890 | 2020-07-15 | ||
| PCT/EP2021/069649 WO2022013307A1 (en) | 2020-07-15 | 2021-07-14 | Pyridazinyl amino derivatives as alk5 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK4182308T3 true DK4182308T3 (en) | 2024-10-21 |
Family
ID=71620257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK21743186.5T DK4182308T3 (en) | 2020-07-15 | 2021-07-14 | Pyridazinylamino derivatives as ALK5 inhibitors |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US12479826B2 (en) |
| EP (1) | EP4182308B1 (en) |
| JP (1) | JP7686741B2 (en) |
| KR (1) | KR20230051500A (en) |
| CN (1) | CN116096719B (en) |
| AR (1) | AR122986A1 (en) |
| AU (1) | AU2021307559A1 (en) |
| BR (1) | BR112023000588A8 (en) |
| CA (1) | CA3184990A1 (en) |
| DK (1) | DK4182308T3 (en) |
| ES (1) | ES2997111T3 (en) |
| FI (1) | FI4182308T3 (en) |
| HR (1) | HRP20241617T1 (en) |
| HU (1) | HUE069150T2 (en) |
| MX (1) | MX2023000521A (en) |
| PL (1) | PL4182308T3 (en) |
| PT (1) | PT4182308T (en) |
| SI (1) | SI4182308T1 (en) |
| TW (1) | TW202216677A (en) |
| WO (1) | WO2022013307A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7702205B2 (en) * | 2021-09-15 | 2025-07-03 | 株式会社東芝 | Novel amine compound, acidic gas absorbent, method for removing acidic gas, and method for removing acidic gas |
| CN114957331A (en) * | 2022-04-22 | 2022-08-30 | 北京康辰药业股份有限公司 | Preparation method of phosphate substituted cyclopropyl amide derived quinazoline compound |
| WO2024180206A1 (en) | 2023-03-02 | 2024-09-06 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
| WO2024180207A1 (en) | 2023-03-02 | 2024-09-06 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
| KR20240159754A (en) * | 2023-04-28 | 2024-11-06 | 한국원자력의학원 | Compound comprising N-methylpiperazine ethanol carbamate structure and use thereof |
| WO2025132458A1 (en) | 2023-12-18 | 2025-06-26 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
| WO2025132460A1 (en) | 2023-12-18 | 2025-06-26 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061576A1 (en) | 1999-04-09 | 2000-10-19 | Smithkline Beecham Corporation | Triarylimidazoles |
| AR029803A1 (en) | 2000-02-21 | 2003-07-16 | Smithkline Beecham Plc | IMIDAZOLS REPLACED WITH PIRIDILE AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM |
| GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
| ATE346064T1 (en) | 2000-09-15 | 2006-12-15 | Vertex Pharma | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS |
| US6710048B2 (en) | 2000-09-20 | 2004-03-23 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazine derivatives as modulators of tyrosine kinases |
| AR039241A1 (en) | 2002-04-04 | 2005-02-16 | Biogen Inc | HETEROARILOS TRISUSTITUIDOS AND METHODS FOR ITS PRODUCTION AND USE OF THE SAME |
| BR0314196A (en) * | 2002-09-10 | 2005-07-26 | Scios Inc | Tgf-beta inhibitors |
| WO2005033105A2 (en) | 2003-09-30 | 2005-04-14 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| ES2393932T3 (en) | 2006-07-14 | 2013-01-02 | Novartis Ag | Pyrimidine derivatives as ALK-5 inhibitors |
| ES2375425T3 (en) | 2007-07-26 | 2012-02-29 | Novartis Ag | ORGANIC COMPOUNDS. |
| JP5456681B2 (en) | 2007-10-17 | 2014-04-02 | ノバルティス アーゲー | Imidazo [1,2-a] pyridine derivatives useful as ALK inhibitors |
| JP5584138B2 (en) | 2008-01-11 | 2014-09-03 | ノバルティス アーゲー | Pyrimidines as kinase inhibitors |
| US8343966B2 (en) * | 2008-01-11 | 2013-01-01 | Novartis Ag | Organic compounds |
| AR070127A1 (en) | 2008-01-11 | 2010-03-17 | Novartis Ag | PIRROLO - PIRIMIDINAS AND PIRROLO -PIRIDINAS |
| EA201001687A1 (en) | 2008-04-29 | 2011-06-30 | Новартис Аг | IMIDAZOPIRIDINE DERIVATIVES AS AN INHIBITOR ACTIVATIVE-LIKE RECEPTOR KINASE (ALK-4 OR ALK-5) |
| AU2010314518B2 (en) * | 2009-11-07 | 2016-04-21 | Merck Patent Gmbh | Heteroarylaminoquinolines as TGF-beta receptor kinase inhibitors |
| CA2841252C (en) | 2011-07-13 | 2019-02-26 | Sk Chemicals Co., Ltd. | 2-pyridyl substituted imidazoles as alk5 and/or alk4 inhibitors |
| WO2015103355A1 (en) * | 2014-01-01 | 2015-07-09 | Medivation Technologies, Inc. | Compounds and methods of use |
| WO2020012357A1 (en) * | 2018-07-10 | 2020-01-16 | Integral Biosciences Pvt. Ltd. | Heterocyclic compounds and methods of use |
-
2021
- 2021-07-14 FI FIEP21743186.5T patent/FI4182308T3/en active
- 2021-07-14 PL PL21743186.5T patent/PL4182308T3/en unknown
- 2021-07-14 ES ES21743186T patent/ES2997111T3/en active Active
- 2021-07-14 MX MX2023000521A patent/MX2023000521A/en unknown
- 2021-07-14 HR HRP20241617TT patent/HRP20241617T1/en unknown
- 2021-07-14 JP JP2023502861A patent/JP7686741B2/en active Active
- 2021-07-14 PT PT217431865T patent/PT4182308T/en unknown
- 2021-07-14 DK DK21743186.5T patent/DK4182308T3/en active
- 2021-07-14 KR KR1020237005127A patent/KR20230051500A/en active Pending
- 2021-07-14 BR BR112023000588A patent/BR112023000588A8/en unknown
- 2021-07-14 HU HUE21743186A patent/HUE069150T2/en unknown
- 2021-07-14 US US18/014,764 patent/US12479826B2/en active Active
- 2021-07-14 EP EP21743186.5A patent/EP4182308B1/en active Active
- 2021-07-14 AU AU2021307559A patent/AU2021307559A1/en active Pending
- 2021-07-14 SI SI202130217T patent/SI4182308T1/en unknown
- 2021-07-14 CN CN202180061803.6A patent/CN116096719B/en active Active
- 2021-07-14 CA CA3184990A patent/CA3184990A1/en active Pending
- 2021-07-14 WO PCT/EP2021/069649 patent/WO2022013307A1/en not_active Ceased
- 2021-07-15 AR ARP210101996A patent/AR122986A1/en unknown
- 2021-07-15 TW TW110126103A patent/TW202216677A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW202216677A (en) | 2022-05-01 |
| PL4182308T3 (en) | 2025-01-07 |
| ES2997111T3 (en) | 2025-03-19 |
| PT4182308T (en) | 2024-12-04 |
| WO2022013307A1 (en) | 2022-01-20 |
| HUE069150T2 (en) | 2025-02-28 |
| US20240018122A1 (en) | 2024-01-18 |
| AR122986A1 (en) | 2022-10-19 |
| BR112023000588A2 (en) | 2023-01-31 |
| AU2021307559A1 (en) | 2023-02-16 |
| JP7686741B2 (en) | 2025-06-02 |
| BR112023000588A8 (en) | 2023-05-09 |
| SI4182308T1 (en) | 2025-04-30 |
| EP4182308B1 (en) | 2024-09-04 |
| FI4182308T3 (en) | 2024-12-07 |
| KR20230051500A (en) | 2023-04-18 |
| CA3184990A1 (en) | 2022-01-20 |
| JP2023533849A (en) | 2023-08-04 |
| CN116096719B (en) | 2025-09-30 |
| MX2023000521A (en) | 2023-02-13 |
| US12479826B2 (en) | 2025-11-25 |
| CN116096719A (en) | 2023-05-09 |
| EP4182308A1 (en) | 2023-05-24 |
| HRP20241617T1 (en) | 2025-01-31 |
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