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DK4097117T3 - Fremgangsmåde til fremstilling af nukleinsyreoligomer - Google Patents

Fremgangsmåde til fremstilling af nukleinsyreoligomer Download PDF

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Publication number
DK4097117T3
DK4097117T3 DK21705632.4T DK21705632T DK4097117T3 DK 4097117 T3 DK4097117 T3 DK 4097117T3 DK 21705632 T DK21705632 T DK 21705632T DK 4097117 T3 DK4097117 T3 DK 4097117T3
Authority
DK
Denmark
Prior art keywords
oligomes
procedure
production
nucleic acid
nucleic
Prior art date
Application number
DK21705632.4T
Other languages
English (en)
Inventor
Takuya Miyagawa
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Application granted granted Critical
Publication of DK4097117T3 publication Critical patent/DK4097117T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
DK21705632.4T 2020-01-29 2021-01-29 Fremgangsmåde til fremstilling af nukleinsyreoligomer DK4097117T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020012789 2020-01-29
PCT/JP2021/003351 WO2021153770A1 (en) 2020-01-29 2021-01-29 Process of preparing nucleic acid oligomer

Publications (1)

Publication Number Publication Date
DK4097117T3 true DK4097117T3 (da) 2024-07-22

Family

ID=74626048

Family Applications (1)

Application Number Title Priority Date Filing Date
DK21705632.4T DK4097117T3 (da) 2020-01-29 2021-01-29 Fremgangsmåde til fremstilling af nukleinsyreoligomer

Country Status (8)

Country Link
US (1) US12391716B2 (da)
EP (1) EP4097117B1 (da)
JP (1) JP7667788B2 (da)
KR (1) KR20220133919A (da)
CN (1) CN115003680B (da)
DK (1) DK4097117T3 (da)
ES (1) ES2981209T3 (da)
WO (1) WO2021153770A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114573652B (zh) * 2022-03-15 2025-02-07 安徽瑞拜药业有限公司 药用核酸合成工艺
AU2023404700A1 (en) 2022-12-02 2025-07-10 Shanghai Argo Biopharmaceutical Co., Ltd. Bicyclic abasic nucleic acid analogs and oligomeric compounds prepared therefrom

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4705716B2 (ja) 1999-02-05 2011-06-22 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション オリゴヌクレオチドの脱保護法
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
BRPI0514644A (pt) 2004-08-26 2008-06-17 Nippon Shinyaku Co Ltd composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna
JP5665317B2 (ja) 2006-10-18 2015-02-04 アイシス ファーマシューティカルズ, インコーポレーテッド アンチセンス化合物
ES2670017T3 (es) 2010-07-08 2018-05-29 Bonac Corporation Molécula de ácido nucleico de cadena simple para el control de la expresión de genes
PT2674494E (pt) 2010-08-03 2015-02-27 Bonac Corp Molécula de arn em cadeia simples com esqueleto licíclico contendo azoto
US8691782B2 (en) 2010-08-03 2014-04-08 Bonac Corporation Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
ES2638147T3 (es) 2011-08-25 2017-10-18 Bonac Corporation Fosforamidatos de nucleósidos para producir ácidos nucleicos
FI3597749T3 (fi) 2012-05-25 2023-10-09 Univ California Menetelmiä ja koostumuksia rna-ohjattua kohde-dna-modifikaatiota varten ja rna-ohjattua transkription modulaatiota varten
CN107250148B (zh) 2014-12-03 2021-04-16 安捷伦科技有限公司 具有化学修饰的指导rna
JP6787398B2 (ja) 2016-04-26 2020-11-18 住友化学株式会社 一本鎖核酸分子用モノマーの製造方法
WO2018182008A1 (ja) 2017-03-31 2018-10-04 株式会社ボナック 遺伝子発現制御機能を有する環状型核酸分子
WO2018212236A1 (ja) 2017-05-16 2018-11-22 日産化学株式会社 オリゴヌクレオチドの製造方法
MA50267A (fr) 2017-09-19 2020-07-29 Alnylam Pharmaceuticals Inc Compositions et méthodes de traitement de l'amylose médiée par la transthyrétine (ttr)
WO2019074110A1 (ja) 2017-10-13 2019-04-18 株式会社ボナック 一本鎖核酸分子およびその製造方法
CN112020507B (zh) 2018-04-24 2023-10-10 住友化学株式会社 酰胺化合物及使用该化合物的多核苷酸的制造方法
JP7087766B2 (ja) 2018-07-20 2022-06-21 日本製鉄株式会社 粒度分布定数推定装置、粒度分布定数推定プログラム、及び粒度分布定数推定方法
EP3972983A4 (en) 2019-05-17 2023-05-24 Ionis Pharmaceuticals, Inc. SYNTHESIS OF OLIGOMERIC COMPOUNDS COMPRISING PHOSPHOROTHIOATE DIESTER AND PHOSPHATE DIESTER BONDS
US20230295207A1 (en) 2019-06-11 2023-09-21 Hoffmann-La Roche Inc. Process for the preparation of oligonucleotides using modified oxidation protocol
WO2021153047A1 (ja) 2020-01-29 2021-08-05 住友化学株式会社 核酸オリゴマーの製造方法

Also Published As

Publication number Publication date
KR20220133919A (ko) 2022-10-05
EP4097117B1 (en) 2024-05-01
US12391716B2 (en) 2025-08-19
CN115003680B (zh) 2025-01-28
JP7667788B2 (ja) 2025-04-23
JP2023514503A (ja) 2023-04-06
EP4097117A1 (en) 2022-12-07
US20230095584A1 (en) 2023-03-30
ES2981209T3 (es) 2024-10-07
WO2021153770A1 (en) 2021-08-05
CN115003680A (zh) 2022-09-02

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