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DK3978483T3 - Krystallinsk toluensolvat af (s)-afoxolaner - Google Patents

Krystallinsk toluensolvat af (s)-afoxolaner Download PDF

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Publication number
DK3978483T3
DK3978483T3 DK21190677.1T DK21190677T DK3978483T3 DK 3978483 T3 DK3978483 T3 DK 3978483T3 DK 21190677 T DK21190677 T DK 21190677T DK 3978483 T3 DK3978483 T3 DK 3978483T3
Authority
DK
Denmark
Prior art keywords
afoxolanes
toluene solvate
crystalline toluene
crystalline
solvate
Prior art date
Application number
DK21190677.1T
Other languages
English (en)
Inventor
Chunhua Yang
Hir De Fallois Loic Patrick Le
Charles Q Meng
Alan Long
De Vries Roelof Johannes Gorter
Bruno Baillon
Sylvaine Lafont
De Saint Michel Myriam Gay
Stephane Kozlovic
Original Assignee
Boehringer Ingelheim Vetmedica Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica Gmbh filed Critical Boehringer Ingelheim Vetmedica Gmbh
Application granted granted Critical
Publication of DK3978483T3 publication Critical patent/DK3978483T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A01N55/08—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK21190677.1T 2016-04-06 2017-04-05 Krystallinsk toluensolvat af (s)-afoxolaner DK3978483T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662319207P 2016-04-06 2016-04-06
EP17718286.2A EP3440062B1 (en) 2016-04-06 2017-04-05 Process for the preparation of enantiomerically enriched isoxazoline compounds - crystalline toluene solvate of (s)-afoxolaner

Publications (1)

Publication Number Publication Date
DK3978483T3 true DK3978483T3 (da) 2024-12-16

Family

ID=58549312

Family Applications (2)

Application Number Title Priority Date Filing Date
DK21190677.1T DK3978483T3 (da) 2016-04-06 2017-04-05 Krystallinsk toluensolvat af (s)-afoxolaner
DK17718286.2T DK3440062T3 (da) 2016-04-06 2017-04-05 Fremgangsmåde til fremstillingen af enantiomerisk berigede isoxazolinforbindelser - krystallinsk toluensolvat af (s)-afoxolaner

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK17718286.2T DK3440062T3 (da) 2016-04-06 2017-04-05 Fremgangsmåde til fremstillingen af enantiomerisk berigede isoxazolinforbindelser - krystallinsk toluensolvat af (s)-afoxolaner

Country Status (32)

Country Link
US (3) US10433552B2 (da)
EP (2) EP3440062B1 (da)
KR (2) KR102403531B1 (da)
CN (2) CN114805234A (da)
AR (1) AR108184A1 (da)
AU (2) AU2017246305B2 (da)
CA (2) CA3019947A1 (da)
CL (2) CL2018002838A1 (da)
CO (3) CO2019013500A2 (da)
CY (1) CY1124797T1 (da)
DK (2) DK3978483T3 (da)
EA (1) EA201892245A1 (da)
ES (2) ES3010321T3 (da)
FI (1) FI3978483T3 (da)
HR (2) HRP20241723T1 (da)
HU (2) HUE069507T2 (da)
IL (2) IL262093B (da)
LT (2) LT3978483T (da)
MD (2) MD20220052A2 (da)
MX (2) MX394199B (da)
MY (1) MY189534A (da)
NZ (1) NZ747676A (da)
PL (2) PL3978483T3 (da)
PT (2) PT3978483T (da)
RS (2) RS62755B1 (da)
SG (1) SG11201808756XA (da)
SI (2) SI3440062T1 (da)
TW (1) TWI753897B (da)
UA (1) UA127309C2 (da)
UY (2) UY37196A (da)
WO (1) WO2017176948A1 (da)
ZA (1) ZA201806675B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016022066A1 (en) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
KR102612648B1 (ko) * 2017-04-05 2023-12-11 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 (s)-아폭솔라너의 결정질 형태
EP3710453A1 (en) 2017-11-16 2020-09-23 Avista Pharma Solutions, Inc. Single enantiomer antiparasitic compounds
KR20250065422A (ko) 2017-12-15 2025-05-12 타르서스 파마수티칼스, 아이엔씨. 안검염을 치료하기 위한 이속사졸린 구충제 제제 및 방법
TWI812673B (zh) * 2018-02-12 2023-08-21 美商富曼西公司 用於防治無脊椎害蟲之萘異噁唑啉化合物
WO2020088949A1 (en) 2018-10-29 2020-05-07 Basf Se Process for preparation of optically enriched aldol compounds
CN115768753B (zh) * 2020-06-19 2024-04-26 东莞市东阳光动物保健药品有限公司 一种gaba抑制剂的晶型及其制备方法
JP7724845B2 (ja) * 2020-07-24 2025-08-18 エランコ・ユーエス・インコーポレイテッド イソオキサゾリン化合物及びその中間体を作製するための方法
CN112724095A (zh) * 2020-09-25 2021-04-30 安徽省公众检验研究院有限公司 氟雷拉钠晶型及其制备方法
AU2022300356A1 (en) * 2021-06-25 2023-11-30 In The Bowl Animal Health, Inc. Oral feline feed and methods for controlling flea infestations in a feline
EP4384514A1 (en) 2021-08-11 2024-06-19 Elanco Us Inc. Process for making diaryl isoxazoline derivative
CN115710185B (zh) * 2021-08-23 2024-05-03 中国石油化工股份有限公司 利用金属碳化物催化剂生产甲胺的方法
CN114113388B (zh) * 2021-11-24 2023-05-23 丽珠集团新北江制药股份有限公司 一种4-肟甲基-1-萘甲酸中有关物质的检测方法
CN116253658B (zh) * 2022-11-25 2023-08-11 济南久隆医药科技有限公司 一种阿福拉纳中间体合成方法
CN115959979A (zh) * 2022-12-29 2023-04-14 南京正荣医药化学有限公司 一种3-氯-4-氟-5-三氟甲基三氟苯乙酮的制备方法
CN116143652B (zh) * 2023-01-13 2024-06-28 四川青木制药有限公司 一种阿福拉纳中间体及其制备方法和应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060084A (en) 1961-06-09 1962-10-23 Du Pont Improved homogeneous, readily dispersed, pesticidal concentrate
US3299566A (en) 1964-06-01 1967-01-24 Olin Mathieson Water soluble film containing agricultural chemicals
US4144050A (en) 1969-02-05 1979-03-13 Hoechst Aktiengesellschaft Micro granules for pesticides and process for their manufacture
US3920442A (en) 1972-09-18 1975-11-18 Du Pont Water-dispersible pesticide aggregates
US4172714A (en) 1976-12-20 1979-10-30 E. I. Du Pont De Nemours And Company Dry compactible, swellable herbicidal compositions and pellets produced therefrom
GB2095558B (en) 1981-03-30 1984-10-24 Avon Packers Ltd Formulation of agricultural chemicals
US5180587A (en) 1988-06-28 1993-01-19 E. I. Du Pont De Nemours And Company Tablet formulations of pesticides
EP0777964B1 (en) 1989-08-30 2001-11-14 Kynoch Agrochemicals (Proprietary) Limited Preparation of a dosage device
BR9106147A (pt) 1990-03-12 1993-03-09 Du Pont Granulos de pesticidas dispersaveis em agua ou soluveis em agua feitos a partir de ligantes termo-ativados
ES2091878T3 (es) 1990-10-11 1996-11-16 Sumitomo Chemical Co Composicion plaguicida.
DE4322211A1 (de) 1993-07-03 1995-01-12 Basf Ag Wäßrige, mehrphasige, stabile Fertigformulierung für Pflanzenschutz-Wirkstoffe und Verfahren zu ihrer Herstellung
CN1930136B (zh) 2004-03-05 2012-02-08 日产化学工业株式会社 异*唑啉取代苯甲酰胺化合物及有害生物防除剂
CA2621228C (en) 2005-09-02 2014-05-27 Nissan Chemical Industries, Ltd. Isoxazoline-substituted benzamide compound and pesticide
US20090143410A1 (en) 2005-12-14 2009-06-04 Kanu Maganbhai Patel Isoxazolines for Controlling Invertebrate Pests
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
WO2007123855A2 (en) 2006-04-20 2007-11-01 E. I. Du Pont De Nemours And Company Pyrazolines for controlling invertebrate pests
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
US8466150B2 (en) 2006-12-28 2013-06-18 Abbott Laboratories Inhibitors of poly(ADP-ribose)polymerase
JP5256753B2 (ja) 2007-03-29 2013-08-07 住友化学株式会社 イソオキサゾリン化合物とその有害生物防除用途
RU2009141185A (ru) 2007-04-10 2011-05-20 Байер КропСайенс АГ (DE) Инсектицидные производные арилизоксазолина
BRPI0809770B8 (pt) * 2007-06-13 2022-12-06 Du Pont Composto e composição para controlar uma praga de invertebrados
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
WO2009001942A1 (ja) 2007-06-27 2008-12-31 Nissan Chemical Industries, Ltd. ３－ヒドロキシプロパン－１－オン化合物、２－プロペン－１－オン化合物およびイソキサゾリン化合物の製造方法
TWI600639B (zh) 2007-08-17 2017-10-01 杜邦股份有限公司 製備５-鹵烷基-４，５-二氫異唑衍生物之化合物
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
KR20100075996A (ko) 2007-10-03 2010-07-05 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충의 방제를 위한 나프탈렌 이속사졸린 화합물
WO2009063910A1 (ja) 2007-11-12 2009-05-22 Nissan Chemical Industries, Ltd. 光学活性イソキサゾリン化合物の触媒的不斉合成方法
KR101680912B1 (ko) 2008-07-09 2016-11-29 바스프 에스이 이속사졸린 화합물 ⅰ을 포함하는 살충 활성 혼합물
NZ593135A (en) 2008-12-19 2013-04-26 Novartis Ag Isoxazoline derivatives and their use as pesticide
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
JP2013520456A (ja) 2010-02-25 2013-06-06 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト イソオキサゾリン誘導体の製造方法
BR112012031093A8 (pt) 2010-06-09 2017-10-10 Syngenta Participations Ag Misturas de pesticidas incluindo derivados da isoxazolina
PL2683723T3 (pl) 2011-03-10 2017-07-31 Zoetis Services Llc Spirocykliczne pochodne izoksazoliny jako środki przeciwpasożytnicze
JP6075563B2 (ja) 2011-11-08 2017-02-08 日産化学工業株式会社 光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物
CN104169276A (zh) 2012-02-03 2014-11-26 佐蒂斯有限责任公司 作为抗寄生物剂的手性异噁唑啉氮杂环丁烷衍生物的制备方法
PL2922854T3 (pl) 2012-11-21 2022-07-18 Zoetis Services Llc Synteza spirocyklicznych pochodnych izoksazoliny
WO2014090918A1 (en) 2012-12-13 2014-06-19 Novartis Ag Process for the enantiomeric enrichment of diaryloxazoline derivatives
US9585871B2 (en) * 2013-01-31 2017-03-07 Merial, Inc. Method for treating and curing leishmaniosis using fexinidazole
AR096022A1 (es) * 2013-04-11 2015-12-02 Basf Se Compuestos de pirimidinio sustituido, útiles para combatir plagas de animales

Also Published As

Publication number Publication date
AU2017246305B2 (en) 2021-04-29
MX2020013754A (es) 2022-07-25
PL3978483T3 (pl) 2025-03-24
HRP20211979T1 (hr) 2022-04-01
AU2021203129A1 (en) 2021-06-10
HUE056909T2 (hu) 2022-04-28
CO2019013841A2 (es) 2020-04-01
ES3010321T3 (en) 2025-04-02
CA3214922A1 (en) 2017-10-12
IL262093B (en) 2021-02-28
KR20220003635A (ko) 2022-01-10
PL3440062T3 (pl) 2022-02-07
CN109195955A (zh) 2019-01-11
MX378893B (es) 2025-03-11
US10433552B2 (en) 2019-10-08
LT3978483T (lt) 2025-02-10
US20190133129A1 (en) 2019-05-09
LT3440062T (lt) 2021-12-10
UY37196A (es) 2017-10-31
CN109195955B (zh) 2022-10-18
MD4846B1 (ro) 2023-02-28
MD4846C1 (ro) 2023-10-31
SG11201808756XA (en) 2018-11-29
IL262093A (en) 2018-11-29
TW201739740A (zh) 2017-11-16
MD20220052A2 (ro) 2023-05-31
ZA201806675B (en) 2024-08-28
AU2021203129B2 (en) 2023-03-16
US10750744B2 (en) 2020-08-25
CL2019003235A1 (es) 2020-02-14
NZ747676A (en) 2023-05-26
TWI753897B (zh) 2022-02-01
MX394199B (es) 2025-03-24
MD20180090A2 (ro) 2019-02-28
CO2018010719A2 (es) 2018-12-28
PT3978483T (pt) 2024-11-04
CO2019013500A2 (es) 2020-02-28
MX2018012184A (es) 2019-02-07
SI3440062T1 (sl) 2021-12-31
UY40619A (es) 2024-02-15
UA127309C2 (uk) 2023-07-19
IL280679B (en) 2021-12-01
AU2017246305A1 (en) 2018-11-15
CL2018002838A1 (es) 2018-11-30
US20170311601A1 (en) 2017-11-02
AR108184A1 (es) 2018-07-25
CA3019947A1 (en) 2017-10-12
HRP20241723T1 (hr) 2025-02-28
DK3440062T3 (da) 2022-01-03
EP3978483A1 (en) 2022-04-06
US20210022344A1 (en) 2021-01-28
EP3440062B1 (en) 2021-10-06
CY1124797T1 (el) 2022-11-25
IL280679A (en) 2021-03-25
KR20180132834A (ko) 2018-12-12
RS66306B1 (sr) 2025-01-31
KR102438541B1 (ko) 2022-08-30
ES2903286T3 (es) 2022-03-31
EA201892245A1 (ru) 2019-07-31
HUE069507T2 (hu) 2025-03-28
SI3978483T1 (sl) 2024-12-31
WO2017176948A1 (en) 2017-10-12
KR102403531B1 (ko) 2022-05-27
PT3440062T (pt) 2021-12-24
NZ786434A (en) 2024-08-30
RS62755B1 (sr) 2022-01-31
BR112018070663A2 (pt) 2019-02-05
MY189534A (en) 2022-02-16
US11324220B2 (en) 2022-05-10
EP3440062A1 (en) 2019-02-13
EP3978483B1 (en) 2024-09-25
FI3978483T3 (fi) 2024-12-13
CN114805234A (zh) 2022-07-29

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