DK3978095T3 - Cpc fordelingskromatografi af cannabinoider - Google Patents
Cpc fordelingskromatografi af cannabinoider Download PDFInfo
- Publication number
- DK3978095T3 DK3978095T3 DK21210058.0T DK21210058T DK3978095T3 DK 3978095 T3 DK3978095 T3 DK 3978095T3 DK 21210058 T DK21210058 T DK 21210058T DK 3978095 T3 DK3978095 T3 DK 3978095T3
- Authority
- DK
- Denmark
- Prior art keywords
- cannabinoids
- cpc
- partition chromatography
- chromatography
- partition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds or centrifugal chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/30—Partition chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N2030/381—Flow patterns centrifugal chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15156901.9A EP3061510A1 (de) | 2015-02-27 | 2015-02-27 | CPC Verteilungschromatographie von Cannabinoiden |
| EP16712219.1A EP3261741B1 (de) | 2015-02-27 | 2016-02-29 | Cpc verteilungschromatographie von cannabinoiden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3978095T3 true DK3978095T3 (da) | 2025-01-20 |
Family
ID=52813883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK21210058.0T DK3978095T3 (da) | 2015-02-27 | 2016-02-29 | Cpc fordelingskromatografi af cannabinoider |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10568863B2 (da) |
| EP (3) | EP3061510A1 (da) |
| DK (1) | DK3978095T3 (da) |
| ES (1) | ES2907151T3 (da) |
| FI (1) | FI3978095T3 (da) |
| SI (1) | SI3978095T1 (da) |
| WO (1) | WO2016135346A1 (da) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11034639B2 (en) * | 2015-01-22 | 2021-06-15 | Phytoplant Research S.L. | Methods of purifying cannabinoids using liquid:liquid chromatography |
| US10207198B2 (en) * | 2015-01-22 | 2019-02-19 | Phytoplant Research S.L. | Methods of purifying cannabinoids using liquid:liquid chromatography |
| EP3061510A1 (de) | 2015-02-27 | 2016-08-31 | Bionorica Ethics GmbH | CPC Verteilungschromatographie von Cannabinoiden |
| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| EP3409339A1 (de) * | 2017-05-29 | 2018-12-05 | Bionorica Ethics GmbH | Verfahren zum trennen von naturstoffgemischen mittels scpc |
| US11299470B2 (en) | 2017-08-07 | 2022-04-12 | Massachusetts Institute Of Technology | Systems and methods for separating cannabis-derived compounds using chromatography with liquid or supercritical carbon dioxide |
| EP3449992A1 (en) * | 2017-09-04 | 2019-03-06 | Bionorica Ethics GmbH | Recovery of acidic cannabinoids from plant material |
| EP3461545A1 (de) * | 2017-09-30 | 2019-04-03 | Bionorica Ethics GmbH | Kurzwegdestillation im vakuum zur anreicherung von naturstoffen |
| EP3746419A1 (en) | 2018-01-29 | 2020-12-09 | Phytoplant Research S.L. | Methods of purifying cannabinoids using liquid:liquid chromatography |
| EP3745884A1 (en) | 2018-01-31 | 2020-12-09 | Canopy Holdings, Llc | Hemp powder |
| US11851415B2 (en) | 2018-03-07 | 2023-12-26 | Cleen Technology Inc. | Continuous isolation of cannabidiol and cannabinoids and conversion of cannabidiol to delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol |
| WO2019173582A1 (en) * | 2018-03-07 | 2019-09-12 | Socati Technologies | Continuous isolation of cannabidiol and conversion of cannabidiol to delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol |
| US11192870B2 (en) | 2018-03-07 | 2021-12-07 | Socati Technologies—Oregon, Llc | Continuous isolation of cannabidiol and conversion of cannabidiol to delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol |
| DE102018001959A1 (de) | 2018-03-10 | 2019-09-12 | Florian Frey | Thermisches Trennverfahren zur Anreicherung von Cannabinoiden |
| AU2019335372B2 (en) * | 2018-09-05 | 2024-12-12 | Purisys Llc | Cannabidiol compositions having modified cannabinoid profiles |
| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
| NL2022614B1 (en) | 2019-02-21 | 2020-08-31 | Patrick Alexander Unger | Pharmaceutical, phyto-cannabinoid based compositions |
| NL2022616B1 (en) | 2019-02-21 | 2020-09-18 | Patrick Alexander Unger | Cannabigerol and pharmaceutical compositions comprising cannabigerol for use in the treatment of insomnia |
| NL2022615B1 (en) | 2019-02-21 | 2020-08-31 | Patrick Alexander Unger | Pharmaceutical composition comprising tetrahydrocannabivarin for the prevention and treatment of overweight |
| US20220152523A1 (en) * | 2019-03-02 | 2022-05-19 | Martha Knight | Cannabinoid Separation by Countercurrent Chromatography |
| CN110590511B (zh) * | 2019-09-11 | 2021-05-28 | 上海同田生物技术股份有限公司 | 一种同时分离次大麻二酚和大麻萜酚的方法 |
| US20220267290A1 (en) * | 2021-02-19 | 2022-08-25 | Gaia Botanicals Llc Dba Bluebird Botanicals | Method for extraction of cannabinoids and synthesis of thc to cbn |
| CN113135885A (zh) * | 2021-04-07 | 2021-07-20 | 上海同田生物技术有限公司 | 一种高速逆流色谱分离纯化四氢次大麻酚的方法 |
| CN113956228B (zh) * | 2021-11-05 | 2023-07-07 | 中国农业科学院麻类研究所 | 一种大麻酚的提取分离方法 |
| CN114814009B (zh) * | 2022-04-07 | 2024-06-07 | 国家烟草质量监督检验中心 | 一种同时适用于新型烟草产品中酚类化合物及尿液中酚类化合物的代谢物的分析方法 |
| US11548864B1 (en) | 2022-06-15 | 2023-01-10 | Zaiput Flow Technologies LLC | Separation of chemical species using multiple liquid phases and related systems |
| US12187695B2 (en) | 2022-06-15 | 2025-01-07 | Zaiput Flow Technologies LLC | Separation of chemical species using multiple liquid phases and related systems |
| EP4520417A1 (de) | 2023-09-08 | 2025-03-12 | Avextra Innovations GmbH | Verfahren zum herstellen von cannabinoiden, insbesondere dronabinol mittels verteilungschromatographie |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10051427C1 (de) | 2000-10-17 | 2002-06-13 | Adam Mueller | Verfahren zur Herstellung eines Tetrahydrocannabinol- und Cannabidiol-haltigen Extraktes aus Cannabis-Pflanzenmaterial sowie Cannabis-Extrakte |
| DE102005028937B4 (de) * | 2005-06-22 | 2009-07-23 | Bionorica Ag | Verfahren zur Herstellung von Dronabinol |
| US20100179098A1 (en) * | 2006-09-07 | 2010-07-15 | Henkan Pharmaceutical Co., Ltd. | Furost-5-ene-3, 22, 26-triol glycoside compound for preventing and treatment cancer |
| JP2013535499A (ja) * | 2010-08-09 | 2013-09-12 | インスティテュート テクノロヒコ イ デ エステューディオス スペリオレス デ モンテレイ | 生物活性化合物が濃縮されたアボカド抽出物由来の抗菌、抗細菌、または芽胞発芽阻止活性 |
| GB2514054A (en) * | 2011-09-29 | 2014-11-12 | Gw Pharma Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
| EP3061510A1 (de) | 2015-02-27 | 2016-08-31 | Bionorica Ethics GmbH | CPC Verteilungschromatographie von Cannabinoiden |
-
2015
- 2015-02-27 EP EP15156901.9A patent/EP3061510A1/de not_active Withdrawn
-
2016
- 2016-02-29 FI FIEP21210058.0T patent/FI3978095T3/fi active
- 2016-02-29 US US15/552,331 patent/US10568863B2/en active Active
- 2016-02-29 WO PCT/EP2016/054250 patent/WO2016135346A1/de not_active Ceased
- 2016-02-29 ES ES16712219T patent/ES2907151T3/es active Active
- 2016-02-29 DK DK21210058.0T patent/DK3978095T3/da active
- 2016-02-29 SI SI201631869T patent/SI3978095T1/sl unknown
- 2016-02-29 EP EP16712219.1A patent/EP3261741B1/de active Active
- 2016-02-29 EP EP21210058.0A patent/EP3978095B1/de active Active
-
2020
- 2020-01-13 US US16/740,863 patent/US11413268B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11413268B2 (en) | 2022-08-16 |
| US20180036278A1 (en) | 2018-02-08 |
| SI3978095T1 (sl) | 2025-02-28 |
| ES2907151T3 (es) | 2022-04-22 |
| EP3061510A1 (de) | 2016-08-31 |
| WO2016135346A1 (de) | 2016-09-01 |
| US20200147034A1 (en) | 2020-05-14 |
| EP3978095A1 (de) | 2022-04-06 |
| EP3261741A1 (de) | 2018-01-03 |
| FI3978095T3 (fi) | 2025-01-21 |
| EP3978095B1 (de) | 2024-11-06 |
| EP3261741B1 (de) | 2021-11-24 |
| US10568863B2 (en) | 2020-02-25 |
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