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DK3809959T3 - Systemer til bestemmelse af hjertevolumen - Google Patents

Systemer til bestemmelse af hjertevolumen Download PDF

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Publication number
DK3809959T3
DK3809959T3 DK19737944.9T DK19737944T DK3809959T3 DK 3809959 T3 DK3809959 T3 DK 3809959T3 DK 19737944 T DK19737944 T DK 19737944T DK 3809959 T3 DK3809959 T3 DK 3809959T3
Authority
DK
Denmark
Prior art keywords
systems
determining cardiac
cardiac volume
volume
determining
Prior art date
Application number
DK19737944.9T
Other languages
English (en)
Inventor
Sonya Sanat Bhavsar
Noam Josephy
Elazer R Edelman
Brian Yale Chang
Steven Keller
Katerji Ahmad El
Qing Tan
Christian Moyer
Alexander Ship
Original Assignee
Abiomed Inc
Massachusetts Inst Technology
Brigham & Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abiomed Inc, Massachusetts Inst Technology, Brigham & Womens Hospital Inc filed Critical Abiomed Inc
Application granted granted Critical
Publication of DK3809959T3 publication Critical patent/DK3809959T3/da

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    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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    • A61B5/02028—Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
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Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12491356B2 (en) 2018-03-20 2025-12-09 Second Heart Assist, Inc. Circulatory assist pump
DE102018207575A1 (de) 2018-05-16 2019-11-21 Kardion Gmbh Magnetische Stirndreh-Kupplung zur Übertragung von Drehmomenten
DE102018207611A1 (de) 2018-05-16 2019-11-21 Kardion Gmbh Rotorlagerungssystem
DE102018208541A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Axialpumpe für ein Herzunterstützungssystem und Verfahren zum Herstellen einer Axialpumpe für ein Herzunterstützungssystem
DE102018208550A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Leitungsvorrichtung zum Leiten eines Blutstroms für ein Herzunterstützungssystem, Herzunterstützungssystem und Verfahren zum Herstellen einer Leitungsvorrichtung
DE102018208538A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Intravasale Blutpumpe und Verfahren zur Herstellung von elektrischen Leiterbahnen
DE102018208549A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Elektronikmodul für ein Herzunterstützungssystem und Verfahren zum Herstellen eines Elektronikmoduls für ein Herzunterstützungssystem
DE102018208539A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Motorgehäusemodul zum Abdichten eines Motorraums eines Motors eines Herzunterstützungssystems und Herzunterstützungssystem und Verfahren zum Montieren eines Herzunterstützungssystems
DE102018208936A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Bestimmvorrichtung und Verfahren zum Bestimmen einer Viskosität eines Fluids
DE102018208899A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Verfahren zum Ermitteln der Schallgeschwindigkeit in einem Fluid im Bereich eines implantierten, vaskulären Unterstützungssystems
DE102018208933A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Verfahren zur Bestimmung einer Strömungsgeschwindigkeit eines durch ein implantiertes, vaskuläres Unterstützungssystem strömenden Fluids
DE102018208870A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Verfahren zur Bestimmung eines Fluid-Volumenstroms durch ein implantiertes, vaskuläres Unterstützungssystem
DE102018208879A1 (de) 2018-06-06 2020-01-30 Kardion Gmbh Verfahren zur Bestimmung eines Fluid-Gesamtvolumenstroms im Bereich eines implantierten, vaskuläres Unterstützungssystems
DE102018208929A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Verfahren zur Bestimmung einer Strömungsgeschwindigkeit eines durch ein implantiertes, vaskuläres Unterstützungssystem strömenden Fluids
DE102018208892A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Sensorkopfvorrichtung für ein minimalinvasives Herzunterstützungssystem und Verfahren zum Herstellen einer Sensorkopfvorrichtung für ein Herzunterstützungssystem
DE102018208862A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Implantierbares, vaskuläres Unterstützungssystem
DE102018208945A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Analysevorrichtung und Verfahren zum Analysieren einer Viskosität eines Fluids
DE102018208913A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Verfahren zum Betreiben eines implantierten, ventrikulären Unterstützungssystems
CN109065170B (zh) * 2018-06-20 2021-11-19 博动医学影像科技（上海）有限公司 获取血管压力差的方法及装置
DE102018210058A1 (de) 2018-06-21 2019-12-24 Kardion Gmbh Statorschaufelvorrichtung zur Strömungsführung eines aus einer Austrittsöffnung eines Herzunterstützungssystems ausströmenden Fluids, Herzunterstützungssystem mit Statorschaufelvorrichtung, Verfahren zum Betreiben einer Statorschaufelvorrichtung und Herstellverfahren
DE102018210076A1 (de) 2018-06-21 2019-12-24 Kardion Gmbh Verfahren und Vorrichtung zum Erkennen eines Verschleißzustands eines Herzunterstützungssystems, Verfahren und Vorrichtung zum Betreiben eines Herzunterstützungssystems und Herzunterstützungssystem
DE102018211297A1 (de) 2018-07-09 2020-01-09 Kardion Gmbh Herzunterstützungssystem und Verfahren zur Überwachung der Integrität einer Haltestruktur eines Herzunterstützungssystems
DE102018211328A1 (de) 2018-07-10 2020-01-16 Kardion Gmbh Laufradgehäuse für ein implantierbares, vaskuläres Unterstützungssystem
DE102018212153A1 (de) 2018-07-20 2020-01-23 Kardion Gmbh Zulaufleitung für eine Pumpeneinheit eines Herzunterstützungssystems, Herzunterstützungssystem und Verfahren zum Herstellen einer Zulaufleitung für eine Pumpeneinheit eines Herzunterstützungssystems
JP2021532931A (ja) 2018-08-07 2021-12-02 カルディオン ゲーエムベーハーKardion Gmbh 心臓補助システム用ベアリング装置、および心臓補助システム用ベアリング装置内の中間空間のフラッシング方法
CA3138340A1 (en) * 2019-05-31 2020-12-03 Ahmad El Katerji Intra-aortic pressure forecasting
DE102019004825A1 (de) * 2019-07-10 2021-01-14 Xenios Ag Steuerung für nicht-okklusive Blutpumpen
DE102020102474A1 (de) 2020-01-31 2021-08-05 Kardion Gmbh Pumpe zum Fördern eines Fluids und Verfahren zum Herstellen einer Pumpe
CN113476737B (zh) * 2021-07-02 2024-01-26 中国科学院江西稀土研究院 一种提高人工心脏泵血流仿生搏动性的方法、装置及存储介质
US20230026732A1 (en) * 2021-07-26 2023-01-26 Open Water Internet Inc. Large Vessel Occlusion Alert from Optical Measurements
CN113769262B (zh) * 2021-08-04 2022-11-08 浙江迪远医疗器械有限公司 一种控制血泵的装置
WO2023048110A1 (ja) * 2021-09-27 2023-03-30 テルモ株式会社 血液循環システム
CN114588530A (zh) * 2022-03-14 2022-06-07 丰凯利医疗器械(上海)有限公司 泵血导管在人体内位置的检测方法和系统
TW202400074A (zh) * 2022-06-03 2024-01-01 美商阿比奧梅德公司 估計通過循環支持裝置之最大流量
WO2024112428A1 (en) * 2022-11-23 2024-05-30 Boston Scientific Scimed Inc. Blood pump control using motor voltage measurement
WO2024123987A1 (en) 2022-12-08 2024-06-13 Abiomed, Inc. Estimating contractile reserve using a mechnical circulatory support device
US20240347189A1 (en) * 2023-04-07 2024-10-17 Abiomed, Inc. Systems and methods for determining cardiac contractility based on signals from a mechanical circulatory support device
WO2024226831A1 (en) * 2023-04-25 2024-10-31 Shifamed Holdings, Llc Catheter blood pumps and associated methods
US20250090831A1 (en) * 2023-09-14 2025-03-20 Boston Scientific Scimed, Inc. Circulatory support devices, systems, and methods
CN116994739B (zh) * 2023-09-27 2024-01-30 深圳核心医疗科技股份有限公司 心室辅助装置的工况偏离确定方法及装置
CN118490976B (zh) * 2024-07-17 2024-10-29 安徽通灵仿生科技有限公司 一种基于右心室导管泵的心输出量估计方法及装置
CN119971296B (zh) * 2025-04-11 2025-09-02 苏州同心医疗科技股份有限公司 血泵流量自适应控制方法、系统及相关产品
CN119971297B (zh) * 2025-04-11 2025-09-02 苏州同心医疗科技股份有限公司 血泵转速脉动控制方法、系统及相关产品

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3677092A (en) 1970-06-17 1972-07-18 Us Health Education & Welfare Volume metering apparatus for circulatory assist pumps
US4598579A (en) 1984-10-23 1986-07-08 Cordis Corporation Portable instrument to test pressure/flow of ventricular shunt valves
US4877035A (en) * 1988-10-12 1989-10-31 Trustees Of The University Of Pennsylvania Measurement of the end-systolic pressure-volume relation using intraaortic balloon occlusion
US5241966A (en) * 1990-10-23 1993-09-07 Hypertension Diagnostics, Inc. Method and apparatus for measuring cardiac output
US5365933A (en) * 1993-03-12 1994-11-22 Siemens Medical Systems, Inc. Apparatus and method for distinguishing heart beats from intra-aortic balloon pump beats
US5437284A (en) 1993-12-30 1995-08-01 Camino Laboratories, Inc. System and method for in vivo calibration of a sensor
US5535753A (en) * 1994-10-04 1996-07-16 Rutgers University Apparatus and methods for the noninvasive measurement of cardiovascular system parameters
DE19625300A1 (de) 1996-06-25 1998-01-02 Guenter Prof Dr Rau Blutpumpe
US5964694A (en) 1997-04-02 1999-10-12 Guidant Corporation Method and apparatus for cardiac blood flow assistance
AU7360798A (en) 1997-09-24 1999-04-12 Cleveland Clinic Foundation, The Flow controlled blood pump system
US6159160A (en) 1998-03-26 2000-12-12 Ethicon, Inc. System and method for controlled infusion and pressure monitoring
US6176822B1 (en) 1998-03-31 2001-01-23 Impella Cardiotechnik Gmbh Intracardiac blood pump
DE19831997A1 (de) 1998-07-16 2000-01-20 Ewald Hennel Verfahren zur Regelung des Drucks eines Fluids
IT1315206B1 (it) 1999-04-27 2003-02-03 Salvatore Romano Metodo e apparato per la misura della portata cardiaca.
US7022100B1 (en) 1999-09-03 2006-04-04 A-Med Systems, Inc. Guidable intravascular blood pump and related methods
AUPQ420599A0 (en) * 1999-11-24 1999-12-16 Duncan Campbell Patents Pty Ltd Method and apparatus for determining cardiac output or total peripheral resistance
DE10060275A1 (de) 2000-12-05 2002-06-13 Impella Cardiotech Ag Verfahren zum Kalibrieren eines Drucksensors oder eines Flussensors an einer Rotationspumpe
US6623420B2 (en) 2001-08-16 2003-09-23 Apex Medical, Inc. Physiological heart pump control
JP3616061B2 (ja) * 2002-03-01 2005-02-02 コーリンメディカルテクノロジー株式会社 動脈硬化検査装置
JP3649703B2 (ja) * 2002-04-17 2005-05-18 コーリンメディカルテクノロジー株式会社 振幅増加指数測定機能付血圧測定装置
US7862513B2 (en) 2002-05-14 2011-01-04 Pacesetter, Inc. Apparatus for minimally invasive calibration of implanted pressure transducers
US6949066B2 (en) * 2002-08-21 2005-09-27 World Heart Corporation Rotary blood pump diagnostics and cardiac output controller
EP1585441A4 (en) * 2003-01-24 2008-05-21 Proteus Biomedical Inc METHOD AND SYSTEMS FOR MEASURING HEART PARAMETERS
AU2003903726A0 (en) * 2003-07-18 2003-07-31 Ventracor Limited A device for detecting heart pumping state
US7422562B2 (en) * 2003-12-05 2008-09-09 Edwards Lifesciences Real-time measurement of ventricular stroke volume variations by continuous arterial pulse contour analysis
US20080097226A1 (en) 2005-06-09 2008-04-24 Mcconnell Patrick I Evaluation of cardiac function using left ventricular pressure during LVAD support
US20100268333A1 (en) * 2009-04-16 2010-10-21 Gohean Jeffrey R System and method for controlling pump
US20080183232A1 (en) * 2007-01-30 2008-07-31 Voss Gregory I Method and system for determining cardiac function
JP5266464B2 (ja) * 2007-05-10 2013-08-21 ライニッシュ−ヴェストフェリッシェ・テクニッシェ・ホッホシューレ・アーヘン 心機能変化評価装置
WO2008144404A1 (en) * 2007-05-16 2008-11-27 Massachusetts Instutute Of Technology Systems and methods for model-based estimation of cardiac output and total peripheral resistance
US20090270739A1 (en) 2008-01-30 2009-10-29 Edwards Lifesciences Corporation Real-time detection of vascular conditions of a subject using arterial pressure waveform analysis
US20100152547A1 (en) * 2008-07-02 2010-06-17 Sterling Bernhard B Method and system for determining cardiac performance
EP2346392A1 (en) 2008-08-26 2011-07-27 Cardiac Pacemakers, Inc. Cardiac output estimation using pulmonary artery pressure
EP2334230A1 (en) * 2008-10-10 2011-06-22 Cardiac Pacemakers, Inc. Systems and methods for determining cardiac output using pulmonary artery pressure measurements
WO2010059291A1 (en) * 2008-11-19 2010-05-27 Cardiac Pacemakers, Inc. Assessment of pulmonary vascular resistance via pulmonary artery pressure
US20100204590A1 (en) * 2009-02-09 2010-08-12 Edwards Lifesciences Corporation Detection of Vascular Conditions Using Arterial Pressure Waveform Data
US10478076B2 (en) * 2009-12-28 2019-11-19 Gambro Lundia Ab Monitoring a property of the cardiovascular system of a subject
US9555174B2 (en) * 2010-02-17 2017-01-31 Flow Forward Medical, Inc. Blood pump systems and methods
US20140288442A1 (en) * 2010-02-25 2014-09-25 Tonino Bombardini Method and apparatus for quantification and monitoring of cardiovascular function during induced stress or physical activity and at rest
US8876686B2 (en) 2011-02-18 2014-11-04 Vascor, Inc Control of blood flow assist systems
US8613696B2 (en) * 2011-08-15 2013-12-24 Thoratec Corporation Non-invasive diagnostics for ventricle assist device
EP2744534A4 (en) * 2011-08-17 2015-07-29 Novita Therapeutics Llc BLOOD PUMP SYSTEMS AND METHOD THEREFOR
WO2013141766A1 (en) 2012-03-21 2013-09-26 Maquet Critical Care Ab Method for continuous and non-invasive determination of effective lung volume and cardiac output
EP2849639B1 (en) * 2012-05-15 2015-09-23 Koninklijke Philips N.V. Monitoring of cardiac output
US20150018632A1 (en) * 2012-09-14 2015-01-15 Mohammad Khair System and Method For Monitoring Cardiac Blood Flow Balance Between The Right and Left Heart Chambers
CN104822400B (zh) * 2012-09-21 2017-07-14 纯净之心有限公司 控制心室辅助设备(vad)的速度的方法和心室辅助设备
US20140107505A1 (en) * 2012-10-11 2014-04-17 Alon Marmor Determination of ventricular pressure and related values
WO2014062911A2 (en) 2012-10-17 2014-04-24 The Trustees Of The University Of Pennsylvania Method for monitoring and improving forward blood flow during cpr
US9259187B2 (en) * 2013-01-30 2016-02-16 Austin Health System and method for monitoring cardiac output with substantially improved accuracy and precision
JP6616405B2 (ja) * 2014-05-29 2019-12-04 セントビンセンツ ホスピタル シドニー リミテッド 心室補助人工心臓の方法及び装置
EP3197517B1 (en) * 2014-09-23 2019-10-23 St Vincent's Hospital Sydney Limited Apparatus for determining aortic valve opening
US11000195B2 (en) 2015-04-06 2021-05-11 Thomas Jefferson University Implantable vital sign sensor
KR101630124B1 (ko) 2015-04-17 2016-06-13 강원대학교산학협력단 심실보조장치를 이식한 환자의 심장기능 모니터링 방법
WO2016195477A1 (en) 2015-06-04 2016-12-08 Jozef Reinier Cornelis Jansen Method and computer system for processing a heart sensor output
US10130743B2 (en) 2015-11-17 2018-11-20 Dale J. Yeatts Wireless diagnostic system for indirect flow measurement in artificial heart pumps
EP3181163A1 (de) 2015-12-14 2017-06-21 Berlin Heart GmbH Blutpumpe zur herzunterstützung und verfahren zu ihrem betrieb
US20180053504A1 (en) * 2016-08-19 2018-02-22 Otis Elevator Company Intention recognition for triggering voice recognition system
ES2754405T3 (es) 2016-08-23 2020-04-17 Abiomed Europe Gmbh Dispositivo de asistencia ventricular
US10376162B2 (en) 2016-09-19 2019-08-13 Abiomed, Inc. Cardiovascular assist system that quantifies heart function and facilitates heart recovery
EP3311859B1 (en) 2016-10-19 2019-12-04 Abiomed Europe GmbH Ventricular assist device control
EP3357523B1 (en) 2017-02-07 2021-01-20 Abiomed Europe GmbH Blood pump

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