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DK3860998T3 - Forbindelser og sammensætninger til behandlinger af tilstande, der er forbundet med APJ-receptoraktivitet - Google Patents

Forbindelser og sammensætninger til behandlinger af tilstande, der er forbundet med APJ-receptoraktivitet Download PDF

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Publication number
DK3860998T3
DK3860998T3 DK19791146.4T DK19791146T DK3860998T3 DK 3860998 T3 DK3860998 T3 DK 3860998T3 DK 19791146 T DK19791146 T DK 19791146T DK 3860998 T3 DK3860998 T3 DK 3860998T3
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Prior art keywords
compositions
compounds
conditions associated
receptor activity
treating conditions
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DK19791146.4T
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English (en)
Inventor
Haifeng Tang
Michael Hanson
Sarah Boyce
Zhe Nie
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Annapurna Bio Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
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  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
DK19791146.4T 2018-10-05 2019-10-04 Forbindelser og sammensætninger til behandlinger af tilstande, der er forbundet med APJ-receptoraktivitet DK3860998T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862742218P 2018-10-05 2018-10-05
PCT/US2019/054880 WO2020073011A1 (en) 2018-10-05 2019-10-04 Compounds and compositions for treating conditions associated with apj receptor activity

Publications (1)

Publication Number Publication Date
DK3860998T3 true DK3860998T3 (da) 2024-03-25

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DK19791146.4T DK3860998T3 (da) 2018-10-05 2019-10-04 Forbindelser og sammensætninger til behandlinger af tilstande, der er forbundet med APJ-receptoraktivitet

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Country Link
US (2) US11471455B2 (da)
EP (2) EP4364798A3 (da)
JP (2) JP7640458B2 (da)
KR (1) KR20210125471A (da)
CN (3) CN113490668B (da)
AR (1) AR116687A1 (da)
AU (2) AU2019353144B2 (da)
BR (1) BR112021006488A2 (da)
CA (1) CA3115472A1 (da)
DK (1) DK3860998T3 (da)
EA (1) EA202190952A1 (da)
ES (1) ES2976515T3 (da)
FI (1) FI3860998T3 (da)
HR (1) HRP20240401T1 (da)
HU (1) HUE066335T2 (da)
IL (2) IL316875A (da)
LT (1) LT3860998T (da)
MX (2) MX2021003904A (da)
PL (1) PL3860998T3 (da)
PT (1) PT3860998T (da)
RS (1) RS65335B1 (da)
SG (1) SG11202103451YA (da)
SI (1) SI3860998T1 (da)
SM (1) SMT202400132T1 (da)
TW (2) TWI891227B (da)
WO (1) WO2020073011A1 (da)

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Publication number Priority date Publication date Assignee Title
IL316875A (en) * 2018-10-05 2025-01-01 Annapurna Bio Inc Compounds and compositions for treating conditions associated with APJ receptor activity
CN112724089B (zh) * 2021-01-05 2022-08-26 烟台皓元生物医药科技有限公司 一种2-氨基-3-溴-6-氯吡嗪的合成工艺
EP4367086A4 (en) * 2021-07-06 2025-06-25 University of Georgia Research Foundation, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF VIRUS INFECTIONS
EP4615845A1 (en) 2022-11-10 2025-09-17 Annapurna Bio Inc. Salts and solid forms of a compound having apj receptor activity
WO2025189141A1 (en) 2024-03-08 2025-09-12 Annapurna Bio, Inc. Methods for treating obesity and increasing weight loss

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