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DK3785733T3 - Farmaceutisk sammensætning til behandling af autisme - Google Patents

Farmaceutisk sammensætning til behandling af autisme Download PDF

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Publication number
DK3785733T3
DK3785733T3 DK20195373.4T DK20195373T DK3785733T3 DK 3785733 T3 DK3785733 T3 DK 3785733T3 DK 20195373 T DK20195373 T DK 20195373T DK 3785733 T3 DK3785733 T3 DK 3785733T3
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DK
Denmark
Prior art keywords
autism
treatment
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
DK20195373.4T
Other languages
English (en)
Inventor
Lynn Durham
Original Assignee
Stalicla S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stalicla S A filed Critical Stalicla S A
Application granted granted Critical
Publication of DK3785733T3 publication Critical patent/DK3785733T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/01Hydrocarbons
    • A61K31/015Hydrocarbons carbocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK20195373.4T 2017-11-06 2018-11-06 Farmaceutisk sammensætning til behandling af autisme DK3785733T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762582141P 2017-11-06 2017-11-06
EP17200219 2017-11-06
US201862663647P 2018-04-27 2018-04-27
EP18169952 2018-04-27
EP18204763.9A EP3498297B1 (en) 2017-11-06 2018-11-06 Pharmaceutical composition for the treatment of autism

Publications (1)

Publication Number Publication Date
DK3785733T3 true DK3785733T3 (da) 2022-04-11

Family

ID=64023965

Family Applications (1)

Application Number Title Priority Date Filing Date
DK20195373.4T DK3785733T3 (da) 2017-11-06 2018-11-06 Farmaceutisk sammensætning til behandling af autisme

Country Status (11)

Country Link
US (3) US10940140B2 (da)
EP (3) EP3785733B1 (da)
JP (2) JP2019089755A (da)
KR (1) KR102372678B1 (da)
CN (2) CN119303086A (da)
AU (1) AU2018260807B2 (da)
BR (1) BR102018072757A2 (da)
CA (1) CA3023014C (da)
DK (1) DK3785733T3 (da)
ES (2) ES2908863T3 (da)
PL (1) PL3785733T3 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3480597A1 (en) 2017-11-06 2019-05-08 Stalicla S.A. Biomarker assay for use in monitoring autism
CA3023014C (en) * 2017-11-06 2023-09-26 Stalicla Sa Pharmaceutical composition for treatment of autism
GB201911603D0 (en) * 2019-08-14 2019-09-25 Healx Ltd Treatment
GB201912760D0 (en) * 2019-09-05 2019-10-23 Healx Ltd Treatment
US20210180130A1 (en) * 2019-12-13 2021-06-17 Seawire Consultoria e Comercio LDA Detection and treatment of autism spectrum disorders
EP3881842A1 (en) * 2020-03-19 2021-09-22 Stalicla S.A. Compositions for the treatment of autism spectrum disorder
JP2023521030A (ja) * 2020-04-06 2023-05-23 メディシノバ・インコーポレイテッド イブジラストを用いる、患者におけるマクロファージ遊走性阻止因子の血漿レベルの減少方法
WO2022079302A1 (en) * 2020-10-16 2022-04-21 Purposeful Ike Compositions and uses thereof
EP4012414A1 (en) 2020-12-11 2022-06-15 Stalicla S.A. Diagnosis of autism spectrum disorder phenotype 1
CN113528650B (zh) * 2021-08-03 2022-03-08 长沙艾克曼生物科技有限公司 Tmp21基因的表达可以作为自闭症早期筛查、早期识别和症状严重程度预测的客观指标
US20240423952A1 (en) * 2021-11-15 2024-12-26 Ibagen Pharmaceuticals, Inc. Compositions and methods for treating congenital disorders
US20250073226A1 (en) * 2021-12-21 2025-03-06 Osaka Universtiy Use of opioid for treatment of autism spectrum disorders
CN120092294A (zh) * 2022-04-15 2025-06-03 上海交通大学医学院附属新华医院 自闭症谱系障碍患者布美他尼治疗反应的预测
CN114974571B (zh) * 2022-05-27 2023-03-24 浙江大学医学院附属儿童医院 多模态数据驱动的孤独症检测系统、设备及存储介质
CH721671A2 (de) 2024-03-21 2025-09-30 Stalicla Sa Behandlung von Autismus-Spektrum-Störungen
CN119386023A (zh) * 2024-10-25 2025-02-07 南方医科大学南方医院 地尔硫卓在制备治疗自闭症的药物中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6294899A (en) * 1998-10-07 2000-04-26 Medical College Of Georgia Research Institute, Inc. Glucose-dependent insulinotropic peptide for use as an osteotropic hormone
US20050282896A1 (en) * 2002-10-07 2005-12-22 The University Of Alberta Methods of cardioprotection using dichloroacetate in combination with an inotrope
WO2004056180A1 (en) * 2002-12-23 2004-07-08 Global Cardiac Solutions Pty Ltd Organ preconditioning, arrest, protection, preservation and recovery (1)
DE10325813B4 (de) * 2003-06-06 2007-12-20 Universitätsklinikum Freiburg Prophylaxe und/oder Therapie bei der portalen Hypertonie
JP2009512711A (ja) * 2005-10-21 2009-03-26 ブレインセルス,インコーポレイティド Pde阻害による神経新生の調節
EP2068850A1 (en) * 2006-06-22 2009-06-17 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists in the treatment of ischemia
WO2008019106A1 (en) * 2006-08-04 2008-02-14 Artesian Therapeutics, Inc. Methods and compositions for the treatment of pulmonary hypertension using a combination of a calcium channel blocker and a phosphodiesterase inhibitor
WO2010085352A2 (en) * 2009-01-22 2010-07-29 Neurotherapeutics Pharma, Inc. Bumetanide, furosemide, piretanide, azosemide, and torsemide analogs, compositions and methods of use
WO2011004166A1 (en) * 2009-07-09 2011-01-13 Cbt Development Limited Combined preparation for use as a medicament
HUE034866T2 (hu) * 2010-01-15 2018-03-28 Inst Nat Sante Rech Med NKCC inhibitorok az autizmus kezelésére
US20130123124A1 (en) 2010-03-12 2013-05-16 Children's Medical Center Corporation Methods and compositions for characterizing autism spectrum disorder based on gene expression patterns
US10220008B2 (en) * 2013-08-14 2019-03-05 Stc.Unm Treatment and prevention of stroke and other neurological disorders
WO2015048590A1 (en) * 2013-09-27 2015-04-02 Sher Justin Nutraceutical compositon for pde4 inhibition, enhanced dopamine metabolism and long term potentiation
CA3023014C (en) * 2017-11-06 2023-09-26 Stalicla Sa Pharmaceutical composition for treatment of autism
CA3118790A1 (en) * 2018-11-06 2020-05-14 Stalicla Sa Metabolic profiling for the diagnosis of a subset of idiopathic autism spectrum disorder patients, asd phenotype 1

Also Published As

Publication number Publication date
BR102018072757A2 (pt) 2019-06-04
JP2019089755A (ja) 2019-06-13
CA3023014A1 (en) 2019-05-06
EP3498297B1 (en) 2023-06-21
US20210145803A1 (en) 2021-05-20
EP3984555A1 (en) 2022-04-20
CN119303086A (zh) 2025-01-14
US11439627B2 (en) 2022-09-13
JP2020059711A (ja) 2020-04-16
US20210154177A1 (en) 2021-05-27
CA3023014C (en) 2023-09-26
EP3785733A1 (en) 2021-03-03
ES2908863T3 (es) 2022-05-04
ES2962383T3 (es) 2024-03-18
KR102372678B1 (ko) 2022-03-10
EP3498297A1 (en) 2019-06-19
AU2018260807A1 (en) 2019-05-23
JP7012054B2 (ja) 2022-02-10
EP3785733B1 (en) 2022-01-05
US20190134011A1 (en) 2019-05-09
PL3785733T3 (pl) 2022-07-11
KR20190051853A (ko) 2019-05-15
CN109821019A (zh) 2019-05-31
AU2018260807B2 (en) 2020-07-09
US10940140B2 (en) 2021-03-09
EP3498297C0 (en) 2023-06-21

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