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DK3610267T3 - Massespektrometri til enkeltcellebilleddannelse - Google Patents

Massespektrometri til enkeltcellebilleddannelse Download PDF

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Publication number
DK3610267T3
DK3610267T3 DK18717611.0T DK18717611T DK3610267T3 DK 3610267 T3 DK3610267 T3 DK 3610267T3 DK 18717611 T DK18717611 T DK 18717611T DK 3610267 T3 DK3610267 T3 DK 3610267T3
Authority
DK
Denmark
Prior art keywords
mass spectrometry
single cell
cell imaging
imaging
spectrometry
Prior art date
Application number
DK18717611.0T
Other languages
English (en)
Inventor
Theodore Alexandrov
Luca Rappez
Original Assignee
European Molecular Biology Laboratory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by European Molecular Biology Laboratory filed Critical European Molecular Biology Laboratory
Application granted granted Critical
Publication of DK3610267T3 publication Critical patent/DK3610267T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0004—Imaging particle spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plasma & Fusion (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK18717611.0T 2017-04-13 2018-04-13 Massespektrometri til enkeltcellebilleddannelse DK3610267T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17166487 2017-04-13
PCT/EP2018/059515 WO2018189365A1 (en) 2017-04-13 2018-04-13 Single-cell imaging mass spectrometry

Publications (1)

Publication Number Publication Date
DK3610267T3 true DK3610267T3 (da) 2023-02-27

Family

ID=58548603

Family Applications (2)

Application Number Title Priority Date Filing Date
DK22208734.8T DK4198514T3 (da) 2017-04-13 2018-04-13 Billeddannende massespektrometri af enkeltcelle(r)
DK18717611.0T DK3610267T3 (da) 2017-04-13 2018-04-13 Massespektrometri til enkeltcellebilleddannelse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK22208734.8T DK4198514T3 (da) 2017-04-13 2018-04-13 Billeddannende massespektrometri af enkeltcelle(r)

Country Status (7)

Country Link
US (1) US11454626B2 (da)
EP (2) EP4198514B1 (da)
AU (1) AU2018252185B2 (da)
CA (1) CA3059818A1 (da)
DK (2) DK4198514T3 (da)
ES (2) ES3035185T3 (da)
WO (1) WO2018189365A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109860014B (zh) * 2019-01-29 2021-05-14 厦门大学 一种快速成像质谱仪
CN114019010A (zh) * 2021-11-04 2022-02-08 上海交通大学 一种微生物单细胞代谢组学分析方法
CN116990292A (zh) * 2022-09-07 2023-11-03 中国药科大学 一种单细胞水平中药显微化学鉴定方法
DE102023104393A1 (de) 2023-02-23 2024-08-29 Bruker Daltonics GmbH & Co. KG Verfahren und Vorrichtung zur spektrometrischen Analyse

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808300A (en) 1996-05-10 1998-09-15 Board Of Regents, The University Of Texas System Method and apparatus for imaging biological samples with MALDI MS
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
DE19937438C2 (de) 1999-08-07 2001-09-13 Bruker Daltonik Gmbh Kopplung Dünnschicht-Chromatographie und Massenspektrometrie (TLC/MS)
CA2440754A1 (en) * 2001-03-12 2002-09-19 Stephen Quake Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
DE602005020421D1 (de) * 2004-02-19 2010-05-20 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
GB201403625D0 (en) * 2014-02-28 2014-04-16 Asrepresented By The Sec Dep Of Health And Human Services The Multiplexed imaging of tissue samples by mass cytometry
US10032615B2 (en) 2014-06-16 2018-07-24 The Brigham And Women's Hospital Systems and methods for single cell culture and analysis by microscopy and MALDI mass spectrometry
WO2016090356A1 (en) * 2014-12-05 2016-06-09 Fluidigm Canada Inc. Mass cytometry imaging
CN106153538A (zh) * 2015-04-20 2016-11-23 中国科学院化学研究所 一种可寻址的样品板及其在单细胞显微成像中的应用

Also Published As

Publication number Publication date
EP4198514A1 (en) 2023-06-21
WO2018189365A1 (en) 2018-10-18
ES3035185T3 (en) 2025-08-29
CA3059818A1 (en) 2018-10-18
EP3610267B1 (en) 2022-11-23
US20200057049A1 (en) 2020-02-20
AU2018252185A1 (en) 2019-10-31
AU2018252185B2 (en) 2024-09-19
ES2939291T3 (es) 2023-04-20
EP3610267A1 (en) 2020-02-19
EP4198514B1 (en) 2025-05-14
DK4198514T3 (da) 2025-06-30
US11454626B2 (en) 2022-09-27

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