[go: up one dir, main page]

DK3505638T3 - Mikrofluid indretning, system og fremgangsmåde til studie af organismer - Google Patents

Mikrofluid indretning, system og fremgangsmåde til studie af organismer Download PDF

Info

Publication number
DK3505638T3
DK3505638T3 DK19153553.3T DK19153553T DK3505638T3 DK 3505638 T3 DK3505638 T3 DK 3505638T3 DK 19153553 T DK19153553 T DK 19153553T DK 3505638 T3 DK3505638 T3 DK 3505638T3
Authority
DK
Denmark
Prior art keywords
organisms
study
microfluidic device
microfluidic
Prior art date
Application number
DK19153553.3T
Other languages
English (en)
Inventor
Matteo Cornaglia
Daniel Migliozzi
Martin Gijs
Original Assignee
Ecole Polytechnique Fed Lausanne Epfl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecole Polytechnique Fed Lausanne Epfl filed Critical Ecole Polytechnique Fed Lausanne Epfl
Application granted granted Critical
Publication of DK3505638T3 publication Critical patent/DK3505638T3/da

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • G01N33/5085Supracellular entities, e.g. tissue, organisms of invertebrates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663Stretching or orienting elongated molecules or particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0655Valves, specific forms thereof with moving parts pinch valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Fluid Mechanics (AREA)
  • Biophysics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK19153553.3T 2014-10-20 2015-10-19 Mikrofluid indretning, system og fremgangsmåde til studie af organismer DK3505638T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2014065472 2014-10-20
EP15807695.0A EP3209790B1 (en) 2014-10-20 2015-10-19 Microfluidic device, system and method for the study of organisms

Publications (1)

Publication Number Publication Date
DK3505638T3 true DK3505638T3 (da) 2021-02-15

Family

ID=54838379

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19153553.3T DK3505638T3 (da) 2014-10-20 2015-10-19 Mikrofluid indretning, system og fremgangsmåde til studie af organismer

Country Status (5)

Country Link
US (2) US11596945B2 (da)
EP (2) EP3505638B1 (da)
DK (1) DK3505638T3 (da)
ES (2) ES2850881T3 (da)
WO (1) WO2016063199A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6164622B1 (ja) * 2016-09-12 2017-07-19 株式会社Hirotsuバイオサイエンス 線虫の嗅覚に基づく匂い物質に対する走性行動の評価方法、および該評価方法に用いるシャーレ
TWI772324B (zh) 2016-09-12 2022-08-01 日商廣津生物化學股份有限公司 基於線蟲嗅覺的對氣味物質之趨性行動之評價方法、以及用於該評價方法的培養皿及行動評價系統
CN110475848B (zh) * 2017-01-31 2024-07-09 格尼亚Ip控股私人有限公司 用于处理生物样本的方法和系统
US11213824B2 (en) 2017-03-29 2022-01-04 The Research Foundation For The State University Of New York Microfluidic device and methods
WO2019133098A2 (en) * 2017-10-20 2019-07-04 President And Fellows Of Harvard College Microfluidic platform for time-resolved tissue and organism analysis
CN107570246B (zh) * 2017-10-23 2022-11-11 广东第二师范学院 一种用于抗菌药物筛选的线虫芯片及其微流控方法
CN110465336A (zh) * 2018-05-11 2019-11-19 中国石油化工股份有限公司 芯片反应装置和手动进样方法及其应用
WO2020005802A1 (en) * 2018-06-24 2020-01-02 University Of Oregon Microinjection chip, device, system and uses thereof for unicellular or multicellular organisms
GB2578144A (en) 2018-10-18 2020-04-22 The Univ Of Durham Method and apparatus for tracking nematode worms
CN109439514B (zh) * 2018-12-14 2024-08-06 贵州大学 一种用于阵列微流体点样微流控制装置的支撑装置
EP3934808A4 (en) * 2019-03-05 2023-04-26 Texas Tech University System AUTOMATED MICROFLUIDIC SYSTEM TO ANALYZE THE LIFE AND HEALTH SPAN IN NEMATODES
CN110940821B (zh) * 2019-12-13 2024-01-26 大连海事大学 一种便携式单线虫并行分析微流控芯片系统及其使用方法
EP4137558A1 (en) 2021-08-17 2023-02-22 Nagi Bioscience SA Apparatus for microscopic worm observation
EP4137555A1 (en) 2021-08-17 2023-02-22 Nagi Bioscience SA Apparatus for biological microorganism observation
CN114208780A (zh) * 2021-12-30 2022-03-22 南通大学 一种可用于线虫培养及即时固定的微流控芯片装置
CN115997732A (zh) * 2022-12-19 2023-04-25 西交利物浦大学 一种微流控线虫培养测试系统
EP4481054A1 (en) * 2023-06-23 2024-12-25 Sysmex Astrego AB Bacteria classification and analysis
WO2025165672A1 (en) * 2024-01-29 2025-08-07 Nemalife Inc. A rapid microfluidic in vivo bioassay for evaluating the cognitive health benefits of compounds
WO2025171389A1 (en) * 2024-02-09 2025-08-14 Colossal Biosciences Inc. An apparatus and method for a microfluidic culture of non-adherent pre-implantation cells, tissues, organoids, or embryos under environmentally controlled, highly customizable microenvironments
CN119549205B (zh) * 2024-10-15 2025-10-28 南通大学 用于捕获并以统一体位固定线虫的微流控芯片及制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009021232A2 (en) 2007-08-09 2009-02-12 Massachusetts Institute Of Technology High-throughput, whole-animal screening system
WO2009039284A1 (en) 2007-09-18 2009-03-26 Georgia Tech Research Corporation Systems and methods for high-throughput detection and sorting
US8702939B2 (en) 2010-09-15 2014-04-22 Mcmaster University Electrotaxis methods and devices
CN102669058A (zh) 2011-03-18 2012-09-19 中国科学院大连化学物理研究所 基于微阀的秀丽隐杆线虫长期培养及双检测微流控芯片
US9723817B2 (en) 2011-11-10 2017-08-08 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Electropharyngeogram arrays and methods of use
CN103461279B (zh) 2012-06-08 2015-11-18 中国科学院上海生命科学研究院 用于线虫培养和/或观察的微流芯片和设备及其应用
CN102972351A (zh) 2012-11-06 2013-03-20 中国科学院大连化学物理研究所 基于微流控芯片的秀丽隐杆线虫单卵捕获及培养方法

Also Published As

Publication number Publication date
WO2016063199A1 (en) 2016-04-28
EP3505638A1 (en) 2019-07-03
US11596945B2 (en) 2023-03-07
EP3209790A1 (en) 2017-08-30
US20170312748A1 (en) 2017-11-02
EP3505638B1 (en) 2020-11-11
ES2795991T3 (es) 2020-11-25
US12325022B2 (en) 2025-06-10
US20230149927A1 (en) 2023-05-18
ES2850881T3 (es) 2021-09-01
EP3209790B1 (en) 2020-01-08

Similar Documents

Publication Publication Date Title
DK3505638T3 (da) Mikrofluid indretning, system og fremgangsmåde til studie af organismer
IL260343A (en) Microfluidic devices for optically-driven convection and displacement, kits and methods thereof
DK3426109T3 (da) Samling og fremgangsmåde til opskumning af fluid
DK3280441T3 (da) Anti-sortilin-antistoffer og fremgangsmåder til anvendelse deraf
DK3227336T3 (da) Anti-CD79b-antistoffer og fremgangsmåder til anvendelse
DK3299469T3 (da) Systemer og fremgangsmåder til at stregkodemarkere nukleinsyre
DK3303394T3 (da) Anti-ctla-4-antistoffer og fremgangsmåder til anvendelse deraf
DK3265947T3 (da) Fremgangsmåde og system til kryptering
DK3129912T3 (da) Fremgangsmåde og system til sikring af data
DK3116911T3 (da) Anti-mcam-antistoffer og tilhørende fremgangsmåder til anvendelse
DK3213065T3 (da) System og fremgangsmåder til todimensionel rplc-sfc-kromatografi
DK3116736T3 (da) Ædruelighedsaflåsningssystemer til køretøj og fremgangsmåder med opvarmningsstøtte til køretøj
DK3626602T3 (da) Styreanordning og fremgangsmåde til styreanordningen
DK3230917T3 (da) System og fremgangsmåde til aktivering af sikker autentificering
DK3183010T3 (da) Anordning og tilhørende fremgangsmåde til behandling af medicinsk affald
DK3094640T3 (da) Fremgangsmåder til steril kromatografi og fremstilling
DK3222717T3 (da) Fremgangsmåde til at amplificere cirkulært dna
DK3821770T3 (da) Anordning og fremgangsmåde til opskumning af fluid
DK3375847T3 (da) Tungoliehydrering-behandlingssystem og tungoliehydrering-behandlingsfremgangsmåde
DK3525733T3 (da) Indføringsenhed til intrauterint system
EP3190801C0 (en) DISPLAY DEVICE, SYSTEM AND ASSOCIATED CONTROL METHOD
DK3100886T3 (da) Køretøj og kraftoverføringssystem deraf
DK3201624T3 (da) Indretning til detektion af hæmolyse, system og fremgangsmåde
DK3334693T3 (da) Kontinuerlig fremgangsmåde og system til behandlingen af spildevand
DK3338642T3 (da) Ultralydsdiagnoseanordning og fremgangsmåde til styring af ultralydsdiagnoseanordning