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DK3573630T3 - Forebyggelse og behandling af skader eller sygdom i knogler og brusk - Google Patents

Forebyggelse og behandling af skader eller sygdom i knogler og brusk Download PDF

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Publication number
DK3573630T3
DK3573630T3 DK18703531.6T DK18703531T DK3573630T3 DK 3573630 T3 DK3573630 T3 DK 3573630T3 DK 18703531 T DK18703531 T DK 18703531T DK 3573630 T3 DK3573630 T3 DK 3573630T3
Authority
DK
Denmark
Prior art keywords
cartilage
bones
disease
prevention
damage
Prior art date
Application number
DK18703531.6T
Other languages
English (en)
Inventor
Christina Uvebrant
Jan Talts
Åkerlund Evy Lundgren
Original Assignee
Xintela Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xintela Ab filed Critical Xintela Ab
Application granted granted Critical
Publication of DK3573630T3 publication Critical patent/DK3573630T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
DK18703531.6T 2017-01-27 2018-01-29 Forebyggelse og behandling af skader eller sygdom i knogler og brusk DK3573630T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762451372P 2017-01-27 2017-01-27
PCT/EP2018/052104 WO2018138322A1 (en) 2017-01-27 2018-01-29 Prevention and treatment of bone and cartilage damage or disease

Publications (1)

Publication Number Publication Date
DK3573630T3 true DK3573630T3 (da) 2021-06-07

Family

ID=61168072

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18703531.6T DK3573630T3 (da) 2017-01-27 2018-01-29 Forebyggelse og behandling af skader eller sygdom i knogler og brusk

Country Status (17)

Country Link
US (2) US11517593B2 (da)
EP (2) EP3919064A1 (da)
JP (1) JP7210829B2 (da)
KR (1) KR102580320B1 (da)
CN (1) CN110234329A (da)
AU (1) AU2018211504B2 (da)
BR (1) BR112019013508A2 (da)
CA (1) CA3050099C (da)
DK (1) DK3573630T3 (da)
ES (1) ES2870776T3 (da)
IL (1) IL266772B (da)
LT (1) LT3573630T (da)
MX (1) MX388960B (da)
PL (1) PL3573630T3 (da)
PT (1) PT3573630T (da)
SG (1) SG11201904535VA (da)
WO (1) WO2018138322A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110809583A (zh) 2017-06-07 2020-02-18 瑞泽恩制药公司 用于内化酶的组合物和方法
KR20200118151A (ko) 2018-02-07 2020-10-14 리제너론 파마슈티칼스 인코포레이티드 치료 단백질 전달을 위한 방법 및 조성물
MX2020012350A (es) 2018-05-17 2021-01-29 Regeneron Pharma Anticuerpos anti-cd63, conjugados y usos de estos.
US12441984B2 (en) 2019-11-08 2025-10-14 Kansas State University Research Foundation Isolation, preservation, and expansion of canine umbilical cord mesenchymal stromal cells
CN112941021A (zh) * 2020-03-13 2021-06-11 深圳市第二人民医院(深圳市转化医学研究院) 一种骨关节炎关节液来源的间充质干细胞的培养方法
BR112022022355A2 (pt) * 2020-05-07 2022-12-13 Xintela Ab Composição, uso de uma composição, e, métodos para tratamento de uma doença, distúrbio ou trauma do sistema respiratório, para tratamento ou promoção de um transplante de um órgão ou tecido do trato respiratório, para prevenir coágulo sanguíneo, para promover estabilidade hemodinâmica, para reduzir a necessidade de suporte inotrópico, para melhorar a capacidade de oxigenação, para prevenir o dano de tecido, para reverter o dano ao tecido, para reduzir contagens de neutrófilo, para aumentar as contagens de linfócito, para diminuir citocinas pró-inflamatórias e para aumentar interferon-alfa
CN113667635A (zh) * 2020-05-14 2021-11-19 梦芊科技知识产权有限公司 无异源培养基及使用其扩增间充质干细胞的方法
CN112430269B (zh) * 2021-01-28 2021-04-20 中赛干细胞基因工程有限公司 一种促进脐带血干细胞成骨分化的组合物及其应用
US20240245726A1 (en) 2021-05-20 2024-07-25 Xintela Ab Mesenchymal Stem Cells for Use in the Treatment of Skin Defects
US20250099507A1 (en) * 2022-01-28 2025-03-27 Beijing Darwin Biotech Co., Ltd. Protein Composition for Repairing Hair Follicle and Preparation Method therefor and Use thereof
CN114540298A (zh) * 2022-03-25 2022-05-27 北京瑷格干细胞科技有限公司 一种干细胞无血清培养基及其制备方法
IL320053A (en) * 2022-10-05 2025-06-01 Brim Biotechnology Inc Preparations include PEDF-derived short peptides and mesenchymal stem cells for bone/cartilage regeneration
CN115651076B (zh) * 2022-12-09 2023-09-29 北京大学口腔医学院 人骨髓间充质干细胞来源凋亡囊泡的表面标志物及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2353061T5 (es) * 2000-04-25 2014-04-07 Osiris Therapeutics, Inc. Reparación de articulaciones utilizando células madre mesenquimatosas
DE60318706T2 (de) * 2002-06-14 2009-04-30 Cartela R & D Ab Marker für stammzellen und dessen verwendung
SE0301087D0 (sv) * 2003-04-14 2003-04-14 Cartela Ab New monoclonal antibody
WO2007099337A1 (en) * 2006-03-01 2007-09-07 Cartela R&D Ab Expansion and differentiation of mesenchymal stem cells
US20100055114A1 (en) 2006-12-15 2010-03-04 Evy Lundgren-Akerlund Use of integrin alpha 10 binding antibody to modulate extracellular matrix (cartilage) turnover
CN101835479A (zh) * 2007-07-25 2010-09-15 佰欧益有限公司 多系祖细胞分化为软骨细胞

Also Published As

Publication number Publication date
KR102580320B1 (ko) 2023-09-19
CA3050099C (en) 2024-04-16
IL266772A (en) 2019-07-31
ES2870776T3 (es) 2021-10-27
PT3573630T (pt) 2021-05-06
PL3573630T3 (pl) 2021-09-13
KR20190107686A (ko) 2019-09-20
CN110234329A (zh) 2019-09-13
IL266772B (en) 2022-04-01
JP2020505916A (ja) 2020-02-27
US20230128397A1 (en) 2023-04-27
US20200038449A1 (en) 2020-02-06
WO2018138322A1 (en) 2018-08-02
AU2018211504A1 (en) 2019-07-04
MX388960B (es) 2025-03-20
JP7210829B2 (ja) 2023-01-24
US11517593B2 (en) 2022-12-06
AU2018211504B2 (en) 2022-08-18
EP3573630A1 (en) 2019-12-04
CA3050099A1 (en) 2018-08-02
EP3573630B1 (en) 2021-03-17
SG11201904535VA (en) 2019-08-27
LT3573630T (lt) 2021-05-25
MX2019008872A (es) 2019-09-18
BR112019013508A2 (pt) 2020-01-07
EP3919064A1 (en) 2021-12-08

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