DK3563156T3 - Fremgangsmåde til separering af biomolekyler - Google Patents

Fremgangsmåde til separering af biomolekyler Download PDF

Info

Publication number: DK3563156T3
Authority: DK; Denmark
Prior art keywords: biomolecules; separation; procedure
Prior art date: 2016-12-28

Application number

DK17840481.0T

Other languages

English (en)

Inventor

Ola Lind

Johan Avallin

Andreas Lundin

Nils Norrman

Ronnie Palmgren

Gustav Rodrigo

Original Assignee

Cytiva Sweden Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-12-28

Filing date

2017-12-27

Publication date

2021-11-08

2016-12-28 Priority claimed from GBGB1622304.2A external-priority patent/GB201622304D0/en

2016-12-28 Priority claimed from GBGB1622305.9A external-priority patent/GB201622305D0/en

2016-12-28 Priority claimed from GBGB1622307.5A external-priority patent/GB201622307D0/en

2017-12-27 Application filed by Cytiva Sweden Ab filed Critical Cytiva Sweden Ab

2021-11-08 Application granted granted Critical

2021-11-08 Publication of DK3563156T3 publication Critical patent/DK3563156T3/da

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/0009—Settling tanks making use of electricity or magnetism
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/30—Combinations with other devices, not otherwise provided for
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C5/00—Separating dispersed particles from liquids by electrostatic effect
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C5/00—Separating dispersed particles from liquids by electrostatic effect
- B03C5/02—Separators
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/07—Means for pre-treatment of biological substances by electrical or electromagnetic forces
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/005—Pretreatment specially adapted for magnetic separation
- B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/305—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
- G01N2333/31—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Sustainable Development (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Cell Biology (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Pathology (AREA)
Food Science & Technology (AREA)
General Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Clinical Laboratory Science (AREA)
Electromagnetism (AREA)
Chemical Kinetics & Catalysis (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)

DK17840481.0T 2016-12-28 2017-12-27 Fremgangsmåde til separering af biomolekyler DK3563156T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB1622304.2A GB201622304D0 (en)	2016-12-28	2016-12-28	Magnetic immunoglobulin-binding particles
GBGB1622305.9A GB201622305D0 (en)	2016-12-28	2016-12-28	Magnetic immunoglobulin-binding particles
GBGB1622307.5A GB201622307D0 (en)	2016-12-28	2016-12-28	A method and system for separating biomolecules
PCT/EP2017/084620 WO2018122246A1 (en)	2016-12-28	2017-12-27	A method and system for separating biomolecules

Publications (1)

Publication Number	Publication Date
DK3563156T3 true DK3563156T3 (da)	2021-11-08

Family

ID=60943003

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK17826229.1T DK3563154T3 (da)	2016-12-28	2017-12-21	Magnetiske immunoglobulin-bindende partikler
DK17840481.0T DK3563156T3 (da)	2016-12-28	2017-12-27	Fremgangsmåde til separering af biomolekyler

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK17826229.1T DK3563154T3 (da)	2016-12-28	2017-12-21	Magnetiske immunoglobulin-bindende partikler

Country Status (8)

Country	Link
US (3)	US11846635B2 (da)
EP (2)	EP3563154B1 (da)
JP (1)	JP7072968B2 (da)
CN (2)	CN110121646B (da)
DK (2)	DK3563154T3 (da)
ES (2)	ES2886173T3 (da)
SI (1)	SI3563156T1 (da)
WO (2)	WO2018122089A1 (da)

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BR112021006773A2 (pt)	2018-10-10	2021-07-13	Stamm Vegh Corporation	microbiorreator de fluxo contínuo
CN111100780A (zh) *	2018-10-26	2020-05-05	南京金斯瑞生物科技有限公司	一种半连续流的磁珠纯化系统
CN113574383A (zh) *	2019-03-27	2021-10-29	思拓凡瑞典有限公司	分离生物分子的方法
US12433985B2 (en) *	2019-09-30	2025-10-07	Hemotune Ag	Assembly for extracorporeal treatment of body fluids
EP4038184A1 (en) *	2019-10-05	2022-08-10	Lab-on-a-Bead AB	Purification process based on magnetic beads
US11899028B2 (en) *	2019-12-31	2024-02-13	Cytiva Us Llc	Buffer management and identification in bioprocessing system
US20210260600A1 (en) *	2020-02-01	2021-08-26	Sunil Mehta	Automated device and method to purify biomaterials from a mixture by using magnetic particles and disposable product-contact materials
JP2023546534A (ja) *	2020-10-12	2023-11-02	ライフ・テクノロジーズ・アクシェセルスカプ	生体細胞と共に使用するための磁性粒子処理システム及び関連する方法
US20220169991A1 (en) *	2020-12-01	2022-06-02	Global Life Sciences Solutions Usa Llc	Viral vector purification apparatus and method
CN113721015B (zh) *	2021-09-08	2023-03-21	中国农业大学	微生物自动化检测装置、系统及方法
CN113583865A (zh) *	2021-10-08	2021-11-02	深圳市瑞沃德生命科技有限公司	分选柱的制备方法及分选柱
WO2023082021A1 (en) *	2021-11-15	2023-05-19	Mcmaster University	Magnetic microgel beads, methods of making and uses thereof
KR102671332B1 (ko) *	2021-12-10	2024-06-03	주식회사 팡세	생물반응기 및 이를 이용한 세포 배양방법
GB202206123D0 (en)	2022-04-27	2022-06-08	Cytiva Bioprocess R & D Ab	A pre-screening method and a method for separating adeno-associated virus capsids
CN115524482A (zh) *	2022-09-27	2022-12-27	深圳赛桥生物创新技术有限公司	磁珠分选方法、设备及存储介质
GB202214280D0 (en)	2022-09-29	2022-11-16	Cytiva Vioprocess R&D Ab	Chromatography ligand and chromatography material, and uses thereof
AR132708A1 (es) *	2023-05-19	2025-07-23	Stamm Vegh Corp	Dispositivo de purificación continua
WO2025031334A1 (zh) *	2023-08-07	2025-02-13	苏州艾博生物科技有限公司	分离mRNA的系统和方法
WO2025195934A1 (en) *	2024-03-18	2025-09-25	Magnify Biotechnologies Gmbh	Utilizing magnetic separation process technology to capture target compounds

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WO2015176018A1 (en)	2014-05-15	2015-11-19	Cristian Ionescu-Zanetti	Methods and systems for cell separation using magnetic-and size-based separation
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2017
- 2017-12-21 ES ES17826229T patent/ES2886173T3/es active Active
- 2017-12-21 CN CN201780081112.6A patent/CN110121646B/zh active Active
- 2017-12-21 DK DK17826229.1T patent/DK3563154T3/da active
- 2017-12-21 WO PCT/EP2017/084033 patent/WO2018122089A1/en not_active Ceased
- 2017-12-21 EP EP17826229.1A patent/EP3563154B1/en active Active
- 2017-12-21 US US16/470,677 patent/US11846635B2/en active Active
- 2017-12-27 WO PCT/EP2017/084620 patent/WO2018122246A1/en not_active Ceased
- 2017-12-27 CN CN201780081042.4A patent/CN110088626B/zh active Active
- 2017-12-27 SI SI201730950T patent/SI3563156T1/sl unknown
- 2017-12-27 US US16/470,607 patent/US11686726B2/en active Active
- 2017-12-27 EP EP17840481.0A patent/EP3563156B1/en active Active
- 2017-12-27 ES ES17840481T patent/ES2896939T3/es active Active
- 2017-12-27 DK DK17840481.0T patent/DK3563156T3/da active
- 2017-12-27 JP JP2019535894A patent/JP7072968B2/ja active Active
2023
- 2023-05-15 US US18/317,411 patent/US20230333098A1/en active Pending

Also Published As

Publication number	Publication date
ES2896939T3 (es)	2022-02-28
US11846635B2 (en)	2023-12-19
DK3563154T3 (da)	2021-09-20
US11686726B2 (en)	2023-06-27
US20200087614A1 (en)	2020-03-19
WO2018122246A1 (en)	2018-07-05
CN110121646B (zh)	2023-06-20
JP2020503865A (ja)	2020-02-06
CN110121646A (zh)	2019-08-13
SI3563156T1 (sl)	2021-12-31
ES2886173T3 (es)	2021-12-16
WO2018122089A1 (en)	2018-07-05
US20230333098A1 (en)	2023-10-19
EP3563156B1 (en)	2021-10-13
EP3563154A1 (en)	2019-11-06
CN110088626B (zh)	2023-06-20
EP3563156A1 (en)	2019-11-06
CN110088626A (zh)	2019-08-02
US20190339261A1 (en)	2019-11-07
EP3563154B1 (en)	2021-07-28
JP7072968B2 (ja)	2022-05-23

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DK3563156T3 (da)	2021-11-08	Fremgangsmåde til separering af biomolekyler
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