[go: up one dir, main page]

DK3418396T3 - Vurdering af cellulær signalvejsaktivitet under anvendelse af probabilistisk modellering af målgenekspression - Google Patents

Vurdering af cellulær signalvejsaktivitet under anvendelse af probabilistisk modellering af målgenekspression Download PDF

Info

Publication number
DK3418396T3
DK3418396T3 DK18180343.8T DK18180343T DK3418396T3 DK 3418396 T3 DK3418396 T3 DK 3418396T3 DK 18180343 T DK18180343 T DK 18180343T DK 3418396 T3 DK3418396 T3 DK 3418396T3
Authority
DK
Denmark
Prior art keywords
probabilist
modeling
assessment
cellular signal
signal route
Prior art date
Application number
DK18180343.8T
Other languages
English (en)
Inventor
Wilhelmus Franciscus Johannes Verhaegh
De Stolpe Anja Van
Ooijen Hendrik Jan Van
Kalyana Chakravarthi Dulla
De Inda Marcia Alves
Ralf Hoffmann
Original Assignee
Koninklijke Philips Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Nv filed Critical Koninklijke Philips Nv
Application granted granted Critical
Publication of DK3418396T3 publication Critical patent/DK3418396T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00—Computing arrangements using knowledge-based models
    • G06N5/04—Inference or reasoning models
    • G06N5/048—Fuzzy inferencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20—Probabilistic models
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Data Mining & Analysis (AREA)
  • Immunology (AREA)
  • Software Systems (AREA)
  • General Engineering & Computer Science (AREA)
  • Evolutionary Computation (AREA)
  • Physiology (AREA)
  • Artificial Intelligence (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Probability & Statistics with Applications (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Mathematical Physics (AREA)
DK18180343.8T 2011-07-19 2012-07-19 Vurdering af cellulær signalvejsaktivitet under anvendelse af probabilistisk modellering af målgenekspression DK3418396T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161509137P 2011-07-19 2011-07-19
EP11178148A EP2549399A1 (en) 2011-07-19 2011-08-19 Assessment of Wnt pathway activity using probabilistic modeling of target gene expression
EP16192584.7A EP3173489B1 (en) 2011-07-19 2012-07-19 Assessment of cellular signaling pathway activity using probabilistic modeling of target gene expression

Publications (1)

Publication Number Publication Date
DK3418396T3 true DK3418396T3 (da) 2021-05-25

Family

ID=44582424

Family Applications (3)

Application Number Title Priority Date Filing Date
DK18180343.8T DK3418396T3 (da) 2011-07-19 2012-07-19 Vurdering af cellulær signalvejsaktivitet under anvendelse af probabilistisk modellering af målgenekspression
DK16192584.7T DK3173489T3 (da) 2011-07-19 2012-07-19 Vurdering af aktiviteten af en cellulær signalvej under anvendelse af probalistisk modellering af målgenekspression
DK12751371.1T DK2734643T3 (da) 2011-07-19 2012-07-19 Vurdering af cellesignaleringsvejaktivitet under anvendelse af probabilistisk modellering af målgenekspression

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK16192584.7T DK3173489T3 (da) 2011-07-19 2012-07-19 Vurdering af aktiviteten af en cellulær signalvej under anvendelse af probalistisk modellering af målgenekspression
DK12751371.1T DK2734643T3 (da) 2011-07-19 2012-07-19 Vurdering af cellesignaleringsvejaktivitet under anvendelse af probabilistisk modellering af målgenekspression

Country Status (12)

Country Link
US (2) US11443831B2 (da)
EP (6) EP2549399A1 (da)
JP (3) JP6204354B2 (da)
KR (1) KR102064004B1 (da)
CN (2) CN109852671A (da)
BR (1) BR112014000965B8 (da)
DK (3) DK3418396T3 (da)
ES (3) ES2874452T3 (da)
IN (1) IN2014CN00675A (da)
MX (1) MX352827B (da)
RU (1) RU2719194C2 (da)
WO (1) WO2013011479A2 (da)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
EP2549399A1 (en) 2011-07-19 2013-01-23 Koninklijke Philips Electronics N.V. Assessment of Wnt pathway activity using probabilistic modeling of target gene expression
RU2017120287A (ru) 2012-02-28 2018-11-15 АйАрЭм ЭлЭлСи ОТБОР БОЛЬНЫХ РАКОМ ДЛЯ ВВЕДЕНИЯ ИНГИБИТОРОВ СИГНАЛЬНОГО ПУТИ Wnt НА ОСНОВАНИИ СТАТУСА МУТАЦИИ RNF43
JP6433896B2 (ja) 2012-08-13 2018-12-05 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 組織再生のためのエキソソームおよびマイクロリボ核酸
CN111961726A (zh) * 2012-12-26 2020-11-20 皇家飞利浦有限公司 使用靶基因表达的线性组合评价细胞信号传导途径活性
TWI582239B (zh) * 2013-03-11 2017-05-11 諾華公司 與ｗｎｔ抑制劑相關之標記
MX366204B (es) 2013-04-26 2019-07-02 Koninklijke Philips Nv Pronostico medico y prediccion de la respuesta al tratamiento utilizando multiples actividades de la trayectoria de señalizacion celular.
EP3014505A4 (en) 2013-06-28 2017-03-08 Nantomics, LLC Pathway analysis for identification of diagnostic tests
EP3052933B1 (en) * 2013-10-02 2019-09-04 Suri Technologies Ltd. Patient-specific immunotherapy for treating heterogeneous tumors
EP3013986B1 (en) 2014-01-03 2016-11-16 Koninklijke Philips N.V. Assessment of the pi3k cellular signaling pathway activity using mathematical modelling of target gene expression
US9838847B2 (en) 2014-09-11 2017-12-05 Google LLP Data driven evaluation and rejection of trained Gaussian process-based wireless mean and standard deviation models
US9810762B2 (en) * 2014-09-11 2017-11-07 Google Inc. Calculating mean wireless signal strengths using a gaussian process approach incorporating predictive standard deviations
US9880257B2 (en) * 2014-09-11 2018-01-30 Google Llc Gaussian process-based approach for identifying correlation between wireless signals
US10557175B2 (en) 2014-09-19 2020-02-11 The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin Method of predicting risk of recurrence of cancer
JP6878274B2 (ja) 2014-10-03 2021-05-26 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 筋ジストロフィーの処置における心筋球由来細胞およびこのような細胞によって分泌されたエキソソーム
EP3210144B1 (en) * 2014-10-24 2020-10-21 Koninklijke Philips N.V. Medical prognosis and prediction of treatment response using multiple cellular signaling pathway activities
JP7065609B6 (ja) * 2014-10-24 2022-06-06 コーニンクレッカ フィリップス エヌ ヴェ 複数の細胞シグナル伝達経路活性を用いる治療応答の医学的予後及び予測
BR112017007965A8 (pt) * 2014-10-24 2022-11-08 Koninklijke Philips Nv Método implantado por computador para inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; aparelho para inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; meio de armazenamento não transitório; programa de computador; kits para medir níveis de expressão de três ou mais genes-alvo da via de sinalização celular de tgf-b em uma amostra de um indivíduo; inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; inferir a atividade de uma via de sinalização celular de tgf-b em um indivíduo; e uso do kit
CN105760707B (zh) * 2014-12-18 2018-07-31 中国科学院大连化学物理研究所 细胞基因翻译过程建模方法
CA2995520A1 (en) 2015-08-14 2017-02-23 Hendrik Jan VAN OOIJEN Assessment of nfkb cellular signaling pathway activity using mathematical modelling of target gene expression
WO2017033154A1 (en) * 2015-08-27 2017-03-02 Koninklijke Philips N.V. An integrated method and system for identifying functional patient-specific somatic aberations using multi-omic cancer profiles
CN106897578B (zh) * 2015-12-15 2020-02-14 中国科学院大连化学物理研究所 一种细胞基因翻译过程建模方法
WO2017123662A1 (en) 2016-01-11 2017-07-20 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
US20170329914A1 (en) * 2016-05-11 2017-11-16 International Business Machines Corporation Predicting Personalized Cancer Metastasis Routes, Biological Mediators of Metastasis and Metastasis Blocking Therapies
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
US10621236B2 (en) * 2016-09-16 2020-04-14 At&T Intellectual Property I, L.P. Concept based querying of graph databases
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS
EP3538673A4 (en) * 2016-11-11 2019-12-04 University of Pittsburgh- Of the Commonwealth System of Higher Education IDENTIFICATION OF INSTRUMENTAL SOMATIC GENOMIC CHANGES WITH FUNCTIONAL EFFECT
JP7186700B2 (ja) 2016-11-25 2022-12-09 コーニンクレッカ フィリップス エヌ ヴェ 腫瘍抑制ｆｏｘｏ活性を酸化ストレスから区別する方法
CN108300783A (zh) * 2017-01-11 2018-07-20 上海易毕恩基因科技有限公司 用于筛选肠癌和/或胃癌的基因标志物的方法、用该方法筛选的基因标志物及其用途
CN106755464A (zh) * 2017-01-11 2017-05-31 上海易毕恩基因科技有限公司 用于筛选肠癌和/或胃癌的基因标志物的方法、用该方法筛选的基因标志物及其用途
CA3059910A1 (en) 2017-04-19 2018-10-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
CN107184991B (zh) * 2017-05-03 2020-05-26 武汉爱博泰克生物科技有限公司 PRDM15基因序列在制备NF-κB抑制剂中的应用
CN107164508A (zh) * 2017-06-16 2017-09-15 上海易毕恩基因科技有限公司 用于检测肝癌的基因标志物及其用途
EP3431582A1 (en) 2017-07-18 2019-01-23 Koninklijke Philips N.V. Cell culturing materials
CN107201411A (zh) * 2017-07-27 2017-09-26 上海市长宁区妇幼保健院 Mylk基因作为诊断子宫内膜癌的标志物
CN107385051A (zh) * 2017-08-04 2017-11-24 上海易毕恩生物技术有限公司 用于检测肝肿瘤良恶性的基因标志物、试剂盒及检测方法
EP3462348A1 (en) * 2017-09-28 2019-04-03 Koninklijke Philips N.V. Bayesian inference
EP3461915A1 (en) * 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat1/2 cellular signaling pathway activity using mathematical modelling of target gene expression
EP3461916A1 (en) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat3 cellular signaling pathway activity using mathematical modelling of target gene expression
EP3692170A1 (en) 2017-10-02 2020-08-12 Koninklijke Philips N.V. Determining functional status of immune cells types and immune response
EP3462349A1 (en) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of notch cellular signaling pathway activity using mathematical modelling of target gene expression
EP3727351A4 (en) 2017-12-20 2021-10-06 Cedars-Sinai Medical Center MANIPULATED EXTRACELLULAR VESICLES FOR ENHANCED RELEASE INTO TISSUE
EP3502279A1 (en) 2017-12-20 2019-06-26 Koninklijke Philips N.V. Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression
WO2019152549A1 (en) 2018-02-05 2019-08-08 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and y-rnas
US11475995B2 (en) * 2018-05-07 2022-10-18 Perthera, Inc. Integration of multi-omic data into a single scoring model for input into a treatment recommendation ranking
CN108875009B (zh) * 2018-06-16 2021-10-22 上海豹云网络信息服务有限公司 一种用于对数据文件进行动态处理的方法及系统
US11354591B2 (en) 2018-10-11 2022-06-07 International Business Machines Corporation Identifying gene signatures and corresponding biological pathways based on an automatically curated genomic database
US20220068491A1 (en) * 2018-12-21 2022-03-03 Phil Rivers Technology, Ltd. Method for predicting a risk of suffering from a disease, electronic device and storage medium
US20220076785A1 (en) * 2018-12-21 2022-03-10 Phil Rivers Technology, Ltd. Method for acquiring intracellular deterministic event, electronic device and storage medium
EP3812474A1 (en) 2019-10-22 2021-04-28 Koninklijke Philips N.V. Methods of prognosis in high-grade serous ovarian cancer
JP7386897B2 (ja) 2019-05-03 2023-11-27 コーニンクレッカ フィリップス エヌ ヴェ 高悪性度漿液性卵巣癌における予後予測の方法
CA3139514A1 (en) * 2019-05-08 2020-11-12 Cedars-Sinai Medical Center Therapeutically active cells and exosomes
EP3739588A1 (en) 2019-05-13 2020-11-18 Koninklijke Philips N.V. Assessment of multiple signaling pathway activity score in airway epithelial cells to predict airway epithelial abnormality and airway cancer risk
WO2021034712A1 (en) 2019-08-16 2021-02-25 Tempus Labs, Inc. Systems and methods for detecting cellular pathway dysregulation in cancer specimens
EP3822368A1 (en) 2019-11-14 2021-05-19 Koninklijke Philips N.V. Assessment of pr cellular signaling pathway activity using mathematical modelling of target gene expression
JP7636414B2 (ja) * 2019-12-12 2025-02-26 テンプス エーアイ，インコーポレイティド 米国乳癌患者における診断検査および処置パターンのリアルワールドエビデンス
EP3835433A1 (en) 2019-12-12 2021-06-16 Koninklijke Philips N.V. Notch signaling pathway activity as prognostic marker in bladder cancer
CN111139300B (zh) * 2020-02-19 2021-08-17 伯克利南京医学研究有限责任公司 一组结肠癌预后相关基因的应用
EP3882363A1 (en) 2020-03-17 2021-09-22 Koninklijke Philips N.V. Prognostic pathways for high risk sepsis patients
WO2021209567A1 (en) 2020-04-16 2021-10-21 Koninklijke Philips N.V. Prognostic pathways for viral infections
EP3978628A1 (en) 2020-10-01 2022-04-06 Koninklijke Philips N.V. Prognostic pathways for viral infections
CN111739586B (zh) * 2020-06-17 2024-04-05 浙江大学 以87个基因作为生物标志物预测细胞增殖活性的模型
EP3940704A1 (en) 2020-07-14 2022-01-19 Koninklijke Philips N.V. Method for determining the differentiation state of a stem cell
EP3960875A1 (en) * 2020-08-28 2022-03-02 Koninklijke Philips N.V. Pcr method and kit for determining pathway activity
EP3965119A1 (en) 2020-09-04 2022-03-09 Koninklijke Philips N.V. Methods for estimating heterogeneity of a tumour based on values for two or more genome mutation and/or gene expression related parameter, as well as corresponding devices
EP3974540A1 (en) 2020-09-25 2022-03-30 Koninklijke Philips N.V. Method for predicting immunotherapy resistance
EP4015651A1 (en) 2020-12-17 2022-06-22 Koninklijke Philips N.V. Treatment prediction and effectiveness of anti-tnf alpha treatment in ibd patients
EP4039825A1 (en) 2021-02-09 2022-08-10 Koninklijke Philips N.V. Comparison and standardization of cell and tissue culture
JP2024514404A (ja) 2021-03-11 2024-04-02 コーニンクレッカ フィリップス エヌ ヴェ 高リスク敗血症患者のための予後経路
CN113278700B (zh) * 2021-06-04 2022-08-09 浙江省肿瘤医院 一种用于乳腺癌分型及预后预测的引物组及试剂盒
EP4434034A1 (en) * 2021-11-15 2024-09-25 InnoSIGN B.V. Assessment of gr cellular signaling pathway activity using mathematical modelling of target gene expression
CN113963745A (zh) * 2021-12-07 2022-01-21 国际竹藤中心 一种构建植物发育分子调控网络的方法及其应用
WO2024033063A1 (en) 2022-08-12 2024-02-15 Innosign B.V. Prediction and monitoring of immunotherapy in cancer
CN116083590B (zh) * 2023-03-23 2024-03-22 雄安妙心医学检验有限公司 一种基因检测试剂盒及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566130B1 (en) * 2000-01-28 2003-05-20 Henry M. Jackson Foundation For The Advancement Of Military Medicine Androgen-regulated gene expressed in prostate tissue
US7371736B2 (en) * 2001-11-07 2008-05-13 The Board Of Trustees Of The University Of Arkansas Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss
EP1380644A1 (en) 2002-07-08 2004-01-14 Kylix B.V. The use of specified TCF target genes to identify drugs for the treatment of cancer, in particular colorectal cancer, in which TCF/beta-catenin/WNT signalling plays a central role
WO2004022575A2 (en) 2002-09-05 2004-03-18 Toolgen, Inc. Bioinformatics analysis of cellular effects of artificial transcription factors
CN101194260A (zh) * 2005-01-24 2008-06-04 利兰·斯坦福青年大学托管委员会 使用贝叶斯网络建立细胞信号传导系统模型的方法
US20090186024A1 (en) 2005-05-13 2009-07-23 Nevins Joseph R Gene Expression Signatures for Oncogenic Pathway Deregulation
US20070112630A1 (en) 2005-11-07 2007-05-17 Scanscout, Inc. Techniques for rendering advertisments with rich media
EP2027549A2 (en) 2006-05-17 2009-02-25 The Trustees Of Boston University Method to determine transcriptional regulation pathways in organisms
WO2008086182A2 (en) * 2007-01-04 2008-07-17 University Of Rochester Use of gene signatures to design novel cancer treatment regimens
JP2010178650A (ja) 2009-02-04 2010-08-19 Univ Of Tokyo 固形癌の再発予測のための試験方法および再発予防剤
US20120252689A1 (en) 2011-04-01 2012-10-04 Zhong Wu Gene expression signature for wnt/b-catenin signaling pathway and use thereof
US20140155280A1 (en) 2011-05-05 2014-06-05 Commonwealth Scientific And Industrial Research Organisation Method of diagnosing neoplasms
EP2549399A1 (en) 2011-07-19 2013-01-23 Koninklijke Philips Electronics N.V. Assessment of Wnt pathway activity using probabilistic modeling of target gene expression

Also Published As

Publication number Publication date
MX2014000557A (es) 2014-05-01
JP2017205129A (ja) 2017-11-24
EP3173489B1 (en) 2018-09-19
US20230105263A1 (en) 2023-04-06
JP2014520566A (ja) 2014-08-25
DK3173489T3 (da) 2018-12-10
EP2734643A2 (en) 2014-05-28
IN2014CN00675A (da) 2015-04-03
BR112014000965B1 (pt) 2021-08-24
DK2734643T3 (da) 2017-03-20
CN103649337B (zh) 2018-11-13
US11443831B2 (en) 2022-09-13
JP6807430B2 (ja) 2021-01-06
WO2013011479A2 (en) 2013-01-24
EP4130291A1 (en) 2023-02-08
EP4130291C0 (en) 2024-01-10
ES2874452T3 (es) 2021-11-05
ES2700617T3 (es) 2019-02-18
BR112014000965A2 (pt) 2017-06-13
MX352827B (es) 2017-12-11
RU2014106026A (ru) 2015-08-27
EP3831957B1 (en) 2022-09-07
CN103649337A (zh) 2014-03-19
EP3831957A1 (en) 2021-06-09
JP6783729B2 (ja) 2020-11-11
JP2019129850A (ja) 2019-08-08
KR102064004B1 (ko) 2020-01-08
WO2013011479A3 (en) 2013-03-14
EP3418396B1 (en) 2021-03-24
EP3173489A1 (en) 2017-05-31
US20140156200A1 (en) 2014-06-05
KR20140046464A (ko) 2014-04-18
CN109852671A (zh) 2019-06-07
EP3418396A1 (en) 2018-12-26
EP2549399A1 (en) 2013-01-23
RU2719194C2 (ru) 2020-04-17
JP6204354B2 (ja) 2017-09-27
EP4130291B1 (en) 2024-01-10
EP2734643B1 (en) 2016-12-07
ES2617195T3 (es) 2017-06-15
BR112014000965B8 (pt) 2022-11-08

Similar Documents

Publication Publication Date Title
DK3418396T3 (da) Vurdering af cellulær signalvejsaktivitet under anvendelse af probabilistisk modellering af målgenekspression
DK2938745T3 (da) Vurdering af cellulær signalvejsaktivitet under anvendelse af lineær(e) kombination(er) af målgenekspressioner
EP2670894A4 (en) SOLID PARALLEL NEIGHBORHOOD IMAGING
DK3689853T3 (da) Fremgangsmåde til syntese af thyreoideahormonanaloger og polymorfer deraf
CO6920291A2 (es) 3-pirmidin-4-il-oxazolidin-2-onas como inhibidores de la idhmutante
CO6821892A2 (es) Anticuerpos anti-angptl3 y usos de los mismos
PL3415531T3 (pl) Białka wiążące antygen
EP2663266C0 (en) ENDOPROSTHESIS
CO6841996A2 (es) Inhibidores de la actividad de las celulas t
EP2683693A4 (en) ROR-GAMMA-T INHIBITORS
DK2771364T3 (da) Fremstilling af heterodimere proteiner
DK3785779T3 (da) Legetøjskonstruktionssystem
CO7010824A2 (es) Inhibidores de aplicación viral
DK3156056T3 (da) Farmaceutiske sammensætninger der består af sorbitanestere
BR112014003878A2 (pt) síntese de r-bifenilalaninol
CO6940376A2 (es) Anticuerpos anti-psgl-1 y usos de los mismos
SMT201600150B (it) Antagonisti di trpv4
EP2935546A4 (en) BIORAFFINATION OF RAW TALL OIL
EP2687879A4 (en) DISCRIMINATION MEDIUM
DE112012002196A5 (de) Eigenfortbewegungsfähige Plattform
EP2747807A4 (en) ARTIFICIAL PLAZENTA
EP2819714A4 (en) TISSUE MEMBRANE COATED WITH COLLAGEN
EP2691361A4 (en) SYNTHESIS OF DIAZIDEN
BR112013025721A2 (pt) métodos de fabricação de elementos absorventes volumosos
HRP20190030T1 (hr) Postupak pročišćavanja protutijela