DK3408407T3 - Fremgangsmåder til påvisning af cpg-methylering af tumorafledt dna i blodprøver - Google Patents
Fremgangsmåder til påvisning af cpg-methylering af tumorafledt dna i blodprøver Download PDFInfo
- Publication number
- DK3408407T3 DK3408407T3 DK17702586.3T DK17702586T DK3408407T3 DK 3408407 T3 DK3408407 T3 DK 3408407T3 DK 17702586 T DK17702586 T DK 17702586T DK 3408407 T3 DK3408407 T3 DK 3408407T3
- Authority
- DK
- Denmark
- Prior art keywords
- derivated
- tumor
- dna
- methods
- blood samples
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16153452 | 2016-01-29 | ||
| PCT/EP2017/051710 WO2017129716A1 (en) | 2016-01-29 | 2017-01-27 | Methods for detecting cpg methylation of tumor-derived dna in blood samples |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3408407T3 true DK3408407T3 (da) | 2021-02-08 |
Family
ID=55272352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17702586.3T DK3408407T3 (da) | 2016-01-29 | 2017-01-27 | Fremgangsmåder til påvisning af cpg-methylering af tumorafledt dna i blodprøver |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20190032148A1 (da) |
| EP (2) | EP3828281B1 (da) |
| JP (2) | JP7261587B2 (da) |
| CN (1) | CN109312404A (da) |
| DK (1) | DK3408407T3 (da) |
| ES (1) | ES2849559T3 (da) |
| HR (1) | HRP20210198T1 (da) |
| HU (1) | HUE054225T2 (da) |
| LT (1) | LT3408407T (da) |
| SI (1) | SI3408407T1 (da) |
| WO (1) | WO2017129716A1 (da) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| CN107532124B (zh) | 2015-03-27 | 2022-08-09 | 精密科学公司 | 检测食管疾病 |
| EP3998353A1 (en) | 2015-10-30 | 2022-05-18 | Exact Sciences Corporation | Multiplex amplification detection assay and isolation and detection of dna from plasma |
| CA3022911A1 (en) | 2016-05-05 | 2017-11-09 | Exact Sciences Development Company, Llc | Detection of lung neoplasia by analysis of methylated dna |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| KR102667067B1 (ko) * | 2017-01-27 | 2024-05-17 | 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 | 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| CA3093971A1 (en) | 2018-03-15 | 2019-09-19 | Grail, Inc. | Tissue-specific methylation marker |
| EP3821039A4 (en) * | 2018-07-09 | 2022-07-13 | Hkg Epitherapeutics Limited | DNA METHYLATION MARKERS FOR NONINVASIVE CANCER DETECTION AND USES THEREOF |
| CN111560431B (zh) * | 2019-02-14 | 2022-11-18 | 博尔诚（北京）科技有限公司 | 一种健康表观基因组学的组合物及其用途 |
| IL265451B (en) | 2019-03-18 | 2020-01-30 | Frumkin Dan | Methods and systems for the detection of methylation changes in DNA samples |
| AU2020406068A1 (en) * | 2019-12-16 | 2022-07-14 | New Day Diagnostics Llc | Methods for detecting colorectal cancer |
| WO2021192397A1 (ja) * | 2020-03-25 | 2021-09-30 | 富士フイルム株式会社 | がん検査方法 |
| CN111540469A (zh) * | 2020-05-29 | 2020-08-14 | 杭州广科安德生物科技有限公司 | 构建体外检测胃癌的数学模型的方法及其应用 |
| CN112375822B (zh) * | 2020-06-01 | 2021-11-02 | 广州市基准医疗有限责任公司 | 用于检测乳腺癌的甲基化生物标记物及其应用 |
| CN114507731B (zh) * | 2020-11-16 | 2024-06-04 | 腾辰生物科技(上海)有限公司 | 一种用于辅助癌症诊断的甲基化标志物及试剂盒 |
| WO2022155118A1 (en) * | 2021-01-12 | 2022-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Layered analysis of methylated biomarkers for use in cancer diagnosis and prognosis |
| WO2023017001A1 (en) | 2021-08-09 | 2023-02-16 | Epigenomics Ag | Improved methods for detecting colorectal cancer |
| WO2024074558A1 (en) | 2022-10-04 | 2024-04-11 | Epigenomics Ag | Improved methods for detecting cancer |
| EP4628597A1 (en) * | 2022-11-29 | 2025-10-08 | GC Genome Corporation | Dna methylation markers for diagnosing esophageal cancer and stomach cancer and use thereof |
| WO2024264010A1 (en) * | 2023-06-21 | 2024-12-26 | Patel Abhijit Ajit | Methods of enriching and analyzing methylated dna |
| CN117248019A (zh) * | 2023-09-28 | 2023-12-19 | 江苏运动健康研究院 | 一种用于食管癌早期筛查的试剂盒及使用方法 |
| KR20250081367A (ko) * | 2023-11-29 | 2025-06-05 | 주식회사 지씨지놈 | 식도암 및 위암 방사선 치료 반응성 예측용 dna 메틸화 마커 및 이의 용도 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2877000A (en) * | 1999-02-10 | 2000-08-29 | University Of Maryland | Photo-induced nucleic acid hybridization |
| MXPA03001834A (es) * | 2000-09-01 | 2003-08-01 | Epigenomics Ag | Metodo para determinar el grado de metilacion de determinadas citocinas en adn genomico en el contexto de secuencia 5'-cpg-3'. |
| EP1394172A1 (en) | 2002-08-29 | 2004-03-03 | Boehringer Mannheim Gmbh | Improved method for bisulfite treatment |
| GB201000688D0 (en) * | 2010-01-15 | 2010-03-03 | Diagenic Asa | Product and method |
| WO2013177265A1 (en) * | 2012-05-22 | 2013-11-28 | The Johns Hopkins University | A QUANTITATIVE MULTIPLEX METHYLATION SPECIFIC PCR METHOD- cMethDNA, REAGENTS, AND ITS USE |
| WO2014036314A2 (en) * | 2012-08-31 | 2014-03-06 | Ignyta, Inc. | Diagnosis of rheumatoid arthritis (ra) using differentially methylated loci identified in peripheral blood mononuclear cells, t-cells, b-cells and monocytes |
| IL280521B (en) * | 2014-06-04 | 2022-07-01 | Quest Diagnostics Invest Inc | Suspended markers for colon and rectal cancer |
-
2017
- 2017-01-27 HR HRP20210198TT patent/HRP20210198T1/hr unknown
- 2017-01-27 US US16/072,792 patent/US20190032148A1/en not_active Abandoned
- 2017-01-27 SI SI201730624T patent/SI3408407T1/sl unknown
- 2017-01-27 EP EP20214665.0A patent/EP3828281B1/en active Active
- 2017-01-27 HU HUE17702586A patent/HUE054225T2/hu unknown
- 2017-01-27 DK DK17702586.3T patent/DK3408407T3/da active
- 2017-01-27 JP JP2018558487A patent/JP7261587B2/ja active Active
- 2017-01-27 EP EP17702586.3A patent/EP3408407B1/en active Active
- 2017-01-27 CN CN201780009085.1A patent/CN109312404A/zh active Pending
- 2017-01-27 LT LTEP17702586.3T patent/LT3408407T/lt unknown
- 2017-01-27 WO PCT/EP2017/051710 patent/WO2017129716A1/en not_active Ceased
- 2017-01-27 ES ES17702586T patent/ES2849559T3/es active Active
-
2022
- 2022-12-28 JP JP2022211507A patent/JP2023052157A/ja active Pending
-
2024
- 2024-11-20 US US18/953,989 patent/US20250333796A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN109312404A (zh) | 2019-02-05 |
| EP3408407A1 (en) | 2018-12-05 |
| ES2849559T3 (es) | 2021-08-19 |
| WO2017129716A1 (en) | 2017-08-03 |
| US20250333796A1 (en) | 2025-10-30 |
| JP7261587B2 (ja) | 2023-04-20 |
| EP3408407B1 (en) | 2021-01-06 |
| JP2023052157A (ja) | 2023-04-11 |
| HRP20210198T1 (hr) | 2021-04-16 |
| SI3408407T1 (sl) | 2021-04-30 |
| EP3828281B1 (en) | 2024-11-27 |
| EP3828281A1 (en) | 2021-06-02 |
| LT3408407T (lt) | 2021-03-10 |
| JP2019504642A (ja) | 2019-02-21 |
| US20190032148A1 (en) | 2019-01-31 |
| HUE054225T2 (hu) | 2021-08-30 |
| EP3828281C0 (en) | 2024-11-27 |
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