DK330880A - Fremgangsmaade til fremstilling af clavulansyrederivater - Google Patents
Fremgangsmaade til fremstilling af clavulansyrederivaterInfo
- Publication number
- DK330880A DK330880A DK330880A DK330880A DK330880A DK 330880 A DK330880 A DK 330880A DK 330880 A DK330880 A DK 330880A DK 330880 A DK330880 A DK 330880A DK 330880 A DK330880 A DK 330880A
- Authority
- DK
- Denmark
- Prior art keywords
- group
- alkyl
- optionally substituted
- preparation
- procedure
- Prior art date
Links
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical class OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000003781 beta lactamase inhibitor Substances 0.000 abstract 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7927236 | 1979-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK330880A true DK330880A (da) | 1981-02-04 |
Family
ID=10506994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK330880A DK330880A (da) | 1979-08-03 | 1980-07-31 | Fremgangsmaade til fremstilling af clavulansyrederivater |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4652560A (da) |
| EP (1) | EP0025271B1 (da) |
| JP (1) | JPS5649386A (da) |
| AT (1) | ATE6652T1 (da) |
| AU (1) | AU535481B2 (da) |
| CA (1) | CA1170658A (da) |
| DE (1) | DE3066974D1 (da) |
| DK (1) | DK330880A (da) |
| ES (3) | ES8105324A1 (da) |
| IE (1) | IE50040B1 (da) |
| MY (1) | MY8500998A (da) |
| NZ (1) | NZ194535A (da) |
| ZA (1) | ZA804670B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK330880A (da) * | 1979-08-03 | 1981-02-04 | Beecham Group Ltd | Fremgangsmaade til fremstilling af clavulansyrederivater |
| JPS58109455A (ja) * | 1981-11-20 | 1983-06-29 | Kureha Chem Ind Co Ltd | Ｎ−ベンジルアミノ酸誘導体及びその製造法 |
| EP0101199A1 (en) * | 1982-07-22 | 1984-02-22 | Beecham Group Plc | Beta-lactam compounds |
| GB8521516D0 (en) * | 1985-08-29 | 1985-10-02 | Beecham Group Plc | Compounds |
| GB0001833D0 (en) * | 2000-01-26 | 2000-03-22 | Isis Innovation | Clavams |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR205682A1 (es) * | 1970-06-11 | 1976-05-31 | Philips Nv | Metodo de produccion de ester (2-dimetilaminoetil) de acido (4-cloro-alfa - metilbenciliden) amino-oxiacetico y sus sales de adicion de acido formadas con acidos farmacologicamente aceptables |
| US4399142A (en) * | 1973-05-03 | 1983-08-16 | Smith Kline & French Laboratories Limited | Pharmacologically active compounds |
| IE41109B1 (en) * | 1974-04-20 | 1979-10-24 | Beecham Group Ltd | Novel -lactam antibiotic from streptomyces clavuligerus |
| AU503489B2 (en) * | 1975-10-13 | 1979-09-06 | Beecham Group Limited | Substituted aminodeoxy clavulanic acid |
| GB1561290A (en) * | 1975-10-16 | 1980-02-20 | Nyegaard & Co As | Pyrimid - 2 - ones |
| GB1515241A (en) * | 1976-01-27 | 1978-06-21 | Beecham Group Ltd | Beta-lactam antibiotics |
| PT66071B (en) * | 1976-01-31 | 1978-06-23 | Beecham Group Ltd | Clavulanic acid thioethers |
| BE858858A (fr) * | 1976-10-16 | 1978-03-20 | Fisons Ltd | Composition de cromoglycate disodique |
| DK471577A (da) * | 1976-10-25 | 1978-04-26 | Glaxo Lab Ltd | Fremgangsmaade til fremstilling af clavamderivater |
| GB1604822A (en) * | 1977-04-22 | 1981-12-16 | Beecham Group Ltd | N-monosubstituted-9-amino-9-deoxyclavulanic acid derivative |
| GB1599907A (en) * | 1977-04-26 | 1981-10-07 | Glaxo Lab Ltd | Isoindolines |
| EP0007152A1 (en) * | 1978-04-28 | 1980-01-23 | Beecham Group Plc | Beta-lactam antibiotics, preparation and use |
| US4446146A (en) * | 1978-07-26 | 1984-05-01 | Beecham Group Limited | β-Lactam containing compounds, their preparation and use |
| DE2963580D1 (en) * | 1978-08-02 | 1982-10-21 | Beecham Group Plc | Beta-lactam antibacterial agents, a process for their preparation and pharmaceutical compositions containing them |
| DE2966349D1 (en) * | 1978-09-09 | 1983-12-01 | Beecham Group Plc | Derivatives of clavulanic acid, a process for their preparation and their use |
| DE2966065D1 (en) * | 1978-09-09 | 1983-09-22 | Beecham Group Plc | Derivatives of clavulanic acid, a process for their preparation and their compositions |
| US4405596A (en) * | 1978-10-16 | 1983-09-20 | Helbig Joachim W | Pharmaceutical preparations for and treatment procedures involving increasing plasma bicarbonate level |
| DE2849646A1 (de) * | 1978-11-16 | 1980-06-04 | Hoechst Ag | Thienylbenzoesaeurederivate und verfahren zu ihrer herstellung |
| CA1152517A (en) * | 1979-06-29 | 1983-08-23 | Ian H. Coates | Heterocyclic compounds, processes for their preparation and their use |
| FI75578C (fi) * | 1979-07-25 | 1988-07-11 | Ciba Geigy Ag | Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider. |
| DK330880A (da) * | 1979-08-03 | 1981-02-04 | Beecham Group Ltd | Fremgangsmaade til fremstilling af clavulansyrederivater |
| DK344180A (da) * | 1979-08-09 | 1981-02-10 | Glaxo Group Ltd | R fremgangsmaade til fremstilling af heterocycliske forbindelse |
| US4402949A (en) * | 1979-11-12 | 1983-09-06 | Sandoz Ltd. | Stable solutions of hydrogenated ergotalkaloids |
| US4315935A (en) * | 1980-04-14 | 1982-02-16 | Smithkline Corporation | N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use |
| US4317826A (en) * | 1980-05-27 | 1982-03-02 | Smithkline Corporation | N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimides and antiallergic compositions and method of use |
| IT1150955B (it) * | 1980-06-06 | 1986-12-17 | Lepetit Spa | Derivati 3h-naft(1.2-d)-imidazolici il procedimento per la loro preparazione, il loro uso come agenti antiinfiammatori e le composizioni farmaceutiche che li contengono |
| EP0043197A1 (en) * | 1980-07-02 | 1982-01-06 | Beecham Group Plc | Beta-Lactam antibiotic, its preparation and use |
| US4321254A (en) * | 1980-09-26 | 1982-03-23 | Smithkline Corporation | Antiallergic imidodisulfamides |
| US4385047A (en) * | 1981-01-05 | 1983-05-24 | Smithkline Beckman Corporation | Antiallergic imidodisulfamides |
| US4350685A (en) * | 1981-02-06 | 1982-09-21 | Smithkline Corporation | Antiallergic imidodisulfamides |
| US4341786A (en) * | 1981-03-02 | 1982-07-27 | Smithkline Corporation | Pharmaceutical compositions and method of producing central alpha1 agonist activity utilizing octahydrobenzo[f]quinoline compounds |
| FR2502153A1 (fr) * | 1981-03-19 | 1982-09-24 | Rech Pharmaceutiq Medicale | Acides (2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio) acetiques, leurs sels et leurs esters, leur procede de preparation et les compositions pharmaceutiques en contenant |
| US4401665A (en) * | 1981-04-14 | 1983-08-30 | Bristol-Myers Company | Sleep-aid composition containing an analgesic and diphenhydramine dihydrogencitrate, and method of use |
| US4402976A (en) * | 1981-04-24 | 1983-09-06 | E. R. Squibb & Sons, Inc. | Method for treating glaucoma with systemic nadolol compositions |
| US4402974A (en) * | 1981-06-23 | 1983-09-06 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
| US4352809A (en) * | 1981-09-04 | 1982-10-05 | Smithkline Corporation | Method of producing alpha2 antagonism |
| US4396619A (en) * | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin betaines |
| US4406898A (en) * | 1981-09-08 | 1983-09-27 | Eli Lilly And Company | Oxazole and oxadiazole cephalosporins |
| US4396620A (en) * | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin quinolinium betaines |
| US4382932A (en) * | 1981-09-08 | 1983-05-10 | Eli Lilly And Company | Isoquinolinium substituted cephalosporins |
| US4401668A (en) * | 1981-10-02 | 1983-08-30 | Eli Lilly And Company | Pyrazinium substituted cephalosporins |
| US4379787A (en) * | 1981-10-02 | 1983-04-12 | Eli Lilly And Company | Oximino-substituted cephalosporin compounds |
| US4402955A (en) * | 1981-10-02 | 1983-09-06 | Eli Lilly And Company | Dioximino cephalosporin antibiotics |
| US4388316A (en) * | 1981-10-02 | 1983-06-14 | Eli Lilly And Company | Amino-substituted oxazole, oxadiazole and isoxazole-substituted cephalosporins |
| US4406899A (en) * | 1982-03-04 | 1983-09-27 | Bristol-Myers Company | Cephalosporins |
| US4397845A (en) * | 1982-05-19 | 1983-08-09 | The Upjohn Company | Lincomycin 3-(5'-adenylate) as anesthetic |
| EP0101199A1 (en) * | 1982-07-22 | 1984-02-22 | Beecham Group Plc | Beta-lactam compounds |
-
1980
- 1980-07-31 DK DK330880A patent/DK330880A/da unknown
- 1980-07-31 ZA ZA00804670A patent/ZA804670B/xx unknown
- 1980-08-01 NZ NZ194535A patent/NZ194535A/en unknown
- 1980-08-01 AU AU61009/80A patent/AU535481B2/en not_active Ceased
- 1980-08-01 IE IE1613/80A patent/IE50040B1/en unknown
- 1980-08-01 ES ES493944A patent/ES8105324A1/es not_active Expired
- 1980-08-01 CA CA000357485A patent/CA1170658A/en not_active Expired
- 1980-08-04 AT AT80302657T patent/ATE6652T1/de not_active IP Right Cessation
- 1980-08-04 DE DE8080302657T patent/DE3066974D1/de not_active Expired
- 1980-08-04 EP EP80302657A patent/EP0025271B1/en not_active Expired
- 1980-08-04 JP JP10761380A patent/JPS5649386A/ja active Pending
-
1981
- 1981-02-28 ES ES499943A patent/ES499943A0/es active Granted
- 1981-02-28 ES ES499944A patent/ES8202556A1/es not_active Expired
-
1983
- 1983-04-13 US US06/484,584 patent/US4652560A/en not_active Expired - Fee Related
-
1985
- 1985-12-30 MY MY998/85A patent/MY8500998A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ194535A (en) | 1984-09-28 |
| ES8202014A1 (es) | 1982-01-01 |
| ATE6652T1 (de) | 1984-03-15 |
| ES499944A0 (es) | 1982-02-01 |
| IE801613L (en) | 1981-02-03 |
| DE3066974D1 (en) | 1984-04-19 |
| AU6100980A (en) | 1981-02-05 |
| ES499943A0 (es) | 1982-01-01 |
| IE50040B1 (en) | 1986-02-05 |
| JPS5649386A (en) | 1981-05-02 |
| US4652560A (en) | 1987-03-24 |
| MY8500998A (en) | 1985-12-31 |
| EP0025271B1 (en) | 1984-03-14 |
| EP0025271A1 (en) | 1981-03-18 |
| ES493944A0 (es) | 1981-06-01 |
| AU535481B2 (en) | 1984-03-22 |
| ZA804670B (en) | 1981-07-29 |
| ES8202556A1 (es) | 1982-02-01 |
| ES8105324A1 (es) | 1981-06-01 |
| CA1170658A (en) | 1984-07-10 |
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