[go: up one dir, main page]

DK3360538T3 - Injicerbar, flydende sammensætning omfattende buprenorphin - Google Patents

Injicerbar, flydende sammensætning omfattende buprenorphin Download PDF

Info

Publication number
DK3360538T3
DK3360538T3 DK17205986.7T DK17205986T DK3360538T3 DK 3360538 T3 DK3360538 T3 DK 3360538T3 DK 17205986 T DK17205986 T DK 17205986T DK 3360538 T3 DK3360538 T3 DK 3360538T3
Authority
DK
Denmark
Prior art keywords
buprenorphine
liquid composition
injectable liquid
injectable
composition
Prior art date
Application number
DK17205986.7T
Other languages
English (en)
Inventor
Richard L Norton
Andrew Watkins
Mingxing Zhou
Original Assignee
Indivior Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42471306&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3360538(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Indivior Uk Ltd filed Critical Indivior Uk Ltd
Application granted granted Critical
Publication of DK3360538T3 publication Critical patent/DK3360538T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK17205986.7T 2010-06-08 2011-06-06 Injicerbar, flydende sammensætning omfattende buprenorphin DK3360538T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1009549.5A GB2481018B (en) 2010-06-08 2010-06-08 Injectable flowable composition comprising buprenorphine
EP11728037.0A EP2579874B1 (en) 2010-06-08 2011-06-06 Injectable flowable composition comprising buprenorphine

Publications (1)

Publication Number Publication Date
DK3360538T3 true DK3360538T3 (da) 2023-03-06

Family

ID=42471306

Family Applications (2)

Application Number Title Priority Date Filing Date
DK17205986.7T DK3360538T3 (da) 2010-06-08 2011-06-06 Injicerbar, flydende sammensætning omfattende buprenorphin
DK11728037.0T DK2579874T3 (da) 2010-06-08 2011-06-06 Injicerbar, flydende sammensætning omfattende buprenorphin

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK11728037.0T DK2579874T3 (da) 2010-06-08 2011-06-06 Injicerbar, flydende sammensætning omfattende buprenorphin

Country Status (32)

Country Link
US (1) US8921387B2 (da)
EP (3) EP2579874B1 (da)
JP (2) JP5986072B2 (da)
KR (1) KR101865689B1 (da)
CN (1) CN103079544B (da)
AU (1) AU2011263478B2 (da)
BR (1) BR112012031290A2 (da)
CA (1) CA2801676C (da)
CL (1) CL2012003462A1 (da)
CO (1) CO6670529A2 (da)
CY (1) CY1120761T1 (da)
DK (2) DK3360538T3 (da)
ES (2) ES2656938T3 (da)
FI (1) FI3360538T3 (da)
GB (2) GB2481018B (da)
HR (1) HRP20180118T1 (da)
HU (1) HUE038275T2 (da)
IL (2) IL223488A (da)
LT (1) LT2579874T (da)
MX (1) MX339209B (da)
MY (1) MY171625A (da)
NO (1) NO2579874T3 (da)
NZ (1) NZ604026A (da)
PL (1) PL2579874T3 (da)
PT (1) PT2579874T (da)
RS (1) RS56820B1 (da)
RU (1) RU2607498C2 (da)
SG (1) SG186200A1 (da)
SI (1) SI2579874T1 (da)
SM (1) SMT201800038T1 (da)
WO (1) WO2011154724A2 (da)
ZA (1) ZA201209233B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
GB2481018B (en) 2010-06-08 2015-03-18 Rb Pharmaceuticals Ltd Injectable flowable composition comprising buprenorphine
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2481017B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
US9566241B2 (en) 2012-02-21 2017-02-14 Auburn University Buprenorphine nanoparticle composition and methods thereof
CN110101702A (zh) 2012-04-17 2019-08-09 普渡制药公司 用于治疗阿片样物质所致不良药效学响应的系统和方法
MY189481A (en) 2012-07-26 2022-02-16 Camurus Ab Opioid formulations
US9937164B2 (en) * 2012-07-26 2018-04-10 Camurus Ab Opioid formulations
EP2931253A1 (en) * 2012-12-13 2015-10-21 Heron Therapeutics, Inc. Pharmaceutical composition comprising antiemetic compounds and polyorthoester
US9393211B2 (en) * 2013-03-15 2016-07-19 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
US9592227B2 (en) * 2013-03-15 2017-03-14 Heron Therapeutics, Inc. Compositions of a polyorthoester and an aprotic solvent
US9636308B2 (en) 2013-03-15 2017-05-02 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
HUE055973T2 (hu) 2014-04-21 2022-01-28 Heron Therapeutics Inc Hosszanható polimerikus célba juttató rendszerek
EP3509601A1 (en) 2014-04-21 2019-07-17 Heron Therapeutics, Inc. A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam
US9801945B2 (en) 2014-04-21 2017-10-31 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
PT3134070T (pt) * 2014-04-21 2020-12-21 Heron Therapeutics Inc Composições de um poliortoéster e de um excipiente de ácido orgânico
JP6568102B2 (ja) 2014-04-28 2019-08-28 オーフォームド,インコーポレイティド ブプレノルフィン二量体及び消化管疾患の治療におけるその使用
GB201419091D0 (en) * 2014-10-27 2014-12-10 Camurus Ab Formulations
ES2808150T3 (es) * 2014-11-07 2021-02-25 Indivior Uk Ltd Regímenes de dosificación de buprenorfina
JP6949820B2 (ja) * 2015-08-03 2021-10-13 トルマー インターナショナル リミテッド 薬物の持続投与のための液体ポリマー送達システム
JP7036718B2 (ja) 2015-11-16 2022-03-15 メドインセルル 滑膜組織への医薬活性成分の小分割化及び/又は標的化の方法
AU2017325910B2 (en) 2016-09-13 2020-08-27 Alar Pharmaceuticals Inc. Sustained-release buprenorphine formulations
WO2018229551A2 (en) 2017-06-16 2018-12-20 Indivior Uk Limited Methods to treat opioid use disorder
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
ES2965836T3 (es) 2018-01-22 2024-04-17 Foresee Pharmaceuticals Co Ltd Composición farmacéutica para administración de liberación mantenida de buprenorfina
TWI838372B (zh) 2018-05-11 2024-04-11 昱展新藥生技股份有限公司 丁基原啡因衍生物之長效注射劑型及結晶型
IL319386A (en) 2018-10-11 2025-05-01 Indivior Uk Ltd Buprenorphine for the treatment of respiratory depression
US12403291B2 (en) * 2019-08-30 2025-09-02 Intersect Ent, Inc. Submucosal bioresorbable drug eluting platform
CN118831057A (zh) * 2023-04-25 2024-10-25 深圳善康医药科技股份有限公司 丁丙诺啡植入剂及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5702716A (en) 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
KR100374098B1 (ko) 1994-04-08 2003-06-09 아트릭스 라보라토리스, 인코포레이션 조절된방출이식편형성에적합한액체전달조성물
US20030211157A1 (en) * 1996-05-06 2003-11-13 Simon David Lew Semi-sol delivery blend for water soluble molecules
US6143314A (en) * 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6565874B1 (en) 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
US6461631B1 (en) 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
HUE039377T2 (hu) * 2002-05-31 2018-12-28 L Molteni & C Dei Fratelli Alitti Soc Di Esercizio S P A Beültethetõ polimer eszköz buprenorfin folytonos kibocsátására
NZ539810A (en) * 2002-11-06 2008-03-28 Alza Corp Controlled release injectable depot formulations
JP2007525429A (ja) * 2003-03-11 2007-09-06 キューエルティー ユーエスエー,インコーポレイテッド. 細胞スケジュール依存性抗癌剤のための処方
BRPI0516308A2 (pt) * 2004-10-04 2010-06-15 Qlt Usa Inc composição fluida, métodos de tratamento de uma doença ou disfunção, métodos de liberação local ou sistêmica de um agente biológico, implantes, método de formação de um implante, kit de agente biológico e usos de uma composição fluida
WO2006053175A2 (en) * 2004-11-10 2006-05-18 Qlt Usa Inc. A stabilized polymeric delivery system
CA2678350C (en) 2007-02-15 2015-11-17 Qlt Usa, Inc. Low-burst poly(lactide-glycolide)
US20090181068A1 (en) * 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
GB2481018B (en) 2010-06-08 2015-03-18 Rb Pharmaceuticals Ltd Injectable flowable composition comprising buprenorphine

Also Published As

Publication number Publication date
ZA201209233B (en) 2014-04-30
EP2579874A2 (en) 2013-04-17
IL254417A0 (en) 2017-11-30
GB201009549D0 (en) 2010-07-21
CO6670529A2 (es) 2013-05-15
SMT201800038T1 (it) 2018-03-08
SG186200A1 (en) 2013-01-30
MX339209B (es) 2016-04-15
MX2012014335A (es) 2013-03-05
KR20130135026A (ko) 2013-12-10
JP5986072B2 (ja) 2016-09-06
US20130210853A1 (en) 2013-08-15
WO2011154724A3 (en) 2012-07-12
IL223488A (en) 2017-10-31
RU2012157244A (ru) 2014-07-20
LT2579874T (lt) 2018-02-12
ES2939612T3 (es) 2023-04-25
JP2013533230A (ja) 2013-08-22
RU2607498C2 (ru) 2017-01-10
GB201413064D0 (en) 2014-09-03
NO2579874T3 (da) 2018-06-09
HUE038275T2 (hu) 2018-10-29
CN103079544B (zh) 2017-06-09
AU2011263478B2 (en) 2015-01-22
BR112012031290A2 (pt) 2016-11-01
JP2016155865A (ja) 2016-09-01
SI2579874T1 (en) 2018-03-30
FI3360538T3 (fi) 2023-03-22
WO2011154724A2 (en) 2011-12-15
EP3360538A1 (en) 2018-08-15
WO2011154724A9 (en) 2012-08-16
EP4218720A1 (en) 2023-08-02
DK2579874T3 (da) 2018-01-29
JP6251774B2 (ja) 2017-12-20
EP3360538B1 (en) 2023-02-15
KR101865689B1 (ko) 2018-06-08
CA2801676A1 (en) 2011-12-15
AU2011263478A1 (en) 2013-01-10
EP2579874B1 (en) 2018-01-10
PL2579874T3 (pl) 2018-05-30
HRP20180118T1 (hr) 2018-03-09
NZ604026A (en) 2015-01-30
GB2481018B (en) 2015-03-18
CL2012003462A1 (es) 2013-04-01
CA2801676C (en) 2018-08-07
GB2481018A (en) 2011-12-14
PT2579874T (pt) 2018-01-29
MY171625A (en) 2019-10-21
CY1120761T1 (el) 2019-12-11
US8921387B2 (en) 2014-12-30
GB2513267B (en) 2015-03-18
GB2513267A (en) 2014-10-22
RS56820B1 (sr) 2018-04-30
ES2656938T3 (es) 2018-03-01
CN103079544A (zh) 2013-05-01

Similar Documents

Publication Publication Date Title
DK3360538T3 (da) Injicerbar, flydende sammensætning omfattende buprenorphin
DK3257890T3 (da) Tværbindelig sammensætning
SMT201700008B (it) Composizione farmaceutica
BR112012031667A2 (pt) composição
EP2526922A4 (en) Viscous composition
PT2593094T (pt) Composição aquosa contendo bromexina
DK3246018T3 (da) Farmaceutisk sammensætning
BR112013022112A2 (pt) composição
BR112013022102A2 (pt) composição
BR112013016037A2 (pt) composição em gel.
DK2686017T3 (da) Oftalmisk sammensætning
BR112014004395A2 (pt) composição
BR112012032683A2 (pt) composição
EP2522643A4 (en) CONCRETE COMPOSITION
EE201300005A (et) Ravimkoostis
EP2636704A4 (en) FILM FORMING COMPOSITION
LT2865271T (lt) Pagerinta kompozicija
BR112013014204A2 (pt) composições de sucops espumantes
EA201201176A1 (ru) Битумная композиция
EP2628769A4 (en) FILM FORMING COMPOSITION
BR112012032980A2 (pt) composição
EP2548563A4 (en) ANTIALLERGIC COMPOSITION
BR112013033808A2 (pt) composição
PL2635269T3 (pl) Kompozycja złożona
DK2553004T3 (da) Sammensatte materialer