|
BR112015013440B1
(pt)
|
2012-12-13 |
2020-12-08 |
Aduro Biotech, Inc |
composições compreendendo dinucleotídeos de purina cíclicos com estereoquímicas
|
|
CA2908154C
(en)
|
2013-04-29 |
2023-11-28 |
Memorial Sloan Kettering Cancer Center |
Compositions and methods for altering second messenger signaling
|
|
SI2996473T1
(sl)
|
2013-05-18 |
2019-12-31 |
Aduro Biotech, Inc. |
Sestavki in postopki za aktiviranje signaliziranja, odvisnega od "stimulator interferonskih genov"
|
|
ES2692226T3
(es)
|
2014-06-04 |
2018-11-30 |
Glaxosmithkline Intellectual Property Development Limited |
Dinucleótidos cíclicos como moduladores de STING
|
|
US10011630B2
(en)
*
|
2014-12-16 |
2018-07-03 |
Invivogen |
Cyclic dinucleotides for cytokine induction
|
|
GB201501462D0
(en)
*
|
2015-01-29 |
2015-03-18 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
JO3746B1
(ar)
|
2015-03-10 |
2021-01-31 |
Aduro Biotech Inc |
تركيبات وطرق لتنشيط الإشارات المعتمدة على "منبه أو تحفيز جين انترفيرون"
|
|
US11453697B1
(en)
|
2015-08-13 |
2022-09-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
CA2995365C
(en)
|
2015-08-13 |
2021-10-12 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
|
US10322177B2
(en)
|
2015-10-07 |
2019-06-18 |
Nant Holdings Ip, Llc |
Activation of immune-related signaling pathways in cells via optofection
|
|
CR20180286A
(es)
|
2015-12-03 |
2018-07-16 |
Glaxosmithkline Ip Dev Ltd |
Dinucleotidos de purina cíclicos como moduladores de sting
|
|
CN109451740B
(zh)
|
2016-01-11 |
2022-09-02 |
先天肿瘤免疫公司 |
用于治疗与sting活性相关的病症诸如癌症的环状二核苷酸
|
|
MX390014B
(es)
*
|
2016-03-18 |
2025-03-20 |
Immune Sensor Llc |
Compuestos de dinucleótidos cíclicos y métodos de uso.
|
|
EP3448393A1
(en)
*
|
2016-04-25 |
2019-03-06 |
Invivogen |
Novel complexes of immunostimulatory compounds, and uses thereof
|
|
US10696985B1
(en)
|
2016-06-06 |
2020-06-30 |
Vanderbilt University |
Reversibly crosslinked endosomolytic polymer vesicles for cytosolic drug delivery
|
|
EP3507367A4
(en)
*
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
|
TWI689514B
(zh)
*
|
2016-07-06 |
2020-04-01 |
美商史貝羅威生物科學有限公司 |
化合物、組合物及用於治療疾病之方法
|
|
MX2019000660A
(es)
*
|
2016-07-15 |
2019-10-02 |
Sperovie Biosciences Inc |
Compuestos, composiciones y métodos para el tratamiento de enfermedades.
|
|
NL2017267B1
(en)
|
2016-07-29 |
2018-02-01 |
Aduro Biotech Holdings Europe B V |
Anti-pd-1 antibodies
|
|
NL2017270B1
(en)
|
2016-08-02 |
2018-02-09 |
Aduro Biotech Holdings Europe B V |
New anti-hCTLA-4 antibodies
|
|
US10537590B2
(en)
*
|
2016-09-30 |
2020-01-21 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds
|
|
CR20190168A
(es)
|
2016-10-04 |
2019-05-17 |
Merck Sharp & Dohme |
Compuestos de benzo[b]tiofeno como agonistas de sting
|
|
US11001605B2
(en)
|
2016-10-07 |
2021-05-11 |
Biolog Life Science Institute Gmbh & Co. Kg |
Cyclic dinucleotides containing benzimidazole, method for the production of same, and use of same to activate stimulator of interferon genes (sting)-dependent signaling pathways
|
|
JOP20170188A1
(ar)
*
|
2016-11-25 |
2019-01-30 |
Janssen Biotech Inc |
ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
|
|
JOP20170192A1
(ar)
|
2016-12-01 |
2019-01-30 |
Takeda Pharmaceuticals Co |
داي نوكليوتيد حلقي
|
|
JP2018090562A
(ja)
*
|
2016-12-01 |
2018-06-14 |
武田薬品工業株式会社 |
環状ジヌクレオチド
|
|
JP2020503303A
(ja)
*
|
2016-12-20 |
2020-01-30 |
メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． |
がんの処置のための環状ジヌクレオチドｓｔｉｎｇアゴニスト
|
|
BR112019012618A2
(pt)
*
|
2016-12-22 |
2019-11-26 |
Mavupharma Inc |
inibidores de fosfodiesterase e métodos de tratamento microbiano
|
|
US20200055883A1
(en)
|
2017-02-17 |
2020-02-20 |
Eisai R&D Management Co., Ltd. |
Cyclic di-nucleotides derivative for the treatment of cancer
|
|
WO2018156625A1
(en)
|
2017-02-21 |
2018-08-30 |
Board Of Regents,The University Of Texas System |
Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling
|
|
CN110651036A
(zh)
|
2017-03-20 |
2020-01-03 |
健诺西生物科学公司 |
治疗方法
|
|
JOP20190218A1
(ar)
*
|
2017-03-22 |
2019-09-22 |
Boehringer Ingelheim Int |
مركبات ثنائية النيوكليوتيدات حلقية معدلة
|
|
SG11201908813QA
(en)
|
2017-04-13 |
2019-10-30 |
Aduro Biotech Holdings Europe B V |
Anti-sirp alpha antibodies
|
|
IL269970B
(en)
|
2017-04-14 |
2022-09-01 |
Tallac Therapeutics Inc |
Polynucleotides that modulate the immune system, their antibody binding, and methods of using them
|
|
WO2018198084A1
(en)
*
|
2017-04-27 |
2018-11-01 |
Lupin Limited |
Cyclic di-nucleotide compounds with tricyclic nucleobases
|
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
|
AR113224A1
(es)
|
2017-04-28 |
2020-02-19 |
Novartis Ag |
Conjugados de anticuerpo que comprenden un agonista de sting
|
|
WO2018208667A1
(en)
|
2017-05-12 |
2018-11-15 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
|
EP3630842A2
(en)
|
2017-05-30 |
2020-04-08 |
Bristol-Myers Squibb Company |
Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent
|
|
JP7186764B2
(ja)
*
|
2017-07-28 |
2022-12-09 |
ブリストル－マイヤーズ スクイブ カンパニー |
抗癌剤としての環状ジヌクレオチド
|
|
WO2019027857A1
(en)
|
2017-08-04 |
2019-02-07 |
Merck Sharp & Dohme Corp. |
COMBINATIONS OF PD-1 ANTAGONISTS AND STING BENZO [B] THIOPHENIC AGONISTS FOR THE TREATMENT OF CANCER
|
|
MA49772A
(fr)
|
2017-08-04 |
2021-04-21 |
Merck Sharp & Dohme |
Agonistes benzo[b]thiophène de sting pour le traitement du cancer
|
|
CA3073919A1
(en)
|
2017-08-30 |
2019-03-07 |
Beijing Xuanyi Pharmasciences Co., Ltd. |
Cyclic di-nucleotides as stimulator of interferon genes modulators
|
|
JP7316263B2
(ja)
*
|
2017-08-31 |
2023-07-27 |
ブリストル－マイヤーズ スクイブ カンパニー |
抗癌剤としての環状ジヌクレオチド
|
|
WO2019051489A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
WO2019051488A1
(en)
*
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
EP3691640A1
(en)
*
|
2017-10-05 |
2020-08-12 |
GlaxoSmithKline Intellectual Property Development Limited |
Methods for administering sting agonists
|
|
EP3697801B1
(en)
*
|
2017-10-16 |
2024-11-20 |
Bristol-Myers Squibb Company |
Cyclic dinucleotides as anticancer agents
|
|
WO2019084060A1
(en)
|
2017-10-24 |
2019-05-02 |
Silverback Therapeutics, Inc. |
CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS
|
|
WO2019092660A1
(en)
|
2017-11-10 |
2019-05-16 |
Takeda Pharmaceutical Company Limited |
Sting modulator compounds, and methods of making and using
|
|
EA038805B1
(ru)
*
|
2017-11-21 |
2021-10-21 |
Такеда Фармасьютикал Компани Лимитед |
Циклические динуклеотиды в качестве агонистов sting (стимулятор генов интерферона)
|
|
CN111566120B
(zh)
|
2017-12-20 |
2023-09-29 |
捷克共和国有机化学与生物化学研究所 |
活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸
|
|
EP3728282B1
(en)
|
2017-12-20 |
2023-11-22 |
Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. |
2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
WO2019125974A1
(en)
|
2017-12-20 |
2019-06-27 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
|
EP3505527A1
(en)
|
2017-12-29 |
2019-07-03 |
Invivogen |
Cyclic dinucleotides for cytokine induction
|
|
TWI818943B
(zh)
*
|
2018-01-04 |
2023-10-21 |
中央研究院 |
用於增加療效之可與細胞結合的免疫佐劑
|
|
US12220462B1
(en)
|
2018-02-13 |
2025-02-11 |
Abionyx Pharma Sa |
Complexes for delivery of cyclic dinucleotides
|
|
US20210015915A1
(en)
*
|
2018-03-23 |
2021-01-21 |
Takeda Pharmaceutical Company Limited |
Sting modulator compounds with sulfamate linkages, and methods of making and using
|
|
CA3093849A1
(en)
*
|
2018-03-23 |
2019-09-26 |
Codiak Biosciences, Inc. |
Extracellular vesicles comprising sting-agonist
|
|
EP3774834A1
(en)
|
2018-03-27 |
2021-02-17 |
Boehringer Ingelheim International GmbH |
Cyclic dinucleotide compounds containing 2-aza-hypoxanthine or 6h-pytazolo[1,5-d][1,2,4]triazin-7-one as sting agonists
|
|
WO2019185476A1
(en)
|
2018-03-27 |
2019-10-03 |
Boehringer Ingelheim International Gmbh |
Modified cyclic dinucleotide compounds
|
|
US11702430B2
(en)
|
2018-04-03 |
2023-07-18 |
Merck Sharp & Dohme Llc |
Aza-benzothiophene compounds as STING agonists
|
|
CN111971277B
(zh)
|
2018-04-03 |
2023-06-06 |
默沙东有限责任公司 |
作为sting激动剂的苯并噻吩及相关化合物
|
|
TWI818007B
(zh)
|
2018-04-06 |
2023-10-11 |
捷克科學院有機化學與生物化學研究所 |
2'3'-環二核苷酸
|
|
TWI833744B
(zh)
|
2018-04-06 |
2024-03-01 |
捷克科學院有機化學與生物化學研究所 |
3'3'-環二核苷酸
|
|
SG11202011434SA
(en)
|
2018-06-01 |
2020-12-30 |
Eisai R&D Man Co Ltd |
Methods for the treatment of bladder cancer
|
|
WO2020014127A1
(en)
|
2018-07-10 |
2020-01-16 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
MX2020013322A
(es)
|
2018-08-16 |
2021-02-22 |
Eisai R&D Man Co Ltd |
Sales de compuestos y cristales de los mismos.
|
|
EP3841112A1
(en)
|
2018-08-24 |
2021-06-30 |
Codiak BioSciences, Inc. |
Extracellular vesicles targeting dendritic cells and uses thereof
|
|
SG11202101980VA
(en)
|
2018-09-12 |
2021-03-30 |
Silverback Therapeutics Inc |
Methods and composition for the treatment of disease with immune stimulatory conjugates
|
|
US12011485B2
(en)
|
2018-09-27 |
2024-06-18 |
Pierre Fabre Medicament |
Sulfomaleimide-based linkers and corresponding conjugates
|
|
WO2020074004A1
(zh)
*
|
2018-10-12 |
2020-04-16 |
上海济煜医药科技有限公司 |
环二核苷酸类化合物及其应用
|
|
WO2020092127A1
(en)
|
2018-10-29 |
2020-05-07 |
Venenum Biodesign, LLC |
Novel sting agonists
|
|
AU2019373241A1
(en)
|
2018-10-29 |
2021-06-10 |
Genocea Biosciences, Inc. |
Treatment methods
|
|
US11110106B2
(en)
|
2018-10-29 |
2021-09-07 |
Venenum Biodesign, LLC |
Sting agonists for treating bladder cancer and solid tumors
|
|
WO2020092633A1
(en)
|
2018-10-30 |
2020-05-07 |
Vanderbilt University |
Graft copolymers, methods of forming graft copolymers, and methods of use thereof
|
|
WO2020092617A1
(en)
|
2018-10-31 |
2020-05-07 |
Novartis Ag |
Dc-sign antibody conjugates comprising sting agonists
|
|
CN111423483B
(zh)
*
|
2019-01-10 |
2025-01-17 |
英诺生物制药(深圳)有限公司 |
环二核苷酸前药分子及其制备方法和应用
|
|
CN113950486A
(zh)
|
2019-01-28 |
2022-01-18 |
罗德岛大学理事会 |
pHLIP®-介导的免疫刺激化合物的细胞内递送
|
|
MX2021011242A
(es)
|
2019-03-21 |
2022-01-19 |
Codiak Biosciences Inc |
Conjugados de vesícula extracelular y usos de estos.
|
|
PH12021552223A1
(en)
|
2019-03-21 |
2022-05-30 |
Codiak Biosciences Inc |
Extracellular vesicles for vaccine delivery
|
|
US12233356B2
(en)
|
2019-03-21 |
2025-02-25 |
Lonza Sales Ag |
Process for preparing extracellular vesicles
|
|
WO2020205688A1
(en)
|
2019-04-04 |
2020-10-08 |
Merck Sharp & Dohme Corp. |
Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes
|
|
EP3962493A2
(en)
|
2019-05-03 |
2022-03-09 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor
|
|
EP3966222A4
(en)
|
2019-05-09 |
2023-10-04 |
Aligos Therapeutics, Inc. |
MODIFIED CYCLIC DI-NUCLEOSIDE COMPOUNDS AS STING MODULATORS
|
|
WO2021003445A1
(en)
|
2019-07-03 |
2021-01-07 |
Codiak Biosciences, Inc. |
Extracellular vesicles targeting t cells and uses thereof
|
|
US12435104B2
(en)
|
2019-07-25 |
2025-10-07 |
Beigene, Ltd. |
Cyclic dinucleotides as sting agonists
|
|
JP2022543086A
(ja)
|
2019-08-02 |
2022-10-07 |
メルサナ セラピューティクス インコーポレイテッド |
がんの処置用のＳＴＩＮＧ（インターフェロン遺伝子刺激因子）アゴニストとしてのビス－［Ｎ－（（５－カルバモイル）－１Ｈ－ベンゾ［ｄ］イミダゾール－２－イル）－ピラゾール－５－カルボキサミド］誘導体および関連化合物
|
|
AU2020328507A1
(en)
|
2019-08-12 |
2022-03-17 |
Purinomia Biotech, Inc. |
Methods and compositions for promoting and potentiating T-cell mediated immune responses through ADCC targeting of CD39 expressing cells
|
|
KR20220092654A
(ko)
|
2019-09-25 |
2022-07-01 |
코디악 바이오사이언시즈, 인크. |
세포외 소포 조성물
|
|
EP4034276A1
(en)
|
2019-09-25 |
2022-08-03 |
Codiak BioSciences, Inc. |
Methods of producing extracellular vesicles
|
|
WO2021062058A1
(en)
|
2019-09-25 |
2021-04-01 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
|
WO2021062060A1
(en)
|
2019-09-25 |
2021-04-01 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes combined with il-12 displaying exosomes for treating a tumour
|
|
WO2021067644A1
(en)
|
2019-10-01 |
2021-04-08 |
Silverback Therapeutics, Inc. |
Combination therapy with immune stimulatory conjugates
|
|
WO2021074695A1
(en)
|
2019-10-16 |
2021-04-22 |
Avacta Life Sciences Limited |
PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
|
|
WO2021113679A1
(en)
|
2019-12-06 |
2021-06-10 |
Mersana Therapeutics, Inc. |
Dimeric compounds as sting agonists
|
|
WO2021168274A1
(en)
|
2020-02-21 |
2021-08-26 |
Silverback Therapeutics, Inc. |
Nectin-4 antibody conjugates and uses thereof
|
|
US11920136B2
(en)
|
2020-02-28 |
2024-03-05 |
Tallac Therapeutics, Inc. |
Transglutaminase-mediated conjugation
|
|
WO2021184017A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Extracellular vesicles for treating neurological disorders
|
|
AU2021236763A1
(en)
|
2020-03-20 |
2022-10-06 |
Lonza Sales Ag |
Extracellular vesicles for therapy
|
|
AU2021248635B2
(en)
|
2020-04-02 |
2025-10-23 |
Mersana Therapeutics, Inc. |
Antibody drug conjugates comprising STING agonists
|
|
WO2021206158A1
(ja)
|
2020-04-10 |
2021-10-14 |
小野薬品工業株式会社 |
がん治療方法
|
|
US20230149560A1
(en)
|
2020-04-20 |
2023-05-18 |
Massachusetts Institute Of Technology |
Lipid compositions for delivery of sting agonist compounds and uses thereof
|
|
KR20230011324A
(ko)
|
2020-05-15 |
2023-01-20 |
이뮨센서 테라퓨틱스, 인코포레이티드 |
면역 체크포인트 억제제를 사용한 sting 작용제 병용 치료
|
|
WO2021237100A1
(en)
|
2020-05-21 |
2021-11-25 |
Codiak Biosciences, Inc. |
Methods of targeting extracellular vesicles to lung
|
|
US20230210968A1
(en)
|
2020-06-11 |
2023-07-06 |
Massachusetts Institute Of Technology |
Ribonucleoprotein approach to boost the sting signaling for cancer immunotherapy
|
|
IL299508A
(en)
|
2020-07-01 |
2023-02-01 |
Ars Pharmaceuticals Inc |
Anti-asgr1 antibody conjugates and uses thereof
|
|
CN111909223A
(zh)
*
|
2020-07-17 |
2020-11-10 |
清华大学 |
环二核苷酸共价修饰物及其制备方法和应用
|
|
WO2022066898A2
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Methods of producing extracellular vesicles
|
|
WO2022066883A1
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Extracellular vesicles comprising kras antigens and uses thereof
|
|
US20240241020A1
(en)
|
2020-09-23 |
2024-07-18 |
Lonza Sales Ag |
Process for preparing extracellular vesicles
|
|
US20230366794A1
(en)
|
2020-09-23 |
2023-11-16 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
|
US20240059729A1
(en)
*
|
2020-10-20 |
2024-02-22 |
Tyligand Bioscience (Shanghai) Limited |
Multifunctional cyclic dinucleotide and use thereof
|
|
CN115160392A
(zh)
*
|
2020-10-20 |
2022-10-11 |
泰励生物科技（上海）有限公司 |
多功能环二核苷酸及其用途
|
|
KR102466750B1
(ko)
|
2020-10-23 |
2022-11-15 |
아주대학교산학협력단 |
인돌리진 유도체를 유효성분으로 포함하는 인터페론 유전자 자극제 조성물
|
|
JP7397996B2
(ja)
|
2020-11-09 |
2023-12-13 |
武田薬品工業株式会社 |
抗体薬物コンジュゲート
|
|
EP4262878A1
(en)
|
2020-12-17 |
2023-10-25 |
Trustees Of Tufts College |
Fap-activated radiotheranostics, and uses related thereto
|
|
WO2022234003A1
(en)
|
2021-05-07 |
2022-11-10 |
Avacta Life Sciences Limited |
Cd33 binding polypeptides with stefin a protein
|
|
AU2022315305A1
(en)
|
2021-07-23 |
2024-02-01 |
Immunesensor Therapeutics, Inc. |
Sting agonist combination treatments with cytokines
|
|
WO2023056468A1
(en)
|
2021-09-30 |
2023-04-06 |
Codiak Biosciences, Inc. |
Extracellular vesicle comprising cholesterol tagged sting-agonist
|
|
TW202334196A
(zh)
|
2021-10-07 |
2023-09-01 |
英商阿法克塔生命科學有限公司 |
Pd-l1結合多肽
|
|
CN119156403A
(zh)
|
2022-03-08 |
2024-12-17 |
阿伦蒂斯治疗股份公司 |
抗紧密连接蛋白-1抗体增加t细胞可用性的用途
|
|
WO2023218243A1
(en)
|
2022-05-12 |
2023-11-16 |
Avacta Life Sciences Limited |
Lag-3/pd-l1 binding fusion proteins
|
|
GB202304385D0
(en)
|
2023-03-24 |
2023-05-10 |
Prostate Cancer Res |
Combinatorial IL-15 therapy
|