DK3279214T3 - Fremgangsmåde til fremstilling af variable immunglobulin-enkeltdomæner - Google Patents
Fremgangsmåde til fremstilling af variable immunglobulin-enkeltdomæner Download PDFInfo
- Publication number
- DK3279214T3 DK3279214T3 DK17192342.8T DK17192342T DK3279214T3 DK 3279214 T3 DK3279214 T3 DK 3279214T3 DK 17192342 T DK17192342 T DK 17192342T DK 3279214 T3 DK3279214 T3 DK 3279214T3
- Authority
- DK
- Denmark
- Prior art keywords
- immunoglobulin single
- single domains
- variable immunoglobulin
- preparing variable
- preparing
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40822810P | 2010-10-29 | 2010-10-29 | |
| EP11775994.4A EP2632946B1 (en) | 2010-10-29 | 2011-10-28 | Method for the production of immunoglobulin single variable domains |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3279214T3 true DK3279214T3 (da) | 2024-12-09 |
Family
ID=44872371
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17192342.8T DK3279214T3 (da) | 2010-10-29 | 2011-10-28 | Fremgangsmåde til fremstilling af variable immunglobulin-enkeltdomæner |
| DK11775994.4T DK2632946T3 (da) | 2010-10-29 | 2011-10-28 | Fremgangsmåde til fremstilling af variable immunglobulin-enkeltdomæner |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11775994.4T DK2632946T3 (da) | 2010-10-29 | 2011-10-28 | Fremgangsmåde til fremstilling af variable immunglobulin-enkeltdomæner |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20130261288A1 (da) |
| EP (3) | EP4458858A3 (da) |
| DK (2) | DK3279214T3 (da) |
| ES (2) | ES2660895T3 (da) |
| HU (1) | HUE069364T2 (da) |
| NO (1) | NO2632946T3 (da) |
| PL (2) | PL3279214T3 (da) |
| PT (1) | PT2632946T (da) |
| WO (1) | WO2012056000A1 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE069364T2 (hu) | 2010-10-29 | 2025-03-28 | Ablynx Nv | Eljárás immunglobulin variábilis egydomének elõállítására |
| WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
| EP3444278A1 (en) | 2013-02-26 | 2019-02-20 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
| PL3294319T3 (pl) | 2015-05-13 | 2024-10-07 | Ablynx Nv | Polipeptydy rekrutujące komórki t na podstawie reaktywności cd3 |
| LT3611192T (lt) | 2015-05-13 | 2025-06-25 | Ablynx N.V. | T ląstelių rekrutingo polipeptidai tcr alfa/beta reaktyvumo pagrindu |
| IL266506B2 (en) | 2016-11-16 | 2025-05-01 | Ablynx Nv | T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta |
| US20230136595A1 (en) | 2020-03-30 | 2023-05-04 | Ablynx Nv | Method for the production and purification of multivalent immunoglobulin single variable domains |
| PH12023500009A1 (en) | 2020-12-18 | 2024-03-11 | Ablynx Nv | T cell recruiting polypeptides based on tcr alpha/beta reactivity |
| TW202423965A (zh) | 2022-07-27 | 2024-06-16 | 比利時商艾伯霖克斯公司 | 與新生兒fc受體的特定表位結合之多肽 |
| CN120712282A (zh) | 2023-02-17 | 2025-09-26 | 阿布林克斯有限公司 | 结合新生儿fc受体的多肽 |
| TW202517676A (zh) | 2023-07-05 | 2025-05-01 | 比利時商艾伯霖克斯公司 | 用於治療ＩｇＧ相關疾病及病症之改良ＦｃＲｎ拮抗劑 |
| WO2025061919A1 (en) | 2023-09-22 | 2025-03-27 | Ablynx Nv | Bi- and multivalent albumin binders |
| WO2025207946A1 (en) | 2024-03-28 | 2025-10-02 | Genzyme Corporation | Polypeptides binding to a specific epitope of the transferrin receptor 1 |
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| WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
| ATE427968T1 (de) | 1992-08-21 | 2009-04-15 | Univ Bruxelles | Immunoglobuline ohne leichtkette |
| ES2162863T3 (es) | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
| FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| CA2258518C (en) | 1996-06-27 | 2011-11-22 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Recognition molecules interacting specifically with the active site or cleft of a target molecule |
| EP1027439B1 (en) | 1997-10-27 | 2010-03-17 | Bac Ip B.V. | Multivalent antigen-binding proteins |
| BR9907241A (pt) | 1998-01-26 | 2000-10-17 | Unilever Nv | Biblioteca de expressão, processo para preparar a mesma, uso de uma fonte não imunizada de sequências de ácido nucleico, e, processos para preparar fragmentos de anticorpos e, para preparar um anticorpo |
| EP1141711A1 (en) | 1999-01-05 | 2001-10-10 | Unilever Plc | Binding of antibody fragments to solid supports |
| ATE276359T1 (de) | 1999-01-19 | 2004-10-15 | Unilever Nv | Verfahren zur herstellung von antikörperfragmenten |
| ID30380A (id) | 1999-04-22 | 2001-11-29 | Unilever Nv | Penghambatan infeksi virus menggunakan protein pengikat antigen bervalensi tunggal |
| US6479280B1 (en) | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
| EP1242460B1 (en) | 1999-11-29 | 2006-10-18 | Unilever Plc | Immobilisation of proteins using a polypeptide segment |
| ATE440111T1 (de) | 1999-11-29 | 2009-09-15 | Bac Ip B V | Immobilisierte antigenbindende moleküle aus einer domäne |
| ATE428733T1 (de) | 2000-03-14 | 2009-05-15 | Unilever Nv | Variabele domänen der schweren kette eines antikörpers gegen menschliche ernährungslipasen und deren verwendungen |
| CA2380443C (en) | 2000-05-26 | 2013-03-12 | Ginette Dubuc | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| AU2002229639A1 (en) | 2000-12-13 | 2002-06-24 | De Haard, Johannes Joseph Wilhelmus | Camelidae antibody arrays |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| EP1433793A4 (en) | 2001-09-13 | 2006-01-25 | Inst Antibodies Co Ltd | METHOD FOR CREATING A CAMEL ANTIBODY LIBRARY |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| WO2003050531A2 (en) | 2001-12-11 | 2003-06-19 | Algonomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| WO2003062375A2 (en) * | 2001-12-19 | 2003-07-31 | Genentech, Inc. | Stabilizing polypeptides which have been exposed to urea |
| JP4323317B2 (ja) | 2001-12-21 | 2009-09-02 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） | 可変領域配列のクローニング方法 |
| EP1461085A2 (en) | 2002-01-03 | 2004-09-29 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Immunoconjugates useful for treatment of tumours |
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| JPWO2004001865A1 (ja) | 2002-06-19 | 2005-10-27 | 株式会社東芝 | 熱電素子とそれを用いた電子部品モジュールおよび携帯用電子機器 |
| NZ540194A (en) | 2002-11-08 | 2008-07-31 | Ablynx Nv | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| EP1558650A2 (en) | 2002-11-08 | 2005-08-03 | Ablynx N.V. | Camelidae antibodies against immunoglobulin e and use thereof for the treatment of allergic disorders |
| JP2006517789A (ja) | 2003-01-10 | 2006-08-03 | アブリンクス エン．ヴェー． | 治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用 |
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| AU2003264053A1 (en) | 2003-08-12 | 2005-03-10 | William M. Yarbrough | Treatment for acne vulgaris and method of use |
| EP2251357A1 (en) | 2003-11-07 | 2010-11-17 | Ablynx N.V. | Camelidae single domain antibodies VHH directed against epidermal growth factor receptor and uses therefor |
| US7563443B2 (en) * | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| US20080107601A1 (en) | 2004-10-13 | 2008-05-08 | Ablynx N.V. | Nanobodies Tm Against Amyloid-Beta and Polypeptides Comprising the Same for the Treatment of Degenerative Neural Diseases Such as Alzheimer's Disease |
| EP1844073A1 (en) | 2005-01-31 | 2007-10-17 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
| CN103254309B (zh) | 2005-05-18 | 2017-09-26 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子α的改进的纳米体TM |
| PL2444424T3 (pl) | 2005-05-20 | 2019-01-31 | Ablynx N.V. | Ulepszone Nanociała TM do leczenia zaburzeń, w których pośredniczy agregacja |
| AU2008219216A1 (en) | 2007-02-21 | 2008-08-28 | Ablynx N.V. | Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization |
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| CA2706200A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Immunoglobulin constructs comprising multiple single variable domains and an fc portion |
| WO2010056550A1 (en) | 2008-10-29 | 2010-05-20 | Wyeth Llc | Methods for purification of single domain antigen binding molecules |
| KR20130119990A (ko) | 2009-04-10 | 2013-11-01 | 아블린쓰 엔.브이. | Ｉｌ－６ｒ에 대한 개선된 아미노산 서열 및 ｉｌ－６ｒ 관련 질환 및 질병의 치료를 위한 그를 포함하는 폴리펩티드 |
| US9464138B2 (en) | 2009-04-30 | 2016-10-11 | Ablynx N.V. | Method for the production of domain antibodies |
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| EP2513145B1 (en) | 2009-12-14 | 2018-01-24 | Ablynx N.V. | Single variable domain antibodies against ox40l, constructs and therapeutic use |
| HUE069364T2 (hu) | 2010-10-29 | 2025-03-28 | Ablynx Nv | Eljárás immunglobulin variábilis egydomének elõállítására |
-
2011
- 2011-10-28 HU HUE17192342A patent/HUE069364T2/hu unknown
- 2011-10-28 EP EP24198210.7A patent/EP4458858A3/en active Pending
- 2011-10-28 ES ES11775994.4T patent/ES2660895T3/es active Active
- 2011-10-28 EP EP11775994.4A patent/EP2632946B1/en active Active
- 2011-10-28 PT PT117759944T patent/PT2632946T/pt unknown
- 2011-10-28 EP EP17192342.8A patent/EP3279214B1/en active Active
- 2011-10-28 PL PL17192342.8T patent/PL3279214T3/pl unknown
- 2011-10-28 ES ES17192342T patent/ES2996232T3/es active Active
- 2011-10-28 DK DK17192342.8T patent/DK3279214T3/da active
- 2011-10-28 NO NO11775994A patent/NO2632946T3/no unknown
- 2011-10-28 WO PCT/EP2011/068982 patent/WO2012056000A1/en not_active Ceased
- 2011-10-28 DK DK11775994.4T patent/DK2632946T3/da active
- 2011-10-28 PL PL11775994T patent/PL2632946T3/pl unknown
- 2011-10-28 US US13/824,481 patent/US20130261288A1/en not_active Abandoned
-
2019
- 2019-08-02 US US16/529,865 patent/US20200392214A9/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20200392214A9 (en) | 2020-12-17 |
| ES2996232T3 (en) | 2025-02-12 |
| PL2632946T3 (pl) | 2018-06-29 |
| EP3279214A1 (en) | 2018-02-07 |
| EP2632946A1 (en) | 2013-09-04 |
| EP3279214B1 (en) | 2024-10-09 |
| NO2632946T3 (da) | 2018-05-05 |
| EP4458858A3 (en) | 2025-02-19 |
| HUE069364T2 (hu) | 2025-03-28 |
| US20130261288A1 (en) | 2013-10-03 |
| PL3279214T3 (pl) | 2025-03-24 |
| EP2632946B1 (en) | 2017-12-06 |
| EP4458858A2 (en) | 2024-11-06 |
| US20200062834A1 (en) | 2020-02-27 |
| DK2632946T3 (da) | 2018-03-12 |
| PT2632946T (pt) | 2018-03-01 |
| ES2660895T3 (es) | 2018-03-26 |
| WO2012056000A1 (en) | 2012-05-03 |
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