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DK3277283T3 - Sublinguale sildenafilsprayformuerlinger - Google Patents

Sublinguale sildenafilsprayformuerlinger Download PDF

Info

Publication number
DK3277283T3
DK3277283T3 DK16774386.3T DK16774386T DK3277283T3 DK 3277283 T3 DK3277283 T3 DK 3277283T3 DK 16774386 T DK16774386 T DK 16774386T DK 3277283 T3 DK3277283 T3 DK 3277283T3
Authority
DK
Denmark
Prior art keywords
sildenafil
sublingual
spray formulations
formulations
spray
Prior art date
Application number
DK16774386.3T
Other languages
English (en)
Inventor
Thrimoorthy Potta
Kiran Amancha
Wesley Giron
Ningxing Yan
Venkat Goskonda
Onkar N Singh
Original Assignee
Benuvia Therapeutics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Benuvia Therapeutics Llc filed Critical Benuvia Therapeutics Llc
Application granted granted Critical
Publication of DK3277283T3 publication Critical patent/DK3277283T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Inorganic Chemistry (AREA)
DK16774386.3T 2015-04-03 2016-04-02 Sublinguale sildenafilsprayformuerlinger DK3277283T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562142746P 2015-04-03 2015-04-03
PCT/US2016/025770 WO2016161397A1 (en) 2015-04-03 2016-04-02 Sildenafil sublingual spray formulations

Publications (1)

Publication Number Publication Date
DK3277283T3 true DK3277283T3 (da) 2021-04-12

Family

ID=57007399

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16774386.3T DK3277283T3 (da) 2015-04-03 2016-04-02 Sublinguale sildenafilsprayformuerlinger

Country Status (7)

Country Link
US (1) US9662334B2 (da)
EP (1) EP3277283B8 (da)
CN (1) CN108367010A (da)
CA (1) CA2981615A1 (da)
DK (1) DK3277283T3 (da)
ES (1) ES2864099T3 (da)
WO (1) WO2016161397A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10111833B2 (en) * 2015-04-03 2018-10-30 Insys Development Company, Inc. Sildenafil sublingual spray formulations
CA3039225A1 (en) 2016-11-08 2018-05-17 Colgate-Palmolive Company Oral care compositions comprising two aqueous phases
CN107296789A (zh) * 2017-07-08 2017-10-27 天津双硕医药科技有限公司 一种含有枸橼酸西地那非的外用药物组合物
WO2023037394A1 (en) * 2021-09-13 2023-03-16 Amman Pharmaceutical Industries Company A pharmaceutical composition of sildenafil and a formulation thereof
PL247528B1 (pl) * 2023-04-08 2025-07-21 Sativa Med Spolka Akcyjna Płynna kompozycja inhibitorów fosfodiesterazy typu 5 (PDE-5), sposób jej wytwarzania oraz jej zastosowanie do leczenia zaburzeń erekcji

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6962691B1 (en) * 1999-05-20 2005-11-08 U & I Pharmaceuticals Ltd. Topical spray compositions
EP1237538A2 (en) * 1999-11-18 2002-09-11 Natco Pharma Limited An improved pharmaceutical composition for treating male erectile dysfunction
WO2002005820A1 (en) 2000-07-19 2002-01-24 Lavipharm Laboratories, Inc. Sildenafil citrate solid dispersions having high water solubility
US20030139384A1 (en) * 2000-08-30 2003-07-24 Dudley Robert E. Method for treating erectile dysfunction and increasing libido in men
US20070087981A1 (en) * 2002-02-08 2007-04-19 Lavipharm Laboratories, Inc. Water Soluble and Palatable Complexes
DK2180844T3 (da) * 2007-08-02 2018-04-23 Insys Dev Co Inc Sublingual fentanylspray
AU2011264941B2 (en) * 2010-06-07 2014-10-16 Suda Ltd Oral spray formulations and methods for administration of sildenafil
WO2012103039A1 (en) 2011-01-24 2012-08-02 Anterios, Inc. Surfactant compositions
WO2013085904A1 (en) 2011-12-05 2013-06-13 Novadel Pharma, Inc. Oral spray formulations and methods for administration of sildenafil
US20140271847A1 (en) * 2013-03-13 2014-09-18 SatisPharma, LLC Formulations and methods for rapid penile erections
JP2016529328A (ja) * 2013-09-10 2016-09-23 インシス・ファーマ・インコーポレーテッド 舌下ブプレノルフィンスプレー
WO2015070049A1 (en) * 2013-11-08 2015-05-14 Insys Pharma, Inc. Sildenafil sublingual spray formulation

Also Published As

Publication number Publication date
CN108367010A (zh) 2018-08-03
US20160287593A1 (en) 2016-10-06
ES2864099T3 (es) 2021-10-13
EP3277283A4 (en) 2018-12-12
EP3277283A1 (en) 2018-02-07
EP3277283B8 (en) 2021-04-28
US9662334B2 (en) 2017-05-30
WO2016161397A1 (en) 2016-10-06
CA2981615A1 (en) 2016-10-06
EP3277283B1 (en) 2021-03-03

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