DK3262168T3 - Værtscelleproteinmodifikation - Google Patents
Værtscelleproteinmodifikation Download PDFInfo
- Publication number
- DK3262168T3 DK3262168T3 DK16710378.7T DK16710378T DK3262168T3 DK 3262168 T3 DK3262168 T3 DK 3262168T3 DK 16710378 T DK16710378 T DK 16710378T DK 3262168 T3 DK3262168 T3 DK 3262168T3
- Authority
- DK
- Denmark
- Prior art keywords
- host cell
- cell protein
- protein modification
- modification
- host
- Prior art date
Links
- 230000009145 protein modification Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562126213P | 2015-02-27 | 2015-02-27 | |
| US201662298869P | 2016-02-23 | 2016-02-23 | |
| PCT/US2016/019915 WO2016138467A1 (en) | 2015-02-27 | 2016-02-26 | Host cell protein modification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3262168T3 true DK3262168T3 (da) | 2019-10-07 |
Family
ID=55538620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16710378.7T DK3262168T3 (da) | 2015-02-27 | 2016-02-26 | Værtscelleproteinmodifikation |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20160251411A1 (da) |
| EP (1) | EP3262168B1 (da) |
| JP (1) | JP6751402B2 (da) |
| KR (1) | KR20170120126A (da) |
| CN (1) | CN107406831A (da) |
| AU (1) | AU2016224988A1 (da) |
| BR (1) | BR112017018149A2 (da) |
| CA (1) | CA2976669A1 (da) |
| DK (1) | DK3262168T3 (da) |
| EA (1) | EA201791918A1 (da) |
| ES (1) | ES2751670T3 (da) |
| HK (1) | HK1248272A1 (da) |
| HU (1) | HUE045862T2 (da) |
| IL (1) | IL253863A0 (da) |
| MX (1) | MX2017011012A (da) |
| MY (1) | MY180896A (da) |
| SG (1) | SG11201706335TA (da) |
| TW (1) | TW201702380A (da) |
| WO (1) | WO2016138467A1 (da) |
| ZA (1) | ZA201705712B (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3504328A1 (en) * | 2016-08-24 | 2019-07-03 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| CN116327963A (zh) | 2016-11-21 | 2023-06-27 | 济世-伊沃泰克生物制品有限公司 | 一种眼科制剂及其用途 |
| KR102578087B1 (ko) * | 2017-08-17 | 2023-09-18 | 저스트-에보텍 바이오로직스, 아이엔씨. | 숙주세포 갈렉틴(galectins) 및 다른 오염물(contaminant)로부터 글리코실화 단백질을 정제하는 방법 |
| CA3081094A1 (en) | 2017-11-20 | 2019-05-23 | Alison J. GILLESPIE | Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof |
| SG11202009499VA (en) * | 2018-05-04 | 2020-11-27 | Sigma Aldrich Co Llc | Producing recombinant proteins with reduced levels of host cell proteins |
| JP2021521873A (ja) * | 2018-05-04 | 2021-08-30 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニーＳｉｇｍａ−Ａｌｄｒｉｃｈ Ｃｏ． ＬＬＣ | 改変された宿主細胞タンパク質プロファイルを有する操作された細胞 |
| WO2020180850A1 (en) * | 2019-03-05 | 2020-09-10 | Regeneron Pharmaceuticals, Inc. | Human serum albumin in formulations |
| US20210096130A1 (en) * | 2019-09-12 | 2021-04-01 | Lonza Ltd | Compositions, methods, and kits for detection of lipolytic activity |
| CA3154522A1 (en) | 2019-10-15 | 2021-04-22 | Christopher Carl Frye | Recombinantly engineered, lipase/esterase-deficient mammalian cell lines |
| WO2024178239A1 (en) * | 2023-02-22 | 2024-08-29 | Shattuck Labs, Inc. | Engineered cell lines and uses thereof |
| EP4438620A1 (en) | 2023-03-30 | 2024-10-02 | Sartorius Stedim Cellca GmbH | Cho cells with optimized host cell protein profile |
| EP4438622A1 (en) | 2023-03-30 | 2024-10-02 | Sartorius Stedim Cellca GmbH | Cho cells with optimized ecm profile |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69734936T2 (de) * | 1996-09-19 | 2006-08-24 | Novozymes A/S | Wirtszellen und methoden für die produktion von proteinen |
| PL2150617T3 (pl) | 2007-06-04 | 2015-04-30 | Regeneron Pharma | Wzmocniona ekspresja i regiony stabilności |
| GB201000587D0 (en) * | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| SG10201606218WA (en) * | 2011-07-29 | 2016-09-29 | Eleven Biotherapeutics Inc | Purified Proteins |
| US8697359B1 (en) * | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| AR097651A1 (es) | 2013-09-13 | 2016-04-06 | Genentech Inc | Métodos y composiciones que comprenden polipéptidos recombinantes purificados |
| JP6546178B2 (ja) * | 2013-09-13 | 2019-07-17 | ジェネンテック， インコーポレイテッド | 細胞株中の宿主細胞タンパク質及び組換えポリペプチド産物を検出及び定量化するための組成物並びに方法 |
| US9932591B2 (en) * | 2013-12-18 | 2018-04-03 | University Of Delaware | Reduction of lipase activity in product formulations |
-
2016
- 2016-02-25 TW TW105105690A patent/TW201702380A/zh unknown
- 2016-02-26 HK HK18107524.0A patent/HK1248272A1/zh unknown
- 2016-02-26 MX MX2017011012A patent/MX2017011012A/es unknown
- 2016-02-26 SG SG11201706335TA patent/SG11201706335TA/en unknown
- 2016-02-26 CA CA2976669A patent/CA2976669A1/en not_active Abandoned
- 2016-02-26 CN CN201680012054.7A patent/CN107406831A/zh active Pending
- 2016-02-26 ES ES16710378T patent/ES2751670T3/es active Active
- 2016-02-26 WO PCT/US2016/019915 patent/WO2016138467A1/en not_active Ceased
- 2016-02-26 AU AU2016224988A patent/AU2016224988A1/en not_active Abandoned
- 2016-02-26 JP JP2017545231A patent/JP6751402B2/ja not_active Expired - Fee Related
- 2016-02-26 KR KR1020177025651A patent/KR20170120126A/ko not_active Withdrawn
- 2016-02-26 HU HUE16710378A patent/HUE045862T2/hu unknown
- 2016-02-26 US US15/055,034 patent/US20160251411A1/en not_active Abandoned
- 2016-02-26 EP EP16710378.7A patent/EP3262168B1/en not_active Revoked
- 2016-02-26 EA EA201791918A patent/EA201791918A1/ru unknown
- 2016-02-26 DK DK16710378.7T patent/DK3262168T3/da active
- 2016-02-26 BR BR112017018149A patent/BR112017018149A2/pt not_active Application Discontinuation
- 2016-02-26 MY MYPI2017702862A patent/MY180896A/en unknown
-
2017
- 2017-08-07 IL IL253863A patent/IL253863A0/en unknown
- 2017-08-22 ZA ZA2017/05712A patent/ZA201705712B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE045862T2 (hu) | 2020-01-28 |
| WO2016138467A1 (en) | 2016-09-01 |
| TW201702380A (zh) | 2017-01-16 |
| HK1248272A1 (zh) | 2018-10-12 |
| BR112017018149A2 (pt) | 2018-04-10 |
| AU2016224988A1 (en) | 2017-09-07 |
| ES2751670T3 (es) | 2020-04-01 |
| US20160251411A1 (en) | 2016-09-01 |
| ZA201705712B (en) | 2020-01-29 |
| CA2976669A1 (en) | 2016-09-01 |
| JP2018506295A (ja) | 2018-03-08 |
| IL253863A0 (en) | 2017-09-28 |
| JP6751402B2 (ja) | 2020-09-02 |
| EA201791918A1 (ru) | 2017-12-29 |
| SG11201706335TA (en) | 2017-09-28 |
| MY180896A (en) | 2020-12-11 |
| EP3262168B1 (en) | 2019-08-21 |
| MX2017011012A (es) | 2017-10-20 |
| EP3262168A1 (en) | 2018-01-03 |
| CN107406831A (zh) | 2017-11-28 |
| KR20170120126A (ko) | 2017-10-30 |
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