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DK3129366T3 - Carbazol-indeholdende amider, carbamater og urinstoffer som kryptokrommodulatorer - Google Patents

Carbazol-indeholdende amider, carbamater og urinstoffer som kryptokrommodulatorer Download PDF

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Publication number
DK3129366T3
DK3129366T3 DK15719041.4T DK15719041T DK3129366T3 DK 3129366 T3 DK3129366 T3 DK 3129366T3 DK 15719041 T DK15719041 T DK 15719041T DK 3129366 T3 DK3129366 T3 DK 3129366T3
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Prior art keywords
carbamates
carbazole
containing amides
cryptochrome
modulators
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Application number
DK15719041.4T
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English (en)
Inventor
Ross Bersot
Paul Humphries
Original Assignee
Synchronicity Pharma Inc
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Publication of DK3129366T3 publication Critical patent/DK3129366T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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DK15719041.4T 2014-04-07 2015-04-06 Carbazol-indeholdende amider, carbamater og urinstoffer som kryptokrommodulatorer DK3129366T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461976350P 2014-04-07 2014-04-07
PCT/US2015/024537 WO2015157182A1 (en) 2014-04-07 2015-04-06 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators

Publications (1)

Publication Number Publication Date
DK3129366T3 true DK3129366T3 (da) 2021-09-13

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DK15719041.4T DK3129366T3 (da) 2014-04-07 2015-04-06 Carbazol-indeholdende amider, carbamater og urinstoffer som kryptokrommodulatorer

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US (6) US10005759B2 (da)
EP (2) EP3129366B1 (da)
JP (4) JP6601916B2 (da)
KR (1) KR102224423B1 (da)
CN (2) CN106458891B (da)
AR (1) AR099970A1 (da)
AU (1) AU2015244060B2 (da)
CA (1) CA2944074C (da)
DK (1) DK3129366T3 (da)
ES (1) ES2886469T3 (da)
HR (1) HRP20211372T1 (da)
HU (1) HUE055547T2 (da)
IL (1) IL248240B (da)
LT (1) LT3129366T (da)
MX (1) MX371096B (da)
NZ (1) NZ724683A (da)
PL (1) PL3129366T3 (da)
RU (1) RU2705094C2 (da)
SG (1) SG11201608020YA (da)
SI (1) SI3129366T1 (da)
TW (1) TWI690521B (da)
WO (1) WO2015157182A1 (da)

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TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
US20190300875A1 (en) * 2016-07-11 2019-10-03 The Regents Of The University Of California Bic inhibitor of cry-cry and cry-cib oligomerization/clustering
US10906905B2 (en) 2016-10-14 2021-02-02 Jiangsu Hengrui Medicine Co., Ltd. Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof
JP6835308B2 (ja) * 2016-10-19 2021-02-24 国立研究開発法人理化学研究所 クリプトクロムの機能を抑制するための組成物
WO2018132383A1 (en) * 2017-01-10 2018-07-19 The Regents Of The University Of California Cry1-clock-bmal1 complex-disrupting agents and methods of identifying and using same
WO2018175443A1 (en) * 2017-03-20 2018-09-27 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Targeted gene therapies for pain and other neuro-related disorders
IL277518B2 (en) * 2018-03-22 2024-01-01 Aurigene Oncology Ltd Substituted imidazolidin-2-one derivatives as prmt5 inhibitors
WO2019246102A1 (en) * 2018-06-18 2019-12-26 Duke University Compositions and methods for treating nafld/nash and related disease phenotypes
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2020115555A2 (en) 2018-12-07 2020-06-11 Neurocrine Biosciences, Inc. Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia
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