DK3198243T3 - Imaging flow cytometer using spatial-temporal transformation - Google Patents
Imaging flow cytometer using spatial-temporal transformation Download PDFInfo
- Publication number
- DK3198243T3 DK3198243T3 DK15847776.0T DK15847776T DK3198243T3 DK 3198243 T3 DK3198243 T3 DK 3198243T3 DK 15847776 T DK15847776 T DK 15847776T DK 3198243 T3 DK3198243 T3 DK 3198243T3
- Authority
- DK
- Denmark
- Prior art keywords
- spatial
- flow cytometer
- imaging flow
- temporal transformation
- temporal
- Prior art date
Links
- 238000003384 imaging method Methods 0.000 title 1
- 230000009466 transformation Effects 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
- G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F17/00—Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/144—Imaging characterised by its optical setup
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/1447—Spatial selection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/1447—Spatial selection
- G01N2015/145—Spatial selection by pattern of light, e.g. fringe pattern
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06113—Coherent sources; lasers
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462057799P | 2014-09-30 | 2014-09-30 | |
| PCT/US2015/053368 WO2016054293A1 (en) | 2014-09-30 | 2015-09-30 | Imaging flow cytometer using spatial-temporal transformation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3198243T3 true DK3198243T3 (da) | 2020-10-19 |
Family
ID=55631472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15847776.0T DK3198243T3 (da) | 2014-09-30 | 2015-09-30 | Imaging flow cytometer using spatial-temporal transformation |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10267736B2 (da) |
| EP (1) | EP3198243B1 (da) |
| CN (1) | CN107209041B (da) |
| DK (1) | DK3198243T3 (da) |
| ES (1) | ES2827022T3 (da) |
| WO (1) | WO2016054293A1 (da) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105008895B (zh) | 2012-10-15 | 2019-02-15 | 纳诺赛莱克特生物医药股份有限公司 | 颗粒分选的系统、设备和方法 |
| JP6338597B2 (ja) | 2013-01-09 | 2018-06-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | 無線周波数多重励起を用いた蛍光イメージングのための装置及び方法 |
| ES2959506T3 (es) | 2014-03-18 | 2024-02-26 | Univ California | Citómetro de flujo paralelo que usa multiplexación por radiofrecuencia, y método |
| US10267736B2 (en) | 2014-09-30 | 2019-04-23 | The Regents Of The University Of California | Imaging flow cytometer using spatial-temporal transformation |
| CA2977481C (en) | 2015-02-24 | 2021-02-02 | The University Of Tokyo | Dynamic high-speed high-sensitivity imaging device and imaging method |
| JP6856635B2 (ja) | 2015-10-13 | 2021-04-07 | オメガ バイオシステムズ インコーポレイテッド | マルチモードの蛍光撮像フローサイトメトリシステム |
| EP3372985B1 (en) | 2015-10-28 | 2025-06-25 | The University Of Tokyo | Analysis device |
| AU2017234815B2 (en) * | 2016-03-17 | 2022-11-03 | Becton, Dickinson And Company | Cell sorting using a high throughput fluorescence flow cytometer |
| US10337975B2 (en) * | 2016-05-06 | 2019-07-02 | Deutsches Rheuma-Forschungszentrum Berlin | Method and system for characterizing particles using a flow cytometer |
| KR102381176B1 (ko) * | 2016-05-12 | 2022-04-01 | 비디 바이오사이언시스 | 개선된 이미지 해상도를 갖는 형광 이미징 유세포 분석법 |
| WO2017201495A1 (en) * | 2016-05-19 | 2017-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for automated single cell cytological classification in flow |
| CN109863384B (zh) * | 2016-06-10 | 2022-10-28 | 加利福尼亚大学董事会 | 基于图像的细胞分选系统和方法 |
| US10006852B2 (en) | 2016-09-13 | 2018-06-26 | Becton, Dickinson And Company | Flow cytometer with optical equalization |
| DE102017201252A1 (de) * | 2017-01-26 | 2018-07-26 | Universität Ulm | Verfahren und Vorrichtung zur Untersuchung von Zellen |
| KR102807611B1 (ko) * | 2017-11-10 | 2025-05-14 | 싸토리우스 바이오애널리티컬 인스트루먼츠, 아이엔씨 | 생세포 시각화 및 분석 |
| EP3752815A4 (en) * | 2018-02-16 | 2021-11-03 | The Regents of The University of California | SYSTEMS, DEVICES AND METHODS FOR THREE-DIMENSIONAL IMAGING OF MOVING PARTICLES |
| WO2019241443A1 (en) * | 2018-06-13 | 2019-12-19 | Thinkcyte Inc. | Methods and systems for cytometry |
| US11815507B2 (en) | 2018-08-15 | 2023-11-14 | Deepcell, Inc. | Systems and methods for particle analysis |
| US10611995B2 (en) | 2018-08-15 | 2020-04-07 | Deepcell, Inc. | Systems and methods for particle analysis |
| EP3850080B1 (en) * | 2018-09-14 | 2025-11-05 | The Regents of the University of California | Cell sorting device and method |
| DE102018131059A1 (de) * | 2018-12-05 | 2020-06-10 | SIKA Dr. Siebert & Kühn GmbH & Co. KG | Strömungsmessverfahren und Strömungsmessvorrichtung zur optischen Strömungsmessung |
| US11284786B2 (en) * | 2019-03-07 | 2022-03-29 | ZSquare Ltd. | Spatial encoding system decoding system imaging system and methods thereof |
| CN119845832A (zh) * | 2019-03-22 | 2025-04-18 | 贝克顿·迪金森公司 | 使用射频多路复用激发数据对荧光成像进行光谱解混 |
| EP3953655A4 (en) | 2019-07-02 | 2023-01-11 | Brentwood Industries, Inc. | Cooling tower splash bar hanger and related assembly |
| WO2021003369A1 (en) * | 2019-07-02 | 2021-01-07 | The Regents Of The University Of California | Magnetically modulated computational cytometer and methods of use |
| EP3997439A4 (en) | 2019-07-10 | 2023-07-19 | Becton, Dickinson and Company | RECONFIGURABLE INTEGRATED CIRCUITS TO ADJUST CELL SORTING CLASSIFICATION |
| CN114829626A (zh) | 2019-10-10 | 2022-07-29 | 1859公司 | 用于微流体筛选的方法和系统 |
| US11125675B2 (en) | 2019-10-18 | 2021-09-21 | Roger Lawrence Deran | Fluid suspended particle classifier |
| CN114556210A (zh) * | 2019-11-04 | 2022-05-27 | 美商新思科技有限公司 | 在校正光刻掩模中使用掩模制造模型 |
| EP4083603A4 (en) | 2019-12-27 | 2024-04-03 | ThinkCyte, Inc. | FLOW CYTOMETER PERFORMANCE EVALUATION METHODS AND STANDARD PARTICLE SUSPENSION |
| US11592386B2 (en) | 2020-02-26 | 2023-02-28 | Becton, Dickinson And Company | Light detection systems having a secondary light scatter detector and methods for using same |
| WO2021200911A1 (ja) * | 2020-04-01 | 2021-10-07 | シンクサイト株式会社 | フローサイトメーター |
| WO2021200960A1 (ja) | 2020-04-01 | 2021-10-07 | シンクサイト株式会社 | 観察装置 |
| US11513058B2 (en) | 2020-05-19 | 2022-11-29 | Becton, Dickinson And Company | Methods for modulating an intensity profile of a laser beam and systems for same |
| EP4610627A1 (en) | 2020-06-26 | 2025-09-03 | Becton Dickinson and Company | Dual excitation beams for irradiating a sample in a flow stream and methods for using same |
| US20230363707A1 (en) * | 2020-09-25 | 2023-11-16 | The Regents Of The University Of California | Devices and related methods for physiological examination |
| US12066368B2 (en) * | 2020-10-15 | 2024-08-20 | Robert R. Alfano | Compact optical virus detection analyzer of nano- and micro-size bio particles using light scattering and fluorescence |
| WO2022080492A1 (ja) * | 2020-10-15 | 2022-04-21 | シンクサイト株式会社 | フローサイトメータ、セルソータ、光学情報生成方法、及びプログラム |
| JPWO2023053679A1 (da) * | 2021-09-30 | 2023-04-06 | ||
| CN114067315B (zh) * | 2021-10-23 | 2022-11-29 | 广州市艾贝泰生物科技有限公司 | 细胞计数方法、装置、计算机设备和存储介质 |
| US20240167957A1 (en) * | 2022-11-23 | 2024-05-23 | Bionano Genomics, Inc. | Top Hat Illumination Biological Sample Imaging Devices, and Methods of Using the Same |
| EP4639286A1 (en) * | 2022-12-24 | 2025-10-29 | Celloptic, Inc. | System, apparatus, and method for improved imaging and holography |
| CN116673079A (zh) * | 2023-06-06 | 2023-09-01 | 武汉大学 | 一种三维聚焦的高通量微流控芯片及其应用和制作方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU712853B2 (en) * | 1995-12-27 | 1999-11-18 | Ken Ishihara | Noninvasive blood analyzer |
| US6778263B2 (en) * | 2000-08-25 | 2004-08-17 | Amnis Corporation | Methods of calibrating an imaging system using calibration beads |
| US6741730B2 (en) * | 2001-08-10 | 2004-05-25 | Visiongate, Inc. | Method and apparatus for three-dimensional imaging in the fourier domain |
| EP2085797B1 (en) * | 2008-01-30 | 2016-06-01 | Palo Alto Research Center Incorporated | Producing Filters with Combined Transmission and/or Reflection Functions |
| CN101278829A (zh) * | 2008-05-26 | 2008-10-08 | 上海理工大学 | 便携式在体流式细胞仪 |
| EP2300800A2 (en) | 2008-06-12 | 2011-03-30 | East Carolina University | Flow cytometer apparatus for three dimensional diffraction imaging and related methods |
| US9645010B2 (en) * | 2009-03-10 | 2017-05-09 | The Regents Of The University Of California | Fluidic flow cytometry devices and methods |
| US9134221B2 (en) * | 2009-03-10 | 2015-09-15 | The Regents Of The University Of California | Fluidic flow cytometry devices and particle sensing based on signal-encoding |
| JP2012521540A (ja) * | 2009-03-20 | 2012-09-13 | バイオ−ラド ラボラトリーズ インコーポレイテッド | 順次ライン走査符号化多色蛍光顕微鏡法および画像フローサイトメトリ |
| US20110001963A1 (en) * | 2009-07-02 | 2011-01-06 | Durack Gary P | System and method for the measurement of multiple emissions from multiple parallel flow channels in a flow cytometry system |
| EP2606127B1 (en) | 2010-08-16 | 2019-03-20 | Salk Institute For Biological Studies | Adenoviral assembly method |
| US9074978B2 (en) * | 2011-07-12 | 2015-07-07 | The Regents Of The University Of California | Optical space-time coding technique in microfluidic devices |
| CA2842681C (en) * | 2011-07-21 | 2020-08-04 | Invitrox, Inc. | Instrument and method for optical particle sensing |
| US10267736B2 (en) | 2014-09-30 | 2019-04-23 | The Regents Of The University Of California | Imaging flow cytometer using spatial-temporal transformation |
-
2015
- 2015-09-30 US US15/514,930 patent/US10267736B2/en active Active
- 2015-09-30 DK DK15847776.0T patent/DK3198243T3/da active
- 2015-09-30 ES ES15847776T patent/ES2827022T3/es active Active
- 2015-09-30 EP EP15847776.0A patent/EP3198243B1/en active Active
- 2015-09-30 WO PCT/US2015/053368 patent/WO2016054293A1/en not_active Ceased
- 2015-09-30 CN CN201580064914.7A patent/CN107209041B/zh active Active
-
2019
- 2019-03-27 US US16/367,071 patent/US10788425B2/en active Active
-
2020
- 2020-09-28 US US17/035,505 patent/US11774362B2/en active Active
-
2023
- 2023-08-24 US US18/455,148 patent/US12152992B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11774362B2 (en) | 2023-10-03 |
| ES2827022T3 (es) | 2021-05-19 |
| EP3198243B1 (en) | 2020-07-22 |
| EP3198243A4 (en) | 2018-07-18 |
| CN107209041B (zh) | 2019-11-05 |
| US20210181113A1 (en) | 2021-06-17 |
| WO2016054293A1 (en) | 2016-04-07 |
| US20190219509A1 (en) | 2019-07-18 |
| US20240094129A1 (en) | 2024-03-21 |
| US20170227466A1 (en) | 2017-08-10 |
| CN107209041A (zh) | 2017-09-26 |
| US10267736B2 (en) | 2019-04-23 |
| US10788425B2 (en) | 2020-09-29 |
| US12152992B2 (en) | 2024-11-26 |
| EP3198243A1 (en) | 2017-08-02 |
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