DK3153508T3 - Naphthofuranderivater til anvendelse som anticancermidler - Google Patents
Naphthofuranderivater til anvendelse som anticancermidler Download PDFInfo
- Publication number
- DK3153508T3 DK3153508T3 DK15807132.4T DK15807132T DK3153508T3 DK 3153508 T3 DK3153508 T3 DK 3153508T3 DK 15807132 T DK15807132 T DK 15807132T DK 3153508 T3 DK3153508 T3 DK 3153508T3
- Authority
- DK
- Denmark
- Prior art keywords
- naphthofurand
- derivatives
- anticancer agents
- anticancer
- agents
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014119113 | 2014-06-09 | ||
| JP2015021492 | 2015-02-05 | ||
| PCT/JP2015/066625 WO2015190489A1 (ja) | 2014-06-09 | 2015-06-09 | 新規抗癌剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3153508T3 true DK3153508T3 (da) | 2020-05-18 |
Family
ID=54833579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15807132.4T DK3153508T3 (da) | 2014-06-09 | 2015-06-09 | Naphthofuranderivater til anvendelse som anticancermidler |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10005752B2 (da) |
| EP (1) | EP3153508B1 (da) |
| JP (3) | JP6549115B2 (da) |
| AU (1) | AU2015272560B2 (da) |
| CA (1) | CA2951627A1 (da) |
| DK (1) | DK3153508T3 (da) |
| ES (1) | ES2792851T3 (da) |
| WO (1) | WO2015190489A1 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6433085B2 (ja) | 2013-04-09 | 2018-12-05 | ボストン バイオメディカル, インコーポレイテッド | がんの処置に使用するための2−アセチルナフト[2,3−b]フラン−4,9−ジオン |
| WO2015190489A1 (ja) | 2014-06-09 | 2015-12-17 | 京都薬品工業株式会社 | 新規抗癌剤 |
| EA201792623A1 (ru) * | 2015-06-03 | 2018-04-30 | Бостон Биомедикал, Инк. | Композиции, содержащие ингибитор стволовости рака и иммунотерапевтический агент, для применения в лечении рака |
| US11299469B2 (en) | 2016-11-29 | 2022-04-12 | Sumitomo Dainippon Pharma Oncology, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| EP3592730B1 (en) | 2017-03-09 | 2021-08-04 | Truly Translational Sweden AB | Prodrugs of sulfasalazine, pharmaceutical compositions thereof and their use in the treatment of autoimmune disease |
| WO2018213424A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
| CN109206390B (zh) * | 2017-07-06 | 2021-04-27 | 北京大学 | 基于呋喃萘醌的亚砜亚胺衍生物及其在制造stat3抑制剂中的用途 |
| CN110818662A (zh) * | 2019-12-11 | 2020-02-21 | 肇庆市万维新材料科技有限公司 | 一种那布卡辛的合成方法 |
| CN110818663A (zh) * | 2019-12-12 | 2020-02-21 | 肇庆市万维新材料科技有限公司 | 一种那布卡辛同系物的合成方法 |
| CN113214201B (zh) * | 2021-03-22 | 2023-08-15 | 毕庶壮 | 一类Napabucasin的衍生物及其药物用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE027443T2 (en) | 2007-09-10 | 2016-10-28 | Boston Biomedical Inc | A novel class of Stat3 pathway inhibitors and tumor stem cell inhibitors |
| EP2419398A4 (en) | 2009-04-14 | 2012-11-28 | Infiniton Ab | PRO-BET WITH BETA-KETO-CARBOXYLIC ACID, BETA-KETO-CARBOXYLIC ACID SALT OR BETA-KETO-CARBOXYLIC ACID ESTERS FOR ACTIVE INHIBITION |
| CN103002890A (zh) | 2010-03-19 | 2013-03-27 | 波士顿生物医学公司 | 靶向癌症干细胞的新的化合物和组合物 |
| CN103025159A (zh) * | 2010-03-19 | 2013-04-03 | 波士顿生物医学公司 | 靶向癌症干细胞的新方法 |
| EP2681203A4 (en) * | 2011-03-04 | 2014-07-30 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co Ltd | NOVEL 4,9-DIHYDROXY-NAPHTO [2,3-B] FURANS ESTERS FOR THERAPEUTIC TREATMENT OF DISEASES |
| CN104080449A (zh) | 2012-02-17 | 2014-10-01 | 舟山海中洲新生药业有限公司 | 4,9-二羟基-萘并[2,3-b]呋喃脂肪酸酯衍生物的纳米颗粒水悬液的制备方法 |
| WO2013166618A1 (en) | 2012-05-08 | 2013-11-14 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. | PRODRUGS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR CIRCUMVENTING CANCER MULTIDRUG RESISTANCE |
| WO2015190489A1 (ja) | 2014-06-09 | 2015-12-17 | 京都薬品工業株式会社 | 新規抗癌剤 |
-
2015
- 2015-06-09 WO PCT/JP2015/066625 patent/WO2015190489A1/ja not_active Ceased
- 2015-06-09 ES ES15807132T patent/ES2792851T3/es active Active
- 2015-06-09 JP JP2016527829A patent/JP6549115B2/ja not_active Expired - Fee Related
- 2015-06-09 DK DK15807132.4T patent/DK3153508T3/da active
- 2015-06-09 EP EP15807132.4A patent/EP3153508B1/en active Active
- 2015-06-09 US US15/317,471 patent/US10005752B2/en active Active
- 2015-06-09 AU AU2015272560A patent/AU2015272560B2/en not_active Ceased
- 2015-06-09 CA CA2951627A patent/CA2951627A1/en not_active Abandoned
-
2018
- 2018-05-23 US US15/987,525 patent/US10377730B2/en not_active Expired - Fee Related
-
2019
- 2019-06-26 JP JP2019117983A patent/JP6963262B2/ja not_active Expired - Fee Related
- 2019-06-27 US US16/455,707 patent/US10689355B2/en not_active Expired - Fee Related
-
2020
- 2020-06-22 US US16/907,463 patent/US11267797B2/en active Active
-
2021
- 2021-10-06 JP JP2021164700A patent/JP2022008894A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015272560B2 (en) | 2019-02-14 |
| JPWO2015190489A1 (ja) | 2017-05-25 |
| US20170121299A1 (en) | 2017-05-04 |
| EP3153508A4 (en) | 2017-11-15 |
| US20190322636A1 (en) | 2019-10-24 |
| WO2015190489A1 (ja) | 2015-12-17 |
| JP2019206529A (ja) | 2019-12-05 |
| EP3153508A1 (en) | 2017-04-12 |
| AU2015272560A1 (en) | 2017-02-02 |
| JP6963262B2 (ja) | 2021-11-05 |
| US10689355B2 (en) | 2020-06-23 |
| JP6549115B2 (ja) | 2019-07-24 |
| US10377730B2 (en) | 2019-08-13 |
| JP2022008894A (ja) | 2022-01-14 |
| US20180265489A1 (en) | 2018-09-20 |
| US11267797B2 (en) | 2022-03-08 |
| ES2792851T3 (es) | 2020-11-12 |
| EP3153508B1 (en) | 2020-03-18 |
| CA2951627A1 (en) | 2015-12-17 |
| US10005752B2 (en) | 2018-06-26 |
| US20200317630A1 (en) | 2020-10-08 |
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