DK3149001T3 - Hidtil ukendte pyrazolopyrimidinderivater og deres anvendelse som MALT1-hæmmere - Google Patents

Hidtil ukendte pyrazolopyrimidinderivater og deres anvendelse som MALT1-hæmmere Download PDF

Info

Publication number: DK3149001T3
Authority: DK; Denmark
Prior art keywords: pyrazolopyrimidine derivatives; malt1 inhibitors; new; new pyrazolopyrimidine; malt1
Prior art date: 2014-05-28

Application number

DK15733899.7T

Other languages

English (en)

Inventor

Soldermann Carole Pissot

Jean Quancard

Achim Schlapbach

Oliver Simic

Marina Tintelnot-Blomley

Thomas Zoller

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-05-28

Filing date

2015-05-27

Publication date

2019-07-22

2015-05-27 Application filed by Novartis Ag filed Critical Novartis Ag

2019-07-22 Application granted granted Critical

2019-07-22 Publication of DK3149001T3 publication Critical patent/DK3149001T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK15733899.7T 2014-05-28 2015-05-27 Hidtil ukendte pyrazolopyrimidinderivater og deres anvendelse som MALT1-hæmmere DK3149001T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP14170408		2014-05-28
PCT/IB2015/053975 WO2015181747A1 (en)	2014-05-28	2015-05-27	Novel pyrazolo pyrimidine derivatives and their use as malt1 inhibitors

Publications (1)

Publication Number	Publication Date
DK3149001T3 true DK3149001T3 (da)	2019-07-22

Family

ID=50828759

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK15733899.7T DK3149001T3 (da)	2014-05-28	2015-05-27	Hidtil ukendte pyrazolopyrimidinderivater og deres anvendelse som MALT1-hæmmere

Country Status (36)

Country	Link
US (2)	US9815842B2 (da)
EP (1)	EP3149001B1 (da)
JP (1)	JP6545197B2 (da)
KR (1)	KR20170007311A (da)
CN (1)	CN106170489B (da)
AP (1)	AP2016009487A0 (da)
AR (1)	AR100645A1 (da)
AU (1)	AU2015265478B2 (da)
BR (1)	BR112016024545A2 (da)
CA (1)	CA2945077A1 (da)
CL (1)	CL2016002942A1 (da)
CR (1)	CR20160548A (da)
CU (1)	CU24393B1 (da)
CY (1)	CY1121946T1 (da)
DK (1)	DK3149001T3 (da)
EA (1)	EA032050B1 (da)
ES (1)	ES2738695T3 (da)
GT (1)	GT201600249A (da)
HR (1)	HRP20191261T1 (da)
HU (1)	HUE044351T2 (da)
IL (1)	IL247949A0 (da)
LT (1)	LT3149001T (da)
MX (1)	MX373846B (da)
MY (1)	MY182487A (da)
PE (1)	PE20170189A1 (da)
PH (1)	PH12016501862B1 (da)
PL (1)	PL3149001T3 (da)
PT (1)	PT3149001T (da)
RS (1)	RS59039B1 (da)
SG (1)	SG11201607895PA (da)
SI (1)	SI3149001T1 (da)
SV (1)	SV2016005328A (da)
TR (1)	TR201910730T4 (da)
TW (1)	TWI709561B (da)
UY (1)	UY36143A (da)
WO (1)	WO2015181747A1 (da)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ604040A (en)	2010-06-03	2015-02-27	Pharmacyclics Inc	The use of inhibitors of bruton’s tyrosine kinase (btk)
KR20150032340A (ko)	2012-07-24	2015-03-25	파마시클릭스, 인코포레이티드	브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
JP6989505B2 (ja)	2015-08-28	2022-01-05	コーネルユニヴァーシティー	Ｍａｌｔ１阻害剤およびその使用
US20200289514A1 (en) *	2015-11-13	2020-09-17	Novartis Ag	Novel Pyrazolo Pyrimidine Derivatives
TWI726969B (zh)	2016-01-11	2021-05-11	比利時商健生藥品公司	用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CN107296807B (zh) *	2016-04-15	2020-03-20	中国科学院上海生命科学研究院	Malt1靶向抑制物在制备malt1依赖性肿瘤治疗药物中的应用
WO2018019755A1 (en)	2016-07-26	2018-02-01	Basf Se	Herbicidal pyridine compounds
WO2018019721A1 (en)	2016-07-26	2018-02-01	Basf Se	Herbicidal pyridine compounds
EP3490995A1 (en)	2016-07-29	2019-06-05	Lupin Limited	Substituted thiazolo-pyridine compounds as malt1 inhibitors
CA3030949A1 (en)	2016-07-29	2018-02-01	Toray Industries, Inc.	Guanidine derivative and medical use thereof
KR20190033607A (ko) *	2016-07-29	2019-03-29	루핀 리미티드	Malt1 저해제로서의 치환 티아졸로-피리딘 화합물
US10689366B2 (en)	2016-11-01	2020-06-23	Cornell University	Compounds for MALT1 degredation
TWI795381B (zh) *	2016-12-21	2023-03-11	比利時商健生藥品公司	作為ｍａｌｔ１抑制劑之吡唑衍生物
EP3564228A4 (en)	2016-12-27	2020-08-12	Kao Corporation	1,3-DIOXANE-5-ONES MANUFACTURING PROCESS
WO2018124149A1 (ja)	2016-12-27	2018-07-05	花王株式会社	グリセリン酸エステルの製造方法
CN109641866B (zh) *	2016-12-27	2022-02-25	花王株式会社	甘油酸酯的制造方法
US20200009135A1 (en)	2017-02-01	2020-01-09	Medivir Ab	Therapeutic applications of malt1 inhibitors
WO2018159650A1 (ja) *	2017-02-28	2018-09-07	東レ株式会社	グアニジン誘導体及びその医薬用途
WO2018165385A1 (en)	2017-03-08	2018-09-13	Cornell University	Inhibitors of malt1 and uses thereof
WO2018226150A1 (en) *	2017-06-05	2018-12-13	Medivir Aktiebolag	Pyrazolopyrimidine as malt-1 inhibitors
EP3636636B1 (en)	2017-06-08	2022-07-06	Mitsui Chemicals Agro, Inc.	Pyridone compound and agricultural and horticultural fungicide
EP3710441A1 (en) *	2017-11-17	2020-09-23	Hepagene Therapeutics, Inc.	Urea derivatives as inhibitors of ask1
SG11202006200RA (en)	2017-12-28	2020-07-29	Massachusetts Gen Hospital	Targeting the cbm signalosome complex induces regulatory t cells to inflame the tumor microenvironment
WO2019243964A1 (en)	2018-06-18	2019-12-26	Janssen Pharmaceutica Nv	Pyrazole derivatives as malt1 inhibitors
EA202092962A1 (ru) *	2018-06-18	2021-09-06	Янссен Фармацевтика Нв	Производные пиразола в качестве ингибиторов malt1
MX2021005877A (es)	2018-11-28	2021-07-16	Takeda Pharmaceuticals Co	Compuesto heterociclico.
CN109503473B (zh) *	2019-01-07	2020-07-07	上海慧川生物医药科技有限公司	2-甲氧基-3-氨基-5-吡啶硼酸频哪醇酯及其中间体的合成方法
JOP20210227A1 (ar)	2019-02-22	2023-01-30	Janssen Pharmaceutica Nv	شكل بلوري من مونوهيدرات 1-(1-أوكسو-1، 2-داي هيدروأيزوكينولين-5-يل)-5-(تراي فلوروميثيل)-n-(2-(تراي فلوروميثيل)بيريدين-4-يل)-1h-بيرازول-4-كربوكساميد
BR112021019799A2 (pt)	2019-04-11	2021-12-07	Janssen Pharmaceutica Nv	Derivados contendo anéis de piridina como inibidores de malt1
WO2021000855A1 (en) *	2019-07-01	2021-01-07	Qilu Regor Therapeutics Inc.	Malt1 inhibitors and uses thereof
CN111138437B (zh) *	2019-12-04	2021-03-05	杭州华东医药集团新药研究院有限公司	取代的吡唑并[1,5-a]嘧啶氨基酸衍生物及其用途
WO2021134004A1 (en) *	2019-12-27	2021-07-01	Schrodinger, Inc.	Cyclic compounds and methods of using same
US20230192685A1 (en)	2020-05-27	2023-06-22	Takeda Pharmaceutical Company Limited	Method for producing heterocyclic compound
US20230235077A1 (en)	2020-06-24	2023-07-27	The General Hospital Corporation	Materials and methods of treating cancer
AU2021319420A1 (en)	2020-08-05	2023-03-16	Richter Gedeon Nyrt.	Pharmacologically active heterocyclic-substituted pyrazolo[1,5-a]pyrimidine derivatives
WO2022081967A1 (en)	2020-10-16	2022-04-21	Rheos Medicines, Inc.	Malt1 modulators and uses thereof
CN116710089A (zh) *	2020-11-12	2023-09-05	莫诺泰罗斯疗法公司	治疗癌症的材料和方法
GB202018412D0 (en)	2020-11-23	2021-01-06	Exscientia Ltd	Malt-1 modulators ii
CN114805037B (zh) *	2021-01-29	2025-08-19	河北圣泰材料股份有限公司	1,2-二甲氧基-1,1,2,2-四氟乙烷的合成方法
KR20240130085A (ko)	2021-12-30	2024-08-28	상하이 한서 바이오메디컬 컴퍼니 리미티드	트리시클릭 유도체 억제제, 이의 제조 방법 및 응용
WO2023139479A1 (en) *	2022-01-18	2023-07-27	Aurigene Oncology Limited	Substituted bicyclic heterocycles as malt-1 inhibitors
CN116535424B (zh) *	2022-01-26	2025-04-11	武汉誉祥医药科技有限公司	作为malt1抑制剂的三并环化合物及其药物组合物和应用
TW202340198A (zh) *	2022-01-28	2023-10-16	大陸商上海齊魯製藥研究中心有限公司	靶向ｍａｌｔ１的蛋白降解化合物、包含其的醫藥組合物及其用途
WO2023149450A1 (ja)	2022-02-02	2023-08-10	小野薬品工業株式会社	Ｍａｌｔ１阻害薬を有効成分として含むがん治療剤
WO2023148501A1 (en)	2022-02-03	2023-08-10	C4X Discovery Limited	Heterocyclic derivatives as malt1 inhibitors
WO2024182599A2 (en) *	2023-03-01	2024-09-06	Rarefied Biosciences, Inc.	Compositions and methods for treating malt1 associated diseases

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7517880B2 (en)	1997-12-22	2009-04-14	Bayer Pharmaceuticals Corporation	Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US20020065296A1 (en)	1999-01-13	2002-05-30	Bayer Corporation	Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors
MXPA04007832A (es)	2002-02-11	2005-09-08	Bayer Pharmaceuticals Corp	Aril-ureas con actividad inhibitoria de angiogenesis.
KR20040097375A (ko)	2002-04-23	2004-11-17	시오노기 앤드 컴파니, 리미티드	피라졸로[1, 5-에이]피리미딘 유도체 및 이를 함유한엔에이디(피)에이취 산화효소 저해제
CA2487211C (en)	2002-06-04	2010-09-14	Neogenesis Pharmaceuticals, Inc.	Pyrazolo(1,5a) pyrimidine compounds as antiviral agents
CN1694705A (zh) *	2002-09-04	2005-11-09	先灵公司	用作依赖细胞周期蛋白激酶抑制剂的吡唑并嘧啶
CA2514733A1 (en)	2003-02-28	2004-09-16	Transform Pharmaceuticals, Inc.	Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
EP2397478A1 (en) *	2005-01-14	2011-12-21	CGI Pharmaceuticals, Inc.	1,3-diaryl substituted ureas as modulators of kinase activity.
EP2102211A2 (en) *	2006-11-20	2009-09-23	Alantos Pharmaceuticals Holding, Inc.	Heterobicyclic metalloprotease inhibitors
US8309523B2 (en)	2007-11-21	2012-11-13	Vib Vzw	Inhibitors of MALT1 proteolytic activity and uses thereof
GB0821307D0 (en)	2008-11-21	2008-12-31	Summit Corp Plc	Compounds for treatment of duchenne muscular dystrophy
AR077468A1 (es)	2009-07-09	2011-08-31	Array Biopharma Inc	Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
JP5802676B2 (ja) *	2009-12-04	2015-10-28	センワバイオサイエンシズインコーポレイテッド	Ｃｋ２阻害剤としてのピラゾロピリミジンおよび関連複素環化合物
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2465928A1 (en)	2010-12-16	2012-06-20	Academisch Medisch Centrum bij de Universiteit van Amsterdam	Treatment of Th17-mediated diseases
WO2013028263A1 (en) *	2011-08-24	2013-02-28	Glaxosmithkline Llc	Pyrazolopyrimidine derivatives as pi3 kinase inhibitors
CN103570723B (zh) *	2012-07-27	2016-07-13	广西梧州制药（集团）股份有限公司	吡唑并嘧啶衍生物及其制备方法和在药物制备中的用途
WO2014078408A1 (en) *	2012-11-13	2014-05-22	Array Biopharma Inc.	Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
BR112015014752B1 (pt)	2012-12-21	2022-07-05	Plexxikon, Inc	Compostos e seus uso para modulação de cinase
WO2014181287A1 (en)	2013-05-09	2014-11-13	Piramal Enterprises Limited	Heterocyclyl compounds and uses thereof
CN103739550B (zh) *	2014-01-02	2016-06-01	中国药科大学	2,3-二甲基-6-脲-2h-吲唑类化合物及其制备方法与应用

2015
- 2015-05-27 PE PE2016002391A patent/PE20170189A1/es unknown
- 2015-05-27 KR KR1020167032664A patent/KR20170007311A/ko not_active Ceased
- 2015-05-27 DK DK15733899.7T patent/DK3149001T3/da active
- 2015-05-27 CA CA2945077A patent/CA2945077A1/en not_active Abandoned
- 2015-05-27 PT PT15733899T patent/PT3149001T/pt unknown
- 2015-05-27 TR TR2019/10730T patent/TR201910730T4/tr unknown
- 2015-05-27 BR BR112016024545A patent/BR112016024545A2/pt active Search and Examination
- 2015-05-27 HU HUE15733899 patent/HUE044351T2/hu unknown
- 2015-05-27 RS RS20190905A patent/RS59039B1/sr unknown
- 2015-05-27 CU CU2016000181A patent/CU24393B1/es unknown
- 2015-05-27 JP JP2016569068A patent/JP6545197B2/ja not_active Expired - Fee Related
- 2015-05-27 EP EP15733899.7A patent/EP3149001B1/en active Active
- 2015-05-27 ES ES15733899T patent/ES2738695T3/es active Active
- 2015-05-27 LT LTEP15733899.7T patent/LT3149001T/lt unknown
- 2015-05-27 SI SI201530825T patent/SI3149001T1/sl unknown
- 2015-05-27 US US15/312,321 patent/US9815842B2/en not_active Expired - Fee Related
- 2015-05-27 EA EA201692105A patent/EA032050B1/ru not_active IP Right Cessation
- 2015-05-27 AP AP2016009487A patent/AP2016009487A0/en unknown
- 2015-05-27 HR HRP20191261TT patent/HRP20191261T1/hr unknown
- 2015-05-27 AU AU2015265478A patent/AU2015265478B2/en not_active Ceased
- 2015-05-27 TW TW104117061A patent/TWI709561B/zh not_active IP Right Cessation
- 2015-05-27 MY MYPI2016703450A patent/MY182487A/en unknown
- 2015-05-27 MX MX2016015544A patent/MX373846B/es active IP Right Grant
- 2015-05-27 PL PL15733899T patent/PL3149001T3/pl unknown
- 2015-05-27 CR CR20160548A patent/CR20160548A/es unknown
- 2015-05-27 SG SG11201607895PA patent/SG11201607895PA/en unknown
- 2015-05-27 WO PCT/IB2015/053975 patent/WO2015181747A1/en not_active Ceased
- 2015-05-27 CN CN201580020935.9A patent/CN106170489B/zh not_active Expired - Fee Related
- 2015-05-28 UY UY0001036143A patent/UY36143A/es not_active Application Discontinuation
- 2015-05-28 AR ARP150101686A patent/AR100645A1/es unknown
2016
- 2016-09-21 IL IL247949A patent/IL247949A0/en unknown
- 2016-09-22 PH PH12016501862A patent/PH12016501862B1/en unknown
- 2016-11-18 CL CL2016002942A patent/CL2016002942A1/es unknown
- 2016-11-28 GT GT201600249A patent/GT201600249A/es unknown
- 2016-11-28 SV SV2016005328A patent/SV2016005328A/es unknown
2017
- 2017-10-11 US US15/729,979 patent/US10442808B2/en not_active Expired - Fee Related
2019
- 2019-07-24 CY CY20191100786T patent/CY1121946T1/el unknown

Also Published As

Publication number	Publication date
SI3149001T1 (sl)	2019-08-30
CU24393B1 (es)	2019-04-04
HUE044351T2 (hu)	2019-10-28
AU2015265478B2 (en)	2017-09-14
AU2015265478A1 (en)	2016-10-20
GT201600249A (es)	2018-12-18
PH12016501862A1 (en)	2016-12-19
ES2738695T3 (es)	2020-01-24
MX373846B (es)	2020-03-26
TW201609740A (zh)	2016-03-16
EP3149001A1 (en)	2017-04-05
BR112016024545A2 (pt)	2017-08-15
PL3149001T3 (pl)	2019-10-31
MY182487A (en)	2021-01-25
SG11201607895PA (en)	2016-12-29
CL2016002942A1 (es)	2017-07-14
US20180030061A1 (en)	2018-02-01
HRP20191261T1 (hr)	2019-10-04
EP3149001B1 (en)	2019-04-24
CY1121946T1 (el)	2020-10-14
MX2016015544A (es)	2017-03-23
US10442808B2 (en)	2019-10-15
TR201910730T4 (tr)	2019-08-21
TWI709561B (zh)	2020-11-11
US20170121335A1 (en)	2017-05-04
CN106170489B (zh)	2019-05-03
CN106170489A (zh)	2016-11-30
CR20160548A (es)	2017-01-02
CA2945077A1 (en)	2015-12-03
JP2017516778A (ja)	2017-06-22
PH12016501862B1 (en)	2019-03-01
RS59039B1 (sr)	2019-08-30
AP2016009487A0 (en)	2016-10-31
EA201692105A1 (ru)	2017-04-28
CU20160181A7 (es)	2017-05-10
PT3149001T (pt)	2019-07-25
US9815842B2 (en)	2017-11-14
SV2016005328A (es)	2018-06-12
IL247949A0 (en)	2016-11-30
JP6545197B2 (ja)	2019-07-17
UY36143A (es)	2016-01-08
KR20170007311A (ko)	2017-01-18
PE20170189A1 (es)	2017-03-15
EA032050B1 (ru)	2019-03-29
LT3149001T (lt)	2019-08-12
WO2015181747A1 (en)	2015-12-03
AR100645A1 (es)	2016-10-19

Publication	Publication Date	Title
DK3149001T3 (da)	2019-07-22	Hidtil ukendte pyrazolopyrimidinderivater og deres anvendelse som MALT1-hæmmere
DK3277681T3 (da)	2019-07-29	Imidazolonylquinoliner og deres anvendelse som atm-kinaseinhibitorer
IL280863A (en)	2021-04-29	Autotaxin inhibitors and uses thereof
DK3221306T3 (da)	2020-01-02	Heteroarylforbindelser som irak-inhibitorer og anvendelser deraf
DK3464271T3 (da)	2020-06-15	Pyrazolderivater som plasma-kallikreininhibitorer
DK3105218T3 (da)	2019-11-04	Cyclopropylaminer som lsd1-inhibitorer
DK3105226T3 (da)	2019-10-14	Cyclopropylaminer som lsd1-inhibitorer
DK3233863T3 (da)	2024-07-15	Kondenserede ringheteroarylforbindelser og anvendelse deraf som trk-hæmmere
LT3303334T (lt)	2021-07-12	Tirozinkinazės inhibitoriai
HUE042335T2 (hu)	2019-06-28	ROR-gamma dihidropirrolopiridin inhibitorai
DK3210977T3 (da)	2019-07-01	Hidtil ukendt aminoalkylbenzothiazepinderivat og anvendelse deraf
BR112016030697A2 (pt)	2018-07-17	inibidores da desmetilase-1 específica da lisina
DK3271349T3 (da)	2019-08-05	Benzimidazolederivater som bromodomain-inhibitorer
DK3143011T3 (da)	2021-05-03	Deutererede heterocykliske forbindelser og deres anvendelse som billeddannende stoffer
DK3310784T3 (da)	2020-11-09	Tricykliske forbindelser og deres anvendelse som phosphodiesterasehæmmere
DK3341379T3 (da)	2019-12-02	EZH2-hæmmere
DK3288944T3 (da)	2019-07-22	Imidazopyrazinoner som pde1-inhibitorer
DK3186242T3 (da)	2021-12-20	Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere
DK3214079T3 (da)	2020-09-28	Seks-leddede benzodiazepinderivater som dpp-4-inhibitorer og hvordan de bruges
DK3347356T3 (da)	2021-04-26	Tricyclic forbundet pyridin-2-one-derivater og deres anvendelse som brd4-hæmmere
EP3454852A4 (en)	2020-02-26	PHOSPHOTIDYLINOSITOL 3-KINASES INHIBITORS
DK3277682T3 (da)	2019-07-29	6-morpholinyl-2-pyrazolyl-9h-purinderivater og anvendelse heraf som pi3k- hæmmere
DK3362450T3 (da)	2020-09-14	N1- og N7-substituerede sibirilin-derivater og anvendelse deraf som inhibitorer af cellulær nekroptose
DK3319970T3 (da)	2019-12-02	Pyrido-oxazinonderivater som tnap-hæmmere
DK3724196T3 (da)	2023-01-16	Substituerede azetidindihydrothienopyridiner og anvendelse deraf som phosphodiesterasehæmmere