[go: up one dir, main page]

DK3140310T3 - SYNTHESIS OF BORONATE SALTS AND USE THEREOF - Google Patents

SYNTHESIS OF BORONATE SALTS AND USE THEREOF Download PDF

Info

Publication number
DK3140310T3
DK3140310T3 DK15788682.1T DK15788682T DK3140310T3 DK 3140310 T3 DK3140310 T3 DK 3140310T3 DK 15788682 T DK15788682 T DK 15788682T DK 3140310 T3 DK3140310 T3 DK 3140310T3
Authority
DK
Denmark
Prior art keywords
synthesis
boronate salts
boronate
salts
Prior art date
Application number
DK15788682.1T
Other languages
Danish (da)
Inventor
Scott Hecker
Serge Boyer
Original Assignee
Rempex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rempex Pharmaceuticals Inc filed Critical Rempex Pharmaceuticals Inc
Application granted granted Critical
Publication of DK3140310T3 publication Critical patent/DK3140310T3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A01N55/08Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
DK15788682.1T 2014-05-05 2015-04-30 SYNTHESIS OF BORONATE SALTS AND USE THEREOF DK3140310T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461988690P 2014-05-05 2014-05-05
PCT/US2015/028613 WO2015171430A1 (en) 2014-05-05 2015-04-30 Synthesis of boronate salts and uses thereof

Publications (1)

Publication Number Publication Date
DK3140310T3 true DK3140310T3 (en) 2019-10-21

Family

ID=54392864

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15788682.1T DK3140310T3 (en) 2014-05-05 2015-04-30 SYNTHESIS OF BORONATE SALTS AND USE THEREOF

Country Status (15)

Country Link
US (2) US10385074B2 (en)
EP (3) EP3140310B1 (en)
CY (1) CY1122222T1 (en)
DK (1) DK3140310T3 (en)
ES (2) ES2750805T3 (en)
FI (1) FI3604316T3 (en)
HR (1) HRP20191932T1 (en)
HU (1) HUE046836T2 (en)
LT (2) LT3604316T (en)
PL (2) PL3604316T3 (en)
PT (1) PT3140310T (en)
RS (1) RS59488B1 (en)
SI (1) SI3140310T1 (en)
SM (1) SMT201900611T1 (en)
WO (1) WO2015171430A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013003045B1 (en) 2010-08-10 2021-08-31 Rempex Pharmaceuticals, Inc. Compound and its use, pharmaceutical composition, sterile container and method for preparing pharmaceutical composition for administration
CA2894891A1 (en) 2013-01-04 2014-07-10 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
KR20170007448A (en) 2014-05-19 2017-01-18 렘펙스 파머수티클스 인코퍼레이티드 Boronic acid derivatives and therapeutic uses thereof
US9511142B2 (en) 2014-06-11 2016-12-06 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
KR102396753B1 (en) 2014-06-11 2022-05-12 베나토알엑스 파마슈티컬스, 인크. Beta-lactamase inhibitors
EP3164406B1 (en) 2014-07-01 2024-12-25 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2016081297A1 (en) 2014-11-18 2016-05-26 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
CN107207537B (en) 2014-12-19 2019-05-31 莱姆派克斯制药公司 Apparatus and continuous flow process for the production of boronic acid derivatives
US20180051041A1 (en) 2015-03-17 2018-02-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
EP3347008B1 (en) 2015-09-11 2022-03-09 Venatorx Pharmaceuticals, Inc. Beta-lactamase inhibitors
WO2017100537A1 (en) 2015-12-10 2017-06-15 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
US10294249B2 (en) 2016-06-30 2019-05-21 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2018027062A1 (en) 2016-08-04 2018-02-08 VenatoRx Pharmaceuticals, Inc. Boron-containing compounds
JOP20190188A1 (en) * 2017-02-01 2019-08-01 Rempex Pharmaceuticals Inc Apparatus and continuous flow process for production of boronic acid derivative
US11332485B2 (en) 2017-05-26 2022-05-17 VenatoRx Pharmaceuticals, Inc. Penicillin-binding protein inhibitors
US11267826B2 (en) 2017-05-26 2022-03-08 VenatoRx Pharmaceuticals, Inc. Penicillin-binding protein inhibitors
US11286270B2 (en) 2017-10-11 2022-03-29 Qpex Biopharma, Inc. Boronic acid derivatives and synthesis thereof
CN118388347A (en) * 2017-11-01 2024-07-26 梅琳塔治疗公司 Compound, borate derivative formed from compound and preparation method of borate derivative
EP3781576B1 (en) 2018-04-20 2024-06-12 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2019226931A1 (en) 2018-05-25 2019-11-28 VenatoRx Pharmaceuticals, Inc. Penicillin-binding protein inhibitors
CN111039965B (en) * 2018-10-12 2020-12-01 新发药业有限公司 Simple preparation method of farborobactam

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194047A (en) 1975-11-21 1980-03-18 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin
US4260543A (en) 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
US4409214A (en) 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
FR2573070B1 (en) 1984-11-13 1987-01-30 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF CARBONYL COMPOUNDS
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
CA1283404C (en) 1986-07-01 1991-04-23 Shigeru Sanai Cephalosporin compounds, processes for their preparation and antibacterial agents
ZA893284B (en) 1988-05-04 1990-03-28 Igen Inc Peptide analogs and their use as haptens to elicit catalytic antibodies
US5442100A (en) 1992-08-14 1995-08-15 The Procter & Gamble Company β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids
US5888998A (en) 1997-04-24 1999-03-30 Synphar Laboratories, Inc. 2-oxo-1-azetidine sulfonic acid derivatives as potent β-lactamase inhibitors
US6184363B1 (en) 1997-06-13 2001-02-06 Northwestern University Inhibitors of β-lactamases and uses therefor
AU8140898A (en) 1997-06-13 1998-12-30 Northwestern University Inhibitors of beta-lactamases and uses therefor
WO2000035905A1 (en) 1998-12-16 2000-06-22 Northwestern University INHIBITORS OF β-LACTAMASES AND USES THEREFOR
AU3124300A (en) 1998-12-16 2000-07-03 Northwestern University Inhibitors of beta-lactamases and uses therefor
EP1216239B1 (en) 1999-09-25 2004-02-11 SmithKline Beecham plc Piperazine derivatives as 5-ht1b antagonists
JP2003513890A (en) 1999-10-28 2003-04-15 メルク エンド カムパニー インコーポレーテッド Novel succinic metallo-beta-lactamase inhibitors and their use in treating bacterial infections
AU2001292732A1 (en) 2000-09-12 2002-03-26 Larry C. Blasczcak Beta-lactam analogs and uses therefor
ES2244666T3 (en) 2000-09-14 2005-12-16 Pantherix Limited ACID DERIVATIVES 3- (HETEROARIL-ACETAMIDE) -2-OXOAZETIDINE-1-SULPHONICS USED AS ANTIBACTERIAL AGENTS.
US6586615B1 (en) 2001-01-10 2003-07-01 Bristol-Myers Squibb Company α-aminoboronic acids prepared by novel synthetic methods
DE10118698A1 (en) 2001-04-17 2002-11-07 Jerini Ag Immobilization method and arrangement of connections produced therewith on a planar surface
FR2835186B1 (en) 2002-01-28 2006-10-20 Aventis Pharma Sa NOVEL HETEROCYCLIC COMPOUNDS ACTIVE AS BETA-LACTAMASES INHIBITORS
JP2003229277A (en) 2002-02-04 2003-08-15 Matsushita Electric Ind Co Ltd Light emitting device material, light emitting device and device using the same
AUPS065102A0 (en) 2002-02-20 2002-03-14 Unisearch Limited Fluorous acetalation
JP3714948B2 (en) 2002-09-11 2005-11-09 呉羽化学工業株式会社 Amine compounds and uses thereof
EP2325226A1 (en) 2002-10-30 2011-05-25 Sumitomo Chemical Company, Limited Complex aryl copolymer compounds and polymer light emitting devices made by using the same
US7439253B2 (en) 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US7271186B1 (en) 2002-12-09 2007-09-18 Northwestern University Nanomolar β-lactamase inhibitors
BR0317613A (en) 2002-12-20 2005-11-29 Migenix Corp Nucleotide translocase (ant) adenine binders and related compositions and methods
TW200418791A (en) 2003-01-23 2004-10-01 Bristol Myers Squibb Co Pharmaceutical compositions for inhibiting proteasome
JP4233365B2 (en) 2003-03-25 2009-03-04 三井化学株式会社 Azadiol complex compound and optical recording medium using the compound
WO2005033090A1 (en) 2003-10-06 2005-04-14 Sumitomo Chemical Company, Limited Aromatic compound
CA2541832C (en) 2003-10-10 2009-11-24 Pfizer Products Inc. Substituted 2h-[1,2,4]triazolo[4,3-a]pyrazines as gsk-3 inhibitors
TW200600494A (en) 2004-03-08 2006-01-01 Chugai Pharmaceutical Co Ltd Bisphenyl compounds useful as vitamin d3 receptor agonists
US20060019116A1 (en) 2004-07-22 2006-01-26 Eastman Kodak Company White electroluminescent device with anthracene derivative host
TW200618820A (en) 2004-11-05 2006-06-16 Alza Corp Liposome formulations of boronic acid compounds
US20060178357A1 (en) 2005-02-10 2006-08-10 Buynak John D Chphalosporin-derived mercaptans as inhibitors of serine and metallo-beta-lactamases
HUE026021T2 (en) 2005-02-16 2016-05-30 Anacor Pharmaceuticals Inc Biocidal boronophthalide compounds
CA2594017C (en) 2005-02-22 2010-04-20 Teva Pharmaceutical Industries Ltd. Preparation of rosuvastatin
WO2006101779A2 (en) 2005-03-15 2006-09-28 The University Of Chicago Non-aqueous electrolytes for lithium ion batteries
TW200734311A (en) 2005-11-21 2007-09-16 Astrazeneca Ab New compounds
SI1965798T1 (en) 2005-12-07 2012-01-31 Basilea Pharmaceutica Ag Useful monobactam antibiotics
BRPI0708051A2 (en) 2006-02-16 2011-05-17 Anacor Pharmaceuticals Inc small molecules containing boron as anti-inflammatory agents
US20100009957A1 (en) 2006-09-27 2010-01-14 Blizzard Timothy A Novel inhibitors of beta-lactamase
RU2488394C2 (en) 2007-03-23 2013-07-27 Базилеа Фармацойтика Аг Combined therapeutic agents for treating bacterial infections
GB0719366D0 (en) 2007-10-03 2007-11-14 Smithkline Beecham Corp Compounds
BRPI0820531A2 (en) 2007-11-13 2012-07-10 Protez Pharmaceuticals Inc beta-lactamase inhibitors
US20100120715A1 (en) 2007-11-13 2010-05-13 Burns Christopher J Beta-lactamase inhibitors
SI2231667T1 (en) 2008-01-18 2013-12-31 Merck Sharp & Dohme Corp. Beta-lactamase inhibitors
US8129398B2 (en) 2008-03-19 2012-03-06 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2009140309A2 (en) 2008-05-12 2009-11-19 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US20110124634A1 (en) 2008-05-13 2011-05-26 Poniard Pharmaceuticals, Inc. Bioactive compounds for treatment of cancer and neurodegenerative diseases
WO2010075286A1 (en) 2008-12-24 2010-07-01 University Of Washington MOLECULAR ACTIVATORS OF THE Wnt/β-CATENIN PATHWAY
WO2010097675A1 (en) 2009-02-27 2010-09-02 Dhanuka Laboratories Ltd. An improved preparation process for cefpodoxime proxetil
US20100292185A1 (en) 2009-05-12 2010-11-18 Burns Christopher J Beta-lactamase inhibitors
CA2764785C (en) 2009-06-08 2015-10-27 California Capital Equity, Llc Triazine derivatives and their therapeutical applications
WO2011017125A1 (en) 2009-07-28 2011-02-10 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
CA2828114A1 (en) 2010-02-26 2011-09-01 Gary Igor DMITRIENKO Cephalosporin derivatives useful as .beta.-lactamase inhibitors and compositions and methods of use thereof
UA110612C2 (en) 2010-03-31 2016-01-25 Мілленніум Фармасьютікалз, Інк. DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYRBORONIC ACID
US20110288063A1 (en) 2010-05-19 2011-11-24 Naeja Pharmaceutical Inc. Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors
BR112013003045B1 (en) 2010-08-10 2021-08-31 Rempex Pharmaceuticals, Inc. Compound and its use, pharmaceutical composition, sterile container and method for preparing pharmaceutical composition for administration
ES2794006T3 (en) 2010-10-26 2020-11-17 Mars Inc Arginase Inhibitors as Therapeutic Agents
TW201221518A (en) 2010-11-18 2012-06-01 Glaxo Group Ltd Compounds
TW201221131A (en) * 2010-11-18 2012-06-01 Glaxo Group Ltd Compounds
EP2487159A1 (en) 2011-02-11 2012-08-15 MSD Oss B.V. RorgammaT inhibitors
EP2508506A1 (en) 2011-04-08 2012-10-10 LEK Pharmaceuticals d.d. Preparation of sitagliptin intermediates
US9012491B2 (en) 2011-08-31 2015-04-21 Rempex Pharmaceuticals, Inc. Heterocyclic boronic acid ester derivatives and therapeutic uses thereof
WO2013053372A1 (en) 2011-10-13 2013-04-18 Therabor Pharmaceuticals Boronic acid inhibitors of beta-lactamases
WO2013056163A1 (en) 2011-10-14 2013-04-18 The Regents Of The University Of California Beta-lactamase inhibitors
EA201400735A1 (en) 2011-12-22 2015-04-30 Арес Трейдинг С.А. DERIVATIVES ALPHA-AMINO BORONIC ACID, SELECTIVE INHIBITORS IMMUNOPROTEASOMA
RU2014131370A (en) 2012-01-09 2016-02-27 Юниверсити Оф Тромсё THERAPEUTIC COMPOUNDS CONTAINING BOR
EP2615080A1 (en) 2012-01-12 2013-07-17 LEK Pharmaceuticals d.d. Preparation of Optically Pure ß-Amino Acid Type Active Pharmaceutical Ingredients and Intermediates thereof
US20150119363A1 (en) 2012-02-15 2015-04-30 Rempex Pharmaceuticals, Inc.. Methods of treating bacterial infections
US9156858B2 (en) 2012-05-23 2015-10-13 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10561675B2 (en) 2012-06-06 2020-02-18 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
KR102147420B1 (en) 2012-12-07 2020-08-25 베나토알엑스 파마슈티컬스, 인크. Beta-lactamase inhibitors
CA2894891A1 (en) 2013-01-04 2014-07-10 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
MX2015008627A (en) 2013-01-04 2015-09-23 Rempex Pharmaceuticals Inc Boronic acid derivatives and therapeutic uses thereof.
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9101638B2 (en) 2013-01-04 2015-08-11 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US8999885B2 (en) 2013-01-09 2015-04-07 General Electric Company Methods of activating charcoal resulting from biomass gasification
WO2014110442A1 (en) 2013-01-10 2014-07-17 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
EP2970340B1 (en) 2013-03-14 2020-02-12 Venatorx Pharmaceuticals, Inc. Beta-lactamase inhibitors
US9687497B1 (en) 2014-05-05 2017-06-27 Rempex Pharmaceuticals, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
KR20170007448A (en) 2014-05-19 2017-01-18 렘펙스 파머수티클스 인코퍼레이티드 Boronic acid derivatives and therapeutic uses thereof
US9511142B2 (en) 2014-06-11 2016-12-06 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
EP3164406B1 (en) 2014-07-01 2024-12-25 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2016065282A1 (en) 2014-10-24 2016-04-28 The Regents Of The University Of Michigan Nasal formulation, nasal kit, and method for enhancing nasal nitric oxide (no) levels
EP3285776B1 (en) 2015-04-24 2022-12-21 Melinta Therapeutics, Inc. Dosage regimen of vaborbactam and meropenem for treating bacterial infections in subjects with reduced renal function

Also Published As

Publication number Publication date
US20200031851A1 (en) 2020-01-30
CY1122222T1 (en) 2020-11-25
SMT201900611T1 (en) 2020-01-14
ES2750805T3 (en) 2020-03-27
US20170057979A1 (en) 2017-03-02
US10385074B2 (en) 2019-08-20
EP4356736A2 (en) 2024-04-24
EP3140310B1 (en) 2019-08-07
EP3604316A1 (en) 2020-02-05
PT3140310T (en) 2019-11-18
ES2972939T3 (en) 2024-06-17
LT3140310T (en) 2019-11-25
SI3140310T1 (en) 2020-01-31
HRP20191932T1 (en) 2020-01-24
WO2015171430A1 (en) 2015-11-12
PL3140310T3 (en) 2020-01-31
RS59488B1 (en) 2019-12-31
EP3140310A1 (en) 2017-03-15
LT3604316T (en) 2024-02-26
HUE046836T2 (en) 2020-03-30
PL3604316T3 (en) 2024-04-29
EP4356736A3 (en) 2024-08-07
US10669292B2 (en) 2020-06-02
EP3140310A4 (en) 2017-12-13
EP3604316B1 (en) 2023-12-06
FI3604316T3 (en) 2024-02-29

Similar Documents

Publication Publication Date Title
DK3140310T3 (en) SYNTHESIS OF BORONATE SALTS AND USE THEREOF
NL301322I2 (en) Repotrectinib and/or pharmaceutically acceptable salts thereof
DK3259253T3 (en) SULPHONYLURAES AND RELATED COMPOUNDS AND USE OF SAME
HUE046000T2 (en) Antiproferative Compounds and Methods of Use
DK3160956T3 (en) Inhibitors of lysine-specific demethylase-1
DK3210977T3 (en) New aminoalkylbenzothiazepine derivative and use thereof
DK3102576T3 (en) DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA
LT3137169T (en) LYSINE-SPECIFIC DEMETYLASE-1 INHIBITORS
DK3240785T3 (en) SMALL MOLECULATE INHIBITORIES OF LACTASE DEHYDROGENASIS AND PROCEDURES FOR USE
DK3215147T3 (en) NEUROTENANT NORKETAMINE COMPOUNDS AND METHODS
DK3205650T3 (en) EGFR INHIBITORS AND MANUFACTURE AND USE THEREOF
DK3511319T3 (en) INHIBITORS OF LYSINE-SPECIFIC DEMETHYLASE-1
DK3015526T3 (en) HYDROFLUOROLEFIN-BASED COMPOSITION AND USE
DK3144001T3 (en) Compositions of selenoorganic compounds and methods of their use
DK3218005T3 (en) GLYCAN INTERACTING COMPOUNDS AND METHODS OF USE
DK3215493T3 (en) SYNTHESIS OF COPANLISIB AND DIHYDROCHLORIDE SALT
DK3227310T3 (en) HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTINES AND CXCR4-CHEMOKIN RECEPTORS
DK3089971T3 (en) Compounds and methods of use
HRP20190527T1 (en) SYNTHESIS OF COPANLISIB AND ITS DIHYDROCHLORIDE SALTS
HRP20181441T1 (en) ALDOSTERON SYNTHESIS INHIBITORS
DK3204352T3 (en) Inhibitors of lysine-gingipain
DK3476830T3 (en) POLYMETHINE COMPOUNDS AND USE THEREOF AS FLUORESCURING MARKERS
DK3328395T3 (en) NEW USE OF DEXTRANSULPHATE
DK3157548T3 (en) THERAPY USE OF A FACTOR XII INHIBITOR IN A NEUROTRAUMATIC DISEASE
DK3189045T3 (en) STILL UNKNOWN SALTS OF NILOTINIB AND ITS POLYMORPHERES