DK3033101T3 - Fremgangsmåder til reducering af eksacerbationsrater for astma ved anvendelse af benralizumab - Google Patents
Fremgangsmåder til reducering af eksacerbationsrater for astma ved anvendelse af benralizumab Download PDFInfo
- Publication number
- DK3033101T3 DK3033101T3 DK14835826.0T DK14835826T DK3033101T3 DK 3033101 T3 DK3033101 T3 DK 3033101T3 DK 14835826 T DK14835826 T DK 14835826T DK 3033101 T3 DK3033101 T3 DK 3033101T3
- Authority
- DK
- Denmark
- Prior art keywords
- benralizumab
- ser
- leu
- thr
- asthma
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
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Claims (12)
1. Effektiv mængde af benralizumab til anvendelse til behandling af astma, hvor benralizumab administreres til en astmapatient, hvor administrationen reducerer patientens eksacerbationsrate, og hvor benralizumab administreres ved en dosis på 30 mg én gang hver 4. uge i 12 uger og herefter én gang hver 8. uge.
2. Benralizumab til anvendelse ifølge krav 1, hvor astmaen er eosinofil astma.
3. Benralizumab til anvendelse ifølge et hvilket som helst af krav 1 eller 2, hvor patienten har et blodeosinofiltal på mindst 300 celler/μΐ.
4. Benralizumab til anvendelse ifølge et hvilket som helst af kravene 1-3, hvor patienten har et forceret ekspiratorisk volumen (FEVi) på mindst 75 % forventet værdi før administration.
5. Benralizumab til anvendelse ifølge et hvilket som helst af kravene 1-4, hvor patienten har en score på astmakontrolspørgeskema på mindst 1,5 før administration.
6. Benralizumab til anvendelse ifølge et hvilket som helst af kravene 1-5, der reducerer den årlige eksacerbationsrate efter administration af antistoffet.
7. Benralizumab til anvendelse ifølge et hvilket som helst af kravene 1-6, hvor den årlige eksacerbationsrate reduceres med mindst 35 %, eventuelt med mindst 40 %, eventuelt med mindst 50 %, eventuelt med mindst 60 %.
8. Benralizumab til anvendelse ifølge et hvilket som helst af kravene 1-7, hvor patienten anvender højdosis inhalerede kortikosteroider (ICS).
9. Benralizumab til anvendelse ifølge et hvilket som helst af kravene 1-8, hvor patienten anvender langtidsvirkende β2-agonister (LABA).
10. Benralizumab til anvendelse ifølge et hvilket som helst af kravene 1-9, hvor patienten har eksacerbationer i anamnesen, eventuelt hvor eksacerbationerne i anamnesen omfatter mindst to eksacerbationer i løbet af året forud for administrationen af benralizumab, eventuelt hvor eksacerbationerne i anamnesen ikke omfatter mere end seks eksacerbationer i løbet af året forud for administrationen af benralizumab.
11. Benralizumab til anvendelse ifølge et hvilket som helst af kravene 1-10, hvor benralizumab administreres parenteralt, eventuelt hvor benralizumab administreres subkutant.
12. Benralizumab til anvendelse ifølge et hvilket som helst af kravene 1-11, hvor benralizumab administreres foruden kortikosteroidterapi.
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| PCT/US2014/050080 WO2015023504A1 (en) | 2013-08-12 | 2014-08-07 | Methods for reducing exacerbation rates of asthma using benralizumab |
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| HUE057065T2 (hu) * | 2013-08-12 | 2022-04-28 | Astrazeneca Ab | Eljárások asztma tüneteinek javítására benralizumab alkalmazásával |
| CN113230399A (zh) * | 2013-10-15 | 2021-08-10 | 阿斯利康(瑞典)有限公司 | 用于使用贝那利珠单抗治疗慢性阻塞性肺疾病的方法 |
| RS62419B1 (sr) * | 2013-10-24 | 2021-10-29 | Astrazeneca Ab | Stabilne vodene formulacije antitela |
| WO2015106080A2 (en) | 2014-01-10 | 2015-07-16 | Anaptysbio, Inc. | Antibodies directed against interleukin-33 (il-33) |
| US10846696B2 (en) | 2015-08-24 | 2020-11-24 | Samsung Electronics Co., Ltd. | Apparatus and method for trusted execution environment based secure payment transactions |
| US10699274B2 (en) | 2015-08-24 | 2020-06-30 | Samsung Electronics Co., Ltd. | Apparatus and method for secure electronic payment |
| HK1255922A1 (zh) | 2015-11-04 | 2019-09-06 | Astrazeneca Ab | 二肽基肽酶-4和骨膜素作为嗜酸性粒细胞疾病中嗜酸性粒细胞靶向治疗药物临床反应的预测因子 |
| ES2981555T3 (es) * | 2017-01-04 | 2024-10-09 | Worg Pharmaceuticals Zhejiang Co Ltd | Péptidos de S-arrestina y usos terapéuticos de los mismos |
| RU2698048C2 (ru) * | 2017-10-03 | 2019-08-21 | Закрытое Акционерное Общество "Биокад" | МОНОКЛОНАЛЬНОЕ АНТИТЕЛО К IL-5Rα |
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| EP1266663A4 (en) | 2000-02-15 | 2003-07-23 | Kyowa Hakko Kogyo Kk | INDUCER OF EOSINOPHILIC SPECIFIC APOPTOSIS |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
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