DK3032927T3 - Stråleformende indretning til neutronindfangningsterapi - Google Patents
Stråleformende indretning til neutronindfangningsterapi Download PDFInfo
- Publication number
- DK3032927T3 DK3032927T3 DK15164481.2T DK15164481T DK3032927T3 DK 3032927 T3 DK3032927 T3 DK 3032927T3 DK 15164481 T DK15164481 T DK 15164481T DK 3032927 T3 DK3032927 T3 DK 3032927T3
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- neutron
- neutrons
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- thermal
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- 229910052796 boron Inorganic materials 0.000 claims description 5
- KLZUFWVZNOTSEM-UHFFFAOYSA-K Aluminium flouride Chemical compound F[Al](F)F KLZUFWVZNOTSEM-UHFFFAOYSA-K 0.000 claims description 3
- 101100004392 Arabidopsis thaliana BHLH147 gene Proteins 0.000 claims description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 3
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 claims description 3
- 229910001634 calcium fluoride Inorganic materials 0.000 claims description 3
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- 230000015572 biosynthetic process Effects 0.000 claims 1
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 claims 1
- 229910052808 lithium carbonate Inorganic materials 0.000 claims 1
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- 150000002500 ions Chemical class 0.000 description 4
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- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 1
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- 229910052790 beryllium Inorganic materials 0.000 description 1
- ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1077—Beam delivery systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/02—Neutron sources
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K1/00—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
- G21K1/10—Scattering devices; Absorbing devices; Ionising radiation filters
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K5/00—Irradiation devices
- G21K5/04—Irradiation devices with beam-forming means
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H3/00—Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
- H05H3/06—Generating neutron beams
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H6/00—Targets for producing nuclear reactions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1094—Shielding, protecting against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1095—Elements inserted into the radiation path within the system, e.g. filters or wedges
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- High Energy & Nuclear Physics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plasma & Fusion (AREA)
- General Chemical & Material Sciences (AREA)
- Optics & Photonics (AREA)
- Radiation-Therapy Devices (AREA)
- Particle Accelerators (AREA)
Claims (6)
1. Stråleformende indretning (10) til neutronindfangningsterapi, der omfatter: en stråleindgang (11); et mål (12), hvor målet (12) har kernereaktion med en indfaldende protonstråle fra stråleindgangen (11) til frembringelse af neutroner, og hvor neutronerne danner en neutronstråle, der definerer en hovedakse (X); en moderator (13) , der støder op til målet, hvor neutronerne modereres af moderatoren (13) til epitermiske neutronenergier, og hvor en ydre overflade af moderatoren (13) indbefatter mindst en første tilspidset del; en reflektor (14), der omgiver moderatoren (13), hvilken reflektor (14) fører de neutroner, der devierer fra hovedaksen, tilbage til forøgelse af epitermisk neutronstråleintensitet, en termisk neutronabsorber (15), der støder op til moderatoren (13), hvilken termiske neutronabsorber (15) anvendes til absorbering af termiske neutroner for at undgå overdosering i overfladisk normalt væv under terapi; et strålingsskjold (16), der er anbragt inde i den stråleformende indretning (10), hvilket strålingsskjold (16) anvendes til afskærmning for lækkende neutroner og fotoner til reducering af dosen for det normale væv, der ikke eksponeres for stråling; og en stråleudgang (17) der er kendetegnet ved, at den ydre overflade af moderatoren (13) indbefatter en anden tilspidset del, der støder op til den første tilspidsede del, hvor tilspidsningsretningen af den første tilspidsede del er modsat tilspidsningsretningen af den anden tilspidsede del.
2. Stråleformende indretning (10) til neutronindfangningsterapi ifølge krav 1, hvilken stråleformende indretning (10) yderligere anvendes til acceleratorbaseret bor-neutronindfangningsterapi.
3. Stråleformende indretning (10) til neutronindfangningsterapi ifølge krav 2, der omfatter an accelerator, der er konfigureret til at accelerere en protonstråle mod målet (12) til overvindelse af elektrostatisk frastødningsenergi i en målatomkerne og frembringelse af kernereaktion med målet til dannelse af neutroner, hvor målet (12) er lavet af et metalmateriale.
4. Stråleformende indretning (10) til neutronindfangningsterapi ifølge krav 1, hvor et epitermisk neutronenergiområde ligger i intervallet fra 0,5 eV til 40 keV, et termisk neutronenergiområde er under 0,5 eV, og et hurtigt neutronenergiområde er over 40 keV, hvor moderatoren (13) er lavet af mindst det ene af D2O, AIF3, Fluental™, CaF2, Li2C03, MgF2 og AI2O3, hvilke materialer har et tværsnit, så de hovedsageligt fungerer med hurtige neutroner, men næsten ikke fungerer med epitermiske neutroner, hvor reflektoren (14) er lavet af mindst det ene af Pb eller Ni, hvilke materialer har en høj neutronreflektionsevne, og hvor den termiske neutronabsorber (15) er lavet af 6Li, hvilket materiale har et tværsnit, så det fungerer med termiske neutroner.
5. Stråleformende indretning (10) til neutronindfangningsterapi ifølge krav 1, hvor der er anbragt en luftpassage mellem den termiske neutronabsorber (15) og stråleudgangen (17).
6. Stråleformende indretning (10) til neutronindfangningsterapi ifølge krav 1, hvor strålingsskjoldet (16) indbefatter et fotonskjold (161) og et neutronskjold (162) .
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410742679.1A CN104548388B (zh) | 2014-12-08 | 2014-12-08 | 用于中子捕获治疗的射束整形体 |
| CN201420765213.9U CN204319539U (zh) | 2014-12-08 | 2014-12-08 | 用于中子捕获治疗的射束整形体 |
| CN201420765424.2U CN204319540U (zh) | 2014-12-08 | 2014-12-08 | 用于中子捕获治疗的射束整形体 |
| CN201410743692.9A CN104511096B (zh) | 2014-12-08 | 2014-12-08 | 用于中子捕获治疗的射束整形体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3032927T3 true DK3032927T3 (da) | 2017-02-06 |
Family
ID=53015534
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15164471.3T DK3032926T3 (da) | 2014-12-08 | 2015-04-21 | Stråleformende indretning til neutronindfangningsterapi |
| DK15164481.2T DK3032927T3 (da) | 2014-12-08 | 2015-04-21 | Stråleformende indretning til neutronindfangningsterapi |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15164471.3T DK3032926T3 (da) | 2014-12-08 | 2015-04-21 | Stråleformende indretning til neutronindfangningsterapi |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9889320B2 (da) |
| EP (4) | EP3032926B1 (da) |
| JP (4) | JP6147296B2 (da) |
| DK (2) | DK3032926T3 (da) |
| PL (2) | PL3032926T3 (da) |
| RU (2) | RU2691322C2 (da) |
| TW (3) | TWI640998B (da) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3570294B1 (en) * | 2015-05-04 | 2020-12-23 | Neuboron Medtech Ltd. | Beam shaping body for neutron capture therapy |
| DK3291884T3 (da) | 2015-05-06 | 2021-05-25 | Neutron Therapeuutics Inc | Neutronmål for behandling med boronneutronindfangning |
| JP6722281B2 (ja) * | 2015-09-30 | 2020-07-15 | 南京中硼▲聯▼康医▲療▼科技有限公司Ｎｅｕｂｏｒｏｎ Ｍｅｄｔｅｃｈ Ｌｔｄ． | 中性子捕捉療法に用いられるビーム整形体 |
| EP3357536B1 (en) * | 2015-11-12 | 2019-09-11 | Neuboron Medtech Ltd. | Neutron capture therapy system |
| EP3369457B1 (en) * | 2015-11-26 | 2019-11-27 | Neuboron Medtech Ltd. | Beam shaping body for neutron capture therapy |
| CN106730414B (zh) | 2015-12-30 | 2017-10-10 | 南京中硼联康医疗科技有限公司 | 用于消除β淀粉样蛋白的中子捕获治疗系统 |
| WO2018076787A1 (zh) * | 2016-10-28 | 2018-05-03 | 南京中硼联康医疗科技有限公司 | 用于中子捕获治疗的射束整形体 |
| JP6831921B2 (ja) * | 2016-10-31 | 2021-02-17 | 南京中硼▲聯▼康医▲療▼科技有限公司Ｎｅｕｂｏｒｏｎ Ｍｅｄｔｅｃｈ Ｌｔｄ． | 中性子捕獲治療システム |
| TWI614042B (zh) * | 2016-12-02 | 2018-02-11 | 財團法人工業技術研究院 | 中子束源產生器及其濾屏 |
| EP3530316B1 (en) * | 2016-12-23 | 2020-11-04 | Neuboron Medtech Ltd. | Neutron capturing therapy system and target material for use in particle beam generating device |
| CN108934120B (zh) * | 2017-05-26 | 2024-04-12 | 南京中硼联康医疗科技有限公司 | 用于中子线产生装置的靶材及中子捕获治疗系统 |
| CN108653935B (zh) * | 2017-03-29 | 2023-06-02 | 南京中硼联康医疗科技有限公司 | 辐射线照射系统及用于辐射线照射系统的定位组件 |
| JP6833064B2 (ja) * | 2017-03-29 | 2021-02-24 | 南京中硼▲聯▼康医▲療▼科技有限公司Ｎｅｕｂｏｒｏｎ Ｍｅｄｔｅｃｈ Ｌｔｄ． | 放射線照射システムおよび放射線照射システム用の位置決めアセンブリ |
| EP3583981B1 (en) | 2017-05-12 | 2020-12-23 | Neuboron Medtech Ltd. | Photon emission detection device and boron neutron capture therapy system having same |
| US10462893B2 (en) | 2017-06-05 | 2019-10-29 | Neutron Therapeutics, Inc. | Method and system for surface modification of substrate for ion beam target |
| RU2734955C1 (ru) | 2017-06-05 | 2020-10-26 | Нойборон Медтех Лтд. | Блок формирования пучка для нейтронно-захватной терапии |
| CN109411108B (zh) * | 2017-08-18 | 2020-06-12 | 南京中硼联康医疗科技有限公司 | 用于慢化中子的缓速体 |
| WO2019037624A1 (zh) | 2017-08-24 | 2019-02-28 | 南京中硼联康医疗科技有限公司 | 中子捕获治疗系统 |
| TWI687249B (zh) * | 2017-08-30 | 2020-03-11 | 中國商南京中硼聯康醫療科技有限公司 | 中子捕獲治療系統 |
| RU2745081C1 (ru) | 2017-09-07 | 2021-03-19 | Нойборон Медтех Лтд. | Система нейтрон-захватной терапии |
| CN109464752B (zh) * | 2017-09-07 | 2024-02-09 | 南京中硼联康医疗科技有限公司 | 中子捕获治疗系统 |
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| JP7405743B2 (ja) * | 2017-09-14 | 2023-12-26 | オーストラリアン ニュークリア サイエンス アンド テクノロジー オーガニゼーション | 照射方法及びシステム |
| JP6947933B2 (ja) * | 2017-12-15 | 2021-10-13 | 南京中硼▲聯▼康医▲療▼科技有限公司Ｎｅｕｂｏｒｏｎ Ｍｅｄｔｅｃｈ Ｌｔｄ． | 中性子捕捉療法システム |
| RU2739171C1 (ru) * | 2017-12-15 | 2020-12-21 | Нойборон Медтех Лтд. | Система нейтронозахватной терапии |
| EP3821448B1 (en) * | 2018-07-09 | 2023-10-04 | Advanced Accelerator Applications | Neutron activator, neutron activation system comprising such neutron activator and method for neutron activation implementing such neutron activator |
| TWI757716B (zh) * | 2019-04-15 | 2022-03-11 | 禾榮科技股份有限公司 | 微創型中子束產生裝置及微創型中子捕獲治療系統 |
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| JP7650695B2 (ja) * | 2021-03-26 | 2025-03-25 | 住友重機械工業株式会社 | 治療準備装置、及び治療設備 |
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