DK3032947T3 - Flydende antimikrobielle hudplejesammensætninger formuleret til anvendelse under kolde temperaturforhold - Google Patents
Flydende antimikrobielle hudplejesammensætninger formuleret til anvendelse under kolde temperaturforhold Download PDFInfo
- Publication number
- DK3032947T3 DK3032947T3 DK13750564.0T DK13750564T DK3032947T3 DK 3032947 T3 DK3032947 T3 DK 3032947T3 DK 13750564 T DK13750564 T DK 13750564T DK 3032947 T3 DK3032947 T3 DK 3032947T3
- Authority
- DK
- Denmark
- Prior art keywords
- skin care
- liquid antimicrobial
- butanol
- weight
- antimicrobial skin
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Claims (14)
1. Flydende antimikrobiel hudplejesammensætning, der er egnet til miljøer med kolde temperaturer, hvilken sammensætning omfatter: - > 5 vægt-% til < 25 vægt-% glycerin; - > 0,1 vægt-% til < 20 vægt-% propylenglycol; ->0,1 vægt-% til < 20 vægt-% af mindst én organisk C2-Ce-monoalkohol valgt fra gruppen, der omfatter ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, isobutanol, tert-butanol, pentanol og/eller hexanol; - > 0,1 vægt-% til < 10 vægt-% sorbitol; og ->0,1 vægt-% til < 15 vægt-% af mindst én organisk C2-Ce-syre; hvor vægt-% af bestanddelene er baseret på totalvægten af den flydende antimikrobielle hudplejesammensætning; hvor sammensætningen har en viskositet ved -8 °C, og/eller ved -20 °C på > 1 mPas til < 35 mPas, målt med et Brookfield-viskometer, ved anvendelse af en spindel 61 ved 12 o/m.
2. Flydende antimikrobiel hudplejesammensætning ifølge krav 1, hvor sammensætningen omfatter glycerin, propylenglycol, af mindst én organisk C2-C6-monoalkohol valgt fra gruppen, der omfatter ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, iso-butanol, tert-butanol, pentanol og/eller hexanol, sorbitol, og af mindst én organisk C2-Ce-syre, i en vægtmængde på > 20 vægt-% og < 80 vægt-%, fortrinsvis > 25 vægt-% og < 60 vægt-%, og mere fortrinsvis > 30 vægt-% og < 50 vægt-%, baseret på totalvægten af den flydende antimikrobielle hudplejesammensætning.
3. Flydende antimikrobiel hudplejesammensætning ifølge krav 1 eller 2, hvor den mindst ene organiske C2-C6-monoalkohol er valgt fra gruppen, der omfatter n-propanol og/eller isopropanol, hvor isopropanol er mest foretrukket.
4. Flydende antimikrobiel hudplejesammensætning ifølge krav 1 til 3, hvor den flydende antimikrobielle hudplejesammensætning endvidere omfatter vand.
5. Flydende antimikrobiel hudplejesammensætning ifølge krav 1 til 4, hvor den flydende antimikrobielle hudplejesammensætning omfatter mindst én organisk Ci-Cio-syre, der er mælkesyre.
6. Flydende antimikrobiel hudplejesammensætning ifølge krav 1 til 5, hvor den flydende antimikrobielle hudplejesammensætning omfatter mindst én chloritgenererende forbindelse, hvor den chloritgenererende forbindelse fortrinsvis er valgt fra gruppen af alkali- og jordalkalihypochloritter, og hvor den mest foretrukne chloritgenererende forbindelse er NaC102.
7. Flydende antimikrobiel hudplejesammensætning ifølge krav 1 til 6, hvor den flydende antimikrobielle hudplejesammensætning omfatter mindst >15 vægt-% til <100 vægt-%, fortrinsvis > 20 vægt-% til < 90 vægt-%, mere fortrinsvis > 25 vægt-% til < 80 vægt-%, også fortrinsvis > 30 vægt-% til < 70 vægt-%, mest fortrinsvis > 40 vægt-% til < 70 vægt-%, og endelig fortrinsvis > 50 vægt-% til < 60 vægt-%, af en blanding, der omfatter: - glycerin, - propylenglycol, - af mindst én organisk C2-C6-monoalkohol valgt fra gruppen, der omfatter ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, iso-butanol, tert-butanol, pentanol og/eller hexanol og - sorbitol.
8. Flydende antimikrobiel hudplejesammensætning ifølge krav 1 til 7, hvor den flydende antimikrobielle hudplejesammensætning omfatter mindst > 15 vægt-% til < 100 vægt-%, fortrinsvis > 20 vægt-% til < 90 vægt-%, mere fortrinsvis > 25 vægt-% til < 80 vægt-%, også fortrinsvis > 30 vægt-% til < 70 vægt-%, mest fortrinsvis > 40 vægt-% til < 70 vægt-%, og endelig fortrinsvis > 50 vægt-% til < 60 vægt-%, af en blanding, der omfatter: - glycerin; - propylenglycol; - mindst én organisk C2-Ce-monoalkohol valgt fra gruppen, der omfatter ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, iso-butanol, tert-butanol, pentanol og/eller hexanol, fortrinsvis n-propanol og/eller isopropanol, hvor isopropanol er mest foretrukket; - sorbitol; og - mindst én organisk C2-C6-syre; hvor bestanddelenes vægt-% er baseret på totalvægten af den flydende antimikrobielle hudplejesammensætning.
9. Flydende antimikrobiel hudplejesammensætning ifølge krav 1 til 8, hvor den flydende antimikrobielle hudplejesammensætning har et frysepunkt <-15 °C og fortrinsvis har et frysepunkt < -20 °C.
10. Flydende antimikrobiel hudplejesammensætning ifølge krav 1 til 9, hvor den flydende antimikrobielle hudplejesammensætning omfatter ud over mindst én alkalikilde, fortrinsvis valgt fra gruppen, der omfatter alkalimetalhydroxider, alkalimetalsalte, phosphater, aminer og blandinger deraf og mere foretrukket triethanolamin.
11. Flydende antimikrobiel hudplejesammensætning ifølge krav 1 til 10, hvor den flydende antimikrobielle hudplejesammensætning omfatter ud over mindst én hydrotrop, hvor hydrotropen fortrinsvis er valgt fra gruppen, der omfatter aromatisk carbonhydridsulfonat, fortrinsvis xylensulfonat, toluensulfonat, cumensulfonat og/eller n-octansulfonat; eller natrium-, kalium- eller ammoniumsalte deraf eller som salte af organiske ammoniumbaser, og hvor cumensulfonat er mest foretrukket.
12. Flydende antimikrobiel hudplejesammensætning ifølge krav 1 til 11, hvor den flydende antimikrobielle hudplejesammensætning omfatter ud over mindst ét overfladeaktivt middel, fortrinsvis et anionisk overfladeaktivt middel, mere fortrinsvis et C6-Cis-ethersulfat, og hvor et laurylethersulfat med 2 EO er mest foretrukket.
13. Flydende antimikrobiel hudplejesammensætning ifølge krav 1 til 12, hvor den flydende antimikrobielle hudplejesammensætning omfatter: - > 5 vægt-% til < 25 vægt-%, fortrinsvis >10 vægt-% til < 20 vægt-% og mere fortrinsvis >13 vægt-% til < 16 vægt-%, glycerin; - > 0,1 vægt-% til < 20 vægt-%, fortrinsvis > 2 vægt-% til < 10 vægt-% og mere fortrinsvis > 3 vægt-% til < 6 vægt-%, propylenglycol; - > 0,1 vægt-% til < 20 vægt-%, fortrinsvis > 2 vægt-% til < 10 vægt-% og mere fortrinsvis > 3 vægt-% til < 6 vægt-%, af mindst en organisk C2-C6-monoalkohol, fortrinsvis propanol og mere fortrinsvis isopropanol; - > 0,1 vægt-% til < 10 vægt-%, fortrinsvis > 0,5 vægt-% til < 5,0 vægt-% og mere fortrinsvis > 1 vægt-% til < 2,5 vægt-%, sorbitol; - > 0 vægt-% til < 5 vægt-%, fortrinsvis > 0,1 vægt-% til < 3 vægt-%, mere fortrinsvis > 0,5 vægt-% til < 2 vægt-% og mest fortrinsvis > 1 vægt-% til <1,5 vægt-%, af mindst ét overfladeaktivt middel, fortrinsvis et anionisk overfladeaktivt middel, mere fortrinsvis et C6-Ci8-ethersulfat og mest fortrinsvis et laurylethersulfat med 2 EO; - > 0,1 vægt-% til < 15 vægt-%, fortrinsvis > 1 vægt-% til < 12 vægt-%, mere fortrinsvis > 5 vægt-% til < 10 vægt-% og mest fortrinsvis > 6 vægt-% til < 8 vægt-%, af mindst én organisk C2-C6-syre, fortrinsvis mælkesyre; - > 0 vægt-% til < 15 vægt-%, fortrinsvis > 1 vægt-% til < 12 vægt-%, mere fortrinsvis > 5 vægt-% til < 10 vægt-% og mest fortrinsvis > 6 vægt-% til < 8 vægt-%, af mindst én alkalikilde, fortrinsvis triethanolamin; - > 0 vægt-% til < 15 vægt-%, fortrinsvis > 1 vægt-% til < 12 vægt-%, mere fortrinsvis > 5 vægt-% til < 10 vægt-% og mest fortrinsvis > 6 vægt-% til < 8 vægt-%, af mindst én hydrotrop, fortrinsvis et aromatisk carbonhydridsulfonat, xylensulfonat, toluensulfonat, cumensulfonat og/eller n-octansulfonat og mest fortrinsvis cumensulfonat; - > 0 vægt-% til < 30 vægt-%, fortrinsvis > 0,01 vægt-% til < 20 vægt-%, mere fortrinsvis > 1 vægt-% til < 10 vægt-%, endnu mere fortrinsvis > 3 vægt-% til < 8 vægt-% og mest fortrinsvis > 5 vægt-% til < 7 vægt-%, af mindst én chloritgenererende forbindelse, fortrinsvis en alkali- og/eller jordalkalihypochlorit og mere fortrinsvis NaCICh; og - > 0 vægt-% vand, hvor resten fortrinsvis er vand.
14. Flydende antimikrobiel hudplejesammensætning ifølge krav 1 til 13 til anvendelse ved behandling af mastitis hos mælkeproducerende dyr, hvilken anvendelse omfatter påføring, fortrinsvis påsprøjtning, af den flydende antimikrobielle hudplejesammensætning på et dyrs patte
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