DK3030578T3 - Fremgangsmåde til fjernelse af kontaminanter - Google Patents
Fremgangsmåde til fjernelse af kontaminanter Download PDFInfo
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- DK3030578T3 DK3030578T3 DK14833626.6T DK14833626T DK3030578T3 DK 3030578 T3 DK3030578 T3 DK 3030578T3 DK 14833626 T DK14833626 T DK 14833626T DK 3030578 T3 DK3030578 T3 DK 3030578T3
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- DK
- Denmark
- Prior art keywords
- apo
- virus
- solution
- range
- filtration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Claims (12)
1. Fremgangsmåde til oprensning af apolipoprotein A-l (Apo A-l), som omfatter trinene: a) tilvejebringelse af en opløsning, der omfatter Apo A-l og guanidinhydrochlorid (GuHCI); og b) filtrering af opløsningen gennem et filter med en porestørrelse i et interval fra 15 nm til 35 nm, hvor opløsningen omfatter GuHCI ved en koncentration i et interval fra 1,3 til 3,2 M.
2. Fremgangsmåde ifølge krav 1, hvor opløsningen omfatter en Apo A-l-proteinkoncentration i et interval fra 5 til 30 g/l eller fra 5 til 20 g/l eller fra 7 til 12 g/l.
3. Fremgangsmåde ifølge et hvilket som helst af ovennævnte krav, hvor opløsningen omfatter GuHCI ved en koncentration, der reducerer eller hæmmer aggregering af Apo A-l.
4. Fremgangsmåde ifølge krav 3, hvor opløsningen omfatter GuHCI ved en koncentration i et interval fra 1,5 til 2,0 M.
5. Fremgangsmåde ifølge et hvilket som helst af ovennævnte krav, hvor pH i opløsningen er i et interval fra 7,1 til 7,5.
6. Fremgangsmåde ifølge et hvilket som helst af ovennævnte krav, hvor filtrering udføres ved et tryk i et interval fra 0,2 til 3,4 bar og ved en temperatur i et interval fra 18 til 26 °C.
7. Fremgangsmåde ifølge et hvilket som helst af ovennævnte krav, hvor opløsningen fremstilles ved hjælp af et eller flere af trinene: 1) suspension af Apo A-l-præcipitat i 4,0 til 4,6 M GuHCI; og/eller 2) fortynding af suspensionen til en Apo A-l-proteinkoncentration i et interval fra 5 til 30 g/l og/eller til en GuHCI-koncentration i et interval fra 1,3 M til 3,2 M.
8. Fremgangsmåde ifølge krav 1 eller krav 7, hvor der før trin a) udføres et varmebehandlingstrin til virusinaktivering eller efter trin b) udføres et varmebehandlingstrin til virusinaktivering.
9. Fremgangsmåde ifølge krav 8, hvor varmebehandlingen omfatter trinene: justering af pH i opløsningen i et interval fra 6,6 til 8,0; og efterfølgende opvarmning af opløsningen ved en temperatur på 55 til 61 °C i ca. 30 minutter til ca. 4 timer.
10. Fremgangsmåde ifølge krav 9, hvor opløsningen med et pH i intervallet fra 6,6 til 8,0 omfatter en GuHCI-koncentration i et interval fra 2,7 M til 3,9 M.
11. Fremgangsmåde ifølge et hvilket som helst af kravene 9 eller 10, hvor pH i opløsningen med et pH i intervallet fra 6,6 til 8,0 er i et interval fra 7,0 til 8,0.
12. Fremgangsmåde ifølge et hvilket som helst af kravene 9 til 11, hvor opløsningen med et pH i intervallet fra 6,6 til 8,0 fremstilles ved hjælp af trinene: 1) suspension af et Apo A-l-præcipitat i 4,0 til 4,6 M GuHCI; og 2) justering af GuHCI-koncentrationen i et interval fra 2,7 M til 3,9 M og pH i et interval fra 6,6 til 8,0.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13179755 | 2013-08-08 | ||
| PCT/AU2014/000790 WO2015017888A1 (en) | 2013-08-08 | 2014-08-08 | Contaminant removal method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3030578T3 true DK3030578T3 (da) | 2018-10-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| DK14833626.6T DK3030578T3 (da) | 2013-08-08 | 2014-08-08 | Fremgangsmåde til fjernelse af kontaminanter |
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| US (3) | US10087235B2 (da) |
| EP (2) | EP3030578B1 (da) |
| JP (1) | JP6530394B2 (da) |
| KR (1) | KR102437202B1 (da) |
| CN (2) | CN105452291B (da) |
| AU (1) | AU2014305646C1 (da) |
| CA (1) | CA2920391C (da) |
| DK (1) | DK3030578T3 (da) |
| ES (1) | ES2689333T3 (da) |
| HK (1) | HK1225737B (da) |
| NZ (1) | NZ631126A (da) |
| PL (1) | PL3030578T3 (da) |
| WO (1) | WO2015017888A1 (da) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015017888A1 (en) | 2013-08-08 | 2015-02-12 | Csl Limited | Contaminant removal method |
| US20200376444A1 (en) * | 2018-02-19 | 2020-12-03 | Bayer Heal Thcare Llc | Modified Filter Membrane and Method |
| FR3090321B1 (fr) * | 2018-12-21 | 2023-07-14 | Lab Francais Du Fractionnement | Procédé de filtration du fibrinogène |
| US20220175973A1 (en) * | 2019-03-29 | 2022-06-09 | National Institutes for Quantum Science and Technology | Method for producing radiopharmaceutical and radiopharmaceutical |
| CN111351893A (zh) * | 2020-04-28 | 2020-06-30 | 黄河三角洲京博化工研究院有限公司 | 一种利用离子色谱检测盐酸胍样品中胍离子含量的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1335077C (en) | 1988-02-08 | 1995-04-04 | Henri Isliker | Process for the manufacture of apolipoproteins from human blood plasma or serum |
| US5652339A (en) * | 1993-12-31 | 1997-07-29 | Rotkreuzstiftung Zentrallaboratorium | Method of producing reconstituted lipoproteins |
| SE9500724D0 (sv) * | 1994-06-23 | 1995-02-24 | Pharmacia Ab | Filtrering |
| SE9603068D0 (sv) * | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| DE10211632A1 (de) | 2002-03-15 | 2003-10-09 | Aventis Behring Gmbh | Verfahren zur Abtrennung von Viren aus einer Proteinlösung durch Nanofiltration |
| ES2282638T3 (es) | 2002-06-14 | 2007-10-16 | Centocor, Inc. | Uso de un modificador de clatrato para promover el paso de proteinas durante nanofiltracion. |
| NZ582170A (en) * | 2007-08-17 | 2012-02-24 | Csl Behring Gmbh | Methods for purification of alpha-1-antitrypsin and apolipoprotein a-i |
| WO2009036460A2 (en) * | 2007-09-14 | 2009-03-19 | Ambrx, Inc. | Modified human apolipoprotein a-i polypeptides and their uses |
| WO2011044545A2 (en) * | 2009-10-09 | 2011-04-14 | Sigalov Alexander B | Methods and compositions for targeted imaging |
| ES2718234T3 (es) * | 2010-06-30 | 2019-06-28 | Csl Ltd | Una formulación de lipoproteína de alta densidad reconstituida y método de producción de la misma |
| EP3466969B1 (en) * | 2011-02-07 | 2024-05-08 | Abionyx Pharma SA | Lipoprotein complexes and manufacturing and use thereof |
| US9125943B2 (en) | 2012-11-02 | 2015-09-08 | Csl Limited | Reconstituted HDL formulation |
| DK3004160T3 (da) | 2013-06-05 | 2023-01-23 | Csl Ltd | Fremgangsmåde til fremstilling af apolipoprotein a-i (apo a-i) |
| WO2015017888A1 (en) * | 2013-08-08 | 2015-02-12 | Csl Limited | Contaminant removal method |
| CN104017076B (zh) * | 2014-01-06 | 2016-07-06 | 宁波博泰生物技术有限公司 | 载脂蛋白aⅰ抗血清的制备方法 |
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2014
- 2014-08-08 WO PCT/AU2014/000790 patent/WO2015017888A1/en not_active Ceased
- 2014-08-08 KR KR1020167006225A patent/KR102437202B1/ko active Active
- 2014-08-08 PL PL14833626T patent/PL3030578T3/pl unknown
- 2014-08-08 ES ES14833626.6T patent/ES2689333T3/es active Active
- 2014-08-08 NZ NZ631126A patent/NZ631126A/en unknown
- 2014-08-08 CN CN201480044463.6A patent/CN105452291B/zh active Active
- 2014-08-08 EP EP14833626.6A patent/EP3030578B1/en active Active
- 2014-08-08 AU AU2014305646A patent/AU2014305646C1/en active Active
- 2014-08-08 EP EP18180083.0A patent/EP3418290A1/en not_active Withdrawn
- 2014-08-08 JP JP2016532164A patent/JP6530394B2/ja active Active
- 2014-08-08 CN CN201910195678.2A patent/CN109701004B/zh active Active
- 2014-08-08 HK HK16113663.1A patent/HK1225737B/en unknown
- 2014-08-08 US US14/910,424 patent/US10087235B2/en active Active
- 2014-08-08 DK DK14833626.6T patent/DK3030578T3/da active
- 2014-08-08 CA CA2920391A patent/CA2920391C/en active Active
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2018
- 2018-07-20 US US16/041,239 patent/US10730927B2/en active Active
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- 2020-07-31 US US16/945,312 patent/US11732028B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11732028B2 (en) | 2023-08-22 |
| JP2016528233A (ja) | 2016-09-15 |
| EP3418290A1 (en) | 2018-12-26 |
| US20210147509A1 (en) | 2021-05-20 |
| AU2014305646A1 (en) | 2016-02-18 |
| HK1225737B (en) | 2017-09-15 |
| US20160176947A1 (en) | 2016-06-23 |
| US20190119354A1 (en) | 2019-04-25 |
| NZ631126A (en) | 2018-06-29 |
| CN109701004B (zh) | 2022-11-08 |
| WO2015017888A8 (en) | 2015-10-01 |
| KR102437202B1 (ko) | 2022-08-29 |
| CA2920391C (en) | 2023-03-28 |
| US10730927B2 (en) | 2020-08-04 |
| CN105452291B (zh) | 2019-03-19 |
| EP3030578A4 (en) | 2017-04-26 |
| EP3030578A1 (en) | 2016-06-15 |
| KR20160040299A (ko) | 2016-04-12 |
| CN109701004A (zh) | 2019-05-03 |
| US10087235B2 (en) | 2018-10-02 |
| ES2689333T3 (es) | 2018-11-13 |
| PL3030578T3 (pl) | 2018-12-31 |
| WO2015017888A1 (en) | 2015-02-12 |
| EP3030578B1 (en) | 2018-07-04 |
| AU2014305646B2 (en) | 2018-06-14 |
| CA2920391A1 (en) | 2015-02-12 |
| CN105452291A (zh) | 2016-03-30 |
| AU2014305646C1 (en) | 2019-01-17 |
| JP6530394B2 (ja) | 2019-06-12 |
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