DK3019153T3 - Tørpulverformulering omfattende et antikolinergikum, et corticosteroid og et beta-adrenergikum til indgivelse ved inhalation - Google Patents
Tørpulverformulering omfattende et antikolinergikum, et corticosteroid og et beta-adrenergikum til indgivelse ved inhalation Download PDFInfo
- Publication number
- DK3019153T3 DK3019153T3 DK14747855.6T DK14747855T DK3019153T3 DK 3019153 T3 DK3019153 T3 DK 3019153T3 DK 14747855 T DK14747855 T DK 14747855T DK 3019153 T3 DK3019153 T3 DK 3019153T3
- Authority
- DK
- Denmark
- Prior art keywords
- particles
- dry powder
- powder formulation
- fraction
- formulation according
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 89
- 238000009472 formulation Methods 0.000 title claims description 70
- 239000000843 powder Substances 0.000 title claims description 52
- 230000001078 anti-cholinergic effect Effects 0.000 title description 10
- 239000003246 corticosteroid Substances 0.000 title description 6
- 239000002245 particle Substances 0.000 claims description 148
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 74
- 239000004480 active ingredient Substances 0.000 claims description 47
- 239000010419 fine particle Substances 0.000 claims description 39
- 235000019359 magnesium stearate Nutrition 0.000 claims description 37
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 30
- 238000002156 mixing Methods 0.000 claims description 29
- 239000011362 coarse particle Substances 0.000 claims description 26
- 238000009826 distribution Methods 0.000 claims description 26
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 21
- 239000011248 coating agent Substances 0.000 claims description 20
- 238000000576 coating method Methods 0.000 claims description 20
- 229940112141 dry powder inhaler Drugs 0.000 claims description 17
- 238000011282 treatment Methods 0.000 claims description 17
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 15
- 229950000210 beclometasone dipropionate Drugs 0.000 claims description 15
- 230000008569 process Effects 0.000 claims description 14
- VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 claims description 13
- 229960002462 glycopyrronium bromide Drugs 0.000 claims description 12
- 229960003610 formoterol fumarate dihydrate Drugs 0.000 claims description 10
- RATSWNOMCHFQGJ-TUYNVFRMSA-N (e)-but-2-enedioic acid;n-[2-hydroxy-5-[(1s)-1-hydroxy-2-[[(2s)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide;dihydrate Chemical compound O.O.OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 RATSWNOMCHFQGJ-TUYNVFRMSA-N 0.000 claims description 9
- 230000002265 prevention Effects 0.000 claims description 9
- 208000023504 respiratory system disease Diseases 0.000 claims description 8
- 230000002757 inflammatory effect Effects 0.000 claims description 7
- 230000000414 obstructive effect Effects 0.000 claims description 3
- 230000004927 fusion Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 238000004833 X-ray photoelectron spectroscopy Methods 0.000 description 11
- 201000010099 disease Diseases 0.000 description 11
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 9
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 8
- 208000006673 asthma Diseases 0.000 description 8
- 229960001375 lactose Drugs 0.000 description 8
- 239000008101 lactose Substances 0.000 description 8
- 239000003814 drug Substances 0.000 description 6
- 239000011777 magnesium Substances 0.000 description 6
- 238000003801 milling Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 208000027866 inflammatory disease Diseases 0.000 description 5
- 229940125389 long-acting beta agonist Drugs 0.000 description 5
- 238000004626 scanning electron microscopy Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- PZSMUPGANZGPBF-UHFFFAOYSA-N 4-[5-(dithiolan-3-yl)pentanoylamino]butanoic acid Chemical compound OC(=O)CCCNC(=O)CCCCC1CCSS1 PZSMUPGANZGPBF-UHFFFAOYSA-N 0.000 description 4
- 239000000556 agonist Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 229960002848 formoterol Drugs 0.000 description 4
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- 208000027771 Obstructive airways disease Diseases 0.000 description 3
- 239000000048 adrenergic agonist Substances 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 3
- 238000012512 characterization method Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000000151 deposition Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000005713 exacerbation Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 210000003918 fraction a Anatomy 0.000 description 3
- 229940125369 inhaled corticosteroids Drugs 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 244000020998 Acacia farnesiana Species 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010061818 Disease progression Diseases 0.000 description 2
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 2
- 208000011623 Obstructive Lung disease Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 208000037883 airway inflammation Diseases 0.000 description 2
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229940124630 bronchodilator Drugs 0.000 description 2
- 239000000168 bronchodilator agent Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000000812 cholinergic antagonist Substances 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- -1 cyclopentylhydroxyphenylacetyl Chemical group 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 230000001627 detrimental effect Effects 0.000 description 2
- 230000005750 disease progression Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000013020 final formulation Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- VPNYRYCIDCJBOM-QQTWVUFVSA-M (2R,3S)-glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CC[C@@H]1OC(=O)[C@](O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-QQTWVUFVSA-M 0.000 description 1
- NWLPAIVRIWBEIT-SEPHDYHBSA-N (e)-but-2-enedioic acid;dihydrate Chemical compound O.O.OC(=O)\C=C\C(O)=O NWLPAIVRIWBEIT-SEPHDYHBSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229910018089 Al Ka Inorganic materials 0.000 description 1
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 206010006448 Bronchiolitis Diseases 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- 206010009126 Chronic respiratory failure Diseases 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000022120 Jeavons syndrome Diseases 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
- ANGKOCUUWGHLCE-HKUYNNGSSA-N [(3s)-1,1-dimethylpyrrolidin-1-ium-3-yl] (2r)-2-cyclopentyl-2-hydroxy-2-phenylacetate Chemical class C1[N+](C)(C)CC[C@@H]1OC(=O)[C@](O)(C=1C=CC=CC=1)C1CCCC1 ANGKOCUUWGHLCE-HKUYNNGSSA-N 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 description 1
- 238000012387 aerosolization Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001022 anti-muscarinic effect Effects 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 description 1
- 102000014974 beta2-adrenergic receptor activity proteins Human genes 0.000 description 1
- 108040006828 beta2-adrenergic receptor activity proteins Proteins 0.000 description 1
- 201000009267 bronchiectasis Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229940001468 citrate Drugs 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 229940125782 compound 2 Drugs 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000007771 core particle Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- DYDNPESBYVVLBO-UHFFFAOYSA-N formanilide Chemical compound O=CNC1=CC=CC=C1 DYDNPESBYVVLBO-UHFFFAOYSA-N 0.000 description 1
- 229940015042 glycopyrrolate Drugs 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- GPGMRSSBVJNWRA-UHFFFAOYSA-N hydrochloride hydrofluoride Chemical compound F.Cl GPGMRSSBVJNWRA-UHFFFAOYSA-N 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000010902 jet-milling Methods 0.000 description 1
- 229940001447 lactate Drugs 0.000 description 1
- 229960001021 lactose monohydrate Drugs 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 229940125386 long-acting bronchodilator Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000009115 maintenance therapy Methods 0.000 description 1
- 238000011418 maintenance treatment Methods 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 208000024696 nocturnal asthma Diseases 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000001050 pharmacotherapy Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000013074 reference sample Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 201000004193 respiratory failure Diseases 0.000 description 1
- 238000001878 scanning electron micrograph Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012453 solvate Chemical group 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 229950000339 xinafoate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Reciprocating Pumps (AREA)
Claims (11)
1. Tørpulverformulering til anvendelse i en tørpulverinhalator (DPI) til afgivelse ved inhalation af en kombination af mikroniserede partikler af glycopyrronium-bromid, beclometasondipropionat og formoterolfumaratdihydrat som aktive bestanddele i en kombineret terapeutisk virksom dosis på 100 til 500 pg, hvor formuleringen omfatter: a) en fraktion af fine partikler bestående af en blanding på 90 til 99,5 vægtprocent af mikroniserede partikler af et fysiologisk acceptabelt hjælpestof og 0,5 til 10 vægtprocent magnesiumstearat, hvor mindst 90 % af alle partiklerne har en volumendiameter på mindre end 12 mikron, den gennemsnitlige volumendiameter af partiklerne er på 3 til 7 mikron, og ikke mere end 10 % af partiklerne har en diameter, der er lavere end 1,5 mikron; b) en fraktion af grove partikler bestående af et fysiologisk acceptabelt hjælpestof, der har en gennemsnitlig massediameter, der er lig med eller højere end 175 mikron, hvor forholdet mellem de fine partikler a) og de grove partikler b) er mellem 1:99 og 30:70 vægtprocent; hvor mindst 90 % af alle mikroniserede partikler af de aktive bestanddele har en volumendiameter, der er lavere end 6,0 mikron, deres gennemsnitlige volumendiameter er mellem 1,2 og 2,5 mikron og bredden af deres partikelstørrelsesfordeling, udtrykt som et spænd, ligger mellem 1,2 og 3,0; hvor formuleringen opnås ved en fremgangsmåde omfattende de følgende trin: i) at fremstille fraktionen af fine partikler a) ved co-blanding i en højenergiindretning i en periode på mindre end 20 minutter, ii) at blande fraktionen af fine partikler a), fraktionen af grove partikler b) og alle de mikroniserede aktive bestanddele.
2. Tørpulverformulering ifølge krav 1, hvor de fine partikler a) co-blandes i et tidsrum på mellem 2 og 15 minutter.
3. Tørpulverformulering ifølge krav 1 eller 2, hvor mindst 90 % af de mikroniserede partikler af de aktive bestanddele har en volumendiameter, der er lig med eller lavere end 5,0 mikron.
4. Tørpulverformulering ifølge krav 3, hvor den gennemsnitlige volumendiameter af partiklerne ligger mellem 1,3 og 2,2 mikron.
5. Tørpulverformulering ifølge et af kravene 1 til 4, hvor magnesiumstearat dækker overfladen af de overskydende partikler a) på en sådan måde, at overfladebelægningens omfang er mindst 50%.
6. Tørpulverformulering ifølge krav 5, hvor højenergi-indretningen er en me-chano-fusionsindretning.
7. Tørpulverformulering ifølge et af de foregående krav, hvor forholdet mellem de fine partikler a) og de grove partikler b) ligger mellem 5:95 og 15:85 vægtprocent.
8. Tørpulverformulering ifølge et af de foregående krav, hvor diameteren af de grove partikler b) ligger mellem 210 og 355 mikron.
9. Tørpulverinhalatorindretning omfattende en tørpulverformulering ifølge et af kravene 1 til 8.
10. Tørpulverformulering ifølge et af kravene 1 til 8 til anvendelse ved forebyggelse og/eller behandling af en inflammatorisk eller obstruktiv luftvejssygdom.
11. Tørpulverformulering ifølge krav 10, hvor den inflammatoriske og/eller ob-struktive luftvejssygdom er kronisk obstruktiv lungesygdom (COPD).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13176114 | 2013-07-11 | ||
| EP13194763 | 2013-11-28 | ||
| PCT/EP2014/064824 WO2015004243A1 (en) | 2013-07-11 | 2014-07-10 | Dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic for administration by inhalation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3019153T3 true DK3019153T3 (da) | 2018-11-19 |
Family
ID=51292914
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14747855.6T DK3019153T3 (da) | 2013-07-11 | 2014-07-10 | Tørpulverformulering omfattende et antikolinergikum, et corticosteroid og et beta-adrenergikum til indgivelse ved inhalation |
| DK19182016.6T DK3569222T3 (da) | 2013-07-11 | 2014-07-10 | Tørpulverformulering omfattende en anticholinergikum, en corticosteroid og en beta-andrenergikum til indgivelse ved inhalering |
| DK18178893.6T DK3409270T3 (da) | 2013-07-11 | 2014-07-10 | Tørpulverformulering omfattende et antikolinergikum, et corticosteroid og et beta-adrenergikum til indgivelse ved inhalation |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19182016.6T DK3569222T3 (da) | 2013-07-11 | 2014-07-10 | Tørpulverformulering omfattende en anticholinergikum, en corticosteroid og en beta-andrenergikum til indgivelse ved inhalering |
| DK18178893.6T DK3409270T3 (da) | 2013-07-11 | 2014-07-10 | Tørpulverformulering omfattende et antikolinergikum, et corticosteroid og et beta-adrenergikum til indgivelse ved inhalation |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US9402825B2 (da) |
| EP (3) | EP3019153B1 (da) |
| JP (1) | JP6426167B2 (da) |
| KR (2) | KR20160029797A (da) |
| CN (1) | CN105338960B (da) |
| AR (1) | AR129501A2 (da) |
| AU (1) | AU2014289185B2 (da) |
| BR (1) | BR112015030914B1 (da) |
| CA (1) | CA2917752C (da) |
| CL (1) | CL2016000028A1 (da) |
| CY (2) | CY1120806T1 (da) |
| DK (3) | DK3019153T3 (da) |
| EA (1) | EA029125B1 (da) |
| ES (3) | ES2699986T3 (da) |
| FI (1) | FI3569222T3 (da) |
| GE (1) | GEP20186853B (da) |
| HR (3) | HRP20241300T1 (da) |
| HU (3) | HUE039827T2 (da) |
| IL (1) | IL243507A0 (da) |
| LT (3) | LT3409270T (da) |
| MX (1) | MX2016000290A (da) |
| MY (1) | MY176176A (da) |
| NZ (1) | NZ715797A (da) |
| PE (2) | PE20212110A1 (da) |
| PH (1) | PH12016500043B1 (da) |
| PL (3) | PL3409270T3 (da) |
| PT (1) | PT3019153T (da) |
| RS (3) | RS65951B1 (da) |
| SA (1) | SA516370373B1 (da) |
| SG (1) | SG11201600110RA (da) |
| SI (3) | SI3409270T1 (da) |
| TN (1) | TN2016000007A1 (da) |
| TW (1) | TWI642450B (da) |
| UA (1) | UA116907C2 (da) |
| WO (1) | WO2015004243A1 (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12012501066A1 (en) * | 2009-12-23 | 2016-03-02 | Chiesi Farm Spa | Combination therapy for copd |
| EP3527197B1 (en) * | 2012-01-25 | 2022-09-07 | Chiesi Farmaceutici S.p.A. | Dry powder formulation comprising a corticosteroid and a beta-adrenergic for administration by inhalation |
| EP3019153B1 (en) * | 2013-07-11 | 2018-09-05 | Chiesi Farmaceutici S.p.A. | Dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic for administration by inhalation |
| GB201321717D0 (en) * | 2013-12-09 | 2014-01-22 | Pharmachemie Bv | Inhalable Medicaments |
| US9554992B2 (en) | 2014-06-09 | 2017-01-31 | Chiesi Farmaceutici S.P.A. | Inhalation particles comprising a combination of an anticholinergic, a corticosteroid and a beta-adrenergic |
| TR201407010A2 (tr) | 2014-06-16 | 2015-12-21 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Vilanterol formülasyonları. |
| JP6600961B2 (ja) * | 2015-03-30 | 2019-11-06 | ブラザー工業株式会社 | 表示制御装置、表示制御方法及び記憶媒体 |
| AU2015393953B2 (en) * | 2015-05-01 | 2021-09-02 | Board Of Regents, The University Of Texas System | Multidrug brittle matrix compositions |
| DK3689379T3 (da) * | 2015-11-16 | 2021-09-06 | Chiesi Farm Spa | Fremgangsmåde til fremstilling af en tørpulverformulering omfattende et anticholinergikum, et corticosteroid og et beta-adrenergikum |
| PT3628331T (pt) * | 2015-11-16 | 2021-10-20 | Chiesi Farm Spa | Processo para preparar uma formulação de pó seco que compreende um anticolinérgico, um corticosteroide e um beta-adrenérgico |
| DE202017007678U1 (de) | 2016-11-10 | 2024-02-27 | Medisca Pharmaceutique Inc. | System zur pharmazeutischen Zubereitung |
| CA3060020A1 (en) * | 2017-05-11 | 2018-11-15 | Chiesi Farmaceutici S.P.A. | A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic |
| CA3059824A1 (en) | 2017-05-11 | 2018-11-15 | Chiesi Farmaceutici S.P.A. | A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic |
| CN109200034A (zh) * | 2017-06-30 | 2019-01-15 | 正大天晴药业集团股份有限公司 | 一种可吸入干粉形式的组合物及其制备方法 |
| WO2019060595A1 (en) | 2017-09-20 | 2019-03-28 | Teva Branded Pharmaceutical Products R&D, Inc. | INHALABLE DRY POWDER MEDICINAL PRODUCT COMPRISING GLYCOPYRRONIUM |
| AU2020356243A1 (en) * | 2019-09-24 | 2022-03-24 | Chiesi Farmaceutici S.P.A. | Novel carrier particles for dry powder formulations for inhalation |
| US12029709B2 (en) * | 2022-08-11 | 2024-07-09 | De Motu Cordis Pty Ltd | Inhalable epinephrine formulation |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070212422A1 (en) * | 1999-11-10 | 2007-09-13 | Manfred Keller | Dry powder for inhalation |
| CA2347856C (en) * | 1998-11-13 | 2009-02-17 | Jago Research Ag | Dry powder for inhalation |
| PE20011227A1 (es) | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
| GB0015043D0 (en) | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Medicament dispenser |
| JP5698423B2 (ja) * | 2000-06-27 | 2015-04-08 | ベクトゥラ・リミテッド | 医薬組成物で使用するための粒子の製造法 |
| PT1920763E (pt) * | 2000-11-30 | 2014-06-25 | Vectura Ltd | Composições farmacêuticas para inalação |
| PT1386630E (pt) | 2002-07-31 | 2006-09-29 | Chiesi Farma Spa | Inalador em po |
| JO3102B1 (ar) * | 2004-03-17 | 2017-09-20 | Chiesi Framaceutici S P A | صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة |
| GB0425758D0 (en) * | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| GB0613161D0 (en) | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
| EP1944018A1 (en) * | 2007-01-10 | 2008-07-16 | CHIESI FARMACEUTICI S.p.A. | Micronised particles of low-dosage strength active agents for powder formulations for inhalation |
| PH12012501066A1 (en) * | 2009-12-23 | 2016-03-02 | Chiesi Farm Spa | Combination therapy for copd |
| KR101738712B1 (ko) | 2009-12-23 | 2017-05-22 | 키에시 파르마슈티시 엣스. 피. 에이. | Ｃｏｐｄ용 조합요법 |
| TR201000681A2 (tr) | 2010-01-29 | 2011-08-22 | B�Lg�� Mahmut | İnhalasyon yoluyla alınan kuru toz formülasyonları. |
| AU2011234751B2 (en) * | 2010-04-01 | 2016-03-17 | Chiesi Farmaceutici S.P.A. | Process for preparing carrier particles for dry powders for inhalation |
| RU2580312C2 (ru) * | 2010-04-21 | 2016-04-10 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Способ получения частиц с пониженным электростатическим зарядом |
| EP2585047A1 (en) * | 2010-06-22 | 2013-05-01 | Chiesi Farmaceutici S.p.A. | Dry powder formulation comprising an antimuscarinic drug |
| EP3527197B1 (en) | 2012-01-25 | 2022-09-07 | Chiesi Farmaceutici S.p.A. | Dry powder formulation comprising a corticosteroid and a beta-adrenergic for administration by inhalation |
| US9393202B2 (en) | 2013-04-26 | 2016-07-19 | Chiesi Farmaceutici S.P.A | Particle size reduction of an antimuscarinic compound |
| EP3019153B1 (en) * | 2013-07-11 | 2018-09-05 | Chiesi Farmaceutici S.p.A. | Dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic for administration by inhalation |
-
2014
- 2014-07-10 EP EP14747855.6A patent/EP3019153B1/en active Active
- 2014-07-10 ES ES14747855T patent/ES2699986T3/es active Active
- 2014-07-10 SI SI201431806T patent/SI3409270T1/sl unknown
- 2014-07-10 PT PT14747855T patent/PT3019153T/pt unknown
- 2014-07-10 GE GEAP201414032A patent/GEP20186853B/en unknown
- 2014-07-10 CA CA2917752A patent/CA2917752C/en active Active
- 2014-07-10 ES ES18178893T patent/ES2867552T3/es active Active
- 2014-07-10 HU HUE14747855A patent/HUE039827T2/hu unknown
- 2014-07-10 TN TN2016000007A patent/TN2016000007A1/en unknown
- 2014-07-10 HR HRP20241300TT patent/HRP20241300T1/hr unknown
- 2014-07-10 US US14/327,920 patent/US9402825B2/en active Active
- 2014-07-10 SI SI201430976T patent/SI3019153T1/sl unknown
- 2014-07-10 KR KR1020167000719A patent/KR20160029797A/ko not_active Ceased
- 2014-07-10 HU HUE18178893A patent/HUE053957T2/hu unknown
- 2014-07-10 DK DK14747855.6T patent/DK3019153T3/da active
- 2014-07-10 CN CN201480037266.1A patent/CN105338960B/zh active Active
- 2014-07-10 BR BR112015030914-3A patent/BR112015030914B1/pt active IP Right Grant
- 2014-07-10 ES ES19182016T patent/ES2986128T3/es active Active
- 2014-07-10 LT LTEP18178893.6T patent/LT3409270T/lt unknown
- 2014-07-10 RS RS20241002A patent/RS65951B1/sr unknown
- 2014-07-10 HR HRP20182008TT patent/HRP20182008T1/hr unknown
- 2014-07-10 SG SG11201600110RA patent/SG11201600110RA/en unknown
- 2014-07-10 PE PE2021000280A patent/PE20212110A1/es unknown
- 2014-07-10 AU AU2014289185A patent/AU2014289185B2/en active Active
- 2014-07-10 TW TW103123763A patent/TWI642450B/zh active
- 2014-07-10 JP JP2016524826A patent/JP6426167B2/ja active Active
- 2014-07-10 NZ NZ715797A patent/NZ715797A/en unknown
- 2014-07-10 FI FIEP19182016.6T patent/FI3569222T3/fi active
- 2014-07-10 RS RS20181254A patent/RS57799B1/sr unknown
- 2014-07-10 PL PL18178893T patent/PL3409270T3/pl unknown
- 2014-07-10 PL PL14747855T patent/PL3019153T3/pl unknown
- 2014-07-10 WO PCT/EP2014/064824 patent/WO2015004243A1/en not_active Ceased
- 2014-07-10 DK DK19182016.6T patent/DK3569222T3/da active
- 2014-07-10 DK DK18178893.6T patent/DK3409270T3/da active
- 2014-07-10 EA EA201690006A patent/EA029125B1/ru unknown
- 2014-07-10 EP EP19182016.6A patent/EP3569222B1/en active Active
- 2014-07-10 EP EP18178893.6A patent/EP3409270B1/en active Active
- 2014-07-10 PL PL19182016.6T patent/PL3569222T3/pl unknown
- 2014-07-10 PE PE2016000025A patent/PE20160372A1/es unknown
- 2014-07-10 HU HUE19182016A patent/HUE068270T2/hu unknown
- 2014-07-10 MY MYPI2016000023A patent/MY176176A/en unknown
- 2014-07-10 LT LTEP19182016.6T patent/LT3569222T/lt unknown
- 2014-07-10 MX MX2016000290A patent/MX2016000290A/es active IP Right Grant
- 2014-07-10 RS RS20210320A patent/RS61652B1/sr unknown
- 2014-07-10 KR KR1020217018070A patent/KR102275904B1/ko active Active
- 2014-07-10 SI SI201432094T patent/SI3569222T1/sl unknown
- 2014-07-10 UA UAA201600204A patent/UA116907C2/uk unknown
- 2014-07-10 LT LTEP14747855.6T patent/LT3019153T/lt unknown
-
2016
- 2016-01-07 IL IL243507A patent/IL243507A0/en active IP Right Grant
- 2016-01-07 PH PH12016500043A patent/PH12016500043B1/en unknown
- 2016-01-07 SA SA516370373A patent/SA516370373B1/ar unknown
- 2016-01-08 CL CL2016000028A patent/CL2016000028A1/es unknown
- 2016-05-20 US US15/160,593 patent/US9808422B2/en active Active
-
2018
- 2018-11-01 CY CY181101132T patent/CY1120806T1/el unknown
-
2021
- 2021-03-12 CY CY20211100219T patent/CY1123937T1/el unknown
- 2021-05-06 HR HRP20210704TT patent/HRP20210704T1/hr unknown
-
2023
- 2023-06-01 AR ARP230101391A patent/AR129501A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3019153T3 (da) | Tørpulverformulering omfattende et antikolinergikum, et corticosteroid og et beta-adrenergikum til indgivelse ved inhalation | |
| US10772896B2 (en) | Process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic | |
| US10959944B2 (en) | Process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic | |
| HK1218712B (zh) | 用於吸入施用的包含抗胆硷能药、皮质类固醇和β-肾上腺素能药的干粉制剂 | |
| HK1255959A1 (en) | A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic |