DK3068406T3 - Gensidigt prodrug omfattende kortkædede fedtsyrer og zebularin eller 1'-cyano-cytarabin til kræftbehandling - Google Patents
Gensidigt prodrug omfattende kortkædede fedtsyrer og zebularin eller 1'-cyano-cytarabin til kræftbehandling Download PDFInfo
- Publication number
- DK3068406T3 DK3068406T3 DK14862419.0T DK14862419T DK3068406T3 DK 3068406 T3 DK3068406 T3 DK 3068406T3 DK 14862419 T DK14862419 T DK 14862419T DK 3068406 T3 DK3068406 T3 DK 3068406T3
- Authority
- DK
- Denmark
- Prior art keywords
- zebularin
- cytarabine
- cyano
- cancer treatment
- including short
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 229960000684 cytarabine Drugs 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361904064P | 2013-11-14 | 2013-11-14 | |
| PCT/KR2014/010972 WO2015072784A1 (en) | 2013-11-14 | 2014-11-14 | Mutual prodrug comprising short chain fatty acids and zebularine or 1'-cyano-cytarabine for cancer treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3068406T3 true DK3068406T3 (da) | 2020-03-30 |
Family
ID=53057653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14862419.0T DK3068406T3 (da) | 2013-11-14 | 2014-11-14 | Gensidigt prodrug omfattende kortkædede fedtsyrer og zebularin eller 1'-cyano-cytarabin til kræftbehandling |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10500224B2 (da) |
| EP (1) | EP3068406B1 (da) |
| JP (1) | JP6215484B2 (da) |
| KR (1) | KR101869940B1 (da) |
| CN (1) | CN105705150B (da) |
| AU (1) | AU2014349328A1 (da) |
| BR (1) | BR112016008934B1 (da) |
| CA (1) | CA2926909A1 (da) |
| DK (1) | DK3068406T3 (da) |
| ES (1) | ES2778524T3 (da) |
| HU (1) | HUE048844T2 (da) |
| MX (1) | MX2016005900A (da) |
| PL (1) | PL3068406T3 (da) |
| WO (1) | WO2015072784A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016195353A1 (en) * | 2015-06-01 | 2016-12-08 | Kainos Medicine, Inc. | A use of 1'-cyano-cytarabine for cancer treatment |
| WO2017158396A1 (en) * | 2016-03-16 | 2017-09-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cytidine deaminase inhibitors for the treatment of pancreatic cancer |
| RU2748103C1 (ru) * | 2019-12-13 | 2021-05-19 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Средство для ингибирования фермента тирозил-ДНК-фосфодиэстеразы 1 человека на основе производных пентафуранозилнуклеозидов |
| CN113387954B (zh) * | 2020-03-11 | 2024-03-19 | 上海特化医药科技有限公司 | 一种瑞德西韦中间体的制备方法 |
| WO2024169774A2 (en) * | 2023-02-17 | 2024-08-22 | Ascletis BioScience Co., Ltd | Nucleoside and nucleotide analogs, methods of making and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1297398A (da) * | 1969-08-06 | 1972-11-22 | ||
| US5736531A (en) * | 1987-10-28 | 1998-04-07 | Pro-Neuron, Inc. | Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides |
| JPH07109289A (ja) | 1993-08-18 | 1995-04-25 | Yamasa Shoyu Co Ltd | 1’位炭素置換ピリミジンヌクレオシドおよびその製造法 |
| EP1418949B1 (en) | 2001-07-31 | 2013-06-19 | THE STATE OF OREGON acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF OREGON | Inhibitor of dna methylation |
| WO2012008845A1 (en) | 2010-07-13 | 2012-01-19 | Clavis Pharma Asa | Parenteral formulations of elacytarabine derivatives |
-
2014
- 2014-11-14 HU HUE14862419A patent/HUE048844T2/hu unknown
- 2014-11-14 DK DK14862419.0T patent/DK3068406T3/da active
- 2014-11-14 WO PCT/KR2014/010972 patent/WO2015072784A1/en not_active Ceased
- 2014-11-14 BR BR112016008934-0A patent/BR112016008934B1/pt active IP Right Grant
- 2014-11-14 ES ES14862419T patent/ES2778524T3/es active Active
- 2014-11-14 JP JP2016554157A patent/JP6215484B2/ja active Active
- 2014-11-14 US US15/029,852 patent/US10500224B2/en active Active
- 2014-11-14 KR KR1020167015696A patent/KR101869940B1/ko active Active
- 2014-11-14 CA CA2926909A patent/CA2926909A1/en active Pending
- 2014-11-14 EP EP14862419.0A patent/EP3068406B1/en active Active
- 2014-11-14 MX MX2016005900A patent/MX2016005900A/es unknown
- 2014-11-14 CN CN201480060553.4A patent/CN105705150B/zh active Active
- 2014-11-14 PL PL14862419T patent/PL3068406T3/pl unknown
- 2014-11-14 AU AU2014349328A patent/AU2014349328A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20160079886A (ko) | 2016-07-06 |
| CN105705150A (zh) | 2016-06-22 |
| JP2016540829A (ja) | 2016-12-28 |
| US10500224B2 (en) | 2019-12-10 |
| EP3068406A1 (en) | 2016-09-21 |
| ES2778524T3 (es) | 2020-08-10 |
| BR112016008934A2 (da) | 2017-08-01 |
| AU2014349328A1 (en) | 2016-06-30 |
| HUE048844T2 (hu) | 2020-12-28 |
| EP3068406A4 (en) | 2017-04-12 |
| KR101869940B1 (ko) | 2018-06-21 |
| WO2015072784A1 (en) | 2015-05-21 |
| CA2926909A1 (en) | 2015-05-21 |
| US20160228562A1 (en) | 2016-08-11 |
| MX2016005900A (es) | 2016-07-13 |
| EP3068406B1 (en) | 2020-01-08 |
| BR112016008934B1 (pt) | 2022-11-08 |
| JP6215484B2 (ja) | 2017-10-18 |
| PL3068406T3 (pl) | 2020-08-10 |
| CN105705150B (zh) | 2021-03-23 |
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